Paulson Laboratory

Corwin Nycholat, Ph.D.
The Scripps Research Institute
10550 North Torrey Pines Road, MB-209
La Jolla, CA 92037
858-784-9690 (FAX)


June 2008 - Ph. D. Organic Chemistry, University of Alberta, Edmonton, AB (Canada)

2001 - M.Sc. University of Saskatchewan, Saskatoon, SK (Canada)

1997 - BSA. University of Saskatchewan, Saskatoon, SK (Canada)


September 2017 to Present - Senior Staff Scientist, The Scripps Research Institute, La Jolla, CA, USA (Advisor: Prof. James C. Paulson)

July 2011 to May 2018 - Director for Carbohydrate Synthesis Core (Programs of Excellence in Glycosciences), The Scripps Research Institute, La Jolla, CA, USA

July 2014 to 2017 - Staff Scientist, The Scripps Research Institute, La Jolla, CA, USA (Advisor: Prof. James C. Paulson)

July 2011 to 2014 - Senior Research Associate, The Scripps Research Institute, La Jolla, CA, USA (Advisor: Prof. James C. Paulson)

Jan 2008 to 2011 - Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA, USA (Advisor: Prof. James C. Paulson)

2002 to 2008 - Doctoral Candidate, University of Alberta, Canada (Advisor: Prof. David R. Bundle)

2001 to 2007 - Teaching Assistant, University of Alberta, Canada

2002 - Research Assistant, University of Alberta, Canada

2001 - Research Assistant, University of Saskatchewan, Canada

1998 to 2001 - M. Sc., University of Saskatchewan, Canada (Advisor: Prof. Soledade Pedras)

1998 to 2000 - Teaching Assistant, University of Saskatchewan, Canada

1997 - Research Technician, Agriculture and Agri-Food Canada (Supervisor: Dr. Wes Taylor)

1996 to 1997 - Undergraduate Research Assistant, University of Saskatchewan, Canada (Supervisor: Prof. Malcolm Devine)


2005-2006: University of Alberta Graduate Students Association Teaching Award

2004-2005: University of Alberta Teaching Services Graduate Student Teaching Award.

2004 & 2005: Judge for Edmonton Regional Science Fairs.

2002-2003: Co-founder/Organizer of the 1st Banff Symposium on Organic Chemistry; a student organized event showcasing graduate research across Canada and featuring keynote lectures by internationally renowned chemists. Supported by industrial and academic funding and attended by 120 paid registrants.

2002: Alberta Research Council Graduate Entrance Scholarship for Carbohydrate Chemistry.

1998: Dr. & Mrs. E.M. von Rudloff Bursary. University of Saskatchewan.


Bednar KJ, Nycholat CM, Rao TS, Paulson JC, Fung-Leung WP, Macauley MS. (2019) Exploiting CD22 to Selectively Tolerize Autoantibody Producing B-cells in Rheumatoid Arthritis. ACS Chem Biol. 14(4):644-654.

Edgar LJ, Kawasaki N, Nycholat CM, Paulson JC. (2019) Targeted Delivery of Antigen to Activated CD169+ Macrophages Induces Bias for Expansion of CD8+ T Cells. Cell Chem Biol. 26(1):131-136.

Wu NC, Thompson AJ, Xie J, Lin CW, Nycholat CM, Zhu X, Lerner RA, Paulson JC, Wilson IA. (2018) A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site. Nat Commun. 9(1):1264.

Sun Y, Hong S, Xie R, Huang R, Lei R, Cheng B, Sun D, Du Y, Nycholat CM, Paulson JC, Chen X. (2018) Mechanistic Investigation and Multiplexing of Liposome-Assisted Metabolic Glycan Labeling. J Am Chem Soc. 140(10):3592-3602.

Spiller F, Nycholat CM, Kikuchi C, Paulson JC, Macauley MS. (2018) Murine Red Blood Cells Lack Ligands for B Cell Siglecs, Allowing Strong Activation by Erythrocyte Surface Antigens. J Immunol. 200(3):949-956.

