Raiees Andrabi, PhD

Institute Investigator
Department of Immunology and Microbiology


 Email

Scripps Research Joint Appointments

Institute Investigator, Department of Immunology and Microbial Science
Faculty, Graduate Program

Research Focus

Raiees Andrabi is an Institute Investigator in the Department of Immunology and Microbiology at The Scripps Research Institute. A major focus in his laboratory is to utilize in vitro directed evolution platform combined with structure-guided design approaches to develop vaccine immunogens against complex pathogens such as HIV, Influenza virus, Arenaviruses and Coronaviruses. The other major area of research in his laboratory is to understand the immunological basis of B cell affinity maturation pathways to complex antigen surfaces, both in vaccination and in infection and to utilize this information for designing more effective vaccines. The overall goal is to design vaccine immunogens and immunization strategies that can induce protective broadly neutralizing antibody responses against complex pathogens through vaccination in humans.

Raiees Andrabi earned his PhD degree from the All India Institute of Medical Sciences in Biochemistry and performed his postdoctoral work in Dennis Burton’s laboratory at The Scripps Research Institute.


Education

Ph.D., Biochemistry, All India Institute of Medical Sciences (AIIMS), Delhi, India, 2012
M.Sc., Biochemistry, Hamdard University, Delhi, India, 2007
B.Sc., Biology, University of Kashmir, Srinagar, India, 2005

Selected References

Zhou P1,2,3†, Song G1,2,3†, He W-t1,2,3, Beutler N1, Tse VL4, Martinez DR4, Schäfer A4, Anzanello F1,2,3, Yong P1,2,3, Peng L1, Dueker K1,2,3, Musharrafieh R1,2,3, Callaghan S1,2,3, Capozzola T1,2,3, Yuan M5, Liu H5, Parren M1, Garcia E1, Rawlings SA6, Smith DM6, Nemazee D1, Wilson IA2,3,5,7, Safonova T8, Rogers TF1,6, Baric RS4,9,#, Gralinski LE4,#, Burton DR1,2,3,10,#,Andrabi R1,2,3,#. Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease. bioRxiv. 2022:2022.03.04.479488. doi: 10.1101/2022.03.04.479488. (#Corresponding author).

Zao F, Berndsen ZT, Pedreño-Lopez N, Burns A, Allen JD, Barman S, Lee W-H, Chakraborty S, Gnanakaran S, Sewall LM, Ozorowski G, Limbo O, Song G, Yong P, Callaghan S, Weisgrau KL, Lifson JD, Nedellec R, Voigt TB, Laurino F, Louw J, Rosen BC, Ricciardi M, Crispin M, Desrosiers RC, Rakasz EG, Watkins DI, Andrabi R#, Ward AB#, Burton DR#, Sok D#. Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus. bioRxiv. 2021:2021.12.22.473937. doi: 10.1101/2021.12.22.473937. (In press, Nature Communications) (2022) (#Corresponding author)

He W-t, Yuan M, Callaghan S, Musharrafieh R, Song G, Silva M, Beutler N, Lee W, Yong P, Torres J, Melo M, Zhou P, Zhao F, Zhu X, Peng L, Huang D, Anzanello F, Ricketts J, Parren M, Garcia E, Ferguson M, Rinaldi W, Rawlings SA, Nemazee D, Smith DM, Briney B, Safonova Y, Rogers TF, Crotty S, Irvine DJ, Ward AB, Wilson IA#, Burton DR#Andrabi R#. Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques. bioRxiv. 2021:2021.07.05.451222. doi: 10.1101/2021.07.05.451222. (In press, Sci. Transl. Med.) (2022). (#Corresponding author)

He W-t, Musharrafieh R, Song G, Dueker K, Callaghan S, Yong P, Beutler N, Torres JL, Volk RM, Zhou P, Yuan M, Liu H, Anzanello F, Parren M, Garcia E, Rawlings SA, Smith DM, Wilson IA, Ward AB, Rogers TF, Burton DR#Andrabi R#. Targeted isolation of diverse human broadly neutralizing antibodies against SARS-like viruses. Nature immunology. 2022;23(6):960-70. doi: 10.1038/s41590-022-01222-1. (#Corresponding author). (Cover and featured article).

