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Hollis Cline Lab

Hiramoto, M., and Cline, H.T. (2020). NMDARs Translate Sequential Temporal Information into Spatial Maps. IScience 23, 101130. PMID: 32480133.

Bestman, J.E., and Cline, H.T. (2020). Morpholino Studies in Xenopus Brain Development. Methods Mol. Biol. 2047, 377–395. PMID: 31552666

McKeown, C.R., and Cline, H.T. (2019). Nutrient restriction causes reversible G2 arrest in Xenopus neural progenitors. Development 146. PMID: 31649012

Schiapparelli, L.M., Shah, S.H., Ma, Y., McClatchy, D.B., Sharma, P., Li, J., Yates, J.R., Goldberg, J.L., Cline, H.T. (2019). The Retinal Ganglion Cell Transportome Identifies Proteins Transported to Axons and Presynaptic Compartments in the Visual System In Vivo. Cell Rep 28, 1935-1947.e5. PMID: 31412257 

Sharma, P., Mesci, P., Carromeu, C., McClatchy, D.R., Schiapparelli, L., Yates, J.R., Muotri, A.R., and Cline, H.T. (2019). Exosomes regulate neurogenesis and circuit assembly. Proc. Natl. Acad. Sci. U.S.A. 116, 16086–16094. PMID: 31320591

He, H.-Y., and Cline, H.T. (2019). What Is Excitation/Inhibition and How Is It Regulated? A Case of the Elephant and the Wisemen. J Exp Neurosci. PMID: 31258334 

Gambrill, A.C., Faulkner, R.L., McKeown, C.R., and Cline, H.T. (2018). Enhanced visual experience rehabilitates the injured brain in Xenopus tadpoles in an NMDAR-dependent manner. J Neurophysiol. PMID:30517041

He, H., Shen, W., Zheng, L., Guo, X., and Cline, H.T. (2018). Excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticity. Nature Communications 9, 2893.

Gambrill, A. C., Faulkner, R. L., & Cline, H. T. (2018). Direct intertectal inputs are an integral component of the bilateral sensorimotor circuit for behavior in Xenopus tadpoles. Journal of neurophysiology, 119(5), 1947-1961. PMID: 29442555.

Liu, H. H., McClatchy, D. B., Schiapparelli, L., Shen, W., Yates III, J. R., & Cline, H. T. (2018). Role of the visual experience-dependent nascent proteome in neuronal plasticity. eLife, 7, e33420. PMID: 29412139.

Lau M, Li J, Cline HT. (2017) In Vivo Analysis of the Neurovascular Niche in the Developing Xenopus Brain. Eneuro Jul-Aug;ecollection. PMID:28795134.

McKeown, C. R., Thompson, C. K., & Cline, H. T. (2017). Reversible developmental stasis in response to nutrient availability in the Xenopus laevis central nervous system. Journal of Experimental Biology, 220(3), 358-368. PMID:27875263.

Pratt, K. G., Hiramoto, M., & Cline, H. T. (2016). An evolutionarily conserved mechanism for activity-dependent visual circuit development. Frontiers in Neural Circuits, 10. PMID:27818623.

Thompson CK, Cline HT. (2016) Thyroid Hormone Acts Locally to Increase Neurogenesis, Neuronal Differentiation, and Dendritic Arbor Elaboration in the Tadpole Visual System. J Neurosci. Oct 5;36(40):10356-10375. PMID: 27707971.

Gambrill AC, Faulkner R, Cline HT. (2016) Experience-dependent plasticity of excitatory and inhibitory intertectal inputs in Xenopus tadpoles. J Neurophysiol. Aug 31:jn.00611.2016. doi: 10.1152/jn.00611.2016. [Epub ahead of print] PMID:27582296.

Truszkowski TL, James EJ, Hasan M, Wishard TJ, Liu Z, Pratt KG, Cline HT, Aizenman CD. (2016) Fragile X mental retardation protein knockdown in the developing Xenopus tadpole optic tectum results in enhanced feedforward inhibition and behavioral deficits. Neural Dev. Aug 8;11(1):14. doi: 10.1186/s13064-016-0069-7. PMID: 27503008.

