Publications

Scheppke, L., Aguilar, E., Gariano, R. F., Jacobson, R., Hood, J., Doukas, J., Cao, J., Noronha, G., Yee, S., Weis, S., Martin, M., B., Soll, R., Cheresh, D. A., and Friedlander, M. (2008). Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits. Journal of Clinical Investigation. doi:10.1172/JCI33361.

Friedlander, M., Dorrell, M.I., Ritter, M.R., Marchetti, V., Moreno, S.K., El-Kalay, M., Bird, A.C., Banin, E., Aguilar, E. (2007). Progenitor cells and retinal angiogenesis. Angiogenesis. 10(2):89-101.

Dorrell, M., Usitalo-Jarvinen, H., Aguilar, E.A. and Friedlander, M. (2007). Ocular angiogenesis; basic mechanisms and therapeutic advances. Survey of Ophthalmology, 52:S3-19.

Dorrell, M., Aguilar, E., Schepke, L., Barnett, F., and M. Friedlander. (2007). Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis. Proc. Natl. Acad. Sci. 104(3):967-72.

Usitalo-Jarvinen, H , T. Kurokawa, B.M. Mueller, P. Andrade-Gordon, M. Friedlander and W. Ruf. (2007). Role of Protease Activated Receptor 1 and 2 Signaling in Hypoxia-Induced Angiogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology, 27:1456-1462.

Roos, K.P., Jordan, M.C., Fishbein, M.C., Ritter, M.R., Friedlander, M., Chang, H.C., Rahgozar, P., Han, T., Garcia, A., MacClellan, W.R., Ross, R.S., and K.D. Philipson. (2007). Hypertrophy and Heart Failure in Mice Overexpressing the Cardiac Sodium-Calcium Exchanger. Journal of Cardiac Failure 13:318-329.

Dorrell, M.I. and Friedlander, M. (2006). Cell guidance in retinal angiogenesis. Progress in Retinal and Eye Research. 25(3):277-95.

Ritter, M., Banin, E., Aguilar, E.A., Dorrell, M.I. Moreno S.K. and M. Friedlander (2006). Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy. J. Clin. Invest. 116:3266-3276.

Banin, E., Dorrell, M.I., Aguilar, E., Ritter, M.R.,Aderman, C.M., Smith, A.C.H., Friedlander, J., and M. Friedlander. (2006). T2-TrpRS inhibits pre-retinal neovascularization and enhances physiological vascular regrowth in oxygen-induced retinopathy as assessed by a new method of quantification. Invest. Ophthal. Vis. Sci., 47(5):2125-34.

Jin, H., Aiyer, A., Su, J., Borgstrom, P., Stupack, D., Friedlander, M. And Varner, J. (2006). A homing mechanism for bone marrow derived progenitor cell recruitment to the neovasculature. J. Clin. Invest., 116(3):652-62.

Ritter, M., Reinisch, J., Friedlander, S.F., and Friedlander, M. (2006). Myeloid Cells in Infantile Hemangioma and a Possible Surrogate Model. Amer. J. Path. 168: 621-628.

Friedlander S.F., Ritter M.R., Friedlander M. (2005). Recent Progress in Our Understanding of the Pathogenesis of Infantile Hemangiomas. Lymphat Res Biol. 2005;3(4):219-225.

Ritter, M., Aguilar, E., Banin, E., Scheppke, L., Uusitalo-Jarvinen, H. and Friedlander, M. (2005). Three Dimensional In Vivo Imaging of the Mouse Ocular Vasculature. Invest. Ophthal. Vis. Sci., 46:3021-6.

Otani, A., Kinder, K., Hanekamp, S., Nussinowitz,S., Heckenlively, J., and Friedlander, M. (2004). Neurotrophic rescue of retinal degeneration by intravitreally injected adult bone marrow derived lineage- hematopoietic stem cells. J. Clinical Investigation, 114:765-774.

Belting, M., Dorrell, M., Sandgren, S., Ahamad, J., Dorfleutner, D., Carmeliet, P., Mueller, B., Friedlander, M. and Ruf, W. (2004). Tissue factor signaling in angiogenesis. Nature Medicine 10:502-509.

