Scripps Research Logo


Link to Publications

1995 - 2020

Wang, C., Zhao, P., Sun, S., Teckman, J., and Balch, W. E. (2020) Leveraging Population Genomics for Individualized Correction of the Hallmarks of Alpha-1 Antitrypsin Deficiency. Chronic Obstr. Pulm. Dis. 7, 224-246.(PubMed).

Tran, D. T., Pottekat, A., Mir, S. A., Loguercio, S., Jang, I., Campos, A. R., Scully, K. M., Lahmy, R., Liu, M., Arvan, P., Balch, W. E., Kaufman, R. J., and Itkin-Ansari, P. (2020) Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role For Peroxiredoxin 4 in Proinsulin Folding. Diabetes. 2020 May 26;db200245. doi: 10.2337/db20-0245. Online ahead of print. (PubMed).
Singh, J., Hutt, D. M., Tait, B. D., Guy, N. C., Sivils, J. C., Ortiz, N. R., Payan, A. N., Komaragiri, S. K., Owens, J. J., Culbertson, D., Blair, L. J., Dickey, C., Kuo, S. Y., Finley, D., Dyson, H. J., Cox, M. B., Chaudhary, J., Gestwicki, J. E., and Balch, W. E. (2020) Management of Hsp90-Dependent Protein Folding by Small Molecule Targeting the Aha1 Co-Chaperone. Cell Chem. Biol. 27(3):292-305.e6, 412908. (PubMed).
Subramanian, K., Hutt, D.M., Scott, S.M., Gupta, V., Mao, S., Balch, W.E. (2020). Correction of Niemann-Pick type C1 trafficking and activity with the histone deacetylase inhibitor valproic acid. J. Biol. Chem. 2020, Apr 30. pii: jbc.RA119.010524. doi: 10.1074/jbc. (PubMed).
Wang, C., Scott, S.M., Sun, S., Zhao. P., Hutt, D.M., Shao, H., Gestwicki, J.E., Balch, W.E. (2020). Individualized Management of Genetic Diversity in Niemann-Pick C1 through Modulation of the Hsp70 Chaperone System. Hum. Mol. Genet.1;29(1):1-19. doi: 10.1093/hmg/ddz215. PubMed PMID: 31509197. (PubMed).
Angles, F., Hutt, D. M. & Balch, W. E. (2019). HDAC Inhibitors Rescue Multiple Disease-Causing CFTR Variants. Hum. Mol. Genet. 28, 1982-2000, doi:10.1093/hmg/ddz026 5308640 [pii]. (PubMed).
Soberanes, S., Misharin, A.V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A.C., Cho, T., Hamanaka, R.B., Meliton, A.Y., Walter, J.M., Chen, C.I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F.J., Antalek, M., Adbala-Valencia, H., Chiarella, S.E., Sun, K.A., Woods, P.S., Ghio, A.J., Jain, M., Perlman, H., Ridge, K.M., Morimoto, R.I., Sznajder, J.I., Balch, W.E., Bhorade, S.M., Bharat, A., Prakriya, M., Chandel, N.S., Mutlu, G.M., Budinger, G.R.S. (2019). Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis. Cell Metab. 5;29(2):503. (PubMed).
Wang, C., Balch, W.E. (2018). Bridging Genomics to Phenomics at Atomic Resolution through Variation Spatial Profiling. Cell Rep. 24(8):2013-2028 e2016. DOI: 10.1016/j.celrep.2018.07.059. (PubMed).
Angles, F., Hutt, D., Balch, W.E. (2018).  HDAC Inhibitors Rescue Multiple Disease-Causing CFTR Variants. bioRxiv. doi:
Hutt, D.M., Loguercio, S., Roth, D.M., Su, A.I., Balch, W.E. (2018). Correcting the F508del-CFTR variant by modulating eukaryotic translation initiation factor 3-mediated translation initiation. J. Biol. Chem. 293(35):13477-13495. doi: 10.1074/jbc.RA118.003192. (PubMed).
Hutt, D.M., Mishra, S.K., Roth, D.M., Larsen, M.B., Angles, F., Frizzell, R.A., Balch, W.E. (2018). Silencing of the Hsp70-specific nucleotide-exchange factor BAG3 corrects the F508del-CFTR variant by restoring autophagy. J. Biol. Chem. 293(35):13682-13695. doi: 10.1074/jbc.RA118.002607. [Epub ahead of print]. (PubMed).
Hutt, D.M., Loguercio, S., Campos, A.R., Balch, W.E. (2018). A Proteomic Variant Approach (ProVarA) for Personalized Medicine of Inherited and Somatic Disease. J. Mol. Biol. 2018 Jun 18. pii: S0022-2836(18)30613-2. doi: 10.1016/j.jmb.2018.06.017. (PubMed) .
Subramanian, K., Rauniyar, N., Lavallee-Adam, M., Yates III, J.R., Balch, W.E. (2017). Quantitative Analysis of the Proteome Response to the Histone Deacetylase Inhibitor (HDACi) Vorinostat in Niemann-Pick Type C1 disease. J. Mol. Proteomics. 16(11):1938-1957. doi: 10.1074/mcp.M116.064949. (PubMed).
