Zaverio Ruggeri, MD

Professor
Department of Molecular Medicine
California Campus



Education

University of Pavia, 1981
University of Pavia, 1973
M.D. (Medicine), University of Milan, 1970

Professional Experience

2007-2017 Professor, Molecular and Experimental Medicine (MEM), Scripps Research
1989-2009 Head, Division of Experimental Hemostasis and Thrombosis, Scripps Research
1989-1993 Associate Professor with tenure, Department of Molecular and Experimental Medicine, Scripps Research
1985-1989 Associate Professor, Department of Basic and Clinical Research, Scripps Clinic and Research Foundation
1982-1985 Assistant Professor, Departments of Immunology and of Basic and Clinical Research, Scripps Clinic and Research Foundation
1980-1982 Associate Director, Hemophilia and Thrombosis Centre, Policlinico Hospital, University of Milan
1978-1980 Visiting Investigator, Department of Molecular Immunology, Research Institute of Scripps Clinic
1972-1980 Assistant Clinical Professor, Policlinico Hospital, University of Milan
1976-1976 Visiting Investigator, Department of Obstetrics and Gynecology, St. Bartholomew's Hospital (London, England)
1974-1975 Visiting Investigator, Department of Hematology, St. Thomas's Hospital (London, England)
1970-1972 Research Fellow, Hemophilia Centre, University of Milan

Selected References

All Publications

Chen, Y., Ruggeri, Z. M. & Du, X. 14-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling. (2018). Blood, 131(22), 2436-2448. PMCID: PMC5981166.

Xu, M., Li, J., Neves, M. A. D., Zhu, G., Carrim, N., Yu, R., Gupta, S., Marshall, J., Rotstein, O., Peng, J., Hou, M., Kunishima, S., et al. GPIbα is required for platelet-mediated hepatic thrombopoietin generation. (2018). Blood, 132(6), 622-634.

Oldstone, M. B. A., Ware, B. C., Horton, L. E., Welch, M. J., Aiolfi, R., Zarpellon, A., Ruggeri, Z. M. & Sullivan, B. M. Lymphocytic choriomeningitis virus Clone 13 infection causes either persistence or acute death dependent on IFN-1, cytotoxic T lymphocytes (CTLs), and host genetics. (2018). Proceedings of the National Academy of Sciences of the United States of America, 115(33), E7814-E7823. PMCID: PMC6099862.

Moccetti, F., Brown, E., Xie, A., Packwood, W., Qi, Y., Ruggeri, Z., Shentu, W., Chen, J., Lopez, J. A. & Lindner, J. R. Myocardial infarction produces sustained proinflammatory endothelial activation in remote arteries. (2018). Journal of the American College of Cardiology, 72(9), 1015-1026. PMCID: PMC6110111.

Kanaji, T., Vo, M. N., Kanaji, S., Zarpellon, A., Shapiro, R., Morodomi, Y., Yuzuriha, A., Eto, K., Belani, R., Do, M. H., Yang, X. L., Ruggeri, Z. M., et al. Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia. (2018). Proceedings of the National Academy of Sciences of the United States of America, 115(35), EB228-EB235. PMCID: PMC6126720.

Dutting, S., Gaits-Iacovoni, F., Stegner, D., Popp, M., Antkowiak, A., van Eeuwijk, J. M. M., Nurden, P., Stritt, S., Heib, T., Aurbach, K., Angay, O., Cherpokova, D., et al. A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis. (2017). Nature Communications, 8.

Jackel, S., Kiouptsi, K., Lillich, M., Hendrikx, T., Khandagale, A., Kollar, B., Hormann, N., Reiss, C., Subramaniam, S., Wilms, E., Ebner, K., von Bruhl, M. L., et al. Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2. (2017). Blood, 130(4), 542-553.

Kossmann, S., Lagrange, J., Jackel, S., Jurk, K., Ehlken, M., Schonfelder, T., Weihert, Y., Knorr, M., Brandt, M., Xia, N., Li, H., Daiber, A., et al. Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension. (2017). Science Translational Medicine, 9.

Kamikubo, Y., Mendolicchio, G. L., Zampolli, A., Marchese, P., Rothmeier, A. S., Orje, J. N., Gale, A. J., Krishnaswamy, S., Gruber, A., Ostergaard, H., Petersen, L. C., Ruf, W., et al. Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex. (2017). Blood, 130(14), 1661-1670.

Rothmeier, A. S., Marchese, P., Langer, F., Kamikubo, Y., Schaffner, F., Cantor, J., Ginsberg, M. H., Ruggeri, Z. M. & Ruf, W. Tissue factor prothrombotic activity is regulated by integrin-arf6 trafficking. (2017). Arteriosclerosis Thrombosis and Vascular Biology, 37(7), 1323-1331. PMCID: PMC5501484.