Brian Lawson, PhD

Institute Investigator - Ne
Department of Immunology and Microbiology
California Campus


Ph.D. (Microbiology), Clemson University, 1998
B.S. (Microbiology), Clemson University, 1992

Professional Experience

2013-2017 Assistant Professor of Immunology, Immunology and Microbial Science (IMS), Scripps Research
2006-2013 Assistant Professor, Immunology and Microbial Science (IMS), Scripps Research

Selected References

All Publications

Gavin, A. L., Huang, D., Huber, C., Martensson, A., Tardif, V., Skog, P. D., Blane, T. R., Thinnes, T. C., Osborn, K., Chong, H. S., Kargaran, F., Kimm, P., et al. PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing. (2018). Nature Immunology, 19(9), 942-953. PMCID: PMC6105523.

Ramadoss, N. S., Schulman, A. D., Choi, S. H., Rodgers, D. T., Kazane, S. A., Kim, C. H., Lawson, B. R. & Young, T. S. An anti-B cell maturation antigen bispecific antibody for multiple myeloma. (2015). Journal of the American Chemical Society, 137(16), 5288-5291.

Wang, R. E., Liu, T., Wang, Y., Cao, Y., Du, J., Luo, X., Deshmukh, V., Kim, C. H., Lawson, B. R., Tremblay, M. S., Young, T. S., Kazane, S. A., et al. An immunosuppressive antibody-drug conjugate. (2015). Journal of the American Chemical Society, 137(9), 3229-3232. PMCID: PMC4472444.

Cao, Y., Axup, J. Y., Ma, J. S. Y., Wang, R. E., Choi, S., Tardif, V., Lim, R. K. V., Pugh, H. M., Lawson, B. R., Welzel, G., Kazane, S. A., Sun, Y., et al. Multiformat T-cell-engaging bispecific antibodies targeting human breast cancers. (2015). Angewandte Chemie-International Edition, 54(24), 7022-7027. PMCID: PMC4492699.

Kularatne, S. A., Deshmukh, V., Ma, J., Tardif, V., Lim, R. K. V., Pugh, H. M., Sun, Y., Manibusan, A., Sellers, A. J., Barnett, R. S., Srinagesh, S., Forsyth, J. S., et al. A CXCR4-targeted site-specific antibody-drug conjugate. (2014). Angewandte Chemie-International Edition, 53(44), 11863-11867. PMCID: PMC4331128.

Lu, H., Zhou, Q., Deshmukh, V., Phull, H., Ma, J., Tardif, V., Naik, R. R., Bouvard, C., Zhang, Y., Choi, S., Lawson, B. R., Zhu, S., et al. Targeting human C-type lectin-like molecule-1 (CLL1) with a bispecific antibody for immunotherapy of acute myeloid leukemia. (2014). Angewandte Chemie-International Edition, 53(37), 9841-9845. PMCID: PMC4280064.

Deshmukh, V. A., Tardif, V., Lyssiotis, C. A., Green, C. C., Kerman, B., Kim, H. J., Padmanabhan, K., Swoboda, J. G., Ahmad, I., Kondo, T., Gage, F. H., Theofilopoulos, A. N., et al. A regenerative approach to the treatment of multiple sclerosis. (2013). Nature, 502(7471), 327-332. PMCID: PMC4431622.

Kim, C. H., Axup, J. Y., Lawson, B. R., Yun, H., Tardif, V., Choi, S. H., Zhou, Q., Dubrovska, A., Biroc, S. L., Marsden, R., Pinstaff, J., Smider, V. V., et al. Bispecific small molecule-antibody conjugate targeting prostate cancer. (2013). Proceedings of the National Academy of Sciences of the United States of America, 110(44), 17796-17801. PMCID: PMC3816437.

Tardif, V., Manenkova, Y., Berger, M., Hoebe, K., Zuo, J. P., Yuan, C., Kono, D. H., Theofilopoulos, A. N. & Lawson, B. R. Critical role of transmethylation in TLR signaling and systemic lupus erythematosus. (2013). Clinical Immunology, 147(2), 133-143. PMCID: PMC3634912.

Koh, Y. T., Scatizzi, J. C., Gahan, J. D., Lawson, B. R., Baccala, R., Pollard, K. M., Beutler, B. A., Theofilopoulos, A. N. & Kono, D. H. Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cells. (2013). Journal of Immunology, 190(10), 4982-4990. PMCID: PMC3729324.