Wang, C., Bouchecareilh, M., Balch, W.E. (2017). Measuring the Effect of Histone Deacetylase Inhibitors (HDACi) on the Secretion and Activity of Alpha-1 Antitrypsin. Methods Mol. Biol. 1639:185-193. (PubMed).
Misharin, A.V., Morales-Nebreda, L., Reyfman, P.A., Cuda, C.M., Walter, J.M., McQuattie-Pimente, A.C., Chen, C., Anekalla, K.R., Joshi, N., Williams, K.J.N., H., A.-V., Yacoub, T.J., Chi, M., Chiu, S., Gonzalez-Gonzalez, F.J., Gates, K., Lam, A.P., Nicholson, T.T., Homan, P.J., Soberanes, S., Dominguez, S., Morgan, V.K., Saber, R., Shaffer, A., Hinchcliff, M., Marshall, S.A., Bharat, A., Berdnikovs, S., Bhorade, S.M., Bartom, E.T., Morimoto, R.I., Balch, W.E., Sznajder, J.I., Chandel, N.S., Mutlu, G.M., Jain, M., Gottardi, C.J., Singer, B.D., Ridge, K.M., Bagheri, N., Shilatifard, A., Budinger, G.R., Perlman, H. (2017) Monocyte-Derived Alveolar Macrophages Drive Lung Fibrosis And Persist In The Lung Over The Lifespan. J. Exp. Med. 214(8):2387-2404. doi: 10.1084/jem.20162152. (PubMed) .
Budinger, G.S., Kohanski, R.A., Gan, W., Kobor, M.S., Amaral, L.A., Armanios, M., Kelsey, K.T., Pardo, A., Tuder, R., Macian, F., Chandel, N., Vaughan, D., Rojas, M., Mora, A.L., Kovacs, E., Duncan, S.R., Finkel, T., Choi, A., Eickelberg, O., Chen, D., Agusti, A., Selman, M., Balch, W.E., Busse, P., Lin, A., Morimoto, R., Sznajder, J.I., Thannickal, V.J. (2017).The Intersection Of Aging Biology and The Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop. J. Gerontol. A. Biol. Sci. Med. Sci.  72(11):1492-1500. doi: 10.1093/gerona/glx090. (PubMed.
Pipalia, N.H., Subramanian, K., Mao, S., Ralph, H., Hutt, D.M., Scott, S.M., Balch, W.E., Maxfield, F.R. (2017). Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells. J. Lipid Res. 58(4):695-708. (PubMed).
Wang, C., Balch, W.E. (2016). Managing the adaptive proteostatic landscape: restoring resilience in Alpha-1 antitrypsin deficiency. In: Adam Wanner, M.a.R.A.S., MD, Ph.D editor. Respir. Med.: Humana Press - Springer International Publishing AG Switzerland; p. 53-83.
Veit, G., Avramescu, R.G., Chiang, A.N., Houck, S.A., Cai, Z., Peters, K.W., Hong, J.S., Pollard, H.B., Guggino, W.B., Balch, W.E., Skach, W.R., Cutting, G.R., Frizzell, R.A., Sheppard, D.N., Cyr, D.M., Sorscher, E.J., Brodsky, J.L., Lukacs, G.L. (2016). From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations. Mol. Biol. Cell. 27(3):424-433. (PutMed).
Pankow, S., Bamberger, C., Calzolari, D., Martinez-Bartolome, S., Lavallee-Adam, M,, Balch, W.E., Yates J.R., 3rd. (2015). F508 CFTR interactome remodelling promotes rescue of cystic fibrosis. Nature. 528(7583):510-6. (PubMed).
Amaral, M.D., Balch, W.E. (2015).  Hallmarks of therapeutic management of the cystic fibrosis functional landscape. J Cyst Fibros. pii: S1569-1993(15)00214-3. doi: 10.1016/j.jcf.2015.09.006. [Epub ahead of print]. (PubMed).
Rauniyar, N., Subramanian, K., Lavallee-Adam, M., Martinez-Bartolome, S., Balch, W.E., Yates, J.R., 3rd. (2015). Quantitative Proteomics of Human Fibroblasts with I1061T Mutation in Niemann-Pick C1 (NPC1) Protein Provides Insights into the Disease Pathogenesis. Mol Cell Proteomics. 14(7):1734-1749. (PubMed).
Singh, J.K., Balch, W.E. Proteostatic hotspots in amyloid fibrils protect us from neurodegeneration. (2015). Dev Cell. 32(6):659-660. (PubMed).
Thannickal, V.J., Murthy, M., Balch, W.E., Chandel, N.S., Meiners, S., Eickelberg, O., Selman, M., Pardo, A., White, E.S., Levy, B.D., Busse, P.J., Tuder, R.M., Antony, V.B., Sznajder, J.I., Budinger, G.R. (2015). Blue Journal Conference: Aging and the Susceptibility to Lung Disease. Am. J. Respir. Crit. Care Med. (PubMed).
Roth, D.M., Hutt, D.M., Tong, J., Bouchecareilh, M., Wang, N., Seeley, T., Dekkers, J.F., Beekman, J.M., Garza, D., Drew, L., Masliah, E., Morimoto, R.I., Balch, W.E. (2014). Modulation of the maladaptive stress response to manage diseases of protein folding. PLoS Biol. 2014; 12(11):e1001998. (PubMed).
