The Brock Grill Laboratory at The Scripps Research Institute Florida



The following articles were published by Brock Grill, his lab members and collaborators. You may view the entire article by clicking on the abstract link at the end of the corresponding title. The link will redirect you to the website.


Giles AC, Desbois M, Opperman KJ, Tavora R, Maroni MJ, Grill B. (2019) A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1regulates GABA neuron function. J Biol Chem. Mar 11. pii: jbc.RA119.007406. doi: 10.1074/jbc.RA119.007406. [Epub ahead of print]

Borgen MA, Giles AC, Wang D and Grill B. (2019) Synapse maintenance is impacted by ATAT-2 tubulin acetyltransferase activity and the RPM-1 signaling hub. eLife 8, pii: e44040. doi: 10.7554/eLife.44040. (abstract)

Desbois M, Crawley O, Evans PR, Baker ST, Masuho I, Yasuda R, Grill B. (2018) PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2. J Biol Chem. 293, 13897-13909. (abstract)

Crawley O, Giles AC, Desbois M, Kashyap S, Birnbaum RL and Grill B. (2017) A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning. PLoS Genetics 13(12):e1007095. (abstract)

Borgen MA, Wang D, Grill B. (2017) RPM-1 regulates axon termination by affecting growth cone collapse and microtubule stability. Development 144, 4658-4672. (abstract)

Opperman KJ, Mulcahy B, Giles AC, Risley MG, Birnbaum RL, Tulgren ED, Dawson-Scully K, Zhen M and Grill B. (2017) The HECT family ubiquitin ligase EEL-1 regulates neuronal function and development. Cell Reports 19:822-835. (abstract)

Baker ST and Grill B. (2017) Defining minimal binding regions in regulator of presynaptic morphology 1 (RPM-1) using C. elegans neurons reveals differential signaling complexes. Journal of Biological Chemistry 292:2519-2530. (abstract)

Risley MG, Kelly SP, Jia K, Grill B, Dawson-Scully K. (2016) Modulating behavior in C. elegans using electroshock and antiepileptic drugs. PLoS One 11(9):e0163786. (abstract)

Grill B, Murphey RK, Borgen MA. (2016) The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration. Neural Development 11:8 doi: 10.1186/s13064-016-0063-0. (abstract)

Giles AC, Opperman KJ, Rankin CH and Grill B. (2015) Developmental function of the PHR protein RPM-1 is required for learning in C. elegans. G3 (Bethesda) 5:2745-2757. (abstract)

Baker S, Turgeon S, Tulgren E, Wigant J, Rahimi O, Opperman K and Grill B. (2015) Neuronal development in Caenorhabditis elegans Is regulated by inhibition of an MLK MAP kinase pathway. Genetics 199:151-156. (abstract)

Sharma J, Baker S, Turgeon S, Gurney A, Opperman K, and Grill B. (2014) Identification of a peptide inhibitor of the RPM-1/FSN-1 ubiquitin ligase complex. Journal of Biological Chemistry 289: 34654-34666. (abstract)

Tulgren E, Turgeon S, Opperman K, and Grill B. (2014) The Nesprin family member ANC-1 regulates synapse formation and axon termination by functioning in a signaling pathway with RPM-1 and beta-Catenin. PLoS Genetics e1004481. doi: 10.1371/journal.pgen.1004481. (abstract)

Opperman KJ, and Grill B (2014). RPM-1 is localized to distinct subcellular compartments and regulates axon length in GABAergic motor neurons. Neural Development doi: 10.1186/1749-8104-9-10 (abstract)

Baker ST, Opperman KJ, Tulgren ED, Turgeon SM, Bienvenut W, Grill B (2014). RPM-1 uses both ubiquitin ligase and phosphatase-based mechanisms to regulate DLK-1 during neuronal development. PLoS Genetics e1004297. doi:10.1371/journal.pgen.1004297. (abstract)

Grill B, Chen L, Tulgren ED, Baker ST, Bienvenut W, Anderson M, Quadroni M, Jin Y, and Garner CC (2012). RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in C. elegans. Journal of Neuroscience 32:2628-2636. (abstract)

Tulgren ED, Baker ST, Rapp L, Gurney AM, Grill B (2011). PPM-1, a PP2C alpha/beta phosphatase, regulates axon termination and synapse formation in Caenohabditis elegans. Genetics 189:1297-1307. (abstract)

Margeta MA, Shen K, Grill B (2008). Building a synapse: Lessons on synapse specificity and presynaptic assembly from the nematode C. elegans. Current Opinion in Neurobiology 18:69-76. (abstract)

Grill B, Bienvenut WV, Brown HM, Ackley BD, Quadroni M, Jin Y (2007). C. elegans RPM-1 regulates axon termination and synaptogenesis through the Rab GEF GLO-4 and the Rab GTPase GLO-1. Neuron 55:587-601. (abstract)