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Kronenberg, M., and Havran, W.L. Immunology: oiling the wheels of autoimmunity. Nature 506, 42-43, 2014. Pubmed

MacLeod, A.S., Rudolph, R., Corriden, R., Ye, I., Garijo, O., and Havran, W.L. Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair. J Immunol 192, 5695-5702, 2014. Pubmed

Nielsen, M.M., Lovato, P., MacLeod, A.S., Witherden, D.A., Skov, L., Dyring-Andersen, B., Dabelsteen, S., Woetmann, A., Odum, N., Havran, W.L., et al. IL-1beta-dependent activation of dendritic epidermal T cells in contact hypersensitivity. J Immunol 192, 2975-2983, 2014. Pubmed

Meehan TF, Witherden DA, Kim CH, Sendaydiego K, Ye I, Garijo O, Komori HK, Kumanogoh A, Kikutani H, Eckmann L, Havran WL.  Protection against colitis by CD100-dependent modulation of intraepithelial γδ T lymphocyte function. Mucosal Immunol. Jan;7(1):134-42, 2014. Pubmed


MacLeod, A.S., Hemmers, S., Garijo, O., Chabod, M., Mowen, K., Witherden, D.A., and Havran, W.L. Dendritic epidermal T cells regulate skin antimicrobial barrier function. J Clin Invest 123, 4364-4374, 2013. Pubmed

Witherden, D.A., and Havran, W.L. Cross-talk between intraepithelial gammadelta T cells and epithelial cells. J Leukoc Biol 94, 69-76, 2013. Pubmed


Komori, H.K., Witherden, D.A., Kelly, R., Sendaydiego, K., Jameson, J.M., Teyton, L., and Havran, W.L. Cutting edge: dendritic epidermal gammadelta T cell ligands are rapidly and locally expressed by keratinocytes following cutaneous wounding. J Immunol 188, 2972-2976, 2012. Pubmed

Witherden, D.A., and Havran, W.L. EPCR: a stress trigger for gammadelta T cells. Nat Immunol 13, 812-814, 2012. Pubmed

Witherden, D.A., Watanabe, M., Garijo, O., Rieder, S.E., Sarkisyan, G., Cronin, S.J., Verdino, P., Wilson, I.A., Kumanogoh, A., Kikutani, H., et al. (2012). The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal gammadelta T cell function. Immunity 37, 314-325, 2012. Pubmed


Macleod, A.S., and Havran, W.L. Functions of skin-resident gammadelta T cells. Cell Mol Life Sci 68, 2399-2408, 2011. Pubmed

Antsiferova, M., Huber, M., Meyer, M., Piwko-Czuchra, A., Ramadan, T., MacLeod, A.S., Havran, W.L., Dummer, R., Hohl, D., and Werner, S. Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response. Nat Commun 2, 576, 2011. Pubmed

Witherden, D.A., and Havran, W.L. Costimulating epithelial gammadelta T cells. Cell Cycle 10, 4-5, 2011. Pubmed

Witherden, D.A., and Havran, W.L. Molecular aspects of epithelial gammadelta T cell regulation. Trends Immunol 32, 265-271, 2011. Pubmed

Verdino, P., Witherden, D.A., Podshivalova, K., Rieder, S.E., Havran, W.L., and Wilson, I.A. cDNA sequence and Fab crystal structure of HL4E10, a hamster IgG lambda light chain antibody stimulatory for gammadelta T cells. PLoS One 6, e19828, 2011. Pubmed

Verdino, P., Witherden, D.A., Ferguson, M.S., Corper, A.L., Schiefner, A., Havran, W.L., and Wilson, I.A. Molecular insights into gammadelta T cell costimulation by an anti-JAML antibody. Structure 19, 80-89, 2011. Pubmed


Verdino P, Witherden DA, Havran WL, Wilson I. The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K. Science 3;329(5996):1210-4, 2010. Pubmed

Witherden DA, Verdino P, Rieder SE, Garijo O, Mills RE, Teyton L, Fischer WH, Wilson IA, Havran WL. The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation. Science 3;329(5996):1205-10, 2010. Pubmed (See following links for access to this Science article: AbstractReprintFull Text).

