Front Row Lecture Series

How the Science of Chirality is Helping the Search for Better Drugs and Origins of Life
Many of the building blocks of life exist in two forms that are mirror images of one another – a phenomenon known as chirality that is necessary for life to exist at all. How chirality arose eons ago is one of the great mysteries of science. What served as the first template – back before DNA, RNA and proteins, before the origin of life, in the prebiotic soup, when the nascent building blocks for life were first being formed? What process was responsible for directing amino acids to turn left, and sugars to turn right? In her Front Row lecture, Donna Blackmond, PhD, will share how deciphering the origins of chirality can help scientists design and develop safer, modern pharmaceuticals and in the search for life on other planets.

Presented: June 17, 2021

Mapping the Secret Complexity of Tumors to Defeat Aggressive Cancers
What makes cancer so difficult to defeat? Why do so many patients respond well to a particular treatment, only to relapse months or years later? The answer lies within the complex cellular makeup of cancerous tumors. Since cells within a tumor vary widely from one another, even if most are destroyed, at least some will survive and rebuild the tumor mass. Cancer biologist Michalina Janiszewska, PhD, assistant professor in the Department of Molecular Medicine at Scripps Research, is bringing a heightened understanding to how a tumor’s diverse cell populations interact and what causes cells with particular mutations to expand. Likening tumors to jigsaw puzzles, Janiszewska is finding patterns that were never before seen. By mapping the intricate tumor ecosystem and finding new ways to detect the most dangerous of cells, she seeks to bring about better treatments for brain cancer and other highly aggressive or treatment-resistant tumors.

Presented: April 21, 2021

Cracking the Code of Chronic Inflammation
Chronic inflammation occurs when the immune system spins out of control, and leads to a host of devastating and incurable immune-mediated diseases. In his Front Row lecture, Mark Sundrud, PhD, shares how he and his colleagues are deciphering new networks of immune regulation that operate locally (in specific tissues), as opposed to globally (throughout the entire body), and how this can inform the development of safer, more targeted therapies for chronic inflammatory diseases that avoid the potentially life-threatening consequences of global immune suppression.

Presented: March 25, 2021
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The Science of Sight: An Eye-Opening Presentation on the Neuroscience of Vision
Our sense of sight is our window into the world. Advances in neuroscience are rapidly unlocking the secrets of vision and paving the way to new therapies for blindness and other vision disorders. In their Front Row lecture, Hollis Cline, PhD, and Kirill Martemyanov, PhD, co-chairs of the Department of Neuroscience at Scripps Research, present their cutting-edge vision research. Among other topics, they discuss recent findings on how molecules in the retina turn light into information, how visual sensations shape brain development and how deciphering the way our visual system works could lead to new avenues to detect, prevent and correct vision impairments.

Presented: February 17, 2021

Accelerating Innovative Medicines in Times of Change
Scripps Research President and CEO Peter Schultz, PhD, discusses how the nonprofit biomedical institute has expanded the bounds of academic research to transform drug development. Using state-of-the-art drug discovery methods and new approaches to translational medicine, the institute is quickly turning new scientific insights into effective drugs. Schultz also will share updates on Scripps Research’s COVID-19 programs and its growing drug pipeline, which encompasses new treatments for cancer, neurodegenerative disease, osteoarthritis and more.

Presented: January 19, 2021

Silencing the HIV Reservoir: The ‘Block and Lock’ Approach
Some viruses avoid immune system antiviral attacks by going into deep sleep until the right moment to reemerge. HIV, the virus that causes AIDS, is one of the sneakiest. While anti-retroviral therapy works well to stop the virus, if people with HIV forget to take their medicine, the latent virus awakens and becomes a threat again. Research by Associate Professor Susana Valente suggests it’s possible to block the virus’ ability to reemerge (or wake up), locking it in a long-term dormant state. She is advancing a possible medicine derived from a marine sponge to do just that.

