Raiees Andrabi, PhD
Scripps Research Joint Appointments
Research Focus
Raiees Andrabi is an Institute Investigator in the Department of Immunology and Microbiology at The Scripps Research Institute. A major focus in his laboratory is to utilize in vitro directed evolution platform combined with structure-guided design approaches to develop vaccine immunogens against complex pathogens such as HIV, Influenza virus, Arenaviruses and Coronaviruses. The other major area of research in his laboratory is to understand the immunological basis of B cell affinity maturation pathways to complex antigen surfaces, both in vaccination and in infection and to utilize this information for designing more effective vaccines. The overall goal is to design vaccine immunogens and immunization strategies that can induce protective broadly neutralizing antibody responses against complex pathogens through vaccination in humans.
Raiees Andrabi earned his PhD degree from the All India Institute of Medical Sciences in Biochemistry and performed his postdoctoral work in Dennis Burton’s laboratory at The Scripps Research Institute.
Selected References
Zhou P, Song G, He WT, Beutler N, Tse LV, Martinez DR, Schäfer A, Anzanello F, Yong P, Peng L, Dueker K, Musharrafieh R, Callaghan S, Capozzola T, Yuan M, Liu H, Limbo O, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Jardine JG, Wilson IA, Safonova Y, Rogers TF, Baric RS#, Gralinski LE#, Burton DR#, Andrabi R#. Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease. bioRxiv. 2022. Epub 20220307. doi: 10.1101/2022.03.04.479488. PubMed PMID: 35291291; PMCID: PMC8923106. (Immunity, in press, 2023) (#Corresponding author)
He W-t, Yuan M, Callaghan S, Musharrafieh R, Song G, Silva M, Beutler N, Lee W-H, Yong P, Torres JL, Melo M, Zhou P, Zhao F, Zhu X, Peng L, Huang D, Anzanello F, Ricketts J, Parren M, Garcia E, Ferguson M, Rinaldi W, Rawlings SA, Nemazee D, Smith DM, Briney B, Safonova Y, Rogers TF, Dan JM, Zhang Z, Weiskopf D, Sette A, Crotty S, Irvine DJ, Ward AB, Wilson IA#, Burton DR#, Andrabi R#. Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques. Science Translational Medicine. 2022;14(657):eabl9605. doi: doi:10.1126/scitranslmed.abl9605. (#Corresponding author) (Featured article)
He W-t, Musharrafieh R, Song G, Dueker K, Tse LV, Martinez DR, Schäfer A, Callaghan S, Yong P, Beutler N, Torres JL, Volk RM, Zhou P, Yuan M, Liu H, Anzanello F, Capozzola T, Parren M, Garcia E, Rawlings SA, Smith DM, Wilson IA, Safonova Y, Ward AB, Rogers TF, Baric RS#, Gralinski LE#, Burton DR#, Andrabi R#. Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses. Nature Immunology. 2022;23(6):960-70. doi: 10.1038/s41590-022-01222-1. (#Corresponding author). (Cover and featured article).
Zhou P, Yuan M, Song G, Beutler N, Shaabani N, Huang D, He W-t, Zhu X, Callaghan S, Yong P, Anzanello F, Peng L, Ricketts J, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Teijaro JR, Rogers TF#, Wilson IA#, Burton DR#, Andrabi R#. A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection. Science Translational Medicine. 2022;0(0):eabi9215. doi: doi:10.1126/scitranslmed.abi9215. (#Corresponding author). (Featured article)
Zhao F, Berndsen ZT, Pedreño-Lopez N, Burns A, Allen JD, Barman S, Lee W-H, Chakraborty S, Gnanakaran S, Sewall LM, Ozorowski G, Limbo O, Song G, Yong P, Callaghan S, Coppola J, Weisgrau KL, Lifson JD, Nedellec R, Voigt TB, Laurino F, Louw J, Rosen BC, Ricciardi M, Crispin M, Desrosiers RC, Rakasz EG, Watkins DI, Andrabi R#, Ward AB#, Burton DR#, Sok D#. Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus. Nature Communications. 2022;13(1). doi: 10.1038/s41467-022-32783-2. (#Corresponding author)
Song G, He WT, Callaghan S, Anzanello F, Huang D, Ricketts J, Torres JL, Beutler N, Peng L, Vargas S, Cassell J, Parren M, Yang L, Ignacio C, Smith DM, Voss JE, Nemazee D, Ward AB, Rogers T, Burton DR#, Andrabi R#. Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection. Nature Communications.2021;12(1):2938. Epub 2021/05/21. doi: 10.1038/s41467-021-23074-3. PubMed PMID: 34011939; PMCID: PMC8134462. (#Corresponding author)
Rogers TF, Zhao F, Huang D, Beutler N, Burns A, He WT, Limbo O, Smith C, Song G, Woehl J, Yang L, Abbott RK, Callaghan S, Garcia E, Hurtado J, Parren M, Peng L, Ramirez S, Ricketts J, Ricciardi MJ, Rawlings SA, Wu NC, Yuan M, Smith DM, Nemazee D, Teijaro JR, Voss JE, Wilson IA, Andrabi R, Briney B, Landais E, Sok D, Jardine JG, Burton DR. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model. Science. 2020;369(6506):956-63. Epub 2020/06/17. doi: 10.1126/science.abc7520. PubMed PMID: 32540903; PMCID: PMC7299280.
