Hans Renata, PhD

Associate Professor
Department of Chemistry
Florida Campus


 Email

Scripps Research Joint Appointments

Faculty, Graduate Program

Research Focus

Despite rapid advances in synthetic organic chemistry, many classes of small molecules remain inefficient to access using conventional methods. Enzymatic reactions, on the other hand, offer unparalleled potential for highly selective chemical transformations. By combining the power of directed evolution and advances in microbial genomics, the Renata laboratory aims to develop practical enzymatic solutions for traditionally challenging organic reactions, especially in the realm of C–H functionalization chemistry. The utility of these transformations will be showcased in the concise, scalable synthesis of bioactive natural products and their analogues. After successfully synthesizing these small molecules, we will take advantage of the state-of-the-art HTS operation at Scripps to rapidly assay their pharmacological profiles. Research projects are designed to be highly interdisciplinary, providing students with broad exposure to synthetic organic chemistry, molecular biology, and enzyme engineering to ensure that they are well-equipped for future careers in both academia and industry.


Education

Ph.D. (Chemistry), Scripps Research, 2013
B.A. (Chemistry), Columbia University, 2008

Professional Experience

2013-2016 Postdoctoral Scholar, California Institute of Technology

Awards & Professional Activities


Selected References

All Publications

Zwick, C. R., Sosa, M. B. & Renata, H. Modular Chemoenzymatic Synthesis of GE81112 B1 and Related Analogues Enables Elucidation of Its Key Pharmacophores. (2021). Journal of the American Chemical Society, 143(3), 1673-1679. PMCID: PMC8133794.

Stout, C. N. & Renata, H. Reinvigorating the Chiral Pool: Chemoenzymatic Approaches to Complex Peptides and Terpenoids. (2021). Accounts of Chemical Research, 54(5), 1143-1156. PMCID: PMC8138964.

Zhang, X., King-Smith, E., Dong, L. B., Yang, L. C., Rudolf, J. D., Shen, B. & Renata, H. Divergent synthesis of complex diterpenes through a hybrid oxidative approach. (2020). Science, 369(6505), 799-806.

Lia, J., Amatuni, A. & Renata, H. Recent advances in the chemoenzymatic synthesis of bioactive natural products. (2020). Current Opinion in Chemical Biology, 55, 111. PMCID: PMC7237303.

Li, J., Li, F., King-Smith, E. & Renata, H. Merging chemoenzymatic and radical-based retrosynthetic logic for rapid and modular synthesis of oxidized meroterpenoids. (2020). Nature Chemistry, 12(2), 173-179.

Amatuni, A., Shuster, A., Adibekian, A. & Renata, H. Concise Chemoenzymatic Total Synthesis and Identification of Cellular Targets of Cepafungin I. (2020). Cell Chemical Biology, 27(10), 1318-1326.

Renata, H. Exploration of Iron- and α-Ketoglutarate-Dependent Dioxygenases as Practical Biocatalysts in Natural Product Synthesis. (2020). Synlett,

Zwick III, C. R. & Renata, H. Harnessing the biocatalytic potential of iron- and α-ketoglutarate-dependent dioxygenases in natural product total synthesis. (2020). Natural Product Reports, 37(8), 1065-1079. PMCID: PMC7426249.

Zwick III, C. R., Sosa, M. B. & Renata, H. Characterization of a citrulline 4-hydroxylase from nonribosomal peptide GE81112 biosynthesis and engineering of its substrate specificity for the chemoenzymatic synthesis of enduracididine. (2019). Angewandte Chemie-International Edition,

Li, J., Zhang, X. & Renata, H. Asymmetric chemoenzymatic synthesis of (-)-podophyllotoxin and related aryltetralin lignans. (2019). Angewandte Chemie-International Edition,