Liu HH, Cline HT. (2016) Fragile X Mental Retardation Protein Is Required to Maintain Visual Conditioning-Induced Behavioral Plasticity by Limiting Local Protein Synthesis J Neurosci. Jul 6;36(27):7325-7339 PMID: 27383604.

He HY, Shen W, Hiramoto M, Cline HT. (2016) Experience-Dependent Bimodal Plasticity of Inhibitory Neurons in Early Development. Neuron. 2016 Jun 15;90(6):1203-14. doi: 10.1016/j.neuron.2016.04.044. Epub May 26. PMID: 27238867.

Muñoz, R, Edwards-Faret, G, Moreno, M, Zuñiga, N, Cline, H, & Larraín, J. (2015). Regeneration of Xenopus laevis spinal cord requires Sox2/3 expressing cells. Developmental biology, 408(2), 229-243. PMID: 25797152.

Bestman JE, Huang LC, Lee-Osbourne J, Cheung P, Cline HT. (2015) An in vivo screen to identify candidate neurogenic genes in the developing Xenopus visual system. Dev Biol Mar 27 doi: 10.1016/j.ydbio.2015.03.010. PMID: 25818835.

Faulkner RL, Wishard TJ, Thompson CK, Liu H-H, Cline HT. (2015) FMRP regulates neurogenesis in vivo in Xenopus laevis tadpoles. Eneuro Jan-Feb;2(1):e0055. Download PDF

Hiramoto M, Cline HT. (2014) Optic flow instructs retinotopic map formation through a spatial to temporal to spatial transformation of visual information. Proc Natl Acad Sci U S A. 2014 Nov 10. Download PDF

Schiapparelli LM, McClatchy DB, Liu HH, Sharma P, Yates JR 3rd, Cline HT. (2014) Direct detection of biotinylated proteins by mass spectrometry. J Proteome Res. 5;13(9);3966-78. PMID: 25117199.

Shen W, Liu HH, Schiapparelli L, McClatchy D, He HY, Yates JR 3rd, Cline HT. (2014) Acute Synthesis of CPEB Is Required for Plasticity of Visual Avoidance Behavior in Xenopus. Cell Rep., Feb 27;6(4):737-47. Download PDF

Bestman JE, Cline HT. (2014) Morpholino studies in Xenopus brain development. Methods Mol Biol. 2014;1082:155-71. doi: 10.1007/978-1-62703-655-9_11. PMID: 24048933.

Sharma P, Schiapparelli L, Cline HT. (2013) Exosomes function in cell-cell communication during brain circuit development. Curr Opin Neurobiol, Dec;23(6):997-1004. Download PDF

McKeown CR, Sharma P, Sharipov HE, Shen W, Cline HT. (2013), Neurogenesis is required for behavioral recovery after injury in the visual system of Xenopus laevis. J Comp Neurol, Jul 1;521(10):2226-78. Download PDF

Lee PC, He HY, Lin CY, Ching YT, Cline HT. (2013) Computer aided alignment and quantitative 4D structural plasticity analysis of neurons. Neuroinformatics, Apr;11(2):249-57. Download PDF

Cline, HT and Kelly, D. (2012), Xenopus as an experimental system for developmental neuroscience: Introduction to a special issue. Dev Neurobiol, 72: 463–4. doi: 10.1002/dneu.22012. PMID:22328291.

Demas JA, Payne H, Cline HT. (2012) Vision drives correlated activity without patterned spontaneous activity in developing Xenopus retina. Dev Neurobiol, Apr;72(4):537-46. Download PDF

Bestman, J. E., Lee-Osbourne, J. and Cline, H.T. (2012), In vivo time-lapse imaging of cell proliferation and differentiation in the optic tectum of Xenopus laevis tadpoles. J. Comp. Neurol, Feb 1;520(2):401–433. Download PDF

Miraucourt LS, Silva JS, Burgos K, Li J, Abe H, Ruthazer ES, Cline HT. (2012) GABA expression and regulation by sensory experience in the developing visual system. PLoS One 7(1):e29086. Download PDF

Shen, W., McKeown, C.R., Demas, J.A., and Cline, H.T. (2011). Inhibition to excitation ratio regulates Visual system responses and behavior in vivo. J Neurophysiol, Nov;106(5):2285-302 Download PDF

Hiramoto, M., and Cline, H.T. (2011). Mapping dynamic branch displacements: A versatile method to quantify spatiotemporal neurite dynamics. Front Neural Circuits 5:13. Epub Sep 30.       Download PDF

