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The Kissil Laboratory


Moleirinho, S.; Hoxha, S.; Mandati, V.; Curtale, G.; Troutman, S.; Ehmer, U.; Kissil, J.L.  "Regulation of localization and function of the transcriptional co-activator YAP by angiomotin." Elife. 2017 May 3;6 pii: e23966. doi: 10.7554/eLife.23966. PMCID: PMC5415356 [PubMed]

Troutman, S.; Moleirinho, S.; Kota, S.; Nettles, K.; Fallahi, M.; Johnson, G.L.; Kissil, J.L. "Crizotinib inhibits NF2-associated schwannoma through inhibition of Focal Adhesion Kinase 1." Oncotarget, 7(34):54515-25, 2016. PMCID: PMC5342359 [PubMed]
Guerrant, W; Kota, S; Troutman, S; Mandati, V; Fallahi, M; Stemmer-Rachamimov, A; Kissil, J.L. “YAP Mediates Tumorigenesis in Neurofibromatosis Type 2 by Promoting Cell Survival and Proliferation through a COX-2-EGFR Signaling Axis”. Cancer Research, 2016 May 23. PMCID: PMC4911274 [PubMed]

Moleirinho, S.; Guerrant, W.; Kissil, J.L.  “The Angiomotins – From discovery to function.”  FEBS Lett. 2014 Feb 15. pii:S0014-5793(14)00125-2.  PMCID: PMC4112001 [PubMed]

Yi, C.; Shen, Z.; Stemmer-Rachamimov, A.; Dawany, N.; Troutman, S.; Showe, L.C.; Liu, Q.; Shimono, A.; Sudol, M.; Holmgren, L.; Stanger, B.Z. and Kissil, J.L. “The p130 isoform of angiomotin is required for Yap-mediated hepatic epithelial cell proliferation and tumorigenesis.”  Science Signal. 2013 Sep 3;6(291):ra77.  PMCID: PMC4175526 [PubMed]

Zhou, C.; Troutman, S.; Maksimoska, J.; Liu, Q., Campbell, D.; Marmorstein, R. and Kissil, J.L. FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of NF2-associated schwannomas.”  J. Biol. Chem., 2013. PMCID: PMC379009 [PubMed]

Licciulli, S.; Avila, J.L.; Hanlon, L.; Troutman, S.; Cesaroni, M.; Keith B.; Simon, M.C.; Pure, E.; Radtke, F.; Capobianco, A.J. and Kissil, J.L. “Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cells survival via p53.” Cancer Res. 2013 Oct 1;73(19):5974-84.  PMCID: PMC3791518  [PubMed]

Avila, J.L. and Kissil, J.L. “Notch signaling in pancreatic cancer: oncogene or tumor suppressor?” Trends Mol Med. 2013 May; 19(5):320-7. PMCID: PMC3648591 [PubMed]

Avila, J.L.; Troutman, S.; Durham, A; and Kissil, J.L. “Notch1 is not required for acinar-to-ductal metaplasia in a model of Kras-induced pancreatic ductal adenocarcinoma." PLoS One. 2012;7(12):e52133. PMCID: PMC3526595 [PubMed]

Zhou, C; Licciulli, S.; Avila, J.L.; Cho, M.; Troutman, S.; Jiang, P.; Kossenkov, A.V.; Showe, L.C.; Liu, Q.; Vachani, A.; Albelda, S.M. and Kissil, J.L. “The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis.”  Oncogene. 2013 Feb 14;32(7):903-7.  PMCID: PMC3384754 [PubMed]

Caino, M.C.; Lopez-Haber, C.; Kissil, J.L.; Kazanietz, M.G. “Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon. PLoS One.  2012;7(2):e31714. PMCID: PMC3288050  [PubMed]

Yi C.; Troutman S.; Fera D.; Stemmer-Rachamimov A.; Avila J.L.; Christian N.; Persson N.L.; Shimono A.; Speicher D.W.; Marmorstein R.; Holmgren L. and Kissil J.L. "A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin’s Regulation of Mitogenic Signaling and Tumor Suppressive Functions." Cancer Cell. 2011 Apr 12;19(4):527-40.  PMCID: PMC3075552 [PubMed]

Yi, C. and Kissil, J.L. "Merlin in organ size control and tumorigenesis: Hippo versus EGFR?" Genes Dev. 2010 Aug 15;24(16):1673-9. PMCID: PMC2922497 [PubMed]

Hanlon, L.; Avila, J.L.; Demarest, R.M.; Troutman, S.; Allen, M.; Ratti, F.; Rustgi, A.K.; Stanger, B.Z.; Radtke, F.; Adsay, V.; Long, F.; Capobianco, A.J. and Kissil, J.L. "Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma." Cancer Res. 2010 Jun 1;70(11):4280-6. PMCID: PMC2880196 [PubMed]

Licciulli, S; Kissil, J.L.  “WT1: a weak spot in KRAS-induced transformation.”  J Clin Invest. 2010 Nov;120(11):3804-7.  PMCID: PMC2965001  [PubMed]

Kissil, J.L.; Blakeley, J.O.; Ferner, R.E.; Huson, S.M.; Kalamarides, M.; Mautner, V.F.; McCormick, F; Morrison, H; Packer, R.; Ramesh, V.; Ratner, N; Rauen, K.A.; Stevenson, D.A.; Hunter-Schaedle, K.; North, K.  “What’s new in neurofibromatosis? Proceedings from the 2009 NF Conference: new frontiers.”  Am J Med Genet A.  2010 Feb;152A(2):269-83.  PMCID: PMC2818482  [PubMed]

Santos, A.M.; Jung, J.; Aziz, N.; Kissil, J.L.* and Puré E.* (*Equal contribution). “Targeting Fibroblast Activation Protein Inhibits Tumor Stromagenesis and Growth in Mice." J Clin Invest. 2009 Dec;119(12):3613-25. PMCID: PMC2786791 [PubMed]

Yi, C.; Wilker, E.W.; Yaffe, M.B.; Stemmer-Rachamimov, A. and Kissil, J.L. "Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2." Cancer Res. 2008 Oct 1;68(19):7932-7. PMCID: PMC2707059 [PubMed]




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