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Welcome to the Hollis Cline Lab
Lab Members
Caroline McKeown Caroline McKeown, Ph.D. 
Staff Scientist (July 2011 – present)
Research Associate (2009-2011)
cmckeown@scripps.edu 
I am a cell biologist with a broad background in development, genetics, and molecular biology, and a specific focus in microscopy and imaging modalities. My research interests have always focused on the establishment and maintenance of form and function. These include development and differentiation and in particular the ability of a seemingly differentiated cell type to de-differentiate, divide, and re-differentiate. I was born and raised in Chicago and earned my B.S. in Biology from Purdue University. I received my Ph.D. in Molecular Biology from the University of Utah, where I studied muscle adhesion in C. elegans with Mary Beckerle. I first joined the Department of Cell Biology at The Scripps Research Institute in 2004 as a postdoctoral fellow with Velia Fowler where I studied myofibril assembly and heart development during mouse embryogenesis and was a George E. Hewitt Foundation for Medical Research Fellow. I began working with Holly Cline in 2009 as a postdoctoral fellow and was appointed to a Staff Scientist position in 2011. My current research in the Cline Lab is to identify the molecular mechanisms involved in recovery from brain injury in Xenopus laevis.

Publications:

McKeown, C.R., and Cline, H.T. 2019. Nutrient restriction causes reversible G2 arrest in Xenopus neural progenitors. Development 146.

Gambrill, A.C., Faulkner, R.L., McKeown, C.R., and Cline, H.T. 2018. Enhanced visual experience rehabilitates the injured brain in Xenopus tadpoles in an NMDAR-dependent manner. J Neurophysiol.

McKeown, C. R., Thompson, C. K., & Cline, H. T. 2017. Reversible developmental stasis in response to nutrient availability in the Xenopus laevis central nervous system. Journal of Experimental Biology, 220(3), 358-368.

McKeown, C.R., Sharma, P., Sharipov, H.E., Shen, W., and Cline, H.T. 2013. Neurogenesis is Required for Behavioral Recovery after Injury in the Visual System of Xenopus Laevis. Journal of Comparative Neurology, 2013 Jul 1;521(10):2262-78.

Shen, W., McKeown, C.R., Demas, J.A., and Cline, H.T. 2011. Inhibition to Excitation Ratio Regulates Visual Function and Behavior in vivo. Journal of Neurophysiology 106(5):2285-302.
 
McKeown, C. R.
, Nowak, R.B., and Fowler, V.M. 2014 Tropomyosin is Required for Cardiac Looping, Myofibrillogenesis, and Cardiomyocyte Cell Adhesion in the Mouse. Dev Dyn. Jun;243(6):800-17. 

Gokhin, D.S., Lewis, R.A., McKeown, C.R., Nowak, R.N., Kim, N.E., Littlefield, R.S., Lieber, R.L., Fowler, V.M. 2010. Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology. Journal of Cell Biology 185(1), 95-109.
 
McKeown, C.R.
, Nowak, R.B., Sussman, M.A., and Fowler, V.M. 2008. Tropomodulin1 is Required in the Heart but not the Yolk Sac for Mouse Embryonic Development. Circulation Research 103, 1241-1248.
 
Fowler, V.M., McKeown, C.R., Fischer, R.S. 2006. Nebulin: Does it Measure up as a Ruler?  Current Biology 16(1), R18-R20.
 
McKeown, C. R.
, Han, H., Beckerle, M. C. 2006. Molecular Characterization of the C. elegans ALP/Enigma gene, alp-1. Developmental Dynamics 235, 530-538.
 
McKeown, C.
, Praitis, V., Austin, J. 1998. sma-1 encodes a bH-spectrin homolog required for Caenorhabditis elegans morphogenesis. Development 125, 2087-2098.

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