The Scripps Research Institute - At The Forefront
May 2015 Connect with us:
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A Breakthrough for Neurodegenerative Diseases

Researchers have linked defects in a molecular motor that performs several critical functions within cells to neurodegenerative diseases such as Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS) and others. But due to the motor's large size, myriad subunits and high flexibility, structural studies have previously been restricted to looking at small pieces of the whole.

Now, biologist Gabriel C. Lander and his laboratory at The Scripps Research Institute (TSRI), in collaboration with Trina A. Schroer and her group at Johns Hopkins University, have determined the motor's basic structural organization. The breakthrough could lead to much-needed new therapies for a range of neurodegenerative disorders.

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Assistant Professor Gabriel C. Lander (back) with the study's first author, Research Associate, Saikat Chowdhury.
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Laura Solt is a biologist at The Scripps Research Institute's Florida campus.
milestones in medical science:
A New Way to Treat Type 1 Diabetes – Before It Starts

Type 1 diabetes is a genetic disease caused when a person's immune system attacks and destroys the pancreatic beta cells responsible for creating insulin in the body, eventually eliminating insulin production entirely. Standard treatment for the disease aims to replace the lost insulin.

However, a team of scientists from Scripps Florida, led by TSRI biologist Laura Solt, Ph.D., have identified a synthetic compound that may prevent the initial devastation of the insulin-producing cells – stopping the disease before it begins.

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Karsten Sauer is an associate professor at The Scripps Research Institute.
Other News:
Using Stem Cells to Prevent Anemia and Other Blood Disorders

Stem cells can generate any type of cell in the body, but when they become too active and divide too often, they risk acquiring cell damage and mutations. In the case of blood stem cells, this can lead to blood cancers, a loss of blood cells and an impaired ability to fight disease.

A team of TSRI scientists has discovered that a particular enzyme in blood stem cells is key to maintaining healthy periods of inactivity. The discovery could lead to new therapies for diseases such as bone marrow failure syndrome, anemia, leukemia, lymphoma and immunodeficiencies.

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Scripps Florida's Run for Brain Cancer Research

Twenty participants from the Scripps Florida campus helped raise a record-breaking $200,000 for cutting-edge brain cancer research during the sixth annual Florida Brain Cancer 5K in March. The event, hosted by Accelerate Brain Cancer Cure, included awards for the male and female brain cancer survivors clocking in with the best times and a Wall of Hope and Remembrance, providing all participants with the opportunity to recognize honorees.
facts & figures

Alzheimer's is the only top-10 cause of death in the U.S. that currently cannot be prevented, slowed or cured.
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