The Scripps Research Institute - At The Forefront

April 2014

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Focus on:
A Deadly Immune System “Storm”

A little-understood immune system overreaction to the flu, known as a “cytokine storm,” can sometimes lead to deadly fluid buildup in the lungs. The cytokine storm is now seen as likely playing a role in the 1918-20 “Spanish flu” – which killed more than 50 million people worldwide, as well as the H1N1 “swine flu” and H5N1 “bird flu” of recent years.

Scientists at The Scripps Research Institute (TSRI) have
mapped key elements of this deadly immune response and identified an anti-inflammatory drug that successfully prevents the reaction in animals.

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Peter Kuhn

Professor Michael B. A. Oldstone, Professor Hugh Rosen and Assistant Professor John Teijaro (left to right) were among the authors of the new study.

TSRI's collaborative approach to research leads to groundbreaking discoveries to help treat and cure diseases ranging from the flu to Alzheimer's. Help us continue our life-saving work.

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Marisa Roberto

TSRI Professor Jeff Kelly

milestones in medical science:
A Technique that Could Help Treat Alzheimer's and Parkinson's

Protein misfolding is a major cause of the tissue damage that contributes to disorders like Alzheimer's and Parkinson's diseases, systemic amyloidoses and prion (“mad cow-type”) infections, as well as common enzyme deficiencies. However, misfolded proteins have never been easy to distinguish from their normally folded counterparts, especially within cells, because both have the same sequence of amino acids.

TSRI scientists have invented
a new probe that enables them to quantify protein misfolding, which could lead to new therapies for these disorders.

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Srini Subramaniam

Authors of the new study include (left to right) Professor Ben Shen, Research Associate Jeffrey Rudolf and Research Associate Tingting Huang of The Scripps Research Institute.

Other News:
Breakthrough in the Fight Against Antibiotic Drug Resistance

Antibiotic resistance has been called one of the biggest health challenges facing humankind. According to the Centers for Disease Control, more than two million people are afflicted with antibiotic-resistant infections annually, and at least 23,000 die because their treatment can't stop the infection. In addition, the pipeline for new antibiotics has grown dangerously thin.

Luckily, scientists at Scripps Florida have uncovered
a mechanism of drug resistance that could have a major impact on the development of drugs, including a pair of highly potent new antibiotic drug candidates.

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Make the Most of Your Charitable Giving in 2014

As a supporter of TSRI, you understand the value of world-class research and its ultimate goal of saving lives. You also understand the value of maximizing your charitable support. For these reasons, we invite you to take advantage of a special benefit that could save you time and money. Visit our Plan-a-Gift™ site to see how your charitable and savings goals can both be met in 2014, or contact us directly for more information on planned giving.

facts & figures

Approximately 284,500 people died from the H1N1 “swine flu” in the pandemic of 2009-2010, and 80% were under the age of 65.

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