Amalio Telenti, MD, PhD
Research Focus
Dr. Telenti led the study of the first 10,000 human genomes that underwent deep sequencing (Telenti et al. PNAS 2016), as well as key studies on the essentiality of coding and non-coding genome elements (Bartha et al. PLoS Comp Biol 2015, Bartha et al. Nat Rev Genet 2018, di Iulio et al. Nat Genet 2018). His lab contributes approaches for the integration of genomic and other data modalities, in particular metabolome and microbiome (Long et al. Nat Genet 2017, Moustafa et al. PLoS Pathogens 2017, Cirulli et al. Cell Metab 2018) and for the joint analyses of two genomes (Bartha et al. eLife 2013). In previous years, the Telenti lab led research in host-pathogen genomics (Fellay et al. Science 2007, Loeuillet et al. PLoS Biol 2008, Rotger et al. J Clin Invest 2011), and earlier, on the genomics of drug resistance (Telenti et al. Lancet 1993, Takiff et al. Antimicrob Agents Chem 1994, Telenti et al. Nat Med 1997). His research is also focused on the development of public resources (https//omni.telentilab.com) and in the implementation of new machine and deep learning tools for genomics (Zou et al. Nat Genet 2018).
Education
M.D., Licence in medicine, University of Oviedo, SpainPh.D., Microbial Genetics, University of Zaragoza, Spain
Professional Experience
Amalio Telenti joined The Scripps Research Institutes in November 2017 as professor of genomics in the department of integrative structural and computational biology, and as chief data scientist of the Scripps Translational Science Institute. Previous to these appointments, he was Chief Scientific Officer at Human Longevity Inc.in La Jolla CA. Prior to joining Human Longevity Inc., Amalio Telenti was faculty of the University of Lausanne, Switzerland where he established a program of host-pathogen genomics. He is member of the Scientific Advisory Board of the Center for Integrative Genomics, University of Lausanne, of the Institute Pasteur – Chinese Academy of Sciences, Shanghai, and of the Swiss Personalized Health Network. Amalio Telenti graduated from the Faculty of Medicine of the University of Oviedo, Spain, and has a doctorate in microbiology from the University of Zaragoza, Spain. He carried out medical training at the Mayo Clinic in Rochester, MN.Awards & Professional Activities
Elected member of the Swiss Academy of Medical SciencesRecipient of the Swiss Cloetta Award for medical research
Selected References
Selected publications
Telenti A. et al. Deep Sequencing of 10,000 Human Genomes. PNAS 2016 Oct 18; 113(42): 11901–11906. PMC5081584.
Long T. et al. Whole-genome sequencing identifies common to rare variants associated with human blood metabolites. Nature Genetics, 2017 Apr;49(4):568-578.
Tang H. et al. Profiling of Short-Tandem-Repeat Disease Alleles in 12,632 Human Whole Genomes. Am J Hum Genet 2017 Nov 2;101(5):700-715. PMC5673627
Moustafa A. et al. The blood DNA virome in 8,000 humans. PLoS Pathogens 2017 Mar; 13(3): e1006292. PMC5378407
Bartha I. et al. Human gene essentiality. Nature Reviews Genetics, 2018 Jan;19(1):51-62.
di Iulio J. et al. The human noncoding genome defined by genetic diversity Nature Genetics 2018 Mar;50(3):333-337. PMID: 29483654.
Cirulli ET et al. Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk. Cell Metab. 2018 Oct 8.pii: S1550-4131(18)30630-2. PMID: 30318341.
Zou J et al. A primer on deeplearning in genomics. Nat Genet. 2019 Jan;51(1):12-18. PMID: 30478442.