The Scripps Research Institute - At The Forefront

July 2014

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Focus on:
Learning More about a Promising Cancer Drug Candidate

Chemists at The Scripps Research Institute (TSRI) discovered a flaw in the published structure of a highly promising anticancer compound approved by the U.S. Food and Drug Administration (FDA) for clinical trials in cancer patients.

They then
identified the correct structure of the molecule, which has shown potent anticancer effects in animals and could lead to new therapeutic approaches to treating cancer.

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Peter Kuhn

A new report shows the structure of a promising anticancer compound, TIC10, differs subtly but importantly from a previously published version.

TSRI's collaborative approach to research is finding new approaches to treat and cure diseases like Alzheimer's and cancer that affect millions of people every day. Help us continue this groundbreaking work.

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Marisa Roberto

“This result was completely unexpected when we started this research,” says Professor Joel Buxbaum.

milestones in medical science:
An Unlikely Stress Responder May Protect Against Alzheimer's

Currently, one in nine Americans over the age of 65 has Alzheimer's disease, and there is no known cure or effective treatment. However, in surprising new findings, TSRI scientists have discovered that transthyretin (TTR), a protein that is produced in the liver and some areas of the brain, can bind together the beta-amyloid proteins associated with Alzheimer's and ultimately lessen the amount of that protein in the brains of those with the disease.

The results suggest that drugs that can boost the protein's production in neurons could one day help ward off Alzheimer's disease.

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Srini Subramaniam

“This is a critical building block that regulates a fundamental process – memory,” said TSRI Associate Professor Kirill Martemyanov of a protein known as RGS7.

Other News:
A New Protein Complex Key to Learning and Memory

Scientists from Scripps Florida identified a protein complex that plays a critical but previously unknown role in learning and memory formation.

The team looked at a protein in the hippocampus, a small part of the brain that helps turn short-term memory into long-term memory and found that it helps regulate a key signaling cascade that is increasingly seen as critical to cognitive development. The findings could help develop new therapies to treat neuropsychiatric conditions such as drug addiction and Down's syndrome.

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TSRI's Class of 2014: “Anything Is Possible”

The Scripps Research Institute graduating class of 2014 includes 38 new biology/chemistry PhDs. While pursuing a degree at TSRI, graduate students get to focus primarily on research that has the potential to change the medical field.

They work closely with their professors and principal investigators on this research, while also learning necessary skills like how to write research grants. Watch three of them speak about their experiences at TSRI and what the program meant to them

facts & figures

Approximately 1,600 Americans die of cancer each day, according to the American Cancer Society.

The Scripps Research Institute

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