Rauniyar, N., Gupta, V., Balch, W.E., Yates, J.R., 3rd. (2014). Quantitative proteomic profiling reveals differentially regulated proteins in cystic fibrosis cells. J Proteome Res. 2014; 13(11):4668-4675. (PubMed)
Balch, W. E., Sznajder, J. I., Budinger, S., Finley, D., Laposky, A. D., Cuervo, A. M., Benjamin, I. J., Barreiro, E., Morimoto, R. I., Postow, L., Weissman, A. M., Gail, D., Banks-Schlegel, S., Croxton, T., and Gan, W. (2014) Malfolded protein structure and proteostasis in lung diseases. Am. J. Respir. Crit. Care Med. 189, 96-103. (PubMed).
Roth, D. M., and Balch, W. E. (2013). Q-bodies monitor the quinary state of the protein fold. Nat. Cell Biol. 15, 1137-1139. (PubMed).
Bannykh, S. I., Balch, W. E., Kelly, J. W., Page, L. J., and Shelton, G. D. (2013). Formation of gelsolin amyloid fibrils in the rough endoplasmic reticulum of skeletal muscle in the gelsolin mouse model of inclusion body myositis: comparative analysis to human sporadic inclusion body myositis. Ultrastruct. Pathol. 37, 304-311. (PubMed).
Balch, W. E., Sznajder, J. I., Budinger, S., Finley, D., Laposky, A. D., Cuervo, A. M., Benjamin, I. J., Barreiro, E., Morimoto, R. I., Postow, L., Weissman, A. M., Gail, D., Banks-Schlegel, S., Croxton, T., and Gan, W. (2013) NHLBI Workshop: Malfolded Protein Structure and Proteostasis in Lung Diseases. Am. J. Respir. Crit. Care Med. (PubMed) 
Pottekat, A., Becker, S., Spencer, K. R., Yates, J. R., 3rd, Manning, G., Itkin-Ansari, P., and Balch, W. E. (2013). Insulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool release. Cell Rep 4, 921-930. (PubMed).
Powers, E.T., Balch, W.E. (2013). Diversity in the origins of proteostasis networks - a driver for protein function in evolution. Nat. Rev. Mol. Cell Biol. 14(4):237-248.  (PubMed) .
Calamini, B., Silva, M. C., Madoux, F., Hutt, D. M., Khanna, S., Chalfant, M. A., Allais, C., Ouizem, S., Saldanha, S. A., Ferguson, J., Mercer, B. A., Michael, C., Tait, B. D., Garza, D., Balch, W. E., Roush, W. R., Morimoto, R. I., and Hodder, P. (2013) ML346: A Novel Modulator of Proteostasis for Protein Conformational Diseases. Probe Reports from the NIH Molecular Libraries Program. (PubMed)
Hamvas, A., Deterding, R., Balch, W. E., Schwartz, D. A., Albertine, K. H., Whitsett, J. A., Cardoso, W. V., Kotton, D. N., Kourembanas, S., and Hagood, J. S. (2013) Diffuse lung disease in children: Summary of a scientific conference. Pediatr. Pulmonol. doi: 10.1002/ppul.22805. [Epub ahead of print].  (PubMed).
Hutt, D.M., Balch, W.E. (2013). Expanding Proteostasis by Membrane Trafficking Networks. Cold Spring Harb. Perspect. Biol. 10.1101/cshperspect.a013383. [Epub ahead of print]. (PubMed).
Gupta, V., and Balch, W.E. (2013). Protein folding: Salty sea regulators of cystic fibrosis. Nat Chem Biol 9, 12-14. (PubMed).
Bouchecareilh, M., Hutt, D.M., Szajner, P., Flotte, T.R., and Balch, W.E. (2012). Histone Deacetylase inhibitor (HDACi) Suberoylanilide Hydroxamic Acid (SAHA) Mediated Correction of Alpha-1 Antitrypsin Deficiency. J Biol Chem 287, 38265-38278. (PubMed).
Hulleman, J.D., Balch, W.E., and Kelly, J.W. (2012). Translational attenuation differentially alters the fate of disease-associated fibulin proteins. FASEB J. 26(11):4548-60. (PubMed).
Coppinger, J., Hutt, D.M., Razvi, A., Pankow, S., Koulov, A.V., Yates III, J.R., and Balch, W.E. (2012). A Chaperone Trap Triggers Cystic Fibrosis. PLoS One, 7(5):e37682.  (PubMed).
Bouchecareilh, M., and Balch, W.E. (2012). Proteostasis, an Emerging Therapeutic Paradigm for Managing Inflammatory Airway Stress Disease. Curr Mol Med. 12(7):815-26.  (PubMed).
Hutt, D.M., Roth, D.M., Chalfant, M.A., Youker, R.T., Matteson, J., Brodsky, J.L., and Balch, W.E. (2012). FK506 Binding Protein 8 Peptidylprolyl Isomerase Activity Manages a Late Stage of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Folding and Stability. J Biol Chem 287, 21914-21925. (PubMed). 