Zhou P, Yuan M, Song G, Beutler N, Shaabani N, Huang D, He WT, Zhu X, Callaghan S, Yong P, Anzanello F, Peng L, Ricketts J, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Teijaro JR, Rogers TF#, Wilson IA#, Burton DR#Andrabi R#. A protective broadly cross-reactive human antibody defines a conserved site of vulnerability on beta-coronavirus spikes. Sci. Transl. Med. 14, eabi9215 (2022). (#Corresponding author). (Featured article)

Song G, He WT, Callaghan S, Anzanello F, Huang D, Ricketts J, Torres JL, Beutler N, Peng L, Vargas S, Cassell J, Parren M, Yang L, Ignacio C, Smith DM, Voss JE, Nemazee D, Ward AB, Rogers T, Burton DR#Andrabi R#. Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection. Nature communications. 2021;12(1):2938. (#Corresponding author)

Andrabi R.,* Pallesen J.,* Allen J., Song G., Zhang J., Alda NV., Gegg G., Su CY., Pauthner M., Newman A., et al. (2019). The Chimpanzee SIV Envelope trimer: structure and deployment as an HIV vaccine template. Cell reports 21, 1-16. (*Co-first authors). (Featured article)

Andrabi, R., Voss, J.E., Liang, C.H., Briney, B., McCoy, L.E., Wu, C.Y., Wong, C.H., Poignard, P., and Burton, D.R. (2015). Identification of Common Features in Prototype Broadly Neutralizing Antibodies to HIV Envelope V2 Apex to Facilitate Vaccine Design. Immunity 43, 959-973. (Cover and featured article)

Andrabi, R.,* Su, C.Y.,* Liang, C.H., Shivatare, S.S., Briney, B., Voss, J.E., Nawazi, S.K., Wu, C.Y., Wong, C.H., and Burton, D.R. (2017). Glycans Function as Anchors for Antibodies and Help Drive HIV Broadly Neutralizing Antibody Development. Immunity 47, 524-537 e523. (*Co-first authors) (Featured article)

Lee, J.H.,* Andrabi, R.,* Su, C.Y., Yasmeen, A., Julien, J.P., Kong, L., Wu, N.C., McBride, R., Sok, D., Pauthner, M., et al.(2017). A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic beta-Hairpin Structure. Immunity 46, 690-702. (*Co-first authors)

Voss, J.E.,* Andrabi, R.,* McCoy, L.E.,* de Val, N., Fuller, R.P., Messmer, T., Su, C.Y., Sok, D., Khan, S.N., Garces, F., et al.(2017). Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model. Cell reports 21, 222-235. (*Co-first authors)

Andrabi, R.#, Bhiman JN., and Burton, D.R.# (2018) Strategies for a multi-stage neutralizing antibody-based HIV vaccine. Curr Opin Immunol 53, 143-151. (#Corresponding author) 

Voss, J.E.,* Gonzalez-Martin, A.,* Andrabi, R.,* Fuller, R.P., Murrell, B., McCoy, L.E., Porter, K., Huang, D., Li, W., Sok, D., et al. (2019). Reprogramming the antigen specificity of B cells using genome-editing technologies. Elife 8. (*Co-first authors)

Turner HL, Andrabi R, Cottrell CA, Richey ST, Song G, Callaghan S, Anzanello F, Moyer TJ, Abraham W, Melo M, Silva M, Scaringi N, Rakasz EG, Sattentau QJ, Irvine DJ, Burton DR, Ward AB. Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization. Sci Adv. 2021;7(31).

Rogers TF, Zhao F, Huang D, Beutler N, Burns A, He WT, Limbo O, Smith C, Song G, Woehl J, Yang L, Abbott RK, Callaghan S, Garcia E, Hurtado J, Parren M, Peng L, Ramirez S, Ricketts J, Ricciardi MJ, Rawlings SA, Wu NC, Yuan M, Smith DM, Nemazee D, Teijaro JR, Voss JE, Wilson IA, Andrabi R, Briney B, Landais E, Sok D, Jardine JG, Burton DR. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model. Science. 2020;369(6506):956-63.

Cao, L., Pauthner, M., Andrabi, R., Rantalainen, K., Berndsen, Z., Diedrich, J.K., Menis, S., Sok, D., Bastidas, R., Park, S.R., et al. (2018). Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer. Nature communications 9, 3693.1.

Andrabi, R., Williams, C., Wang, X.H., Li, L., Choudhary, A.K., Wig, N., Biswas, A., Luthra, K., Nadas, A., Seaman, M.S., et al.(2013). Cross-neutralizing activity of human anti-V3 monoclonal antibodies derived from non-B clade HIV-1 infected individuals. Virology 439, 81-88.

Andrabi, R., Bala, M., Kumar, R., Wig, N., Hazarika, A., and Luthra, K. (2012a). Neutralization of tier-2 viruses and epitope profiling of plasma antibodies from human immunodeficiency virus type 1 infected donors from India. PloS one 7, e43704.

 

Complete List of my Published Work: https://pubmed.ncbi.nlm.nih.gov/?term=andrabi+r&sort=date


Links

COVID-19 patient antibodies point researchers toward broad coronavirus vaccines

Scripps Research discovery could enable broad coronavirus vaccine

Versatile coronavirus antibody may be starting point for broader-acting vaccines

Monkey-infecting virus may provide part of future HIV vaccine

Scripps Research Study Reveals New Clues to How a Successful HIV Vaccine Could Work

TSRI Scientists Find Surprising Trait in Anti-HIV Antibodies