Jeanne Loring, PhD

Professor Emeritus
Director of The Center For Regenerative Medicine
Department of Molecular Medicine


Scripps Research Joint Appointments

Faculty, Graduate Program

Other Joint Appointments

Adjunct Professor, Graduate School of Public Health, San Diego State University
Adjunct Professor, Human Genetics, Sanford Burnham Prebys Medical Discovery Institute
Research Fellow of the Zoological Society of San Diego

Research Focus

We focus on human pluripotent stem cells, the remarkable cultured cells that can become every cell type in the human body.  Most of our research is on induced pluripotent stem cells (iPSCs), which we make from cells cultured from skin biopsies.

Since these stem cells are pluripotent, we as scientists need to be "pluripotent" too.  We have a diverse group of stem cell research projects, ranging from the molecular (genomics and epigenetics) to the clinical (cell therapies).

Genomics and Epigenetics
On one end of the spectrum, we study the genomics and epigenetics of iPSCs, the fascinating symphony of changes in the DNA landscape as cells differentiate into beating heart cells or functioning nerve cells.  These studies give us never-before-available access into the complex processes that occur during human embryonic development, and hints about the embryonic origins of mental illness. We are focusing on Fragile X syndrome, an inherited form of autism.

Parkinson's disease cell replacement therapy
On the other end of the spectrum, we are moving toward using iPSCs to treat Parkinson's disease (PD).  This is a cell replacement therapy, in which cells are to be transplanted into the part of the brain that requires dopamine to function properly.  Working with our clinical partner, Dr. Melissa Houser, who is Director of the Movement Disorder Center at Scripps Clinic, we have made iPSC lines from 8 Parkinson's patients, and have turned 3 of the lines so far into bona fide dopamine neurons, the cell type that dies during progression of the disease.  We have confirmed that the cells function by studying their electrical activity (with colleague Pietro Sanna) and by reversing PD-like symptoms in a rat model of the disease.

Multiple sclerosis therapy development
Another of our clinical paths is for treatment of multiple sclerosis (MS).  We recently discovered a cell type derived from human pluripotent stem cells that reverses the clinical symptoms in a mouse model of MS.  This program is not as advanced as the PD program, but we are following a path to developing a clinically relevant treatment.

We are using iPSCs from patients with Fragile X syndrome, an inherited form of autism, to understand the disease and identify drugs that might be used to treat it. This project uses high throughput screening, the technique used by pharmaceutical companies to find drugs.

Drugs often work differently in different people.  A drug that works in African Americans, for example, might be toxic to people with a different genetic ancestry.  We are generating an ethnically diverse bank of iPSCs that we plan to provide to pharmaceutical drug developers so they may be able to predict the effects of a drug in different populations before testing it in people.

The Stem Cell Zoo
Some highly endangered species will inevitably become extinct in our lifetimes if we do not take extraordinary measures to save them.  One of these approaches is to make iPSCs from endangered animals, like the Northern White Rhino, a species that has only 7 animals left.  Working with the San Diego Zoo's Conservation Research Institute, we are generating iPSCs from endangered species, in the hope that someday these cells can be used to repopulate the species.


Ph.D. (Developmental Neurobiology), University of Oregon, Institute of Molecular Biology, 1979
B.S. (Molecular Biology), University of Washington, 1972

Professional Experience

2017-2019 Professor of Developmental Neurobiology, Molecular Medicine, Scripps Research
2007-2017 Professor of Developmental Neurobiology, Chemical Physiology, Scripps Research
2004-2007 Co-Director, Stem Cell Center, Sanford Burnham Prebys Medical Discovery Institute
1997-2003 CSO and Founder, Arcos Bioscience
1997-2001 Senior Director, Incyte Genomics
1995-1997 Senior Research Fellow, Molecular Dynamics
1989-1995 Senior Scientist, GenPharm International Inc.
1987-1989 Staff Scientist, Hana Biologics, Inc.
1982-1987 Assistant Professor/Lecturer, Embryology and Neurobiology, University of California, Davis