He HY, Cline H.T. (2011) Diadem X: automated 4 dimensional analysis of morphological data. Neuroinformatics Sep 9(2-3);107-12. Download PDF

Li, J., Erisir, A. and Cline, H. (2011) In vivo time-lapse imaging and serial section electron microscopy reveal developmental synaptic rearrangements. Neuron. Jan 27;69(2);273-86. Download PDF

Sharma, P and Cline, HT (2010) Visual Activity Regulates Neural Progenitor Cells in Developing Xenopus CNS through Musashi1. Neuron Nov 4;68(3):442-455. Download PDF

Wurdak, H, Zhu, S., Min, K H, Aimone, L, Lairson, LL, Watson, J, Chopluk, G, Demas, J., Charette, B., Weerapana, E., Cravatt, B.F., Cline, H.T., Peters, E.C., Zhang, J., Walker, J.R., Wu. C., Chang, J., Tuntland, T., Cho, C.Y., Schultz, P.G. (2010) A small molecule accelerates neuronal differentiation in the adult rat. Proc Natl Acad Sci U S A. Sept 21;107(38);16542-7. Download PDF

Ruthazer, E.S., Schohl, A., Schwartz, N., Tavakoli, A. Tremblay, M and Cline, H.T. (2010) Axons and Dendrites: In Vivo Time-Lapse Imaging of Neuronal Development in Xenopus. in Imaging:  A Laboratory Manual (eds. R. Yuste, F. Lani and A. Konnerth), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.

Li, J. and Cline H.T. (2010) Visual deprivation increases accumulation of dense core vesicles in developing optic tectal synapses in Xenopus laevis. J Comp Neurol. Jun 15;518(12):2365-81. Download PDF

Chiu, SL and Cline, HT (2010) Insulin receptor signaling in the development of neuronal structure and function. Neural Dev 5:7 Mar 15;5:7. Download PDF 

Li, J., Wang, Y., Chiu, SL., and Cline, HT (2010) Membrane targeted horseradish peroxidase as a marker for correlative fluorescence and electron microscopy studies. Front. Neural Circuits 2010 Feb 26;4:6. Download PDF

Hiramoto, M. and Cline, H.T. (2009) Convergence of multisensory inputs into Xenopus tadpole tectum. Developmental Neurobiology Dec;69(14):959-71. PMID:19813244 Download PDF

Chen, C-M., Chiu, S-L., Shen, W., and Cline, H.T. (2009) Co-expression of Argonaute2 enhances short hairpin RNA-induced RNA interference in Xenopus CNS neurons in vivo. Front in Neurosci. Jul 9;3:63. PMID:20582287 Download PDF

Shen, W., Santos Da Silva, J.S., He, H. and Cline, H.T. (2009) Type A GABAAR-receptor-dependent synaptic transmission sculpts dendritic arbor structure in Xenopus laevis in vivo. J Neurosci. Apr 15;29(15);5032-43. PMID:19369572 Download PDF

Ewald, RC and Cline, HT (2009) Cloning and Phylogenetic Analysis of NMDA Receptor Subunits NR1, NR2A and NR2B in Xenopus laevis Tadpoles. Front in Mol Neurosci. 2:4. PMID:19826620 Download PDF

Bestman, J.E., and Cline, H.T. (2009) The relationship between dendritic branch dynamics and CPEB-labeled RNP granules captured in vivo. Front Neural Circuits 3:10 PMID:19753328 Download PDF

Ewald, R.C. and Cline, H.T. (2009) NMDA Receptors and Brain Development in Biology of the NMDA receptor (ed A. M. Van Dongen) CRC Press. PMID:21204419 Download PDF

Bestman, J.E., and Cline, H.T. (2008) The RNA binding protein CPEB controls dendrite growth and neural circuit assembly in vivo. Proc Natl Acad Sci U S A. Dec 23;105(51):20494-9. PMID:19074264

Van Keuren-Jensen, K.R., and Cline, H.T. (2008). Homer proteins shape Xenopus optic tectal cell dendritic arbor development in vivo. Dev Neurobiol. Sep 15;68(11):1315-24. PMID:18636533