Presented: December 16, 2020
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Can Medicines That Alter the Microbiome Prevent Cardiovascular Disease?
Promoting a healthy gut microbiome may be a powerful strategy for lowering cholesterol and other heart attack risk factors. In this Front Row lecture, Professor Reza Ghadiri will present research on molecules that can alter the bacterial population of intestines to a healthier state and how they have shown—through experiments in mice—that this reduces cholesterol levels and strongly inhibits the thickened-artery condition known as atherosclerosis.

Presented: November 13, 2020

Harnessing Chemical Biology for Cancer Drug Discovery
Gene regulation is the study of how cells turn certain genes on or off and plays a central role in the development and treatment of cancer. In this Front Row lecture, Assistant Professor Michael Erb will share his research applying chemical tools to study how chromatin, a molecular machine that plays a key role in transcription, becomes disrupted in cancer. He will discuss his research developing small molecule drugs targeting these genetic malfunctions.

Presented: October 15, 2020

Citizen Science: Empowering the Public to Help Solve Biomedical Challenges
Modern scientific research is primarily performed by individuals with specialized training and as their full-time careers. But in recent years, there has also been rapid growth in “Citizen Science”—engaging the general public as partners in research. In this Front Row lecture, Andrew Su, PhD, professor in Scripps Research’s Department of Integrative Structural & Computational Biology, will discuss recent discoveries that were only possible by leveraging the Citizen Scientist community. He will also highlight the many ways in which you, too, can contribute to cutting-edge scientific research, both at Scripps Research and elsewhere.

Presented: September 10, 2020
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Preventing Opioid Addiction and Overdose Fatalities Through Novel Therapies
Addiction to opioids, including illicit substances and prescription pain medications, has reached epidemic proportions in the United States. In this Front Row lecture, Scripps Research Professors Laura Bohn and Kim Janda presented their latest research on innovative strategies for developing therapies to address opioid addiction and preventing related fatalities. They also discussed advances in understanding the body’s pain pathways that could lead to improvements in pain therapy.

Presented: August 13, 2020

Designing Universal Vaccines for Influenza and Coronaviruses
As the ongoing COVID-19 pandemic edges up on the onset of flu season, the need for effective vaccines for these viruses and others is abundantly clear. In this Front Row Lecture, Ian Wilson, DPhil, chair of Scripps Research's Department of Integrative Structural and Computational Biology, discusses advances in designing and developing universal vaccines that could either treat or protect people against all strains of a virus. He focuses on progress developing universal vaccines against influenza and how research on flu has paved the way for current efforts to find a pan-coronavirus vaccine.

Presented: July 16, 2020

Intelligent Intervention Into Multiple Sclerosis With Next-Generation Therapies
As scientists learn more about the underlying causes of multiple sclerosis (MS), they are developing intelligent interventions that slow or halt the progression of the disease. In this Front Row lecture, Scripps Research Professor Hugh Rosen will share how he and his collaborators at Scripps Research created ozanimod (Zeposia), the first disease-altering MS therapy, recently approved in the United States and Europe. Luke Lairson, an associate professor at Scripps Research, will discuss how his research targeting another aspect of the disease is laying the groundwork for the next generation of MS therapies.

Presented: July 1, 2020

Mapping Weak Spots on the New Coronavirus: Nanoscale Discoveries Drive Vaccine Development
Understanding the precise structure of a newly emerged virus—such as the SARS-CoV-2 virus at the root of COVID-19—is a critical first step in creating a vaccine. In this Front Row lecture, Scripps Research structural biologist Andrew Ward, PhD, shares how a revolutionary technique known as cryo-electron microscopy is generating powerful 3-D images of the coronavirus and its interactions with the human immune system, unearthing discoveries that are already shaping the future of medicine.

Presented: June 17, 2020

 

How We Can Tackle the COVID-19 Crisis Beyond Testing
If you wear a smartwatch or fitness tracker, you can play a role in monitoring the spread of COVID-19 and other viral diseases like the flu. In this Front Row lecture, Eric Topol, MD, and Jennifer Radin, PhD, discuss how they’re calling on the public to share data from wearable devices for a study that’s helping scientists flag the early onset of contagious respiratory illnesses. By harnessing this key data—including heart rates, sleep and activity levels—from hundreds of thousands of individuals, they seek to improve real-time disease surveillance.