Barnett, F.H., Scharer-Schusz Wood, M.M., Yu, X., Wagner, T.E. and Friedlander, M. (2004). Intra-arterial delivery of endostatin gene to brain tumors prolongs survival and alters tumor vessel ultrastructure. Gene Therapy, 11:1283-1289.

Campochiaro, P.A. and the C99-PKC412-003 Study Group (Sall, K., Puliafito, C., Duker, J., Friedlander, M., Kinyoun, J., Saperstein, D., Gottlieb, J., Garber, F., Cunha Vaz, J., Schmidt-Urfurth, U., Ferrone, P.J., and McMillan, T.A.). (2004). Reduction of diabetic macular edema by oral administration of the kinase inhibitor PKC412. Investigative Ophthal. Vis. Sci. 45:922-931.

Dorrell, M.I., Otani, A., Aguilar, E.A., Moreno, S. and Friedlander, M. (2004). Adult bone marrow-derived stem cells utilize R-cadherin to target sites of neovascularization in the developing retina. Blood 103: 3420-3427.

Dorrell, M.I., Aguilar, E. and Friedlander, M. (2004). Global gene expression analysis of the developing post-natal retina.Investigative Ophthal. Vis. Sci., 45:1009-29.

Ritter, M.R., Hanekamp, S., Dorrell, M.I., Rubens, J., Ney, J., Friedlander, D.F., Bergman, J., Cunningham, B.J., Eichenfield, L., Reinisch, J., Cohen, S., Veccione, T., Holmes, R., Friedlander, S.F., and Friedlander, M. (2004). Identifying potential regulators of infantile hemangioma progression through large-scale expression analysis - A possible role for the immune system and IDO during involution. Lymphatic Research and Biology 1:291-299.

The Anecortave Acetate Clinical Study Group (J.S. Slakter, K. Binder, M. Blumenkranz, M. DeSmet, G. Fish, M. Friedlander, K. Gitter, B. Godley, A. Ho, H. Hudson, E. Van Kuijk, M. Lewis, P. Rosenfeld, S. Russell, F. Sabates, A. Schachat, U. Schmidt-Erfurth, S. Schwartz, L. Singerman, G. Soubrane, L. Yanuzzi, D.J. D'Amico, C. Regillo, W. Mieler, C. Schneebaum, C. Beasley, A. Ciardella, D. Orlock, M. Goldberg, J. Jerdan, S. Krueger, S. Luna, S. Robertson, E. Sullivan and P. Zilliox.). (2003). Anecortave Acetate as monotherapy for the treatment of subfoveal lesions in patients with exudative age-related macular degeneration (ARMD): 12 month clinical outcomes. Ophthalmology, 110:2372-84.

Gariano, R., Aguilar, E.A. and Friedlander, M. (2003). Endothelial Proliferation in Diabetic Retinal Microaneurysms. Archives of Ophthalmology 121:740-741.

The Anecortave Acetate Clinical Study Group (J.S. Slakter, K. Binder, M. Blumenkranz, M. DeSmet, G. Fish, M. Friedlander, K. Gitter, B. Godley, A. Ho, H. Hudson, E. Van Kuijk, M. Lewis, P. Rosenfeld, S. Russell, F. Sabates, A. Schachat, U. Schmidt-Erfurth, S. Schwartz, L. Singerman, G. Soubrane, L. Yanuzzi, D.J. D'Amico, C. Regillo, W. Mieler, C. Schneebaum, C. Beasley, A. Ciardella, D. Orlock, M. Goldberg, J. Jerdan, S. Krueger, S. Luna, S. Robertson, E. Sullivan and P. Zilliox.). (2003). Anecortative Acetate as monotherapy for the treatment of subfoveal lesions in patients with exudative age-related macular degeneration (ARMD): Interim (month 6) analysis of clinical safety and efficacy. Retina 23:14-23.

