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The McDonald Laboratory

Publications

H Zhang, E Sturchler, J Xie, L He, D Ruiz, A Niete, PG, Griffin, J Sharma, T Jones, K Yea, P Dawson, J Zhu, PH McDonald* and RA Lerner*..* Co-corresponding author.  Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects from combinatorial peptide libraries'  Nature Communications, Dec 2015; 6; 8918

TR Valero, E Sturchler, MJ Afferjee, G Rento, V Magafa, P Cordopatis, PH McDonald, WJ Koch, and A Lymperopoulos.  Structure-activity relationship study of angiotension II analogos in terms of barrestin-dependent signaling to aldosterone production.  Pharm Res and Perspectives, March 2016 DOI: 10. 1002/prp2.226

E Sturchler and PH McDonald. Qualitative and Quantitative Analysis of Ligand-induced GPCR Desensitization using Label-free, Impedance-based Technology: Implications in Early Drug Discovery. (in preparation), 2015

JD Robinson and PH McDonald. The Orexin 1 Receptor Modulates Kappa Opioid Receptor Function via a JNK-dependent Mechanism. Cellular Signaling, April 2015 [Epub ahead of Print], 27, I449-1456.

J Robinson, A Smith, E Sturchler, S Tabrizifard, and PH McDonald. Development of a High Throughput Screening-compatible Cell-based Functional Assay to Identify Small Molecule Probes of the Galanin 3 receptor (GalR3). ASSAYS and Drug Development Technologies, Oct; 2013; 11(8):468-77.

PH McDonald and E Sturchler. GPCRs: New Opportunities and Challenges for Drug Discovery. European Pharmaceutical Review; Drug Targets: In-depth Focus. 17 (6), 2012.

PH McDonald, WE Miller, ME Field, S Cai and RJ Lefkowitz. Identification of a Motif in the Carboxy Terminus of βArrestin2 Responsible for the Activation of JNK3.  J Biol Chem. 2001; 276(30): 27770-7.

PH McDonald, CW Chow, WE Miller, SA Laporte, ME Field, FT Lin, RJ Davis and RJ Lefkowitz. βArrestin2, a novel scaffold protein for JNK3 activation Science. 2000; 290: 1574-77.

SK Shenoy, PH McDonald, TA Kohout and RJ Lefkowitz. Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science. 2001 Nov 9; 294(5545):1307-13.

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