Thirumalai, V., and Cline, H.T. (2008). Endogenous dopamine suppresses initiation of swimming in pre-feeding zebrafish larvae. J Neurophysiol. Sep;100(3):1635-48. PMID:18562547

Chiu, S.L., Chen, C.M., and Cline, H.T. (2008). Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo. Neuron. Jun 12;58(5): 708-19. PMID:18549783

Cantallops, I., and Cline, H.T. (2008). Rapid activity-dependent delivery of the neurotrophic protein CPG15 to the axon surface of neurons in intact Xenopus tadpoles. Dev Neurobiol. May;68(6):744-59. PMID:18383547

Ewald, R.C., Van Keuren-Jensen, K.R., Aizenman, C.D., and Cline, H.T. (2008). Roles of NR2A and NR2B in the development of dendritic arbor morphology in vivo. J Neurosci. Jan23;28(4);850-61. PMID:18216193

Haas, K. and Cline, H (2008) The regulation of dendritic arbor development and plasticity by glutamatergic synaptic input:  a review of the synaptotrophic hypothesis. J. Physiol. 586: 1509-17. PMID:18202093

Thirumalai V, Cline HT. (2008) A commanding control of behavior. Nat Neurosci. Mar;11(3):246-8. PMID:18301430

Jan, Y-H., Cline, H. T. and Ghosh, A. (2008) Regulation of Dendritic Development in Fundamentals of Neuroscience (eds. L. R. Squire, J. L. Roberts, N. C. Spitzer, and M.J. Zigmond) Elsevier.

Akerman, CJ, and Cline, H.T. (2007) Refining the roles of GABAergic transmission during neural circuit formation. Trends Neurosi. Aug;30(8):382-9. PMID:17590449

Aizenman, C.D. and Cline, H.T. (2007) Enhanced visual activity in vivo forms nascent synapses in the developing retinotectal projection. J. Neurophysiol. Apr;97(4):2949-57. PMID:172677161

Demas, J. and Cline, H.T. (2007) The blu Blur: Mutation of a Vesicular Glutamate Transporter Reduces the Resolution of Zebrafish Vision. Neuron 53:4-6. PMID:17196524

Cline, H.T., Santos Da Silva, J., Bestman, J. (2007) Dendrite Development in Dendrites (eds. G. Stuart, N. Spruston, M. Hausner) Oxford Univ. Press, London.

Rial Verde, E.M., Lee-Osbourne, J., Worley, P.F., Malinow, R., Cline, H.T. (2006) Increased expression of the immediate-early gene arc/arg31 reduces AMPA receptor-mediated synaptic transmission.  Neuron. Nov 9;52(3):461-74. PMID:17088212

Haas, K., Li, J. and Cline, H.T. (2006) AMPA receptors regulate experience-dependent dendritic arbor growth in the intact brain. Proc. Natl Acad. Sci. U S A. Aug 8;103(32):12127-31. PMID:16882725

Van Keuren-Jensen, K. and Cline, H.T (2006) Visual experience regulated metabotropic glutamate receptor-regulated plasticity of AMPA receptor transmission by Homer1a induction. J. Neurosci. Jul 19;26(29):2727-80. PMID:16855085

Bestman, J.E., Ewald, R.C., Chiu, S-L., and Cline, H.T. (2006) In vivo single-cell electroporation for transfer of DNA and macromolecules. Nature Protocols 1: 1267-1272. PMID:17406410 Download PDF

Haas, K. and Cline, H.T (2006) Plasticity in Visual Connections: Retinal ganglion cell axonal development and regeneration. In Neural Repair (ed: M. Selzer)

Akerman, C.J. and Cline, H.T. (2006) Depolarizing GABAergic conductances regulate the development of balance of excitation to inhibition in the retinotectal circuit in vivo J. Neurosci. May 10;26(19):5117-30. PMID:16687503

Ruthazer, E.S. Li, J. and Cline, H. T. (2006) Stabilization of axon branch dynamics by synaptic maturation. J Neurosci. Mar 29;26(13):3594-603. PMID:16571768

Cline, H.T. and Spruston, N., editors. (2005) Special Issue on Dendrites. Journal of Neurobiology. Vol 64.

