Raiees Andrabi, PhD

Institute Investigator
Department of Immunology and Microbiology
California Campus


Scripps Research Joint Appointments

Institute Investigator, Department of Immunology and Microbial Science

Research Focus

Raiees Andrabi is an Institute Investigator in the Department of Immunology and Microbiology at Scripps Research. A major focus in his laboratory is to utilize in vitro directed evolution platform coupled with structure-guided design approaches to develop vaccine immunogens against complex pathogens like HIV and Influenza virus. The other major area of research in his Lab is to understand the immunological basis of B cell affinity maturation pathways to complex antigen surfaces, both in vaccination and in infection and to utilize this information for designing robust vaccines. The overall goal is to design vaccine immunogens and immunization strategies that can induce protective broadly neutralizing antibody responses against complex pathogens through vaccination in humans.

Raiees Andrabi earned his PhD degree from the All India Institute of Medical Sciences in Biochemistry and performed his postdoctoral work in Dennis Burton’s laboratory at The Scripps Research Institute.

Selected References

All Publications

Selected Publications

Andrabi R.,* Pallesen J.,* Allen J., Song G., Zhang J., Alda NV., Gegg G., Su CY., Pauthner M., Newman A., et al. (2019). The Chimpanzee SIV Envelope trimer: structure and deployment as an HIV vaccine template. Cell reports 21, 1-16. (*Co-first authors). (Featured article)

Andrabi, R., Voss, J.E., Liang, C.H., Briney, B., McCoy, L.E., Wu, C.Y., Wong, C.H., Poignard, P., and Burton, D.R. (2015). Identification of Common Features in Prototype Broadly Neutralizing Antibodies to HIV Envelope V2 Apex to Facilitate Vaccine Design. Immunity 43, 959-973. (Cover and featured article)

Andrabi, R.,* Su, C.Y.,* Liang, C.H., Shivatare, S.S., Briney, B., Voss, J.E., Nawazi, S.K., Wu, C.Y., Wong, C.H., and Burton, D.R. (2017). Glycans Function as Anchors for Antibodies and Help Drive HIV Broadly Neutralizing Antibody Development. Immunity 47, 524-537 e523. (*Co-first authors) (Featured article)

Lee, J.H.,* Andrabi, R.,* Su, C.Y., Yasmeen, A., Julien, J.P., Kong, L., Wu, N.C., McBride, R., Sok, D., Pauthner, M., et al.(2017). A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic beta-Hairpin Structure. Immunity 46, 690-702. (*Co-first authors)

Voss, J.E.,* Andrabi, R.,* McCoy, L.E.,* de Val, N., Fuller, R.P., Messmer, T., Su, C.Y., Sok, D., Khan, S.N., Garces, F., et al.(2017). Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model. Cell reports 21, 222-235. (*Co-first authors)

Andrabi, R.,# Bhiman JN., and Burton, D.R.# (2018) Strategies for a multi-stage neutralizing antibody-based HIV vaccine. Curr Opin Immunol 53, 143-151. (#Co-corresponding author)

Voss, J.E.,* Gonzalez-Martin, A.,* Andrabi, R.,* Fuller, R.P., Murrell, B., McCoy, L.E., Porter, K., Huang, D., Li, W., Sok, D., et al. (2019). Reprogramming the antigen specificity of B cells using genome-editing technologies. Elife 8. (*Co-first authors)

von Bredow, B., Andrabi, R., Grunst, M., Grandea, A.G., 3rd, Le, K., Song, G., Berndsen, Z.T., Porter, K., Pallesen, J., Ward, A.B., et al. (2019). Differences in the Binding Affinity of an HIV-1 V2 Apex-Specific Antibody for the SIVsmm/mac Envelope Glycoprotein Uncouple Antibody-Dependent Cellular Cytotoxicity from Neutralization. mBio 10.

Cao, L., Pauthner, M., Andrabi, R., Rantalainen, K., Berndsen, Z., Diedrich, J.K., Menis, S., Sok, D., Bastidas, R., Park, S.R., et al. (2018). Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer. Nature communications 9, 3693.1.

Andrabi, R., Williams, C., Wang, X.H., Li, L., Choudhary, A.K., Wig, N., Biswas, A., Luthra, K., Nadas, A., Seaman, M.S., et al.(2013). Cross-neutralizing activity of human anti-V3 monoclonal antibodies derived from non-B clade HIV-1 infected individuals. Virology 439, 81-88.

Andrabi, R., Bala, M., Kumar, R., Wig, N., Hazarika, A., and Luthra, K. (2012a). Neutralization of tier-2 viruses and epitope profiling of plasma antibodies from human immunodeficiency virus type 1 infected donors from India. PloS one 7, e43704.

Andrabi, R., Makhdoomi, M.A., Kumar, R., Bala, M., Parray, H., Gupta, A., Kotnala, A., Thirumurthy, V., and Luthra, K. (2014). Highly efficient neutralization by plasma antibodies from human immunodeficiency virus type-1 infected individuals on antiretroviral drug therapy. Journal of clinical immunology 34, 504-513.

Andrabi, R., Kumar, R., Bala, M., Nair, A., Biswas, A., Wig, N., Kumar, P., Pal, R., Sinha, S., and Luthra, K. (2012b). Production and characterization of human anti-V3 monoclonal antibodies from the cells of HIV-1 infected Indian donors. Virology journal 9, 196.

Andrabi, R., Choudhary, A.K., Bala, M., Kalra, R., Prakash, S.S., Pandey, R.M., and Luthra, K. (2011). Relative reactivity of HIV-1 polyclonal plasma antibodies directed to V3 and MPER regions suggests immunodominance of V3 over MPER and dependence of high anti-V3 antibody titers on virus persistence. Archives of virology 156, 1787-1794.