Better Health as We Age, Within Our Grasp

A Unique Effort to Extend Healthspan

Aging affects everyone, and few questions are more important than how we can age more healthfully. Researchers at The Scripps Research Institute (TSRI) are working to find ways to make healthy aging a possibility within the grasp of us all. TSRI has a track record of translating basic discoveries into new therapies. And TSRI has a department dedicated to research on aging – one of only a few in the nation focused on age-related metabolic changes. TSRI scientists are poised to develop new approaches to expand what some call our “healthspan.”

An Urgent Challenge

  • Aging results in impaired function of all organs and tissues.
  • Currently those over the age of 65 comprise the fastest growing segment of the world’s population. It is estimated that by 2030, there will be about 72.1 million people 65 or older in the US, more than twice their number in 2000.
  • Aging is associated with a range of diseases and conditions, including coronary heart disease and stroke, cancer, Alzheimer’s, Parkinson’s, vision and hearing loss, osteoarthritis, osteoporosis and Type II diabetes.

The Need for Philanthropy

Despite the great need for research on aging, federal funding for basic biomedical research has declined by 30% in the last decade. The National Institutes of Health (NIH), the primary source for basic biomedical research funding in the US, favors lower-risk projects that can only impact medicine incrementally. Tackling aging requires high-risk, high-reward endeavors – the kind particularly difficult to fund through conventional government grants. Greatly expanded private support is needed to find new ways to extend our healthspan. As funding for vital research dwindles, we need your help!

Our Initiatives

Since aging affects all organs and is the number one risk factor for a variety of debilitating diseases, research on aging demands a team approach. TSRI cultivates an interdisciplinary spirit where chemists, biologists and others work hand-in-hand toward a common goal. Scientists specializing in a variety of approaches come together to synergistically address critical issues, shedding light on the underlying causes of aging and novel therapeutic targets for expanding healthspan.

Your support will enable us to expand personnel in critical areas and fund innovative research projects, so we can find breakthroughs in the shortest time possible. Add to that the federal funding that is sure to result from discoveries at TSRI due to this initiative, and together we will have an enormous impact on our generation and generations to come.

Potential healthy aging projects will be geared to:

  • Discovering novel therapeutic and preventive strategies to extend healthspan including, adult stem cells, small molecule drug candidates, and natural products.
  • Establishing the safety and efficacy of drug candidates.
  • Developing early diagnostics of unhealthy aging.

Our Discoveries

Future discoveries will build on a strong track record of breakthroughs at TSRI, including, to name only a few:

  • Identifying signaling pathways activated with aging that represent novel therapeutic targets.
  • Finding therapeutic targets to prevent onset of metabolic syndrome—which raises the risk for heart disease, diabetes and stroke—during aging.
  • Pioneering approaches for the treatment and prevention of osteoarthritis.
  • Developing the use of adult stem cells for treating age-related diseases, including vision loss.

Please Join Us in the Fight for Cures

If you have a loved one who is facing chronic disease related to aging, you know that every discovery is crucial in the quest for cures. Gifts of all sizes are needed to make the next breakthrough a reality. Make a tax-deductible gift to TSRI and make a difference today!

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Professor Paul Robbins is investigating just how damage that accumulates over time drives the human aging process. Read More.


Hiroshi Asahara, MD, PhD
Joel Buxbaum, MD
Anutosh Chakraborty
Bruno Conti, PhD
Boaz Cook, PhD
Sandra Encalada, PhD
Eros Lazzerini Denchi, PhD
Martin Friedlander, MD, PhD
Larry Gerace, PhD
Matt Gill, PhD
John Griffin, PhD
Patrick Griffin, PhD
Wendy Havran, PhD
William Ja, PhD
Eric Johnson, PhD
Shuji Kishi, MD, PhD
Thomas Kodadek, PhD
Anastasia Kralli, PhD
Luke Leman, PhD
Jeanne Loring, PhD
Martin Lotz, MD
Courtney Miller, PhD
Richard Milner, PhD
Ulrich Mueller, PhD
Laura Niedernhofer, MD, PhD
Takanori Otomo, PhD
Michael Petrascheck
Howard Petrie, PhD
Steve Reed, PhD
Paul Robbins, PhD
Karsten Sauer, PhD
Peter Schultz, PhD
Roy Smith, PhD
Supriya Srinivasan, PhD
Andrew Su, PhD
Peiqing Sun, PhD
Mark Sundrud,PhD
Paul Thompson, PhD
Seth Tomchik, PhD
Eric Topol, MD
Luke Wiseman, PhD
Xiaohua Wu, PhD
Xiang-Lei Yang, PhD


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