Solomon, J.P., L.J. Page, W.E. Balch, and J.W. Kelly. (2012). Gelsolin amyloidosis: Genetics, biochemistry, pathology and possible strategies for therapeutic intervention. Crit. Rev. Biochem. Mol. Biol. 47(3):282-96  (PubMed)
Calamini, B., Silva, M. C., Madoux, F., Hutt, D. M., Khanna, S., Chalfant, M. A., Saldanha, S. A., Hodder, P., Tait, B. D., Garza, D., Balch, W. E., and Morimoto, R. I. (2012) Small-molecule proteostasis regulators for protein conformational diseases. Nat. Chem. Biol. 8, 185-196.   (PubMed).
Hulleman, J.D., Kaushal, S., Balch, W.E., and Kelly, J.W. (2011). Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration. Mol Biol Cell 22, 4765-4775.  (PubMed).
Hutt, D.M., Olsen, C.A., Vickers, C.J., Herman, D., Chalfant, M., Montero, A., Leman, L.J., Burkle, R., Maryanoff, B.E., Balch, W.E., Ghadiri, M.R. (2011). Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of DeltaF508-CFTR. ACS Med Chem Lett 2, 703-707.  (PubMed).
Peters, K.W., T. Okiyoneda, W.E. Balch, I. Braakman, J.L. Brodsky, W.B. Guggino, C.M. Penland, H.B. Pollard, E.J. Sorscher, W.R. Skach, P.J. Thomas, G.L. Lukacs, and R.A. Frizzell. (2011). CFTR Folding Consortium: Methods Available for Studies of CFTR Folding and Correction. Methods Mol. Biol. 742:335-53. ( PubMed).
Balch, W.E., and J.R. Yates, 3rd. (2011). Application of mass spectrometry to study proteomics and interactomics in cystic fibrosis. Methods Mol. Biol. 742:227-47.  (PubMed).
Balch, W.E. (2011). Introduction to Section II: Omics in the Biology of Cystic Fibrosis. Methods Mol. Biol. 742:189-91.  (PubMed).
Bouchecareilh, M., and W.E. Balch. (2011). Proteostasis: a new therapeutic paradigm for pulmonary disease. Proc Am Thorac Soc. 8:189-95. (PubMed).
Zhang, X., C. Dong, Q.J. Wu, W.E. Balch, and G. Wu. (2011). Di-acidic motifs in the membrane-distal C-termini modulate the transport of angiotensin II receptors from the endoplasmic reticulum to the cell surface. J. Biol. Chem. ( PubMed).
Balch, W.E., D.M. Roth, and D.M. Hutt. (2011). Emergent properties of proteostasis in managing cystic fibrosis. Cold Spring Harb Perspect Biol. 3(2). ( PubMed).
Powers, E.T., and W.E. Balch. (2011). Protein folding: Protection from the outside. Nature. 471:42-3.  (PubMed).
Roth, D.M., and W.E. Balch. (2011). Modeling general proteostasis: proteome balance in health and disease. Curr. Opin. Cell Biol. 2010 Dec 3. [Epub ahead of print].  (PubMed).
Routledge, K.E., V. Gupta, and W.E. Balch. (2010). Emergent properties of proteostasis-COPII coupled systems in human health and disease. Mol. Membr. Biol. 27:385-97.  (PubMed).
Bouchecareilh, M., J.J. Conkright, and W.E. Balch. (2010). Proteostasis Strategies for Restoring {alpha}1-Antitrypsin Deficiency. Proc Am Thorac Soc. 7:415-22.  (PubMed)
Hutt, D., and W.E. Balch. (2010). Cell Biology. The proteome in balance. Science. 329(5993):766-7.  (PubMed).
Murray, A.N., J.P. Solomon, W.E. Balch, and J.W. Kelly. (2010). Discovery and characterization of a mammalian amyloid disaggregation activity. Protein Sci. 19(4):836-46.  (PubMed).
Koulov, A.V., P. Lapointe, B. Lu, A. Razvi, J. Coppinger, M.Q. Dong, J. Matteson, R. Laister, C. Arrowsmith, J.R. Yates, 3rd, and W.E. Balch. (2010). Biological and Structural Basis for Aha1 Regulation of Hsp90 ATPase Activity in Maintaining Proteostasis in the Human Disease Cystic Fibrosis. Mol. Biol. Cell. 21(6):871-84  (PubMed).
Hutt, D.M., D. Herman, A.P. Rodrigues, S. Noel, J.M. Pilewski, J. Matteson, B. Hoch, W. Kellner, J.W. Kelly, A. Schmidt, P.J. Thomas, Y. Matsumura, W.R. Skach, M. Gentzsch, J.R. Riordan, E.J. Sorscher, T. Okiyoneda, J.R. Yates, 3rd, G.L. Lukacs, R.A. Frizzell, G. Manning, J.M. Gottesfeld, and W.E. Balch. (2010). Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat. Chem. Biol. 6(1):25-33  (PubMed).
Balch, W.E., I. Braakman, J. Brodsky, R.A. Frizzell, G. Guggino, G.L. Lukacs, C. Penland, H. Pollard, W.R. Skach, E.J. Sorscher, and P.J. Thomas. (2010). Folding Biology of Cystic Fibrosis: A consortium-Based Approach to Disease. In Protein Misfolding Diseases. M. Ramirez-Alvarado, J.W. Kelly, and C.M. Dobson, editors. John Wiley and Sons, Inc, Hoboken, New Jersey. 425-452.
