The Cravatt Lab

Protein and Ligand Discovery on a Global Scale

Genomics has revolutionized our understanding of the genetic basis of human physiology and disease. Nonetheless, many disease-relevant genes code for proteins that remain poorly characterized and therapeutically unactionable due, in large part, to a dearth of selective chemical tools. Our research aims to address this challenge by developing and applying innovative chemical proteomic platforms, such as activity-based protein profiling, to enrich our understanding of disease-relevant proteins and to accelerate the discovery of chemical probes for these proteins.

Recent Publications

Cover Illustration by David S. Goodsell, RCSB Protein Data Bank. doi: 10.2210/rcsb_pdb/goodsell-gallery-041