Hans Renata, PhD

Assistant Professor
Department of Chemistry
Florida Campus


Scripps Research Joint Appointments

Faculty, Graduate Program

Research Focus

Despite rapid advances in synthetic organic chemistry, many classes of small molecules remain inefficient to access using conventional methods. Enzymatic reactions, on the other hand, offer unparalleled potential for highly selective chemical transformations. By combining the power of directed evolution and advances in microbial genomics, the Renata laboratory aims to develop practical enzymatic solutions for traditionally challenging organic reactions, especially in the realm of C–H functionalization chemistry. The utility of these transformations will be showcased in the concise, scalable synthesis of bioactive natural products and their analogues. After successfully synthesizing these small molecules, we will take advantage of the state-of-the-art HTS operation at Scripps to rapidly assay their pharmacological profiles. Research projects are designed to be highly interdisciplinary, providing students with broad exposure to synthetic organic chemistry, molecular biology, and enzyme engineering to ensure that they are well-equipped for future careers in both academia and industry.


Ph.D. (Chemistry), Scripps Research, 2013
B.A. (Chemistry), Columbia University, 2008

Professional Experience

2013-2016 Postdoctoral Scholar, California Institute of Technology

Awards & Professional Activities

Selected References

All Publications

Zhang, X., King-Smith, E., Dong, L. B., Yang, L. C., Rudolf, J. D., Shen, B. & Renata, H. Divergent synthesis of complex diterpenes through a hybrid oxidative approach. (2020). Science, 369(6505), 799-806.

Li, J., Li, F., King-Smith, E. & Renata, H. Merging chemoenzymatic and radical-based retrosynthetic logic for rapid and modular synthesis of oxidized meroterpenoids. (2020). Nature Chemistry, 12(2), 173-179.

Lia, J., Amatuni, A. & Renata, H. Recent advances in the chemoenzymatic synthesis of bioactive natural products. (2020). Current Opinion in Chemical Biology, 55, 111. PMCID: PMC7237303.

Li, J., Zhang, X. & Renata, H. Asymmetric chemoenzymatic synthesis of (-)-podophyllotoxin and related aryltetralin lignans. (2019). Angewandte Chemie-International Edition,

Zwick III, C. R., Sosa, M. B. & Renata, H. Characterization of a citrulline 4-hydroxylase from nonribosomal peptide GE81112 biosynthesis and engineering of its substrate specificity for the chemoenzymatic synthesis of enduracididine. (2019). Angewandte Chemie-International Edition,

Dong, L. B., Zhang, X., Rudolf, J. D., Deng, M. R., Kalkreuter, E., Cepeda, A. J., Renata, H. & Shen, B. Cryptic and stereospecific hydroxylation, oxidation, and reduction in platensimycin and platencin biosynthesis. (2019). Journal of the American Chemical Society, 141(9), 4043-4050.

Zhang, X. & Renata, H. Efficient chemoenzymatic synthesis of (2S,3R)-3-hydroxy-3-methylproline, a key fragment in polyoxypeptin A and FR225659. (2019). Tetrahedron, 75(24), 3253-3257.

Li, F., Zhang, X. & Renata, H. Enzymatic C-H functionalizations for natural product synthesis. (2019). Current Opinion in Chemical Biology, 49, 25. PMCID: PMC6437013.

Zhang, R. J. K., Chen, K., Huang, X., Wohlschlager, L., Renata, H. & Arnold, F. H. Enzymatic assembly of carbon-carbon bonds via iron-catalysed sp(3) C-H functionalization. (2019). Nature, 565(7737), 67-72.

Amatuni, A. & Renata, H. Identification of a lysine 4-hydroxylase from the glidobactin biosynthesis and evaluation of its biocatalytic potential. (2019). Organic & Biomolecular Chemistry, 17(7), 1736-1739. PMCID: PMC6374188.