Yonemoto, I.T., M.R. Wood, W.E. Balch, and J.W. Kelly. (2009). A general strategy for the bacterial expression of amyloidogenic peptides using BCL-XL-1/2 fusions. Protein Sci. 18(9):1978-86.  (PubMed).
Solomon, J.P., I.T. Yonemoto, A.N. Murray, J.L. Price, E.T. Powers, W.E. Balch, and J.W. Kelly. (2009). The 8 and 5 kDa Fragments of Plasma Gelsolin Form Amyloid Fibrils by a Nucleated Polymerization Mechanism, while the 68 kDa Fragment Is Not Amyloidogenic. Biochemistry (Mosc). 48:11370-80.  (PubMed).
Hutt, D.M., E.T. Powers, and W.E. Balch. (2009). The proteostasis boundary in misfolding diseases of membrane traffic. FEBS Lett. 583:2639-46. (PubMed).
An, Y., C.Y. Chen, B. Moyer, P. Rotkiewicz, M.A. Elsliger, A. Godzik, I.A. Wilson, and W.E. Balch. (2009). Structural and Functional Analysis of the Globular Head Domain of p115 Provides Insight into Membrane Tethering. J. Mol. Biol. 391:26-41.  (PubMed)
Page, L.J., J.Y. Suk, L. Bazhenova, S.M. Fleming, M. Wood, Y. Jiang, L.T. Guo, A.P. Mizisin, R. Kisilevsky, G.D. Shelton, W.E. Balch, and J.W. Kelly. (2009). Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins. Proc. Natl. Acad. Sci. U. S. A. 27:11125-30.  (PubMed)/div>
Powers, E.T., R.I. Morimoto, A. Dillin, J.W. Kelly, and W.E. Balch. (2009). Biological and Chemical Approaches to Diseases of Proteostasis Deficiency. Annu. Rev. Biochem. 78:959-91.  (PubMed)
Subramanian, K., and W.E. Balch. 2008. (2008). NPC1/NPC2 function as a tag team duo to mobilize cholesterol. Proc Natl Acad Sci U S A. 105:15223-15224.  (PubMed)
Mu, T.W., D.S. Ong, Y.J. Wang, W.E. Balch, J.R. Yates, 3rd, L. Segatori, and J.W. Kelly. (2008). Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell. 134:769-81. (PubMed)
Yonemoto, I.T., G.J. Kroon, H.J. Dyson, W.E. Balch, and J.W. Kelly. (2008). Amylin Proprotein Processing Generates Progressively More Amyloidogenic Peptides that Initially Sample the Helical State. Biochemistry. 47:9900-10. (Mosc).  (PubMed)
Wang, X., A.V. Koulov, W.A. Kellner, J.R. Riordan, and W.E. Balch. (2008). Chemical and Biological Folding Contribute to Temperature-Sensitive DeltaF508 CFTR Trafficking. Traffic (Copenhagen, Denmark). 9:1878-93.  (PubMed)
Stagg, S.M., P. LaPointe, A. Razvi, C. Gurkan, C.S. Potter, B. Carragher, and W.E. Balch. (2008). Structural basis for cargo regulation of COPII coat assembly. Cell. 134:474-84.  (PubMed).
Powers, E.T., and W.E. Balch. (2008). Costly mistakes: translational infidelity and protein homeostasis. Cell. 134:204-6. (PubMed)
Balch, W.E., R.I. Morimoto, A. Dillin, and J.W. Kelly. (2008). Adapting proteostasis for disease intervention. Science. 319:916-9.  (PubMed).
Brown, W.J., H. Plutner, D. Drecktrah, B.L. Judson, and W.E. Balch. (2008). The lysophospholipid acyltransferase antagonist CI-976 inhibits a late step in COPII vesicle budding. Traffic (Copenhagen, Denmark). 9:786-97. (PubMed).
Hutt, D.M., and W.E. Balch. (2008). Rab1b silencing using small interfering RNA for analysis of disease-specific function. Methods Enzymol. 438:1-10. (PubMed).
Gurkan, C., A.V. Koulov, and W.E. Balch. (2007). An evolutionary perspective on eukaryotic membrane trafficking. Adv. Exp. Med. Biol. 607:73-83. (PubMed).
Wiseman, R.L., E.T. Powers, J.N. Buxbaum, J.W. Kelly, and W.E. Balch. (2007). An adaptable standard for protein export from the endoplasmic reticulum. Cell. 131:809-21. (PubMed).
Wiseman, R.L., A. Koulov, E. Powers, J.W. Kelly, and W.E. Balch. (2007). Protein energetics in maturation of the early secretory pathway. Curr Opin Cell Biol. 19:359-67. (Pub.Med)
Fowler, D.M., A.V. Koulov, W.E. Balch, and J.W. Kelly. (2007). Functional amyloid - from bacteria to humans. Trends Biochem Sci. 32:217-224. (Pub.Med).