Awards & Professional Activities

1968    National Merit Undergraduate Scholarship (Doherty Foundation)
1972    Phi Beta Kappa
1972    BS magna cum laude, U. Washington
1973    National Science Foundation Predoctoral Fellowship (individual award)
1978    National Institutes of Health Predoctoral Traineeship, Genetics
1980    National Institutes of Health Postdoctoral Fellowship, Neurobiology

Recent honors:
2005    Brandeis University National Women’s Committee Award
2006    Korean Society of Developmental Biology Commendation
2006    San Diego Chapter of Clinical Research Professionals Educational Award
2007    Burnham Institute for Medical Research Leadership Award
2009    Marie Mayer Award for Melanoma Research
2009    Esther O’Keeffe Foundation Award for Stem Cell Research
2008    Millipore Foundation Award for Stem Cell Research
2015    Stem Cell Action Advocacy Award, World Stem Cell Summit
2015    Stem Cell Person of the Year, The Niche
2016    Benning Medical Society Lecturer
2019    XConomy 2019 Award, Stem Cell Pioneer

Selected References

All Publications

Whole-genome mutational burden analysis of three pluripotency induction methods. Bhutani, K, Nazor, KL, Williams, R, Tran, H, Dai, H, Dzakula, Z, Cho, EH, Pang AWC, Rao M, Cao H, Schork NJ, Loring JF. Nat Commun. 2016 Feb 19;7:10536. doi:10.1038/ncomms10536. PMID: 26892726 PMCID: PMC476882 (2016).

Rewinding the process of mammalian extinction.  Saragusty J, Diecke S, Drukker M, Durrant B, Friedrich Ben-Nun I, Galli C, Göritz F, Hayashi K, Hermes R, Holtze S, Johnson S, Lazzari G, Loi P, Loring JF, Okita K, Renfree MB, Seet S, Voracek T, Stejskal J, Ryder OA, Hildebrandt TB.  Zoo Biol. 2016 Jul;35(4):280-92. doi: 10.1002/zoo.21284. [Epub 2016 May 3] PMID: 27142508 (2016).

Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specificationZdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapillar N, Giritharan G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C, Laurent LC, Loring JF, Fisher SJ.  Development. 2015 Dec 1;142(23):4010-25. doi: 10.1242/dev.122846. Epub Oct 19. PMID: 26483210 PMCID: PMC4712832 (2015).

HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation. Jia H, Morris CD, Williams RM, Loring JF, Thomas EA. Pro Nat Acad Sci USA 2015 Jan 6;112(1):E56-64, doi:10.1073/pnas. 1415195112. [Epub 2014 Dec 22] PMCID: PMC4291662 (2015).

Generation of induced pluripotent stem cells from mammalian endangered species.  Ben-Nun IF, Montague SC, Houck ML, Ryder O, Loring JF. Methods Mol Biol. 1330:101-9. doi: 10.1007/978-1-4939-2848-4_10. PMID: 26621593 (2015).

Dynamic changes in replication timing and gene expression during lineage specification of human pluripotent stem cells. Rivera-Mulia JC, Buckley Q, Sasaki T, Zimmerman J, Didier RA, Nazor K, Loring JF, Lian Z, Weissman S, Robins AF, Schulz TC, Menedez L, Kulik MJ, Dalton S, Gabr H, Kahveci T, Gilbert DM. Genome Res. doi:10.1101/gr.187989.114. PMCID: PMC4509994 (2015).

Enabling consistency in pluripotent stem cell-derived products for research and development and clinical applications through material standards.  French, A. et al.  Stem Cells Translational Medicine 4, 217-223, doi:10.5966/sctm.2014-0233 (2015).

Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions.  Garitaonandia, I., Amir, H., Boscolo, F. S., Wambua, G. K., Schultheisz, H. L., Sabatini, K., Morey, R., Waltz, S., Wang, Y. C., Tran, H., Leonardo, T. R., Nazor, K., Slavin, I., Lynch, C., Li, Y., Coleman, R., Gallego Romero, I., Altun, G., Reynolds, D., Dalton, S., Parast, M., Loring, J. F., Laurent, L. C.  PloS One 10, e0118307, doi:10.1371/journal.pone.0118307 (2015).

Glycosyltransferase ST6GAL1 contributes to the regulation of pluripotency in human pluripotent stem cells.  Wang, Y.C., Stein, J.W., Lynch, C.L., Tran, H.T., Lee, C.Y., Coleman, R., Hatch, A., Antontsev, V.G., Chy, H.S., O'Brien, C.M., Murthy, S.K., Laslett, A.L., Peterson, S.E., Loring, J.F., . Scientific Reports 5, 13317. (2015).

Stem cell reprogramming: Basic implications and future perspective for movement disorders.  Brandl, B., Schneider, S. A., Loring, J. F., Hardy, J., Gribbon, P., Muller, F. J.   Movement Disorders: official journal of the Movement Disorder Society 30, 301-312, doi:10.1002/mds.26113 (2015).

The 'sweet' spot of cellular pluripotency: protein glycosylation in human pluripotent stem cells and its applications in regenerative medicine.  Wang, Y. C., Lin, V., Loring, J. F. & Peterson, S. E.  Expert Opinion On Biological Therapy, 1-9, doi:10.1517/14712598.2015.1021329 (2015).

DNA methylation fingerprint of neuroblastoma reveals new biological and clinical insights.  Gomez, S., Castellano, G., Mayol, G., Sunol, M., Queiros, A., Bibikova, M., Nazor, K.L., Loring, J.F., Lemos, I., Rodriguez, E., de Torres, C., Mora, J., Martin-Subero, J.I., Lavarino, C., . Epigenomics, 1-17. (2015).

A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics.  Gallego Romero, I., Pavlovic, B.J., Hernando-Herraez, I., Zhou, X., Ward, M.C., Banovich, N.E., Kagan, C.L., Burnett, J.E., Huang, C.H., Mitrano, A., Chavarria, C.I., Friedrich Ben-Nun, I., Li, Y., Sabatini, K., Leonardo, T.R., Parast, M., Marques-Bonet, T., Laurent, L.C., Loring, J.F., Gilad, Y.,. . eLife 4, doi:10.7554/eLife.07103 (2015).

Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI).  Andrews, P. et al.  Regenerative Medicine 10, 1-44, doi:10.2217/rme.14.93 (2015).

Human neural precursor cells promote neurologic recovery in a viral model of multiple sclerosis. Chen, L., Coleman, R., Leang, R., Tran, H., Kopf, A., Walsh, C.M., Sears-Kraxberger, I., Steward, O., Macklin, W.B., Loring, J.F., Lane, T.E.,  Stem cell reports 2, 825-837. (2014).

Genomic instability in pluripotent stem cells: implications for clinical applications. Peterson, S.E., Loring, J.F. The Journal of biological chemistry 289, 4578-4584. (2014)

A compass for stem-cell differentiation. Müller FJ, Loring JF.  Network biology:  Nature. Sep 25;513(7519):498-9. doi: 10.1038/513498a (2014)

Neural stem cells genetically modified to express neprilysin reduce pathology in Alzheimer transgenic models.  Blurton-Jones, M., Spencer, B., Michel, S., Castello, N.A., Agazaryan, A.A., Davis, J.L., Müller, F-J., Loring, J.F., Masliah, E., LaFerla, F.  Stem Cell Research and Therapy 5:46 (2014).

Nerem, R.M., Loring, J., McDevitt, T.C., Palecek, S.P., Schaffer, D., Zandstra, P.W.,. A Global Assessment of Stem Cell Engineering. Tissue engineering. Part A. (2014).

