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Faculty Lecture Series


Wednesday, April 15, 2010
5 PM - 6 PM


Valerie Timken Amphitheater
Green Hospital


Ron Milligan, Ph.D.
Department of Cell Biology


"Mechanisms of Molecular Motors "
  Kinesin motors operate on microtubule tracks and play critical roles in cell division and intracellular trafficking. The lecture will describe the molecular mechanisms by which various members of this motor superfamily bring about plus-end and minus-end directed transport, and microtubule depolymerization. This work illustrates how a single protein module can be used to power diverse cellular activities.

Selected Publications

  Vale, R.D. and R.A. Milligan. 2000. The way things move: Looking under the hood of molecular motor proteins. Science 288:88-95
  Moores, C.A., M. Hekmat-Nejad, R. Sakowicz and R.A. Milligan. 2003. Regulation of KinI kinesin ATPase activity by binding to the microtubule lattice. J. Cell Biol. 163:963-971.
  Endres, N.F., C. Yoshioka, R.A. Milligan and R.D. Vale. 2006. A lever arm rotation drives motility of the minus-end-directed kinesin, Ncd. Nature 439:875-878.
  Carter, A.P., J.E. Garbarino, E.M. Wilson-Kubalek, W.E. Shipley, C. Cho, R.A. Milligan, R.D. Vale and I.R. Gibbons. 2008. Structure and Functional Role of Dyneinís Microtubule-Binding Domain. Science 322:1691-1695.
  Mulder, A., A. Glavis-Bloom, C.A. Moores, M. Wagenbach, B. Carragher, L. Wordeman and R.A. Milligan. 2009. A New Model for Binding of Kinesin 13 to Curved Microtubule Protofilaments. J. Cell Biol. 185:51-57.


Previous Speakers

John Tainer, Ph.D.
Jeffery Kelly, Ph.D.
Paul Schimmel, Ph.D.
Ann Feeney, Ph.D.
Benjamin F. Cravatt, Ph.D.