Stagg, S.M., P. Lapointe, and W.E. Balch. (2007). Structural design of cage and coat scaffolds that direct membrane traffic. Curr Opin Struct Biol. 17:221-8. (PubMed).
Cui, L., L. Aleksandrov, X.B. Chang, Y.X. Hou, L. He, T. Hegedus, M. Gentzsch, A. Aleksandrov, W.E. Balch, and J.R. Riordan. 2007. Domain interdependence in the biosynthetic assembly of CFTR. J Mol Biol. 365:981-94. (PubMed)
Sawkar, A.R., M. Schmitz, K.P. Zimmer, D. Reczek, T. Edmunds, W.E. Balch, and J.W. Kelly. (2006). Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants. ACS Chem Biol. 1:235-51. (PubMed).
Wang, X., J. Venable, P. Lapointe, D.M. Hutt, A.V. Koulov, J. Coppinger, C. Gurkan, W. Kellner, J. Matteson, H. Plutner, J.R. Riordan, J.W. Kelly, J.R. Yates, 3rd, and W.E. Balch. (2006). Hsp90 Cochaperone Aha1 Downregulation Rescues Misfolding of CFTR in Cystic Fibrosis. Cell. 127:803-815. (PubMed).
Gurkan, C., S.M. Stagg, P. Lapointe, and W.E. Balch. (2006). The COPII cage: unifying principles of vesicle coat assembly. Nat Rev Mol Cell Biol. 7:727-38.  (PubMed).
Kelly, J.W. and Balch, W.E. (2006) The integration of cell and chemical biology in protein folding. Nat Chem Biol, 2, 224-227.  (PubMed).
Chen, C.Y. and Balch, W.E. (2006) The Hsp90 Chaperone Complex Regulates GDI-dependent Rab Recycling. Mol Biol Cell. 17:3494-507.  (PubMed).
Suk, J.Y., Zhang, F., Balch, W.E., Linhardt, R.J. and Kelly, J.W. (2006) Heparin Accelerates Gelsolin Amyloidogenesis. Biochemistry, 45, 2234-2242.  (PubMed).
Stagg, S.M., Gurkan, C., Fowler, D.M., LaPointe, P., Foss, T.R., Potter, C.S., Carragher, B. and Balch, W.E. (2006) Structure of the Sec13/31 COPII coat cage. Nature, 439, 234-238.  (PubMed).
Wiseman, R.L. and Balch, W.E. (2005) A new pharmacology - drugging stressed folding pathways. Trends Mol Med, 11, 347-350.  (PubMed).
Bannykh, S.I., Plutner, H., Matteson, J. and Balch, W.E. (2005) The Role of ARF1 and Rab GTPases in Polarization of the Golgi Stack. Traffic, 6, 803-819 .(PubMed).
Page, L.J., Suk, J.Y., Huff, M.E., Lim, H.J., Venable, J., Yates, J., Kelly, J.W. and Balch, W.E. (2005) Metalloendoprotease cleavage triggers gelsolin amyloidogenesis. Embo J, 24, 4124-4132. (PubMed).
Fowler, D.M., Koulov, A.V., Alory-Jost, C., Marks, M.S., Balch, W.E. and Kelly, J.W. (2006) Functional Amyloid Formation within Mammalian Tissue. PLoS Biol, 4, e6. (PubMed).
Sekijima, Y., R. L. Wiseman, J. Matteson, P. Hammarstrom, S. R. Miller, A. R. Sawkar, W. E. Balch, and J. W. Kelly. 2005. The biological and chemical basis for tissue-selective amyloid disease. Cell 121:73-85. (PubMed).
Gurkan, C., H. Lapp, C. Alory, A. I. Su, J. B. Hogenesch, and W. E. Balch. 2005. Large-Scale Profiling of Rab GTPase Trafficking Networks: The Membrome. Mol Biol Cell 16:3847-64.  (PubMed).
Wiseman, R. L., and W. E. Balch. 2005. A new pharmacology - drugging stressed folding pathways. Trends Mol Med.PMID: 16005683.  (PubMed).
Gurkan, C. and Balch, W.E. (2005) Recombinant production in baculovirus-infected insect cells and purification of the mammalian Sec13/Sec31 complex. Methods Enzymol, 404, 58-66.  (PubMed).
LaPointe, P. and Balch, W.E. (2005) Purification and properties of mammalian Sec23/24 from insect cells. Methods Enzymol, 404, 66-74. (PubMed).
Chen, C.Y., Sakisaka, T. and Balch, W.E. (2005) Use of Hsp90 inhibitors to disrupt GDI-dependent Rab recycling. Methods Enzymol, 403, 339-347.(PubMed).
Wang, X., J. Matteson, Y. An, B. D. Moyer, J. S. Yoo, S. Bannykh, I. A. Wilson, J. R. Riordan, and W. E. Balch. (2004). COPII-dependent export of cystic fibrosis transmembrane conductance regulator (CFTR) from the ER utilizes a di-acidic exit code. J Cell Biol 167:65-74.  (PubMed).
Page, L. J., M. E. Huff, J. W. Kelly, and W. E. Balch. (2004). Ca(2+) binding protects against gelsolin amyloidosis. Biochem Biophys Res Commun 322:1105-10.  (PubMed).