Protein post-translational modifications and regulation of pluripotency in human stem cells. Wang, Y.C., Peterson, S.E., Loring, J.F., Cell Research 24, 143-160. (2014)

Intraspinal transplantation of  mouse and human neural precursor cellsWeinger, J.G., Chen, L., Coleman, R., Leang, R., Plaisted, W.C., Loring, J.F., Lane, T.E., 2013. Current protocols in stem cell biology 26, Unit 2D 16.

 Epigenetic regulation of pluripotency and differentiation.  Boland, M. J., Nazor, K. L. & Loring, J. F. Circulation research 115, 311-324, (2014).

Melanocytes derived from transgene-free human induced pluripotent stem cells. Jones JC, Sabatini K, Liao X, Tran HT, Lynch CL, Morey RE, Glenn-Pratola V, Boscolo FS, Yang Q, Parast MM, Liu Y, Peterson SE, Laurent LC, Loring JF, Wang YC.  J Invest Dermatol. 2013 Mar 20. doi: 10.1038/jid.2013.139. [Epub ahead of print] No abstract available. PMID: 23514962 [PubMed - as supplied by publisher]    

 Conversion of human fibroblasts to angioblast-like progenitor cells. Kurian L, Sancho-Martinez I, Nivet E, Aguirre A, Moon K, Pendaries C, Volle-Challier C, Bono F, Herbert JM, Pulecio J, Xia Y, Li M, Montserrat N, Ruiz S, Dubova I, Rodriguez C, Denli AM, Boscolo FS, Thiagarajan RD, Gage FH, Loring JF, Laurent LC, Izpisua Belmonte JC. Nat Methods. 2013 Jan;10(1):77-83. doi: 10.1038/nmeth.2255. Epub 2012 Dec 2.
PMID: 23202434

Ethnically diverse pluripotent stem cells for drug development.
Fakunle ES, Loring JF.
Trends Mol Med. 2012 Dec;18(12):709-16. doi: 10.1016/j.molmed.2012.10.007. Epub 2012 Nov 9.
PMID: 23142148 [PubMed - in process]

The functions of microRNAs in pluripotency and reprogramming.
Leonardo TR, Schultheisz HL, Loring JF, Laurent LC.
Nat Cell Biol. 2012 Nov;14(11):1114-21. doi: 10.1038/ncb2613.
PMID: 23131918 [PubMed - in process]

Equally potent? Does cellular reprogramming justify the abandonment of human embryonic stem cells?
Nazor KL, Loring JF, Laurent LC.
EMBO Rep. 2012 Oct;13(10):890-4. doi: 10.1038/embor.2012.134. Epub 2012 Sep 18. No abstract available.
PMID: 22986548 [PubMed - in process]

Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells.
Ramsköld D, Luo S, Wang YC, Li R, Deng Q, Faridani OR, Daniels GA, Khrebtukova I, Loring JF, Laurent LC, Schroth GP, Sandberg R.
Nat Biotechnol. 2012 Aug;30(8):777-82.
PMID: 22820318 [PubMed - in process]

Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives.
Nazor KL, Altun G, Lynch C, Tran H, Harness JV, Slavin I, Garitaonandia I, Müller FJ, Wang YC, Boscolo FS, Fakunle E, Dumevska B, Lee S, Park HS, Olee T, D'Lima DD, Semechkin R, Parast MM, Galat V, Laslett AL, Schmidt U, Keirstead HS, Loring JF, Laurent LC.
Cell Stem Cell. 2012 May 4;10(5):620-34. doi: 10.1016/j.stem.2012.02.013.
PMID: 22560082 [PubMed - indexed for MEDLINE]

