Roberto Baccala, PhD

Associate Professor of Immunology
Department of Immunology and Microbiology
California Campus


Ph.D., University of Paris Diderot (Paris VII), 1989

Professional Experience

2000-2017 Associate Professor of Immunology, Immunology and Microbial Science (IMS), Scripps Research

Selected References

All Publications

Gonzalez-Quintial, R., Nguyen, A., Kono, D. H., Oldstone, M. B. A., Theofilopoulos, A. N. & Baccala, R. Lupus acceleration by a MAVS-activating RNA virus requires endosomal TLR signaling and host genetic predisposition. (2018). PLoS One, 13. PMCID: PMC6130858.

Theofilopoulos, A. N., Kono, D. H. & Baccala, R. The multiple pathways to autoimmunity. (2017). Nature Immunology, 18(7), 716-724.

Han, K. H., Gonzalez-Quintial, R., Peng, Y., Baccala, R., Theofilopoulos, A. N. & Lerner, R. A. An agonist antibody that blocks autoimmunity by inducing anti-inflammatory macrophages. (2016). FASEB Journal, 30(2), 738-747.

Lawson, B. R., Gonzalez-Quintial, R., Eleftheriadis, T., Farrar, M. A., Miller, S. D., Sauer, K., McGavern, D. B., Kono, D. H., Baccala, R. & Theofilopoulos, A. N. Interleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation. (2015). Clinical Immunology, 161(2), 260-269. PMCID: PMC4658267.

Baccala, R., Welch, M. J., Gonzalez-Quintial, R., Walsh, K. B., Teijaro, J. R., Nguyen, A., Ng, C. T., Sullivan, B. M., Zarpellon, A., Ruggeri, Z. M., de la Torre, J. C., Theofilopoulos, A. N., et al. Type I interferon is a therapeutic target for virus-induced lethal vascular damage. (2014). Proceedings of the National Academy of Sciences of the United States of America, 111(24), 8925-8930. PMCID: PMC4066519.

Raveendra, B. L., Wu, H., Baccala, R., Reddy, M. M., Schilke, J., Bennett, J. L., Theofilopoulos, A. N. & Kodadek, T. Discovery of peptoid ligands for anti-aquaporin 4 antibodies. (2013). Chemistry & Biology, 20(3), 351-359. PMCID: PMC3640264.

Baccala, R., Gonzalez-Quintial, R., Blasius, A. L., Rimann, I., Ozato, K., Kono, D. H., Beutler, B. & Theofilopoulos, A. N. Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. (2013). Proceedings of the National Academy of Sciences of the United States of America, 110(8), 2940-2945. PMCID: PMC3581947.

Koh, Y. T., Scatizzi, J. C., Gahan, J. D., Lawson, B. R., Baccala, R., Pollard, K. M., Beutler, B. A., Theofilopoulos, A. N. & Kono, D. H. Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cells. (2013). Journal of Immunology, 190(10), 4982-4990. PMCID: PMC3729324.

Kono, D. H., Baccala, R. & Theofilopoulos, A. N. TLRs and interferons: a central paradigm in autoimmunity. (2013). Current Opinion in Immunology, 25(6), 720-727. PMCID: PMC4309276.

Baccala, R., Gonzalez-Quintial, R., Schreiber, R. D., Lawson, B. R., Kono, D. H. & Theofilopoulos, A. N. Anti-IFN-alpha/beta receptor antibody treatment ameliorates disease in lupus-predisposed mice. (2012). Journal of Immunology, 189(12), 5976-5984. PMCID: PMC3530925.