Cline, H.T. (2005) Synaptogenesis: A balancing act between excitation and inhibition. Current Biology 15: R203-205. PMID:15797012

Foa, L., Jensen, K., Rajan, I., Bronson, K., Gasperini, R., Worley, P.F., Tu, J.C., and Cline, H.T. (2005) Homer expression in the Xenopus tadpole nervous system. J. Comp. Neurol. 487: 42-53. PMID:15861458 

Javaherian, A. and Cline, H.T. (2005) Coordinated motor neuron axon growth and neuromuscular synaptogenesis are promoted by CPG15 in vivo. Neuron 45: 505-512. PMID:15721237

Ruthazer, E.S. and Cline, H.T. (2004) Time-Lapse Imaging of CNS Neuron Development in Vivo. In Imaging: A Laboratory Manual (eds. R. Yuste, F. Lani and A. Konnerth), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.

Van Aelst, L. and Cline, H.T. (2004) Rho GTPases and activity-dependent dendrite development. Curr. Opin. Neurobiol. 14: 297-304. PMID:15194109

Ruthazer, E. S. and Cline, H.T (2004) Insights into Activity-Dependent Map Formation from the Retinotectal System: A Middle-of-the-Brain Perspective. J. Neurobiol. 59: 134-146. PMID:15007832

Cline, H.T. (2003) Sperry and Hebb: Oil and Vinegar? TINS: 26:655-661. PMID:14624849

Cline, H.T. (2003) Synaptic plasticity: importance of proteasome-meidate protein turnover. Curr. Biol. 13: R514-516. PMID:12842027

Aizenman, C.D. Akerman, C.J., Jensen, K.R., Cline, H.T. (2003) Visually driven regulation of intrinsic neuronal excitability improves stimulus detection in vivo. Neuron 39: 831-842. PMID:12948449 

Ruthazer, E. S., Akerman, C.J. and Cline, H.T. (2003) Control of axon branch dynamics by correlated activity in vivo. Science 301: 66-70. PMID:12843386 

Wu, G.Y., Cline, H.T. (2003) Time-lapse in vivo imaging of the morphological development of Xenopus optic tectal interneurons, J. Comp. Neural. 459: 392-406. PMID:12687706 

Ruthazer, E. and Cline, H.T. (2002) Multiphoton Imaging of Neurons in Living Tissue: Acquisition And Analysis of Time-Lapse Morphological Data. Journal of Real-Time Imaging, Special Issue on Imaging in Bioinformatics 8:175-188.

Haas, K., Jensen, K., Sin, W.C., Cline, H.T. (2002) Targeted electroporation in Xenopus tadpoles in vivo - from single cells to the entire brain. Differentiation 70:148-154. PMID:12147134

Lisman, J., Schulman, H. and Cline, H.T. (2002) The molecular basis of CaMKII function in synaptic plasticity and memory. Nature Reviews/Neurosci. 3:175-190. PMID:11994750

Debski, E.A. and Cline, H.T (2002) Activity-dependent mapping in the retinotectal projection. Current Opinion in Neurobiology. 12: 93-99. PMID:11861170

Ruthazer, E., and Cline, H.T. (2002) Multiphoton Imaging of Neurons in Living Tissue: Acquisition and Analysis of Morphological Data. Journal of Real-Time Imaging Special Issues on Imaging in Bioinformatics 8:175-188.

Sin, W-C, Haas, H., Ruthazer, E. S. and Cline, H.T. (2002) Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases. Nature 419: 475-480. PMID:12368855

Haas, K., Jensen, K., Sin, W.C., Foa, L., Cline, H.T. (2002) Targeted electroporation in Xenopus tadpoles in vivo - from single cells to the entire brain. Differentiation 70: 148-154. PMID:12147134 

Aizenman, C.D., Munoz-Elias, G. and Cline, H. T. (2002) Visually driven modulation of glutamatergic synaptic transmission is mediated by the regulation of intracellular polyamines. Neuron 34: 623-634. PMID:12062045

Li, Z., Aizenman, C.D. and Cline, H.T. (2002) Regulation of Rho GTPases by Crosstalk and Neuronal Activity in Vivo. Neuron 33: 741-750. PMID:11879651 

Peunova, N., Shenker, V., Cline, H.T., Enikolopov, G. (2001) Nitric oxide is an essential negative regulator of cell proliferation in Xenopus brain. J. Neurosci. 21: 8809-8818. PMID:11698593 