Presented: June 3, 2020

 

Survivors of Coronavirus Infections May Hold the Secret to Stopping COVID-19
Soon after the COVID-19 pandemic reached the United States, a team of Scripps Research scientists began studying blood samples from patients recovering from infection by the novel coronavirus. In this virtual Front Row lecture, Dennis Burton, PhD, shared how he and his collaborators are analyzing COVID-19 survivors' blood for proteins, known as antibodies, that the immune system creates after encountering the virus. Antibodies to the new coronavirus could be used as much-needed therapeutics to COVID-19 or to help design a vaccine to protect against the disease.

Presented: May 20, 2020

 

Leveraging the World’s Leading Drug Repurposing Collection Against COVID-19
In the weeks and months after the novel coronavirus emerged, Calibr at Scripps Research transformed into an international hub for COVID-19 drug discovery. In this Front Row lecture, Arnab Chatterjee, PhD, shares how Calibr scientists and their many collaborators are leveraging a unique resource—the ReFRAME drug repurposing collection—to help identify safe antiviral drugs that can be rapidly advanced to patients. Learn why Calibr was especially well poised to meet the COVID-19 challenge, and how current experiences will help prepare for the next pandemic.

Presented: May 6, 2020

 

Addressing the Coronavirus Challenge
How do scientists create vaccines and drugs against a virus that simply didn’t exist months ago? That’s the challenge that virologist Michael Farzan, PhD, is facing head on—along with his team on the Jupiter, Florida, campus of Scripps Research. In this Front Row lecture, Farzan, a professor and co-chair of the Department of Immunology and Microbiology, shares his early findings on efforts to develop a safe and effective vaccine that triggers antibodies against the novel coronavirus.

Presented: April 22, 2020
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Outsmarting Emerging Pathogens in an Interconnected World
At the beginning of the COVID-19 pandemic, Kristian Andersen, PhD, a genomic epidemiologist, was one of the first to begin tracing the origins and spread of the novel coronavirus based on public genome sequencing data. In this virtual Front Row lecture, Andersen will share unique insights on how the COVID-19 pandemic emerged and spread around the world, as well as what science tells us has worked and not worked to mitigate the public health crisis. He’ll discuss how the lessons learned from the current pandemic and other infectious disease epidemics can help us prepare for future outbreaks.

Presented: April 15, 2020

California Campus

Advancing Precision Medicines to Stop Cancer, ALS, Muscular Dystrophy – and Coronavirus
Innovative chemist Matthew Disney, PhD, delivers the first pandemic edition of the popular Scripps Research Front Row lectures, via webinar. Watch as he describes his unique drug-discovery tools, now revealing new ways of attacking the RNA virus that causes COVID-19. Rather than targeting proteins, as most drugs do, Disney spent a decade developing an effective way to target RNAs involved in genetic diseases like ALS and cancer. That’s proving important as the novel coronavirus spreads globally.

Presented: March 18, 2020

 

New Understanding of Brain Diseases: Toward Disease-Modifying Therapies
Alzheimer’s, Lewy-body dementia, fronto-temporal dementia, Parkinson’s and ALS appear to be very different diseases, yet they share something striking in common: an accumulation of “aggregates” or toxic, misfolded proteins. Professor Lasmézas is an authority on neurological diseases that are caused by protein misfolding and her lab is working on potential treatments for these diseases as well as prion diseases including Creutzfeldt-Jacob disease (CJD).

Presented: February 19, 2020

 

A New Model for Biomedical Research
Our understanding of what drives disease at the molecular level is expanding exponentially in this age of genomics and artificial intelligence. Yet we still face major challenges finding effective treatments for diseases ranging from cancer to dementia. How can biomedical research institutes bridge this gap? In the first lecture of Florida’s new Front Row Lecture Series, Peter Schultz, PhD, a pioneering chemist and president and CEO of Scripps Research, shares his vision for ensuring that discoveries made in biomedical research institutes reach patients and improve lives.

Presented: January 22, 2020

 

To view all Front Row Lectures from the California and Florida campuses click here.