Highly parallel genome-wide expression analysis of single mammalian cells.
Fan JB, Chen J, April CS, Fisher JS, Klotzle B, Bibikova M, Kaper F, Ronaghi M, Linnarsson S, Ota T, Chien J, Laurent LC, Loring JF, Nisperos SV, Chen GY, Zhong JF.
PLoS One. 2012;7(2):e30794. doi: 10.1371/journal.pone.0030794. Epub 2012 Feb 8. Erratum in: PLoS One. 2012;7(2). doi: 10.1371/annotation/3f0ddf41-2e7a-4b56-93c2-2731f2890b19. Loring, Jeanne F [added].
PMID: 22347404 [PubMed - indexed for MEDLINE]

Teratoma generation in the testis capsule.
Peterson SE, Tran HT, Garitaonandia I, Han S, Nickey KS, Leonardo T, Laurent LC, Loring JF.
J Vis Exp. 2011 Nov 7;(57):e3177. doi: 10.3791/3177.
PMID: 22158256 [PubMed - indexed for MEDLINE]

Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome.
Sheridan SD, Theriault KM, Reis SA, Zhou F, Madison JM, Daheron L, Loring JF, Haggarty SJ.
PLoS One. 2011;6(10):e26203. doi: 10.1371/journal.pone.0026203. Epub 2011 Oct 12.
PMID: 22022567 [PubMed - indexed for MEDLINE]

Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis.
Wang YC, Nakagawa M, Garitaonandia I, Slavin I, Altun G, Lacharite RM, Nazor KL, Tran HT, Lynch CL, Leonardo TR, Liu Y, Peterson SE, Laurent LC, Yamanaka S, Loring JF.
Cell Res. 2011 Nov;21(11):1551-63. doi: 10.1038/cr.2011.148. Epub 2011 Sep 6.
PMID: 21894191 [PubMed - indexed for MEDLINE]

Induced pluripotent stem cells from highly endangered species.
Ben-Nun IF, Montague SC, Houck ML, Tran HT, Garitaonandia I, Leonardo TR, Wang YC, Charter SJ, Laurent LC, Ryder OA, Loring JF.
Nat Methods. 2011 Sep 4;8(10):829-31. doi: 10.1038/nmeth.1706.
PMID: 21892153 [PubMed - indexed for MEDLINE]

Evidence that gene activation and silencing during stem cell differentiation requires a transcriptionally paused intermediate state. Golob JL, Kumar RM, Guenther MG, Pabon LM, Pratt GA, Loring JF, Laurent LC, Young RA, Murry CE.
PLoS One. 2011;6(8):e22416. doi: 10.1371/journal.pone.0022416. Epub 2011 Aug 19.
PMID: 21886766 [PubMed - indexed for MEDLINE]

Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy.
Peterson SE, Westra JW, Rehen SK, Young H, Bushman DM, Paczkowski CM, Yung YC, Lynch CL, Tran HT, Nickey KS, Wang YC, Laurent LC, Loring JF, Carpenter MK, Chun J.
PLoS One. 2011;6(8):e23018. doi: 10.1371/journal.pone.0023018. Epub 2011 Aug 16.
PMID: 21857983 [PubMed - indexed for MEDLINE]

Basic approaches to gene expression analysis of stem cells by microarrays.
Schuldt B, Lin Q, Müller FJ, Loring J.
Methods Mol Biol. 2011;767:269-82. doi: 10.1007/978-1-61779-201-4_20.
PMID: 21822882 [PubMed - indexed for MEDLINE]

FISH analysis of human pluripotent stem cells.
Peterson SE, Chun J, Loring J.
Methods Mol Biol. 2011;767:191-200. doi: 10.1007/978-1-61779-201-4_14.
PMID: 21822876 [PubMed - indexed for MEDLINE]