Wu NC, Zost SJ, Thompson AJ, Oyen D, Nycholat CM, McBride R, Paulson JC, Hensley SE, Wilson IA. (2017) A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine. PLoS Pathog. 13(10):e1006682.

Pang L, Macauley MS, Arlian BM, Nycholat CM, Paulson JC. (2017) Encapsulating An Immunosuppressant Enhances Tolerance Induction by Siglec Engaging Tolerogenic Liposomes. Chembiochem. 18(13):1226-1233.

Wu NC, Xie J, Zheng T, Nycholat CM, Grande G, Paulson JC, Lerner RA, Wilson IA. (2017) Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin. Cell Host Microbe. 21(6):742-753.

Wu NC, Xie J, Zheng T, Nycholat CM, Grande G, Paulson JC, Lerner RA, Wilson IA. (2017) Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin. Cell Host Microbe. 22(2):247-248.

Yu H, Gonzalez-Gil A, Wei Y, Fernandes SM, Porell RN, Vajn K, Paulson JC, Nycholat CM, Schnaar RL. (2017) Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties. Glycobiology. 27(7):657-668.

Tzarum N, McBride R, Nycholat CM, Peng W, Paulson JC, Wilson IA. (2017) Unique structural features of influenza H15 HA. J Virol. 91(2):e00046-17.

Guo, H., de Vries, E., McBride, R., Dekkers. J., Peng, W., Bouwman, K.M., Nycholat, C., Verheije, M.H., Paulson, J.C., van Kuppeveld, F.J., de Haan, C.A.M. (2017) Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity. Emerg Infect Dis. 23(2):220-231.

Angata, T., Nycholat, C.M., Macauley, M.S. (2015) Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches. Trends Pharmacol Sci. 36(10):645-60.

Cheng, C.W., Chou, C.C., Hsieh, H.W., Tu, Z., Lin, C.H., Nycholat, C., Fukuda, M., Khoo, K.H. (2015) Efficient Mapping of Sulfated Glycotopes by Negative Ion Mode nanoLC-MS/MS-Based Sulfoglycomic Analysis of Permethylated Glycans. Anal Chem. 87(12):6380-8.

Nycholat, C.M., Peng, W., McBride, R., Antonopoulos, A., de Vries, R.P., Polonskaya, Z., Finn, M.G., Dell, A., Haslam, S.M., and Paulson, J.C. (2013) Synthesis of biologically active N- and O-linked glycans with multi-sialylated poly-N-acetyllactosamine extensions using P. damsela a2-6 sialyltransferase. J Am Chem Soc. 135(49):18280-18283.

Xu, R., de Vries, R.P., Zhu, X., Nycholat, C.M., McBride, B., Yu, W., Paulson, J.C., and Wilson, I.A. (2013) Preferential Recognition of Avian-Like Receptors in Human Influenza A H7N9 Viruses. Science. 342(6163):1230-35.

Macauley, M.S., Pfrengle, F., Rademacher, C., Nycholat, C.M., Gale, A.J., von Drygalski, A., and Paulson, J.C. (2013) Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis. J Clin Invest. 123(7):3074-3083.

Kawasaki, N., Vela, J.L., Nycholat, C., Rademacher, C., Khurana, A., van Rooijen, N., Crocker, P.R., Kronenberg, M., and Paulson, J.C. (2013) Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation. Proc Natl Acad Sci U S A. 110(19):7826-31.

Zhu, X., McBride, R., Nycholat, C.M., Yu, W., Paulson, J.C., and Wilson, I.A. (2012) Influenza virus neuraminidases with reduced enzymatic activity that avidly bind sialic acid receptors. J Virol. 86:13371-13383.

Peng, W., Pranskevich, J., Nycholat, C., Gilbert, M., Wakarchuk, W., Paulson, J.C., and Razi, N. (2012) Helicobacter pylori b1,3-N-acetylglucosaminyltransferase for versatile synthesis of type 1 and type 2 poly LacNAcs on N-linked, O-linked and I-antigen glycans. Glycobiology. 22(11):1453-1464.