Heckenlively, J.R., Hawes, N.L., Friedlander, M., Nusinowitz, S., Ronald Hurd, R., Davisson, M. and Chang, B. (2003). Mouse model of subretinal neovascularization with choroidal anastomosis. Retina, 23(4):518-522.

Kanner, E., Friedlander, M. and Simon, S.M. (2003). Co-translational targeting and translocation of the amino terminus of opsin across the ER membrane requires GTP but not ATP. J. Biol. Chem. 278:7920-7926.

Von Seggern, D. J., Aguilar, E., Kinder, K., Fleck, S. K., Armas, J. C. G., Stevenson, S. C., Ghazal, P., Nemerow, G. R. and Friedlander, M. (2003). In vivo transduction of photoreceptors or ciliary body by intravitreal injection of pseudotyped adenoviral vectors. Molecular Therapy, 7, 27-34.

Dorrell, M., Aguilar de Diaz, E., and Friedlander, M. (2002). Developmental vascularization of the retina is mediated by a pre-existing astrocytic template and specific R-cadherin adhesion. Investigative Ophthalmology and Visual Science 43:3500-3510.

Otani, A., Kinder, K., Ewalt, K., Otero, F., Schimmel, P. and Friedlander, M. (2002). Bone marrow derived stem cells cells target retinal astrocytes and have pro- or anti-angiogenic activity. Nature Medicine 8:1004-1010.

Kanner, E., Klein, I.K., Friedlander, M., and Simon, S.M. (2002). The amino terminus of opsin translocates "post-translationally" as efficiently as co-translationally. Biochemistry 41:7707-7715.

Ritter, M., Dorrell, M., Edmonds, J. Friedlander, S., and Friedlander, M. (2002). Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis. Proc. Natl. Acad. of Sci., ( U.S.A.) 99:7455-7460.

Strömblad, S, Fotedar, A., Brickner, H., Theesfeld, C., Aguilar de Diaz, E., Friedlander, M. and Cheresh, D.A. (2002). Loss of p53 compensates for alpha v function in retinal neovascularization. J. Biol. Chem. 277(16):13371-4.

Otani, A., Slike, B., Dorrell, M. I., Hood, J., Kinder, K., Ewalt, K., Cheresh, D.A., Schimmel, P. and Friedlander, M. (2002). A fragment of human TrpRS as a potent antagonist of ocular angiogenesis. Proc. Natl. Acad. of Sci., ( U.S.A.) 99:178-183.

Wakasugi, K., Slike, B., Ewalt, K., Hood, J., Otani, A., Ewalt, K.L., Friedlander, M., Cheresh, D.A., and Schimmel, P. (2002). A human aminoacyl-tRNA synthetase as a regulator of angiogenesis. Proc. Natl. Acad. of Sci., ( U.S.A.) 173-177.

Barshop, B., Nyhan, W.L., Naviaus, R.K., McGowan, K.A., Friedlander, M. and Haas, R.H. (2000). Kearns-Sayre syndrome presenting as 2-oxoadipic aciduria. Mol. Gen. Metabol. 69:64-68.

McKiernan, C.J. and Friedlander, M. (1999). The retinal rod Na+/Ca2+,K+ exchanger contains a non-cleaved signal sequence required for translocation of the N-terminus. J. Biol. Chem. 274:38177-38182.

Brooks, P.C., Siletti, S., von Schalscha, T.L., Friedlander, M. and Cheresh, D.A. (1998). Disruption of angiogenesis by PEX, a non-catalytic metalloproteinase fragment with integrin binding activity. Cell 92:391-400.

Friedlander, M., Theesfeld, C.L., Sugita, M., Fruttiger, M., Thomas, M.A., Chang, S. and Cheresh, D.A. (1996). Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases. Proc. Natl. Acad. Sci. (U.S.A.) 93:9764-9769.

Shaffer, R. and Friedlander, M. (1996). A method for the in vivo quantitation of angiogenesis in the rabbit corneal model. in "Molecular, Cellular and Clinical Aspects of Angiogenesis" (M.E. Maragoudakis, ed.), Plenum Press, New York.