Chromatin insulator elements block transgene silencing in engineered human embryonic stem cell lines at a defined chromosome 13 locus. Macarthur CC, Xue H, Van Hoof D, Lieu PT, Dudas M, Fontes A, Swistowski A, Touboul T, Seerke R, Laurent LC, Loring JF, German MS, Zeng X, Rao MS, Lakshmipathy U, Chesnut JD, Liu Y.
Stem Cells Dev. 2012 Jan 20;21(2):191-205. doi: 10.1089/scd.2011.0163. Epub 2011 Aug 4.
PMID: 21699412 [PubMed - indexed for MEDLINE]

A bioinformatic assay for pluripotency in human cells. Muller, F.J., Schuldt, B.M., Williams, R., Mason, D., Altun, G., Papapetrou, E.P., Danner, S., Goldmann, J.E., Herbst, A., Schmidt, N.O., Aldenhoff, J.B., Laurent, L.C., Loring, J.F., 2011. Nat Methods. 2011 Apr;8(4):315-7. Epub 2011 Mar 6
PMID:21378979[PubMed - indexed for MEDLINE]

Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Laurent, L.C., Ulitsky, I., Slavin, I., Tran, H., Schork, A., Morey, R., Lynch, C., Harness, J.V., Lee, S., Barrero, M.J., Ku, S., Martynova, M., Semechkin, R., Galat, V., Gottesfeld, J., Izpisua Belmonte, J.C., Murry, C., Keirstead, H.S., Park, H.S., Schmidt, U., Laslett, A.L., Muller, F.J., Nievergelt, C.M., Shamir, R., Loring, J.F., 2011. Cell Stem Cell. 2011 Jan 7;8(1):106-18
PMID: 21211785 [PubMed - in process]

Harness, J.V., Turovets, N.A., Seiler, M.J., Nistor, G., Altun, G., Agapova, L.S., Ferguson, D., Laurent, L.C., Loring, J.F., Keirstead, H.S., 2011. Equivalence of conventionally-derived and parthenote-derived human embryonic stem cells. PLoS One 6, e14499. PMID: 21249129 [PubMed - in process] - Free PMC Article

Targeted Gene Correction of Laminopathy-Associated LMNA Mutations in Patient-Specific iPSCs  Guang-Hui Liu,Keiichiro Suzuki, Jing Qu, Ignacio Sancho-Martinez, Fei Yi, Mo Li, Sachin Kumar, Emmanuel Nivet, Jessica Kim, Rupa Devi Soligalla, Ilir Dubova, April Goebl, Nongluk Plongthongkum, Ho-Lim Fung, Kun Zhang, Jeanne F. Loring, Louise C. Laurent, and Juan Carlos Izpisua Belmonte.  Cell Stem Cell 8, 688-694 (2011)

A Call for Standardized Naming and Reporting of Human ESC and iPSC Lines. Luong, M.X., Auerbach, J., Crook, J.M., Daheron, L., Hei, D., Lomax, G., Loring, J.F., Ludwig, T., Schlaeger, T.M., Smith, K.P., Stacey, G., Xu, R.H., Zeng, F., 2011.  Cell Stem Cell 8, 357-359.

Friedreich's ataxia induced pluripotent stem cells model intergenerational GAATTC triplet repeat instability.  Ku, S., Soragni, E., Campau, E., Thomas, E.A., Altun, G., Laurent, L.C., Loring, J.F., Napierala, M., and Gottesfeld, J.M. (2010). Cell Stem Cell 7, 631-637.

A call to standardize teratoma assays used to define human pluripotent cell lines.  Müller FJ, Goldmann J, Löser P, Loring JF. Cell Stem Cell. 2010 May 7;6(5):412-4. PMID: 20452314

Dynamic changes in the human methylome during differentiation.  Laurent LC, Wong E, Li G, Huynh T, Tsirigos A, Ong CT, Low HM, Sung KWK, Rigoutsos I*, Loring J*, Wei C-L*.   (*Co-Senior authors). Genome Research, 20(3):320-31. (2010).