LaPointe, P., C. Gurkan, and W. E. Balch. (2004). Mise en place - this bud's for the Golgi. Mol Cell 14:413-414. (PubMed).
Balch, W. E. 2004. Vesicle traffic in vitro. Cell 116:S17-9, 2 p following S19. (PubMed).
Huff, M. E., W. E. Balch, and J. W. Kelly. (200)3. Pathological and functional amyloid formation orchestrated by the secretory pathway. Curr Opin Struct Biol 13:674-82. (PubMed).
Alory, C., and W.E. Balch. (200). Molecular evolution of the Rab-escort-protein/guanine-nucleotide-dissociation-inhibitor superfamily. Mol Biol Cell. 14:3857-3867. (PubMed).
Huff, M.E., L. Page, W.E. Balch, and J.W. Kelly. (2003). Gelsolin domain 2 Ca2+ affinity determines susceptibility to furin proteolysis and familial amyloidosis of finnish type. J Mol Biol. 334:119-27. (PubMed).
Kelly, J.W., and W.E. Balch. (2003). Amyloid as a natural product. J Cell Biol. 161:461-462 .(PubMed).
An, Y., Y. Shao, C. Alory, J. Matteson, T. Sakisaka, W. Chen, R.A. Gibbs, I.A. Wilson, and W.E. Balch. (2003). GDI-Rab GTPase recycling. Structure. 11:347-57. (PubMed).
Yoo, J.S., B.D. Moyer, S. Bannykh, H.M. Yoo, J.R. Riordan, and W.E. Balch. 2002. Non-conventional trafficking of the cystic fibrosis transmembrane conductance regulator through the early secretory pathway. J Biol Chem. 277:11401-9.  (PubMed).
Sawkar, A.R., W.-C. Cheng, E. Beutler, C.-H. Wong, W.E. Balch, and J.W. Kelly. 2002. Chemical chaperones increase the cellular activity of N370S b-glucosidase: A therapeutic strategy for Gaucher disease. Proc Natl Acad Sci U S A. 99:15428-15433. (PubMed)
Sakisaka, T., T. Meerlo, J. Matteson, H. Plutner, and W.E. Balch. (2002). Rab-aGDI activity in neurotransmitter release is regulated by an Hsp90 chaperone complex. Embo J. 21:6125-6135.  (PubMed).
Nishimura, N., H. Plutner, K. Hahn and W.E. Balch. (2002). The delta-subunit of AP-3 is required for efficient transport of VSV-G from the trans golgi network (TGN) to the cell surface. Proc Natl Acad Sci U S A. 99(10):6755-60.  (PubMed).
Huang, M., J.T. Weissman, C. Wang, W.E. Balch, and I.A. Wilson. (2002). Protein engineering for crystallization of the GTPase Sar1 that regulates ER vesicle budding. Acta Crystallogr. 58:700-3.  (PubMed).
Beraud-Dufour, S., and W.E. Balch. (2002). A journey through the exocytic pathway. J Cell Sci. 115:1779-80.  (PubMed).
Chen, C.D., M.E. Huff, J. Matteson, L. Page, R. Phillips, J.W. Kelly, and W.E. Balch. (2001). Furin initiates gelsolin familial amyloidosis (FAF) in the golgi through a defect in Calcium stabilization. The Embo Journal. 20:6277-87.  (PubMed).
Huang, M., J.T. Weissman, S. Beraud-Dufour, P. Luan, C. Wang, W. Chen, M. Aridor, I.A. Wilson, and W.E. Balch. (2001). Crystal structure of Sar1-GDP at 1.7 Å resolution and the role of the NH2-terminus in ER export. J Cell Biol. 155:937-948.  (PubMed).
W. E. Balch, C. J. Der, A. Hall. Methods in Enzymology. J. N. A. a. M. I. Simon, Ed., Regulators and effectors of small GTPases. Part G. Ras Family II (Academic Press, 2001), vol. 333.
W. E. Balch, C. J. Der, A. Hall. Methods in Enzymology. J. A. Abelson, M. I. Simon, Eds., Regulators and effectors of small GTPases. Part E. GTPases involved in vesicular traffic (Academic Press, 2001), vol. 329.
Alory, C., and W.E. Balch. (2001). Organization of the Rab-GDI/CHM superfamily: the functional basis for choroideremia disease.  Traffic2:532-543.  (PubMed).
Weissman, J. T., Plutner, H., and Balch, W. E. (2001). The mammalian guanine nucleotide exchange factor mSec12 is essential for activation of the Sar1 GTPase directing endoplasmic reticulum export  Traffic2(7)465-475. (PubMed).
Aridor, M, Fish, K.N., Bannykh, S.I., Weissman, J. and Balch, W.E. (2001). The Sar1 GTPase coordinates biosynthetic cargo selection with endoplasmic reticulum export site assembly.  J. Cell Biol152:213-229.  (PubMed).
Moyer, B. D., Allan, B. B., and Balch, W. E. (2001). Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis-Golgi tethering. Traffic  2(4), 268-76 .(PubMed).
