Scripps Research Logo

Welcome to the Hollis Cline Lab
Lab Members
Photo of Wan Hua Shen, Ph.D.


Wan Hua Shen
Research Associate (2006 - present)
shen@scripps.edu

Current Projects:

Mechanisms of inhibition to excitation ratio regulating neural information processing and behavior.

Education:

Chinese Pharmaceutical University B.A. 1998

Xuzhou Medical College M.S. - Biochemistry 2002

Institute of Neuroscience, Ph.D. Chinese Academy of Sciences Neurobiology 2006

Positions and Employment:

2000-2001 Research assistant, Dept. of Biochem. and Mol. Bio., Xuzhou Medical College.Advisor: Guangyi Zhang.

2002-2006 Research assistant, Lab of Synapse Dev. and Plasticity, ION, CAS. Advisor: Shumin Duan.

2006-2008 Postdoctoral fellow, Neuroscience, Cold Spring Harbor Laboratory. Advisor: Hollis Cline.

2008-present Research associate, Neuroscience, The Scripps Research Institute. Advisor: Hollis Cline.

Publications:

  1. Shen, W. H., Mckeown, C., Demas, J., and Cline, H. T. (2011) Inhibition to excitation ratio regulates integration of visual system and behavior in Xenopus in vivo, Submitted.
  2. Chen, C. M., Chiu, S. L., Shen, W. H., and Cline, H. T. (2009) Co-expression of Argonaute2 enhances short hairpin RNA-induced RNA interference in Xenopus CNS neurons in vivo, Frontiers in Neuroscience Methods.
  3. Tong, X. P., Li, X. Y., Zhou, B., Shen, W. H., Zhang, Z. J., Xu, T. L., and Duan, S. M. (2009) Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration, J. Cell Biol. 186, 113-128.
  4. Shen, W. H.*, Da Silva, J. S.*, He, H. Y, and Cline, H. T. (2009) Type A GABA-receptor-dependent synaptic transmission sculpts dendritic arbor structure in Xenopus tadpoles in vivo, J. Neurosci. 29, 5032-5043. (*Co-author)
  5. Zheng, J., Shen, W. H., Lu, T. J., Zhou, Y., Chen, Q., Wang, Z., Xiang, T., Zhu, Y. C., Zhang, C., Duan, S. M., and Xiong, Z. Q. (2008) Clathrin-dependent endocytosis is required for TrkB-dependent Akt-mediated neuronal protection and dendritic growth, J Biol Chem 283, 13280-13288.
  6. Yu, H.-M., Wen, J., Wang, R., Shen, W. H., Duan, S. M., and Yang, H.-T. (2008) Critical role of type 2 ryanodine receptor in mediating activity-dependent neurogenesis from embryonic stem cells, Cell Calcium 43, 417-431.
  7. Shen, W. H.*, Wu, B.*, Zhang, Z. J., Dou, Y., Rao, Z. R., Chen, Y. R., and Duan, S. M. (2006) Activity-induced rapid synaptic maturation mediated by presynaptic cdc42 signaling, Neuron 50, 401-414. (*Co-author) (This article was featured on this month's NEURON cover and preview by Atasoy and Kavalali)
  8. Ge, W. P.*, Yang, X. J.*, Zhang, Z. J., Wang, H. K., Shen, W. H., Deng, Q. D., and Duan, S. M. (2006) Long-term potentiation of neuron-glia synapses mediated by Ca2+-permeable AMPA receptors, Science 312, 1533-1537. (*Co-author)
  9. Zhang, C. Y., Shen, W. H., and Zhang, G. Y. (2004) Ischemia-induced release of cytochrome c from mitochondria and up-regulation of Bcl-2 expression in rat hippocampus, Sheng Li Xue Bao 56, 147-152.
  10. Yang, Y. L., Ge, W. P., Chen, Y. R., Zhang, Z. J., Shen, W. H., Wu, C. P., Poo, M. M., and Duan, S. M. (2003) Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine, Proc Natl Acad Sci U S A 100, 15194-15199.
  11. Shen, W. H., Zhang, C. Y., and Zhang, G. Y. (2003) Modulation of IkappaB kinase autophosphorylation and activity following brain ischemia, Acta Pharmacol Sin 24, 311-315.
  12. Shen, W. H., Zhang, C. Y., and Zhang, G. Y. (2003) Antioxidants attenuate reperfusion injury after global brain ischemia through inhibiting nuclear factor-kappa B activity in rats, Acta Pharmacol Sin 24, 1125-1130.
  13. Fu, Y., Pei, D. S., Sun, B., Shen, W. H., Lu, L., Hu, S. Q., and Zhao, H. R. (2003) Identification of important amino acid residues for human IL-18 function by mutant construction, Acta Biochimica et Biophysica Sinica 35, 409-415.
  14. Zhu, G.-Y., Liu, D.-L., Wang, X., Peng, M.-Q., Liu, H., Shen, W. H., Zhang, H.-Z., Wang, W., and Chen, J. (2002) Detection of micrometastases of lung cancer by using lunx mRNA specific reverse transcription-polymerase chain reaction, Chinese Journal of Cancer Research 14, 54-59.
  15. Zhang, C. Y., Shen, W. H., and Zhang, G. Y. (2002) N-methyl-D-aspartate receptor and L-type voltage-gated Ca2+ channel antagonists suppress the release of cytochrome c and the expression of procaspase-3 in rat hippocampus after global brain ischemia, Neurosci Lett 328, 265-268.
  16. Shen, W. H., Zhang, C. Y., and Zhang, G. Y. (2002) Nuclear factor kappaB activation is mediated by NMDA and non-NMDA receptor and L-type voltage-gated Ca2+ channel following severe global ischemia in rat hippocampus, Brain Res 933, 23-30.
  17. Fang, H., Xia, L., Shen, W. H., Li, M. Y., and Ni, P. Z. (2002) Synthesis of drug of anti-prostate hyperplasia SL-89.0519-08, J China Pharma. Univ. 33, 98-100.

Abstracts:

  1. Wanhua Shen, Bei Wu, Ying Dou, Shumin Duan. Rapid activity-induced synaptic maturation mediated by brain-derived neurotrophic factor. 2005 Chinese Academy of Sciences-Columbia University Joint Conference on Neuroscience.
  2. Wanhua Shen, Bei Wu, Zhijun Zhang, Ying Dou, Shumin Duan. Rapid activity-induced synaptic maturation mediated by brain-derived neurotrophic factor. Molecular & Cellular Neurobiology, Gordon Conference. HongKong, China, June 6-11, 2004
  3. Wanhua Shen, Jorge Santos Da Silva, Hollis T. Cline. Inhibitory GABAAR-dependent transmission sculpts dendritic structure in vivo. Society for Neuroscience. San Diego, California, USA, November 3-7, 2007
  4. Wanhua Shen, Caroline Mckeown, James Demas, Hollis T. Cline. Inhibition to excitation ratio regulates neural information prcessing and behavior in Xenopus in vivo. Society for Neuroscience. San Diego, California, USA, November 13-17, 2010