Bryan Briney, Ph.D.

Assistant Professor
Department of Immunology & Microbiology
The Scripps Research Institute

EDUCATION

Ph.D. (Microbiology and Immunology), Vanderbilt University 2012

B.S. (Biochemistry and Cell Biology), University of California, San Diego 2007

POSITIONS

2017-2018 Assistant Professor of Immunology and Microbiology, Immunology & Microbiology, The Scripps Research Institute

2015-2017 Assistant Professor of IMS, Immunology and Microbial Science (IMS), The Scripps Research Institute

2012-2015 Postdoctoral Fellow, The Scripps Research Institute

PUBLICATIONS

Zhao F, Joyce C, Burns A, Nogal B, Cottrell CA, Ramos A, Biddle T, Pauthner M, Nedellec R, Qureshi H, Mason R, Landais E, Briney B, Ward AB, Burton DR, Sok D. Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques. Cell Rep. 2020 Sep 8;32(10):108122.

Sas-Chen A, Thomas JM, Matzov D, Taoka M, Nance KD, Nir R, Bryson KM, Shachar R, Liman GLS, Burkhart BW, Gamage ST, Nobe Y, Briney CA, Levy MJ, Fuchs RT, Robb GB, Hartmann J, Sharma S, Lin Q, Florens L, Washburn MP, Isobe T, Santangelo TJ, Shalev-Benami M, Meier JL, Schwartz S. Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping. Nature. 2020 Jul;583(7817):638-643.

Rogers TF, Zhao F, Huang D, Beutler N, Burns A, He WT, Limbo O, Smith C, Song G, Woehl J, Yang L, Abbott RK, Callaghan S, Garcia E, Hurtado J, Parren M, Peng L, Ramirez S, Ricketts J, Ricciardi MJ, Rawlings SA, Wu NC, Yuan M, Smith DM, Nemazee D, Teijaro JR, Voss JE, Wilson IA, Andrabi R, Briney B, Landais E, Sok D, Jardine JG, Burton DR. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model. Science. 2020 Aug 21;369(6506):956-963.

Rogers TF, Zhao F, Huang D, Beutler N, Burns A, He WT, Limbo O, Smith C, Song G, Woehl J, Yang L, Abbott RK, Callaghan S, Garcia E, Hurtado J, Parren M, Peng L, Ricketts J, Ricciardi MJ, Rawlings SA, Smith DM, Nemazee D, Teijaro JR, Voss JE, Andrabi R, Briney B, Landais E, Sok D, Jardine JG, Burton DR. Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model. bioRxiv. 2020 May 15:2020.05.11.088674.

Bergholtz SE, Briney CA, Najera SS, Perez M, Linehan WM, Meier JL. An Oncometabolite Isomer Rapidly Induces a Pathophysiological Protein Modification. ACS Chem Biol. 2020 Apr 17;15(4):856-861.

Joyce C, Burton DR, Briney B. Comparisons of the antibody repertoires of a humanized rodent and humans by high throughput sequencing. Sci Rep. 2020 Jan 24;10(1):1120.

Smakaj E, Babrak L, Ohlin M, Shugay M, Briney B, Tosoni D, Galli C, Grobelsek V, D'Angelo I, Olson B, Reddy S, Greiff V, Trück J, Marquez S, Lees W, Miho E. Benchmarking immunoinformatic tools for the analysis of antibody repertoire sequences. Bioinformatics. 2020 Mar 1;36(6):1731-1739.

Havenar-Daughton C, Carnathan DG, Boopathy AV, Upadhyay AA, Murrell B, Reiss SM, Enemuo CA, Gebru EH, Choe Y, Dhadvai P, Viviano F, Kaushik K, Bhiman JN, Briney B, Burton DR, Bosinger SE, Schief WR, Irvine DJ, Silvestri G, Crotty S. Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization. Cell Rep. 2019 Nov 12;29(7):1756-1766.e8.

Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR. A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses. Science. 2019 Dec 6;366(6470):eaax4380.

Blasco A, Endres MG, Sergeev RA, Jonchhe A, Macaluso NJM, Narayan R, Natoli T, Paik JH, Briney B, Wu C, Su AI, Subramanian A, Lakhani KR. Advancing computational biology and bioinformatics research through open innovation competitions.
PLoS One. 2019 14(9):e0222165.