Nedivi, E., Javaherian, A., Cline, H.T. (2001) Developmental regulation of CPG15 function and expression in Xenopus. J. Comp. Neurol.435: 464-474. PMID:11406826 

Foa, L., Rajan, I., Haas, H., Wu. G-Y., Brakeman, P., Worley, P. Cline, H.T. (2001) The scaffold protein, Homer 1b/c, regulates axon pathfinding in the CNS in vivo. Nature Neurosci. 4: 499-506. PMCID:11319558

Haas, K., Sin, W-C., Javaherian. A., Li, Z., Cline, H.T. (2001) Single cell electroporation for gene transfer in vivo. Neuron 29: 1-9. PMID:11301019

Cline, H.T. (2001) Dendritic arbor development and synaptogenesis. Current Opinion in Neurobiology. 11: 118-126. PMID:11179881

Dickson, B.J., Cline, H.T., Polleux, F., Ghosh, A. (2001) Making connections. Meeting: axon guidance and neural plasticity. EMBO Rep. 2001 Mar;2:182-6. PMID:11266357

Cantallops, I. and Cline, H.T. (2000) Synapse formation: if it looks like a duck and quacks like a duck. Curr Biol. 10:R6203. PMID:10996085

Cantallops, I., Haas, K., Cline, H.T. (2000) Postsynaptic CPG15 promotes synaptic maturation and presynaptic axon arbor elaboration in vivo. Nat. Neurosci. 3: 1004-1011. PMID:11017173

Li, Z. Van Aelst, L. , Cline, H.T. (2000) Rho GTPases regulate distinct aspects of dendritic arbor growthin Xenopus central neurons in vivo. Nature Neurosci.3: 217-225. PMID:10700252 

Kay, A.R., Alfonso, A., Alford, S. Cline, H.T., Holgado, A.M., Sakmann, B., Snitsarev, V.A., Stricker, T.P., Takahashi, M., Wu, L-G. (1999) Imaging synaptic activity in intact brain and slices with FM1-43 in C. elegans, lamprey and rat. Neuron 24: 809-817. PMID:10624945

Zou, D-J. and Cline, H.T. (1999) Postsynaptic CaMKII is required to limit elaboration of presynaptic and postsynaptic neuronal arbors. J. Neurosci. 19: 8909-8918. PMID:10516310 

Wu, GY., Zou, DJ, Rajan, I, Cline, H.T. (1999) Dendritic dynamics in vivo change during maturation. J. Neurosci. 19: 4472-4483. PMID:10341248 

Edwards, J.A. and Cline, H.T. (1999) Light-induced calcium influx into retinal axons is regulated by presynaptic nicotinic acetylcholine receptor activity in vivo. J. Neurophysiol. 81: 895-907. PMID:10036287 

Rajan, I., Witte, S. and Cline, H.T. (1999) NMDA receptor activity stabilizes presynaptic retinotectal axons and postynaptic optic tectal cell dendrites in vivo. J. Neurobiol. 38: 357-368. PMID:10022578

Cline, H.T. (1999) Dendrite Development in Dendrites (eds. G. Stuart, N. Spruston, M. Hausner) Oxford Univ. Press, London.

Cline, H.T. , Edwards, J.A., Rajan, I., Wu, G.Y. and Zou, D.J. (1999) In vivo imaging of CNS neuron development. In Imaging: A Laboratory Manual (eds. R. Yuste, F. Lani and A. Konnerth), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.

Cline, H.T. (1998) Topographic maps: Developing roles of synaptic plasticity. Current Biology 8: R836-839. PMID:9822571

Constantine-Paton, M. and Cline, H.T. (1998) LTP and activity-dependent synaptogenesis: The more alike they are the more different they become. Current Opinions in Biology 8: 139-148. PMID:9568401

Haas, K., Cline, H.T., Malinow, R. (1998) No change in NMDA receptor-mediated response rise-time during development: evidence against transmitter spillover . J. Neuropharm. 37: 1393-1398. PMID:9849674 

Rajan, I. and Cline, H.T. (1998) Glutamate receptor activity is required for normal development of tectal cell dendrites in vivo. J. Neurosci. 18: 7836-7846. PMID:9742152 

Nedivi, E., Wu, G-Y. and Cline, H.T. (1998) Promotion of dendritic growth by CPG15, an activity-induced signaling molecule. Science 281: 1863-1866. PMID:9743502 