Restricted Ethnic Diversity in Human Embryonic Stem Cells.  Laurent LC, Nievergelt CM, Lynch C, Fakunle E, Harness J, Schmidt U, Galat V, Laslett, AL, Otonkoski T, Keirstead H, Schork A, Park H-S, Loring, JF.  Nature Methods, 7(1):6-7. 2010. PMID: 20038950

A 3-dimensional extracellular matrix as a delivery system for the transplantation of glioma-targeting neural stem/progenitor cells. Hansen, K., Muller, F.J., Messing, M., Zeigler, F., Loring, J.F., Lamszus, K., Westphal, M., and Schmidt, N.O. (2010). Neuro Oncol.12(7): 645-654.

DNA Methylation in Embryonic Stem Cells.  Altun G, Loring JF, Laurent LC.  J Cell Biochem 109:1-6, 2010.

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Müller FJ, Loring JF, Yamasaki TR, Poon WW, Green KN, Laferla FM.  Proc Natl Acad Sci U S A. 106(32):13594-9. 2009 PMCID: PMC2715325

Preparation of autogenic human feeder cells for growth of human embryonic stem cells.  Gonzalez R, Loring JF, Snyder EY. Curr Protoc Stem Cell Biol. 2008; Mar; Chapter 1:Unit 1C.5.1-1C.5.15.

Regulatory networks define phenotypic classes of human stem cell lines.  Müller FJ, Laurent LC, Kostka D, Ulitsky I, Williams R, Lu C, Park I-H, Rao MS, Shamir R, Schwartz PH, Schmidt NO, Loring JF.  Nature 2008;455:401.

Comprehensive MicroRNA profiling reveals a unique human embryonic stem cell signature dominated by a single seed sequence.  Laurent LC, Chen J, Ulitsky I, Mueller F-J, Lu C, Shamir R, Fan J-B and Loring JF.  Stem Cells 2008;26:1506-16.

Unraveling Epigenetic Regulation in Embryonic Stem Cells. Bibikova M, Laurent LC, Ren B, Loring JF, Fan JB.
Cell Stem Cell. 2008 Feb 7;2(2):123-34. Review. PMID: 18371433 [PubMed - indexed for MEDLINE]

Isolation of human embryonic stem cell-derived teratomas for the assessment of pluripotency. Gertow K, Przyborski S, Loring JF, Auerbach JM, Epifano O, Otonkoski T, Damjanov I, Ahrlund-Richter L.  Curr Protoc Stem Cell Biol. 2007 Oct; Chapter 1:Unit1B.4.

Human embryonic stem cells have a unique epigenetic signature  Bibikova M, Chudin E, Wu B, Zhou L, Garcia EW, Liu Y, Shin S, Plaia TW, Auerbach JM, Arking DE, Gonzalez R, Crook J, Davidson B, Schulz TC, Robins A, Khanna A, Sartipy P, Hyllner J, Vanguri P, Savant-Bhonsale S, Smith AK, Chakravarti A, Maitra A, Rao M, Barker DL, Loring JF, Fan JB.. . Genome Res 2006;16:1075-1083. PMCID: PMC1557765.

Adhesive interactions between human neural stem cells and inflamed human vascular endothelium are mediated by integrins.  Mueller FJ, Serobyan N, et al.  Stem Cells 2006;24:2367-2372.

Assessing self-renewal and differentiation in human embryonic stem cell lines. Cai J, Chen J, et al.  Stem Cells 2006;24:516-30. PMCID: PMC2528840

Transcriptome coexpression map of human embryonic stem cells  Li H, et al. . BMC Genomics 2006;7:103. PMCID: PMC1523211.

Genome wide profiling of human embryonic stem cells (hESCs), their derivatives and embryonal carcinoma cells to develop base profiles of U.S. Federal government approved hESC lines.  Liu Y, Shin S, et al.  BMC Developmental Biology 2006;6:20. PMCID: PMC1523200.


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