Umotoy J, Bagaya BS, Joyce C, Schiffner T, Menis S, Saye-Francisco KL, Biddle T, Mohan S, Vollbrecht T, Kalyuzhniy O, Madzorera S, Kitchin D, Lambson B, Nonyane M, Kilembe W; IAVI Protocol C Investigators; IAVI African HIV Research Network, Poignard P, Schief WR, Burton DR, Murrell B, Moore PL, Briney B, Sok D, Landais E. Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan. Immunity. 2019 51(1):141-154.

Briney B, Inderbitzin A, Joyce C, Burton DR. Commonality despite exceptional diversity in the baseline human antibody repertoire. Nature. 2019 Feb;566(7744):393-397.

Voss JE, Gonzalez-Martin A, Andrabi R, Fuller RP, Murrell B, McCoy LE, Porter K, Huang D, Li W, Sok D, Le K, Briney B, Chateau M, Rogers G, Hangartner L, Feeney AJ, Nemazee D, Cannon P, Burton DR. Reprogramming the antigen specificity of B cells using genome-editing technologies. Elife. 2019 8.pii:e42995.

Landais E, Murrell B, Briney B, Murrell S, Rantalainen K, Berndsen ZT, Ramos A, Wickramasinghe L, Smith ML, Eren K, de Val N, Wu M, Cappelletti A, Umotoy J, Lie Y, Wrin T, Algate P, Chan-Hui PY, Karita E; IAVI Protocol C Investigators; IAVI African HIV Research Network, Ward AB, Wilson IA, Burton DR, Smith D, Pond SLK, Poignard P. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity. 2017 47(5):990-1003.e9.

Andrabi R, Su CY, Liang CH, Shivatare SS, Briney B, Voss JE, Nawazi SK, Wu CY, Wong CH, Burton DR. Glycans Function as Anchors for Antibodies and Help Drive HIV Broadly Neutralizing Antibody Development. Immunity. 2017 Nov 21;47(5):1004.

Magnani DM, Rogers TF, Beutler N, Ricciardi MJ, Bailey VK, Gonzalez-Nieto L, Briney B, Sok D, Le K, Strubel A, Gutman MJ, Pedreño-Lopez N, Grubaugh ND, Silveira CGT, Maxwell HS, Domingues A, Martins MA, Lee DE, Okwuazi EE, Jean S, Strobert EA, Chahroudi A, Silvestri G, Vanderford TH, Kallas EG, Desrosiers RC, Bonaldo MC, Whitehead SS, Burton DR, Watkins DI. Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques. Sci Transl Med. 2017 9(410). pii:eaan8184.

Andrabi, R., Su, C. Y., Liang, C. H., Shivatare, S. S., Briney, B., Voss, J. E., Nawazi, S. K., Wu, C. Y., Wong, C. H., Burton, D. R. Glycans function as anchors for antibodies and help drive HIV broadly neutralizing antibody development Immunity 2017 47:524-537

Magnani, D. M., Rogers, T. F., Beutler, N., Ricciardi, M. J., Bailey, V. K., Gonzalez-Nieto, L., Briney, B., Sok, D., Le, K., Strubel, A., Gutman, M. J., Pedreno-Lopez, N., et al. Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques Science Translational Medicine 2017 9

Havenar-Daughton, C., Carnathan, D. G., Torrents de la Peña, A., Pauthner, M., Briney, B., Reiss, S. M., Wood, J. S., Kaushik, K., van Gils, M. J., Rosales, S. L., van der Woude, P., Locci, M., et al. Direct probing of germinal center responses reveals immunological features and bottlenecks for neutralizing antibody responses to HIV Env trimer Cell Reports 2016 17:2195-2209

Steichen, J. M., Kulp, D. W., Tokatlian, T., Escolano, A., Dosenovic, P., Stanfield, R. L., McCoy, L. E., Ozorowski, G., Hu, X., Kalyuzhniy, O., Briney, B., Schiffner, T., et al. HIV vaccine design to target germline precursors of glycan-dependent broadly neutralizing antibodies Immunity 2016 45:483-496

Jardine, J. G., Kulp, D. W., Havenar-Daughton, C., Sarkar, A., Briney, B., Sok, D., Sesterhenn, F., Ereno-Orbea, J., Kalyuzhniy, O., Deresa, I., Hu, X., Spencer, S., et al. HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogene Science 2016 351:1458-1463