Pinches, E.M. and Cline, H.T. (1998) The distribution of synaptic vesicle proteins within single retinotectal axons of Xenopus tadpoles. J. Neurobiol. 35:426-434. PMID:9624623 

Wu, G-Y. and Cline, H.T. (1998) Stabilization of dendritic arbor structure in vivo by CaMKII. Science 279: 222-226. PMID:9422694

Jones, K.W., Berry, W.J., Borsay, D.J., Cline, H.T., Conner, W.C., Jr., and Fullmer, C.S. (1997) Applications of synchrotron radiation-induced X-ray emission (SRIXE) X-Ray Spectrometry 26: 350-358.

Cline, H.T. Wu, G.Y & Malinow, R. (1996) In vivo development of neuronal structure and function. Cold Spring Harbor Symp. Quant. Biol. LXI: 95-104. PMID:9246439

Wu, G.Y., Malinow, R., and Cline, H. T. (1996). Maturation of a central glutamatergic synapse. Science 274, 972-976. PMID:8875937 

Cline, H.T., Witte, S. and Jones, K. (1996) Low lead levels stunt neuronal growth in a reversible manner. Proc. Natl. Acad. Sci. (USA). 93: 9915-9919. Pubmed

Witte, S., Stier, H. and Cline, H.T. (1996) In vivo observations of the timecourse and distribution of morphological dynamics in retinal axon arbors. J. Neurobiology 31: 219-234. Pubmed

Zou, D.J. and Cline, H.T. (1996) Expression of constitutively active CaMKII in target tissue modifies presynaptic axon arbor growth. Neuron 16: 529-539 Pubmed

Zou, D-J., and Cline, H.T. (1996) Control of retinotectal axon arbor growth by postsynaptic CaMKII. in Neural Development and Plasticity (R.R. Mize and R.S. Erzurumlu, eds.) Prog. Brain. Res.108: 303-312. Elsevier, Amsterdam

Cline, H.T. (1996) Can there be growth without growth cones? Seminars in Neuroscience 8: 89-96

Wu, G-Y, Zou, D-J, Koothan, T., and Cline, H.T. (1995) Infection of frog neurons with vaccinia virus permits in vivo expression of foreign proteins. Neuron 14: 681-684. Pubmed

O'Rourke, N.A., Cline, H.T. & Fraser, S.E. (1994) Rapid remodeling of retinal arbors in the tectum with and without blockade of synaptic transmission.Neuron 12:921-934. Pubmed

Cline, H.T., McDonald, J. W. and Constantine-Paton, M. (1994) Glutamate receptor binding in juvenile and adult Rana pipiens CNS. J. Neurobiol. 25: 488-502. Pubmed

Cline, H.T. & Witte, S. (1994) "Can synaptic remodelling contribute to synaptic plasticity in the adult CNS?" in Flexibility and Constraint in Behavior Systems, Dahlem Workshop Report. (R. Greenspan & B. Kyriacou, eds) Wiley & Sons.

Cline, H.T. (1992) Regulatory Mechanisms in the developing retinotectal projection. In Proc. German Zool. Soc. Vol 82 pp.149-159 (H-D Pfannenstrel. ed.) Springer-Verlag, Berlin.

Cline, H.T. (1992) NMDA receptor regulation of visual system development in the frog. In The Visual System from Genesis to Maturity (R. Lent, ed.) Birkhauser Press. Boston. Cline, H.T. (1992) Regulatory mechanisms in the developing retinotectal projection. In Proc. German Zool. Soc. Vol. 82 pp 149-159. (H-D Pfannenstrel, ed.) Springer-Verlag, Berlin.

Debski, E.A., Cline, H.T., McDonald, J.W. and Constantine-Paton, M. (1991) Chronic application of NMDA decreases the NMDA sensitivity of the evoked tectal potential in the frog. J. Neuroscience. 11: 2947-2957. Pubmed

Cline, H.T. and Tsien, R.W. (1991) Glutamate-induced increases in intracellular Ca2+ in cultured frog tectal cells mediated by direct activation of NMDA receptor channels. Neuron 6:259-267. Pubmed

Cline, H.T. (1991) Sweeping visions. Current Biology 1: 275-277. Pubmed

Cline, H.T. (1991) A role for the NMDA receptor in the development of topographic retinotectal projections and in the regulation of retinal arbor morphology in the frog. In The Development of the Visual System. pp 231-241 (D.M-K Lam and C.J. Shatz, eds) MIT Press, Boston.

