June 2009

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The scripps research institute

An e-Newsletter for Philanthropists



Focus On

Philanthropists Arnold and Arlene Goldstein

A Patient Giving Back

Arnold Goldstein got to see Professor Jeffery Kelly's work on protein folding disorders first hand. As a patient with amyloidosis, he enrolled in the clinical trials for a new drug being developed from the Kelly lab's initial research. Amyloidosis causes a range of debilitating diseases, as misfolded proteins dangerously deposit in organs, including the brain.

Impressed with what he saw, Goldstein, a New York businessman, made a gift to Scripps Research that will expand the research and enable the institute to hire a new researcher whose work will focus on developing the next generation of drugs to treat amyloidosis.


Milestones in Medical Science

John Cleveland

New Hope from an Old Drug for Fighting Childhood Cancer

Thirty years ago, a promising cancer-fighting drug was shelved because of toxicity concerns. But John Cleveland, chair of the Scripps Florida Department of Cancer Biology, didn't give up on it so quickly.

Running tests using small doses, his team found that "it likely works in a large cast of tumors, even those having poor prognosis, like high-risk neuroblastoma," one of the most devastating cancers among young children.

When other researchers had turned their attention elsewhere, Cleveland's team at Scripps Research investigated the biomedical foundation of the shelved drug and is providing new knowledge about potential drug pathways.


Other News

Backbone structures of SUMO (green) superimposed on Rad60 (blue)

Mimicry's Role in Genome Integrity

Genome replication is a critical but fragile moment in an organism's health. At least 160 different proteins are involved in the replication of the human genome, and errors can promote tumors, aging, and neurodegenerative disorders like Alzheimer's, Parkinson's, and Huntington's diseases.

Now, Scripps Research scientists have brought understanding of the process one step forward by identifying an enzyme using mimicry as playing a part in the process.



Facts & Figures

Every single day, approximately 46 U.S. children are diagnosed with pediatric cancer.

Release from the Fetters of Pediatric Cancer

Most children look forward to a summer of fun and freedom - but millions are not so lucky. Your gift can help Scripps Research make the advances that will bring these children true freedom.

Donate now

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Lessons from 48 Years of Extraordinary History

When Frank Dixon, Charles Cochrane, and a handful of biomedical researchers left the University of Pittsburgh for La Jolla, California - a place virtually unheard of in the East at that time - their colleagues said they'd be back in a year.

Instead, they built an Institute that rested on a foundation of scientific excellence, prized the independence of the scientists, and encouraged the overlapping of disciplines.


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email: philanthropy@scripps.edu - www.scripps.edu/philanthropy/