Sahin-Toth, M., Kaback, R., Friedlander, M. (1996). Association between the amino and carboxy terminal halves of lactose permease is specific and mediated by multiple transmembrane domains. Biochemistry, 35:2016-2021.

Friedlander, M., Brooks, P., Shaffer, R., Kincaid, C., Varner, J., Cheresh, D. (1995). Two pathways of angiogenesis defined by homologous alpha v integrins. Science, 270:1500-1502.

Sahin-Toth, M., Nicoll, D.A., Frank, J., Philipson, K., Friedlander, M. (1995). The cleaved N-terminal signal sequence of the cardiac sodium-calcium exchanger is not required for functional membrane integration. Biochem. Biophys. Res. Comm. 212:968-974.

Audigier, Y., M. Friedlander and G. Blobel (1989). Multiple topogenic sequences in bovine opsin. Proc. Natl. Acad. Sci. (U.S.A.) 84:5783-5787.

Haik, B.G., L. Saint-Lewis, M.E. Smith, R.M. Ellsworth, M. Deck, and M. Friedlander (1987). Magnetic resonance imaging in choroidal tumors. Ann. Ophthalmol. 19:218-238.

Mostov, K.E., Friedlander M., and G. Blobel (1986). Structure and function of the receptor for polymeric immunoglobulins. Biochem. Soc. Symp. 51:113-5 .

Friedlander, M. and G. Blobel (1985). Bovine opsin has more than one signal sequence. Nature 318:338-343.

Mostov, K.M., M. Friedlander and G. Blobel (1984). The receptor for transepithelial transport of IgA and IgM contains multiple Ig-like domains. Nature 308:37-43.

Hertzberg, E.L., D.A. Anderson, M. Friedlander, and N.B. Gilula (1982). Comparative analysis of the major polypeptides from liver gap junctions and lens fiber junctions. J. Cell Biol. 92:53-59.

Friedlander, M. and D.A. Fischman (1979). Immunological studies of the embryonic muscle cell surface. I. Antiserum to the prefusion myoblast. J. Cell Biol. 81:193-214.

Friedlander, M., E.P. Beyer and D.A. Fischman (1978). Muscle cell fusion and differentiation following X-irradiation. Develop. Biol. 66:225-237.

Friedlander, M. and D.A. Fischman (1977). Surface antigens of the embryonic chick myoblast; expression on freshly dissociated cells. J. Supramol. Struct. 7:323-338.

REVIEW ARTICLES AND BOOKS:

Friedlander, M. (2001). Anti-angiogenesis for Neovascular Eye Diseases: Clinical Trials and New Directions. "Advances in Ocular Oncology," Audio Digest OPHTHALMOLOGY, 39:09.

Friedlander, M. (2001). Angiogenesis in Tumors and Neovascular Eye Disease. "Advances in Ocular Oncology," Audio Digest OPHTHALMOLOGY, 39:09.

Friedlander, M. and Mueckler, M. (eds.) (1993). Receptors and Membrane Proteins: Molecular Biology of Membrane Transport. Pumps, Transporters and Channels. IRC 137C. Academic Press, San Diego.

Friedlander, M. and Mueckler, M. (eds.) (1992). Receptors and Membrane Proteins: Molecular Biology of Membrane Transport. Bacterial and Glucose Transporters. International Review of Cytology (IRC) 137A; 137B. Academic Press, San Diego.

Friedlander, M. (ed). (1980). Immunological Approaches to Embryonic Development and Differentiation, Part II.Current Topics in Developmental Biology 14. Academic Press, New York.

Friedlander M. (ed.) (1979). Immunological Approaches to Embryonic Development and Differentiation, Part I.Current Topics in Developmental Biology 13. Academic Press, New York.

Friedlander, M. (1980). Immunological approaches to the study of myogenesis and lens fiber junction formation. Curr. Topics Develop. Biol. 14:321-358.

Fischman, D.A., J.L. Doering and M. Friedlander (1976). Muscle development in vitro: regulation of cell fusion and serological analysis of the myogenic cell surface. in Tests of Teratogenicity in vitro (A. Marois, ed.), North Holland Publishers, pp. 233-259.