Brian Modena, MD

Assistant Professor of Molecular Medicine
Assistant Professor of Scripps Translational Science Institute
Department of Molecular Medicine
California Campus

Scripps Research Joint Appointments

Assistant Professor, Scripps Translational Science Institute
Faculty, Graduate Program

Other Joint Appointments

Scripps Health

Research Focus

Brian Modena, M.D., M.Sc. is a physician & researcher with trained expertise in Allergy-Immunology. He completed a 2-year Allergy-Immunology clinical fellowship with a focus on treating severe asthma patients at the University of Pittsburgh, a hub for the NIH-funded Severe Asthma Research Program. He obtained a M.Sc. in Clinical & Translational Research at the Scripps Research Institute (TSRI) with a focus in Genomics and Translational research, and joined STSI and TSRI as a joint Assistant Professor in 2016. He serves as a clinical preceptor to medical students and Allergy-Immunology fellows by maintaining a faculty appointment in the Scripps Health Allergy-Immunology Division.

His research interest involves the use of mRNA gene expression, epigenetic methylation changes, genetic variation, microbiome changes (‘dysbiosis’) and utilization of new health monitoring technologies to improve biological and clinical understanding of clinical disease, particularly in patients with severe asthma and organ transplantation. 




B.S., Mechanical Engineering, Virginia Polytechnic Institute & State University, 2000
M.D., Medicine, West Virginia University School of Medicine, 2006
M.Sc., Clinical & Translational Research, The Scripps Research Institute, 2016

Professional Experience

Mechanical Engineering, Virginia Polytechnic Institute & State University

Medicine, West Virginia University School of Medicine  

Internal Medicine, Scripps Clinic & Green Hospital

Internal Medicine, Scripps Clinic & Green Hospital 

Clinical Fellowship 
Allergy & Immunology, University of Pittsburgh

Masters in Science
Clinical & Translational Reserach, The Scripps Research Institute

Awards & Professional Activities

2016 Chairman’s Award of Research Excellence, Scripps Health, San Diego, CA
2015 "Going the Extra Mile" Teaching Award, University of California San Diego
2015 The Scripps Translational Science Institute’s KL2 Scholar Pilot Award
2014 Scripps Health Pilot Award 
2014 The Scripps Translational Science Institute’s KL2 Scholar Pilot Award           
2014 KL2 Clinical Scholar Program Scholarship
2014 Winner of American Academy of Allergy, Asthma, and Immunology National Conference Abstract Competition

Selected References

Modena, Brian D; Eugene R Bleecker; William W Busse; Serpil C. Erzurum; Benjamin M Gaston; Nizar N. Jarjour; Deborah A Meyers; Jadranka Milosevic; John R Tedrow; Wei Wu; Naftali Kaminski; Sally E Wenzel; Gene Expression Correlated to Severe Asthma Characteristics Reveals Heterogeneous Mechanisms of Severe Disease. In Press, Published online December 16, 2016. American Journal of Respiratory and Critical Care Medicine (AJRCCM).

Modena B, Tedrow J, Milosevic J, Bleecker E, Meyers D, Wu W, Bar-Joseph Z, Erzurum S, Gaston B, Busse W, Jarjour N, Kaminski N & Wenzel S. (2014). Gene Expression in Relation to Exhaled NO Identifies Novel Asthma Phenotypes with Unique Biomolecular Pathways. American Journal of Respiratory and Critical Care Medicine (AJRCCM). Vol. 190, No. 12 (2014), pp. 1363-1372. doi: 10.1164/rccm.201406-1099OC.

Modena Brian, Sunil M Kurian, Lillian W Gaber, Jill Waalen, Terri Gelbart, Tony S Mondala, Steven R Head, Suzanne Papp, Raymond Heilman, John J Friedewald, Stuart Flechner, Christopher L Marsh, Randall S. Sung, Hamid Shidban, Laurence Chan, Michael M Abecassis, Daniel R Salomon. (2016). Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms that Correlate with Worse Long-term Outcomes.  American Journal of Transplantation (AJT). March 15, 2016. 

Modena, Brian D Rachel Milam, Frank Harrison, Jennifer A Cheeseman, Michael M Abecassis, John Friedewald, Allan D. Kirk, Daniel R Salomon. Changes in urinary microbiome populations correlate in kidney transplants with interstitial fibrosis and tubular atrophy documented in early surveillance biopsies. Sept 6, 2016. American Journal of Transplantation (AJT)

Modena, Brian D, Sally E Wenzel. Consistency of T2 Gene Signatures in Severe Asthma: Key to Effective Treatments or Merely the Tip of the Iceberg? In Press. 2016. American Journal of Respiratory and Critical Care Medicine (AJRCCM).

Modena, Brian, Kristen M Dazy, Andrew White Emerging Concepts: mast cell involvement in allergic diseases (2016). Translational Research. Feb 24, 2016

Cook K, Modena B, Wineinger N, Woessner, K, Simon R, White A. Use of a Composite Symptom Score during Challenge in Patients with Suspected Aspirin-Exacerbated Respiratory Disease. In Press (2017). Annals of Allergy, Asthma & Immunology.

Cook K, Modena B, Simon R. Improvement in Asthma Control Using a Minimally Burdensome and Proactive Smartphone Application. The Journal of Allergy and Clinical Immunology (JACI): In Practice. Jul-Aug;4(4):730-737.e1. doi: 10.1016/j.jaip.2016.03.005 (2016).