Bryan Briney, Ph.D.

Assistant Professor
Department of Immunology & Microbiology
The Scripps Research Institute


Ph.D. (Microbiology and Immunology), Vanderbilt University 2012

B.S. (Biochemistry and Cell Biology), University of California, San Diego 2007


2017-2018 Assistant Professor of Immunology and Microbiology, Immunology & Microbiology, The Scripps Research Institute

2015-2017 Assistant Professor of IMS, Immunology and Microbial Science (IMS), The Scripps Research Institute

2012-2015 Postdoctoral Fellow, The Scripps Research Institute



Andrabi, R., Su, C. Y., Liang, C. H., Shivatare, S. S., Briney, B., Voss, J. E., Nawazi, S. K., Wu, C. Y., Wong, C. H., Burton, D. R. Glycans function as anchors for antibodies and help drive HIV broadly neutralizing antibody development Immunity 2017 47:524-537

Magnani, D. M., Rogers, T. F., Beutler, N., Ricciardi, M. J., Bailey, V. K., Gonzalez-Nieto, L., Briney, B., Sok, D., Le, K., Strubel, A., Gutman, M. J., Pedreno-Lopez, N., et al. Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques Science Translational Medicine 2017 9

Havenar-Daughton, C., Carnathan, D. G., Torrents de la Peña, A., Pauthner, M., Briney, B., Reiss, S. M., Wood, J. S., Kaushik, K., van Gils, M. J., Rosales, S. L., van der Woude, P., Locci, M., et al. Direct probing of germinal center responses reveals immunological features and bottlenecks for neutralizing antibody responses to HIV Env trimer Cell Reports 2016 17:2195-2209

Steichen, J. M., Kulp, D. W., Tokatlian, T., Escolano, A., Dosenovic, P., Stanfield, R. L., McCoy, L. E., Ozorowski, G., Hu, X., Kalyuzhniy, O., Briney, B., Schiffner, T., et al. HIV vaccine design to target germline precursors of glycan-dependent broadly neutralizing antibodies Immunity 2016 45:483-496

Jardine, J. G., Kulp, D. W., Havenar-Daughton, C., Sarkar, A., Briney, B., Sok, D., Sesterhenn, F., Ereno-Orbea, J., Kalyuzhniy, O., Deresa, I., Hu, X., Spencer, S., et al. HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogene Science 2016 351:1458-1463

Stapleton, J. A., Kim, J., Hamilton, J. P., Wu, M., Irber, L. C., Maddamsetti, R., Briney, B., Newton, L., Burton, D. R., Brown, C. T., Chan, C., Buell, C. R., et al. Haplotype-phased synthetic long reads from short-read sequencing PLoS One 2016 11

McCoy, L. E., van Gils, M. J., Ozorowski, G., Messmer, T., Briney, B., Voss, J. E., Kulp, D. W., Macauley, M. S., Sok, D., Pauthner, M., Menis, S., Cottrell, C. A., et al. Holes in the glycan shield of the native HIV Envelope are a target of trimer-elicited neutralizing antibodies Cell Reports 2016 16:2327-2338

Andrabi, R., Voss, J. E., Liang, C. H., Briney, B., McCoy, L. E., Wu, C. Y., Wong, C. H., Poignard, P., Burton, D. R. Identification of common features in prototype broadly neutralizing antibodies to HIV envelope V2 apex to facilitate vaccine design Immunity 2015 43:959-973

Jardine, J. G., Ota, T., Sok, D., Pauthner, M., Kulp, D. W., Kalyuzhniy, O., Skog, P. D., Thinnes, T. C., Bhullar, D., Briney, B., Menis, S., Jones, M., et al. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen Science 2015 349:156-161

Sok, D., Doores, K. J., Briney, B., Le, K. M., Saye-Francisco, K. L., Ramos, A., Kulp, D. W., Julien, J. P., Menis, S., Wickramasinghe, L., Seaman, M. S., Schief, W. R., et al. Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV Science Translational Medicine 2014 6:236ra63

Sok, D., van Gils, M. J., Pauthner, M., Julien, J. P., Saye-Francisco, K. L., Hsueh, J., Briney, B., Lee, J. H., Le, K. M., Lee, P. S., Hua, Y., Seaman, M. S., et al. Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex Proceedings of the National Academy of Sciences of the United States of America 2014 111:17624-17629

Briney, B. S., Willis, J. R., Finn, J. A., McKinney, B. A., Crowe Jr., J. E. Tissue-specific expressed antibody variable gene repertoires PLoS One 2014 9:e100839

Willis, J. R., Briney, B. S., DeLuca, S. L., Crowe Jr., J. E., Meiler, J. Human germline antibody gene segments encode polyspecific antibodies PLoS Computational Biology 2013 9:e1003045

Briney, B. S., Crowe Jr., J. E. Secondary mechanisms of diversification in the human antibody repertoire Frontiers in Immunology 2013 4:42

Sok, D., Laserson, U., Laserson, J., Liu, Y., Vigneault, F., Julien, J. P., Briney, B., Ramos, A., Saye, K. F., Le, K., Mahan, A., Wang, S., et al. The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies PLoS Pathogens 2013 9:e1003754

Briney, B. S., Willis, J. R., Hicar, M. D., Thomas II, J. W., Crowe Jr., J. E. Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire Immunology 2012 137:56-64

Briney, B. S., Willis, J. R., McKinney, B. A., Crowe Jr., J. E. High-throughput antibody sequencing reveals genetic evidence of global regulation of the naive and memory repertoires that extends across individuals Genes and Immunity 2012 13:469-473

Briney, B. S., Willis, J. R., Crowe Jr., J. E. Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes PLoS One 2012 7:e36750

Briney, B. S., Willis, J. R., Crowe Jr., J. E. Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity Genes and Immunity 2012 13:523-529

Krause, J. C., Tsibane, T., Tumpey, T. M., Huffman, C. J., Briney, B. S., Smith, S. A., Basler, C. F., Crowe Jr., J. E. Epitope-specific human influenza antibody repertoires diversify by B cell intraclonal sequence divergence and interclonal convergence Journal of Immunology 2011 187:3704-3711

Hicar, M. D., Chen, X., Briney, B., Hammonds, J., Neupert, P., Wang, J. J., Kalams, S., Spearman, P. W., Crowe Jr., J. E. Pseudovirion particles bearing native HIV envelope trimers facilitate a novel method for generating human neutralizing monoclonal antibodies against HIV JAIDS-Journal of Acquired Immune Deficiency Syndromes 2010 54:223-235