Brian Paegel, PhD

Associate Professor
Department of Chemistry
Florida Campus

Scripps Research Joint Appointments

Associate Professor, Department of Molecular Medicine
Faculty, Graduate Program

Research Focus

All of contemporary biology and most chemistry is compartmentalized. For example, beakers, flasks or microplate wells spatially segregate individual chemical reactions. Likewise, membranes compartmentalize individual cells and subcellular organelles, tissues and organs organize the metabolism of multi-cellular organisms, and even organisms themselves are merely the vehicles for selfishly replicating genes in a population. Reaction vessels, seemingly innocuous entities, actually play starring roles in activities ranging from drug discovery laboratory automation and technology development to natural selection and the origins of life on Earth. We are broadly interested in the rational construction of microscopic reaction vessels and the interesting chemical and biological operations that we can conduct within their confines.


Ph.D. (Chemistry), University of California, Berkeley, 2003
B.S. (Chemistry), Duke University, 1998

Professional Experience

2017-2017 Associate Professor (Joint Appointment), Molecular Medicine, Scripps Research
2015-2017 Associate Professor, Chemistry, Scripps Research
2015-2017 Associate Professor, Molecular Therapeutics, Scripps Research
2009-2015 Assistant Professor, Chemistry, Scripps Research
2009-2015 Assistant Professor (Joint Appointment), Molecular Therapeutics, Scripps Research
2004-2008 Postdoctoral Fellow with Dr. Gerald Joyce, Molecular Biology, Scripps Research

Awards & Professional Activities

NSF CAREER Award (2013)
NIH Director's New Innovator Award (2011)
NIH Pathway to Independence Award (2007)
NIH NRSA Postdoctoral Fellow (2004)

Selected References

All Publications

MacConnell, A. B., Price, A. K. & Paegel, B. M. An integrated microfluidic processor for DNA-encoded combinatorial library functional screening. (2017). ACS Combinatorial Science, 19(3), 181-192. PMCID: PMC5350604.

Malone, M. L., Cavett, V. J. & Paegel, B. M. Chemoselective coupling preserves the substrate integrity of surface-immobilized oligonucleotides for emulsion PCR-based gene library construction. (2017). ACS Combinatorial Science, 19(1), 9-14. PMCID: PMC5243130.

Mendes, K. R., Malone, M. L., Ndungu, J. M., Suponitsky-Kroyter, I., Cavett, V. J., McEnaney, P. J., MacConnell, A. B., Doran, T. M., Ronacher, K., Stanley, K., Utset, O., Walzl, G., et al. High-throughput identification of DNA-encoded IgG ligands that distinguish active and latent Mycobacterium tuberculosis infections. (2017). ACS Chemical Biology, 12(1), 234-243. PMCID: PMC5250564.

Cochrane, W. G., Hackler, A. L., Cavett, V. J., Price, A. K. & Paegel, B. M. Integrated, continuous emulsion creamer. (2017). Analytical Chemistry, 89(24), 13227-13234.

MacConnell, A. B. & Paegel, B. M. Poisson statistics of combinatorial library sampling predict false discovery rates of screening. (2017). ACS Combinatorial Science, 19(8), 524-532. PMCID: PMC5558193.

Price, A. K. & Paegel, B. M. Discovery in droplets. (2016). Analytical Chemistry, 88, 339. PMCID: PMC4865373.

Tran, D. T., Cavett, V. J., Dang, V. Q., Torres, H. L. & Paegel, B. M. Evolution of a mass spectrometry-grade protease with PTM-directed specificity. (2016). Proceedings of the National Academy of Sciences of the United States of America, 113(51), 14686-14691. PMCID: PMC5187733.

Malone, M. L. & Paegel, B. M. What is a "DNA-compatible" reaction?. (2016). ACS Combinatorial Science, 18(4), 182-187. PMCID: PMC4946796.

Price, A. K., MacConnell, A. B. & Paegel, B. M. hvSABR: photochemical dose-response bead screening in droplets. (2016). Analytical Chemistry, 88(5), 2904-2911. PMCID: PMC4776284.

MacConnell, A. B., McEnaney, P. J., Cavett, V. J. & Paegel, B. M. DNA-encoded solid-phase synthesis: encoding language design and complex oligomer library synthesis. (2015). ACS Combinatorial Science, 17(9), 518-534. PMCID: PMC4571006.


Pubmed Publication List