Andrabi R*, Pallesen J*, Allen JD, Song G, Zhang J, de Val N, Gegg G, Porter K, Su CY, Pauthner M, Newman A, Bouton-Verville H, Garces F, Wilson IA, Crispin M, Hahn BH, Haynes BF, Verkoczy L, Ward AB, Burton DR. The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template. Cell reports. 2019;27(8):2426-41.e6. doi: 10.1016/j.celrep.2019.04.082. PubMed PMID: 31116986; PMCID: PMC6533203. (*first author). (Featured article)
Voss JE*, Gonzalez-Martin A*, Andrabi R*, Fuller RP, Murrell B, McCoy LE, Porter K, Huang D, Li W, Sok D, Le K, Briney B, Chateau M, Rogers G, Hangartner L, Feeney AJ, Nemazee D, Cannon P, Burton D. Reprogramming the antigen specificity of B cells using genome-editing technologies. Elife. 2019;8. Epub 2019/01/17. doi: 10.7554/eLife.42995. PubMed PMID: 30648968. (*first author)
Andrabi R#, Bhiman JN, Burton DR#. Strategies for a multi-stage neutralizing antibody-based HIV vaccine. Curr Opin Immunol. 2018;53:143-51. doi: 10.1016/j.coi.2018.04.025. PubMed PMID: 29775847. (#Corresponding author)
Andrabi R*, Su CY*, Liang CH, Shivatare SS, Briney B, Voss JE, Nawazi SK, Wu CY, Wong CH, Burton DR. Glycans Function as Anchors for Antibodies and Help Drive HIV Broadly Neutralizing Antibody Development. Immunity. 2017. doi: 10.1016/j.immuni.2017.08.006. PubMed PMID: 28916265. (*first author) (Featured article)
Voss JE*, Andrabi R*, McCoy LE*, de Val N, Fuller RP, Messmer T, Su CY, Sok D, Khan SN, Garces F, Pritchard LK, Wyatt RT, Ward AB, Crispin M, Wilson IA, Burton DR. Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model. Cell reports. 2017;21(1):222-35. doi: 10.1016/j.celrep.2017.09.024. PubMed PMID: 28978475. (*first author)
Lee JH*, Andrabi R*, Su CY, Yasmeen A, Julien JP, Kong L, Wu NC, McBride R, Sok D, Pauthner M, Cottrell CA, Nieusma T, Blattner C, Paulson JC, Klasse PJ, Wilson IA, Burton DR, Ward AB. A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic beta-Hairpin Structure. Immunity. 2017;46(4):690-702. doi: 10.1016/j.immuni.2017.03.017. PubMed PMID: 28423342; PMCID: PMC5400778. (*first author)
Andrabi R, Voss JE, Liang CH, Briney B, McCoy LE, Wu CY, Wong CH, Poignard P, Burton DR. Identification of Common Features in Prototype Broadly Neutralizing Antibodies to HIV Envelope V2 Apex to Facilitate Vaccine Design. Immunity. 2015;43(5):959-73. doi: 10.1016/j.immuni.2015.10.014. PubMed PMID: 26588781; PMCID: PMC4654981. (Cover and featured article)
Andrabi R, Williams C, Wang XH, Li L, Choudhary AK, Wig N, Biswas A, Luthra K, Nadas A, Seaman MS, Nyambi P, Zolla-Pazner S, Gorny MK. Cross-neutralizing activity of human anti-V3 monoclonal antibodies derived from non-B clade HIV-1 infected individuals. Virology. 2013;439(2):81-8. Epub 2013/03/08. doi: 10.1016/j.virol.2012.12.010. PubMed PMID: 23466102; PMCID: PMC3756680.
Complete List of my Published Work: https://pubmed.ncbi.nlm.nih.gov/?term=andrabi+r&sort=date
Links
COVID-19 patient antibodies point researchers toward broad coronavirus vaccines
Scripps Research discovery could enable broad coronavirus vaccine
Versatile coronavirus antibody may be starting point for broader-acting vaccines
Monkey-infecting virus may provide part of future HIV vaccine
Scripps Research Study Reveals New Clues to How a Successful HIV Vaccine Could Work
TSRI Scientists Find Surprising Trait in Anti-HIV Antibodies