Bundle, D.R., Nycholat, C., Costello, C., Rennie, R., and Lipinski, T. (2012) Design of a Candida albicans disaccharide conjugate vaccine by reverse engineering a protective monoclonal antibody. ACS Chemical Biology. 7(10): 1754-1763.

Nycholat, C., Rademacher, C., Kawasaki, N., and Paulson, J.C. (2012) In silico aided design of a glycan ligand of sialoadhesin for in vivo targeting of macrophages. J. Am. Chem. Soc. 134:15696-99.

Rhee, J-K., Baksh, M., Nycholat, C., Gilbert, Paulson, J.C., Kitagishi, H., and Finn, MG. (2012) Glycan-Targeted Virus-like Nanoparticles for Photodynamic Therapy. Biomacromolecules. 13(8):2333-8.

Xu, R., Zhu, X., McBride, R., Nycholat, C.M., Yu, W., Paulson, J.C., and Wilson, I.A. (2012) Functional balance of the hemagglutinin and neuraminidase activities accompanies the emergence of the 2009 H1N1 influenza pandemic. J Virol. 86(17):9221-32.

Rademacher, C., Bru, T., McBride, R., Robison, E., Nycholat, C.M., Kremer, E.J., and Paulson, J.C. (2012) A Siglec-like sialic acid binding motif revealed in an adenovirus capsid protein. Glycobiology. 22(8):1086-91.

Chen, W.C., Kawasaki, N., Nycholat, C., Han, S., Pilotte, J., Crocker, P.R., and Paulson, J.C. (2012) Antigen delivery to macrophages using liposomal nanoparticles sargeting Sialoadhesin/CD169. PLoS One. 7(6):e39039.

Nycholat, C.M., McBride, R., Ekiert, D.C., Xu, R., Rangarajan, J., Peng, W., Razi, N., Gilbert, M., Wakarchuk, W., Wilson, I.A., and Paulson, J.C. (2012) Recognition of Sialylated Poly-N-acetyllactosamine Chains on N- and O-Linked Glycans by Human and Avian Influenza A Virus Hemagglutinins. Angew Chem Int Ed Engl. 51(20):4860-63.

Xu, R., McBride, R., Nycholat, C.M., Paulson, J.C. & Wilson, I.A. (2012). Structural characterization of the hemagglutinin receptor specificity from the 2009 H1N1 influenza pandemic. J Virol. 86(2):9.

Rhee, J.K., Hovlid, M., Fiedler, J.D., Brown, S.D., Manzenrieder, F., Kitagishi, H., Nycholat, C., Paulson, J.C. & Finn, M.G. (2011). Colorful Virus-like Particles: Fluorescent Protein Packaging by the Qbeta Capsid. Biomacromolecules. 12(11):3977-81.

Zeng, Y., Rademacher, C., Nycholat, C.M., Futakawa, S., Lemme, K., Ernst, B. & Paulson, J.C. (2011). High affinity sialoside ligands of myelin associated glycoprotein. Bioorg Med Chem Lett. 21, 5045-9.

Nycholat, C. M. & Bundle, D. R. (2009). Synthesis of monodeoxy and mono-O-methyl congeners of methyl-b-D-mannopyranosyl-(1->2)-b-D-mannopyranoside for epitope mapping of anti-Candida albicans antibodies. Carbohydr Res 344, 555-69.

Shukla, A., Nycholat, C., Subramanian, M. V., Anderson, R. J. & Devine, M. D. (2004). Use of resistant ACCase mutants to screen for novel inhibitors against resistant and susceptible forms of ACCase from grass weeds. J Agric Food Chem 52, 5144-50.

Pedras, M. S., Nycholat, C. M., Montaut, S., Xu, Y. & Khan, A. Q. (2002). Chemical defenses of crucifers: elicitation and metabolism of phytoalexins and indole-3-acetonitrile in brown mustard and turnip. Phytochemistry 59, 611-25.