Stapleton, J. A., Kim, J., Hamilton, J. P., Wu, M., Irber, L. C., Maddamsetti, R., Briney, B., Newton, L., Burton, D. R., Brown, C. T., Chan, C., Buell, C. R., et al. Haplotype-phased synthetic long reads from short-read sequencing PLoS One 2016 11

McCoy, L. E., van Gils, M. J., Ozorowski, G., Messmer, T., Briney, B., Voss, J. E., Kulp, D. W., Macauley, M. S., Sok, D., Pauthner, M., Menis, S., Cottrell, C. A., et al. Holes in the glycan shield of the native HIV Envelope are a target of trimer-elicited neutralizing antibodies Cell Reports 2016 16:2327-2338

Andrabi, R., Voss, J. E., Liang, C. H., Briney, B., McCoy, L. E., Wu, C. Y., Wong, C. H., Poignard, P., Burton, D. R. Identification of common features in prototype broadly neutralizing antibodies to HIV envelope V2 apex to facilitate vaccine design Immunity 2015 43:959-973

Jardine, J. G., Ota, T., Sok, D., Pauthner, M., Kulp, D. W., Kalyuzhniy, O., Skog, P. D., Thinnes, T. C., Bhullar, D., Briney, B., Menis, S., Jones, M., et al. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen Science 2015 349:156-161

Sok, D., Doores, K. J., Briney, B., Le, K. M., Saye-Francisco, K. L., Ramos, A., Kulp, D. W., Julien, J. P., Menis, S., Wickramasinghe, L., Seaman, M. S., Schief, W. R., et al. Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV Science Translational Medicine 2014 6:236ra63

Sok, D., van Gils, M. J., Pauthner, M., Julien, J. P., Saye-Francisco, K. L., Hsueh, J., Briney, B., Lee, J. H., Le, K. M., Lee, P. S., Hua, Y., Seaman, M. S., et al. Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex Proceedings of the National Academy of Sciences of the United States of America 2014 111:17624-17629

Briney, B. S., Willis, J. R., Finn, J. A., McKinney, B. A., Crowe Jr., J. E. Tissue-specific expressed antibody variable gene repertoires PLoS One 2014 9:e100839

Willis, J. R., Briney, B. S., DeLuca, S. L., Crowe Jr., J. E., Meiler, J. Human germline antibody gene segments encode polyspecific antibodies PLoS Computational Biology 2013 9:e1003045

Briney, B. S., Crowe Jr., J. E. Secondary mechanisms of diversification in the human antibody repertoire Frontiers in Immunology 2013 4:42

Sok, D., Laserson, U., Laserson, J., Liu, Y., Vigneault, F., Julien, J. P., Briney, B., Ramos, A., Saye, K. F., Le, K., Mahan, A., Wang, S., et al. The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies PLoS Pathogens 2013 9:e1003754

Briney, B. S., Willis, J. R., Hicar, M. D., Thomas II, J. W., Crowe Jr., J. E. Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire Immunology 2012 137:56-64

Briney, B. S., Willis, J. R., McKinney, B. A., Crowe Jr., J. E. High-throughput antibody sequencing reveals genetic evidence of global regulation of the naive and memory repertoires that extends across individuals Genes and Immunity 2012 13:469-473

Briney, B. S., Willis, J. R., Crowe Jr., J. E. Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes PLoS One 2012 7:e36750

Briney, B. S., Willis, J. R., Crowe Jr., J. E. Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity Genes and Immunity 2012 13:523-529

Krause, J. C., Tsibane, T., Tumpey, T. M., Huffman, C. J., Briney, B. S., Smith, S. A., Basler, C. F., Crowe Jr., J. E. Epitope-specific human influenza antibody repertoires diversify by B cell intraclonal sequence divergence and interclonal convergence Journal of Immunology 2011 187:3704-3711

Hicar, M. D., Chen, X., Briney, B., Hammonds, J., Neupert, P., Wang, J. J., Kalams, S., Spearman, P. W., Crowe Jr., J. E. Pseudovirion particles bearing native HIV envelope trimers facilitate a novel method for generating human neutralizing monoclonal antibodies against HIV JAIDS-Journal of Acquired Immune Deficiency Syndromes 2010 54:223-235