Cline, H.T. (1991) Activity-dependent plasticity in the visual systems of frogs & fish. Trends in Neurosciences. 14:104-111. Pubmed

Cline, H.T. and Constantine-Paton, M. (1991) Synaptic rearrangements in the developing and regenerating visual system. In Development and plasticity in the visual system. (J. Cronly-Dillon, ed.) MacMillan Press, London.

Constantine-Paton, M., Cline, H.T. and Debski, E. (1990) Patterned activity, synaptic convergence and the NMDA receptor in developing visual pathways. Ann. Rev. Neurosci. 13:129-54. Pubmed

Debski, E.A., Cline, H.T. and Constantine-Paton, M. (1990) Activity-dependent tuning and the NMDA receptor. J. Neurobiol. 21:18-32. Pubmed

Cline, H.T., Debski, E.A. and Constantine-Paton, M. (1990) The role of the NMDA receptor in the development of the frog visual system. In Adv. Exp. Med. Biol. Vol 268:197-203. Pubmed

Cline, H.T. and Constantine-Paton, M. (1990) The differential influence of protein kinase inhibitors on retinal arbor morphology and eye-specific stripes in the frog retinotectal system. Neuron 4:899-908. Pubmed

Cline, H.T. and Constantine-Paton, M. (1990) NMDA receptor agonist and antagonists alter retinal ganglion cell arbor structure in the developing frog retinotectal projection. J. Neurosci. 10:1197-1216. Pubmed

Cline, H.T. and Constantine-Paton, M. (1989) NMDA receptor antagonists disrupt the retinotectal topographic map Neuron 3:413-426. Pubmed

McDonald, J.W., Cline, H.T., Constantine-Paton, M., Maragos, W.F., Johnston, M.V., and Young, A.B. (1989) Quantitative autoradiographic localization of NMDA, Quisqualate and PCP receptor in the frog tectum. Brain Research 482:155-159. Pubmed

Constantine-Paton, M., Cline, H.T. and Debski, E. (1989) Neural activity, synaptic convergence and synapse stabilization in the developing CNS. In The Assembly of the Nervous System. (L. Landmesser, ed.) A.R. Liss, NY.

Malinow, R. and Cline, H.T. (1988) Post synaptic mechanisms may regulate synaptic strength by controlling synapse lifetimes. In: Synaptic Plasticity in the hippocampus. (H.L. Hass & G. Buzsaki, eds) Springer-Verlag, Berlin, pp. 17-20.

Cline, H.T., Debski, E. and Constantine-Paton, M. (1987) NMDA receptor antagonist desegregates eye-specific stripes. Proc. Natl. Acad. Sci. 84:4342-4345. Pubmed

Glover, J.C., Stuart, D.K., Cline, H.T., McCaman, R.E., Magill, C., and Stent, G.S. (1987) Development of neurotransmitter metabolism in embryos of the leech Haementeria ghilianii. J. Neurosci. 7:581-594. Pubmed

Cline, H.T. (1986) Evidence for GABA as a neurotransmitter in the leech. J. Neurosci. 6:2848-2856. Pubmed

Cline, H.T. Nusbaum, M.P. and Kristan, W., Jr. (1985) Identified GABA-ergic motor neurons in the leech central nervous system take up GABA. Brain Res. 385:359-362. Pubmed

Cline, H.T. (1983) 3H-GABA uptake selectively labels identifiable neurons in the leech central nervous system. J. Comp. Neurol. 215:351-358. Pubmed

Schneider, A.S., Cline, H.T., Rosenheck, K., and Sonenberg, H. (1981) Stimulus-secretion coupling in isolated adrenal chromaffin cells: Calcium channel activation and possible role of cytoskeletal elements. J. Neurochem. 37:567-575 . Pubmed

Schneider, A.S., Cline, H.T. and Lemaire, S. (1979) Rapid rise in cyclic GMP accompanies catecholamine secretion in suspensions of isolated adrenal chromaffin cells. Life Sci. 24:1389-1394. Pubmed

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