Antibodies and Infectious Disease

The perception of man as the easy victor over microbes has changed dramatically in the last two decades. Vaccination has offered protection against a number of viral pathogens, but it is increasingly recognized that the strategies used in the past will not be successful against all viruses. We are focused on developing rational vaccine strategies, particularly against HIV and particularly using an approach termed “Reverse Vaccinology 2.0”. In this approach, broadly neutralizing antibodies isolated from natural HIV infection are investigated in interaction with their sole viral target, the HIV Envelope, and the data used to guide immunogen design and immunization strategies. Immunogens are then evaluated in detail in animal models and the results used to iteratively improve immunogens as we move toward an HIV vaccine suitable to protect humans.


Endpoints News: Inside The 30-Year Hunt For The Perfect Antibody

San Diego scientists looking for COVID-19 survivors whose blood might help fight the virus

COVID-19 survivors needed for Scripps Research antibody study

Scripps Research-led consortium receives $129 million NIH award to bring new HIV vaccination approach into clinical testing

Monkey-infecting virus may provide part of future HIV vaccine

Scripps Research discoveries pave way to clinical trial of new type of HIV vaccine

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HIV vaccine protects non-human primates from infection

Scripps Research scientists receive $12 million for malaria and flu vaccine research

Scripps Research Study Reveals New Clues to How a Successful HIV Vaccine Could Work

Focus: In struggle against HIV, scientists get help from cows

NIH-supported scientists elicit broadly neutralizing antibodies to HIV in calves

San Diego Team Tests Best Delivery Mode for Potential HIV Vaccine

Team Discovers Antibodies that Target Holes in HIV's Defenses

Team Harnesses Antibody Evolution on the Path to an AIDS Vaccine

Study Supports Strategy of Series of Shots to Vaccinate Against AIDS

Researchers Discover New Ebola-Fighting Antibodies in Blood of Outbreak Survivor

Team Finds New Point of Attack on HIV for Vaccine Development

Promising HIV Vaccine Target Found

Hitting a Moving Target: AIDS Vaccine Could Work Against Changeable Site on HIV

AIDS Vaccine Candidate Successfully 'Primes" Immune System

Scientists Find Surprising Trait in Anti-HIV Antibodies

Featured Articles

Hangartner L, Beauparlant D, Rakasz E, Nedellec R, Hozé N, McKenney K, Martins MA, Seabright GE, Allen JD, Weiler AM, Friedrich TC, Regoes RR, Crispin M, Burton DR. (2021) Effector function does not contribute to protection from virus challenge by a highly potent HIV broadly neutralizing antibody in nonhuman primates. Sci Transl Med. 13(585):eabe3349.

Burton DR, Topol EJ. (2021) Toward superhuman SARS-CoV-2 immunity? Nat Med. 27(1):5-6.

Burton DR, Topol EJ. (2021) Variant-proof vaccines – invest now for the next pandemic. Nature. 590(7846):386-388.

Burton DR. (2021) A new lease on life for an HIV-neutralizing antibody class and vaccine target. Proc Natl Acad Sci U S A. 118(7):e2026390118.

Conti S, Kaczorowski KJ, Song G, Porter K, Andrabi R, Burton DR, Chakraborty AK, Karplus M. (2021) Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site. Proc Natl Acad Sci U S A. 118(9):e2018338118.

Rappazzo CG, Tse LV, Kaku CI, Wrapp D, Sakharkar M, Huang D, Deveau LM, Yockachonis TJ, Herbert AS, Battles MB, O’Brien CM, Brown ME, Geoghegan JC, Belk J, Peng L, Yang L, Hou Y, Scobey TD, Burton DR, Nemazee D, Dye JM, Voss JE, Gunn BM, McLellan JS, Baric RS, Gralinski LE, Walker LM. (2021) Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody. Science. 371(6531):823-829.

Rogers TF, Zhao F, Huang D, Beutler N, Burns A, He WT, Limbo O, Smith C, Song G, Woehl J, Yang L, Abbott RK, Callaghan S, Garcia E, Hurtado J, Parren M, Peng L, Ramirez S, Ricketts J, Ricciardi MJ, Rawlings SA, Wu NC, Yuan M, Smith DM, Nemazee D, Teijaro JR, Voss JE, Wilson IA, Andrabi R, Briney B, Landais E, Sok D, Jardine JG, Burton DR. (2020) Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model. Science. 369(6506):956-963.

Wec AZ, Wrapp D, Herbert AS, Maurer DP, Haslwanter D, Sakharkar M, Jangra RK, Dieterle ME, Lilov A, Huang D, Tse LV, Johnson NV, Hsieh CL, Wang N, Nett JH, Champney E, Burnina I, Brown M, Lin S, Sinclair M, Johnson C, Pudi S, Bortz R 3rd, Wirchnianski AS, Laudermilch E, Florez C, Fels JM, O’Brien CM, Graham BS, Nemazee D, Burton DR, Baric RS, Voss JE, Chandran K, Dye JM, McLellan JS, Walker LM. (2020) Broad neutralization of SARS-related viruses by human monoclonal antibodies. Science. 369(6504):731-736.

Yuan M, Liu H, Wu NC, Lee CD, Zhu X, Zhao F, Huang D, Yu W, Hua Y, Tien H, Rogers TF, Landais E, Sok D, Jardine JG, Burton DR, Wilson IA. (2020) Structural basis of a shared antibody response to SARS-CoV-2. Science. 369(6507):1119-1123.


Designing an HIV Vaccine - Dennis Burton | The Scripps Research Institute

Cow antibodies prove promising in developing HIV vaccine

The Front Row: Lecture Series: Dennis Burton: COVID-19