Havran WL, Jameson JM. Epidermal T cells and wound healing. J. Immunol. 184(10):5423-8, 2010. Pubmed


Toulon A, Breton L, Taylor KR, Tenenhaus M, Bhavsar D, Lanigan C, Rudolph R, Jameson J, Havran WL. A role for human skin-resident T cells in wound healing. J Exp Med. 206(4):743-50, 2009. Pubmed


Kim CH, Witherden DA, Havran WL. Characterization and TCR variable region gene use of mouse resident nasal gammadelta T lymphocytes. J Leukoc Biol. 84(5):1259-63. 2008 Pubmed

Yu D, Cook MC, Shin DM, Silva DG, Marshall J, Toellner KM, Havran WL, Caroni P, Cooke MP, Morse HC, MacLennan IC, Goodnow CC, Vinuesa CG Axon growth and guidance genes identify T-dependent germinal centre B cells.Immunol Cell Biol. 86(1):3-14. 2008. Pubmed


Jameson J, Havran WL. Skin γδ T cell functions in homeostasis and wound healing. Immunol Rev. 215:114-22. 2007. Pubmed

Kronenberg M, Havran WL. Frontline T cells: γδ T cells and intrapithelial lymphocytes. Immunol Rev. 215:5-7. 2007. Pubmed


Komori, HK, Meehan, RF, Havran WL. Epithelial and mucosal γδ T cells. Curr Opin Immunol. 18(5):534-8. 2006. Pubmed


Havran, WL, Jameson JM, Witherden DA. Epithelial cells and their neighbors. III. Interactions between intrapepithelial lymphocytes and neighboring epithelial cells. Am J Physiol Gastrointest Liver Physiol. 289(4) G627-10, 2005. Pubmed

Jameson, J., Cauvi, G., Sharp, L., Witherden, D., and Havran, W.L. γδ T cells induce hyaluronan production by epithelial cells: A mechanism for regulating inflammation. J. Exp. Med., 201(8):1269-19, 2005. Pubmed

Sharp, L., Jameson, J., Witherden, D., Komori, H.K., and Havran, W.L. Activation requirements for dendritic epidermal γδ T cells. Critical Rev. Immunol., 25(1):1-18, 2005. Pubmed

Baccala, R.*, Witherden, D.*, Gonzalez-Quintial, R., Dummer, W., Surh, C.D., Havran, W.L., and Theofilopoulos, A.N. γδ T cell homeostasis is controlled by interleukins 7 and 15 together with subset-specific ligands. J. Immunol., 174(8):4604-12, 2005. *contributed equally Pubmed


Sharp, L.*, Jameson, J.*, Cauvi, G., and Havran, W.L. Dendritic epidermal T cells regulate skin homeostasis through local production of Insulin Like Growth Factor-1. Nature Immunol. 6:73-79, 2004. *contributed equally Pubmed

Yui, M., Sharp, L.L., Havran, W.L., and Rotherberg, E.V. Preferential activation of an IL-2 regulatory sequence transgene in TCR γδ and NKT cells: subset-specific differences in IL-2 regulation. J. Immunol., 172:4691, 2004. Pubmed

Jameson, J.M., Sharp, L., Witheren, D.A., and Havran, W.L. Regulation of skin cell homeostasis by γδ T cells. Frontiers in Bioscience, 9:2640, 2004. Pubmed

Jameson, J., Cauvi, G., Witherden, D., and Havran, W.L. A keratinocyte-responsive γδ TCR is necessary for dendritic epidermal T cell activation by damaged keratinocytes and maintenance in the epidermis. J. Immunol., 172:3573, 2004. Pubmed

Jameson, J., Witherden, D., and Havran, W.L. T cell effector mechanisms: γδ and CD1-restricted subsets. Current Opinion in Immunology 15:349, 2003. Pubmed

Chen, Y., Chou, K., Fuchs, E., Havran, W.L., and Boismenu, R. Protection of the intestinal mucosa by intraepithelial γδ T cells. Proc. Nat. Acad. Sci. USA, 99:14338, 2002. Pubmed

Jameson, J., Ugarte, K., Chen, N., Yachi, P., Fuchs, E., Boismenu, R., and Havran, W.L. A role for skin γδ T cells in wound healing. Science 296:747-749, 2002. Pubmed

Witherden, D., Rieder, S.E., Boismenu, R., and Havran, W.L. A role for epithelial γδ T cells in tissue repair. Springer Seminars in Immunopathology. 22:265, 2000. Pubmed

Havran, W.L. A role for epithelial γδ T cells in tissue repair. Immunol. Res. 21/2-3:63, 2000. Pubmed

Boismenu, R., Chen, Y., and Havran, W.L. The role of intraepithelial γδ T cells: A gut feeling. Microbes and Infection 1:235, 1999. Pubmed

Boismenu, R., Havran, W.L. Modulation of epithelial cell growth by intraepithelial γδ T cells. Science 266:1253, 1994. PubMed