Weissman, J.T., Aridor, M. and Balch, W.E. (2001). Purification and properties of rat liver Sec23-Sec24 complex.  Methods in Enzymology, Academic Press Publishers, New York, NY, W.E. Balch, C. Der and A. Hall, Editors,  329: 431-438.  (PubMed).
Beraud-Dufour, S. and Balch, W.E. (2001). Structural and functional organization of ARF proteins - an overview.  Methods in Enzymology, Academic Press Publishers, New York, NY, W.E. Balch, C. Der and A. Hall, Editors,.  329:245-247.  (PubMed).
Moyer, B.D., Matteson, J. and Balch, W.E. (2001). Expression of wild-type and mutant GFP-Rab1 for fluorescence microscopy analysis.  Methods in Enzymology, Academic Press Publishers, New York, NY, W.E. Balch, C. Der and A. Hall, Editors,  329:6-14. (PubMed).
Moyer, B.D. and Balch, W.E. (2001). Structural basis for rab function - an overview.  Methods in Enzymology, Academic Press Publishers, New York, NY, W.E. Balch, C. Der and A. Hall, Editors,  329:3-6. (PubMed).
Allan, B.B., Weissman, J., Aridor, M., Moyer, B.D., Chen, C.D., Yoo, J.-S., and Balch, W.E. (2000) Stage-specific assays to study biosynthetic cargo selection and role of SNAREs in export from the endoplasmic reticulum and delivery to the Golgi.  Methods  20 (4):411-416. (PubMed).
Der, C.J. and Balch, W.E. (2000) GTPase traffic control.  Nature  405(6788): 749, 751-752 .(PubMed).
Bannykh, S.I., Bannykh, G.I., Fish, K.N., Moyer, B.D., Riordan, J.R. and Balch, W.E. (2000) Traffic pattern of cystic fibrosis transmembrane regulator through the early exocytic pathway.  Traffic  1(11):852-870.  (PubMed).
Aridor, M. and Balch, W.E. (2000) Kinase signaling initiates COPII recruitment and export from the mammalian endoplasmic reticulum.  J. Biol. Chem.  275:35673-35676. (PubMed).
Alory, C and Balch, W.E. (2000) Molecular basis for rab prenylation.  J. Cell Biol.,  150:89-103. (PubMed).
Allan, B.B., Moyer, B.D. and Balch, W.E. (2000) Rab1 recruitment of the effector p115 into a cis-SNARE complex programs budding COPII vesicles for fusion.  Science289:444-448. (PubMed).
Luan, P., Heine, A., Zeng, K., Moyer, B., Greasely, S.E., Kuhn, P., Balch, W.E., Wilson, I.A. (2000) A new functional domain of guanine nucleotide dissociation inhibitor (-GDI) involved in rab recycling.  Traffic  1:270. (PubMed).
Nishimura, N., Bannykh, S.I., Slabough, S., Matteson, J., Hahn, K. and Balch, W.E. (1999) A di-acidic (DxE) code directs concentration of cargo during export from the endoplasmic reticulum.  J. Biol. Chem274:15937-15946. (PubMed).
Luan, P., Balch, W.E., Emr, S.D. and Burd, C.G. (1999) Molecular Dissection of Guanine Nucleotide Dissociation Inhibitor Function in Vivo.  J. Biol. Chem274:14806-14817. (PubMed).
Allan, B.B. and Balch, W.E. (1999) Protein sorting by directed maturation of Golgi compartments.  Science  285:63-66. (PubMed).
Aridor, M. and Balch, W.E. (1999) Integration of endoplasmic reticulum signaling in health and disease.  Nature Medicine  5:745-751 .(PubMed).
Allan, B.B. and Balch, W.E. (1998) In vitro analysis of endoplasmic reticulum to Golgi transport in mammalian cells. Current Protocols in  Cell Biology, 11.3.1 — 11.3.22.
Luan, P., Balch, W.E., Emr, S.D. and Burd, C.G. (1998) Molecular Dissection of Guanine Nucleotide Dissociation Inhibitor Function in Vivo.  J. Biol. Chem274:14806-14817. (PubMed).
Tandon, A., Tan, P.K., Bannykh, S.I., Banerjee, A. and Balch, W.E. (1998) Neurotransmitter release from semi-intact synaptosomes. Methods: A Companion to Methods in Enzymology  16:198 .(PubMed).
Aridor, M., Bannykh, S.I., Rowe, T. and Balch, W.E. (1998) Cargo Can Modulate COPII Vesicle Formation from the Endoplasmic Reticulum.  J. Biol. Chem.,  274:4389-4399.  (PubMed).
Wu, S.-K., Matteson, J., Zeng, K., Nishimura, N. and Balch, W.E. (1998) Molecular role for the rab binding pocket of guanine nucleotide dissociation inhibitor (GDI) in endoplasmic reticulum to Golgi transport.  J. Biol. Chem273:26931-26938.  (PubMed).
D'Adamo. P., Menegon, A., Lo Nigro, C., Grasso, M., Gulisano, M., Tamanini, F., Bienvenu, T., Gedeon, A.K., Oostra, B., Wu, S.K., Tandon, A., Valtorta, F., Balch, W.E., Chelly, J., Toniolo, D. (1998) Mutations in GDI1 are responsible for x-linked non-specific mental retardation.  Nature Genetics  19:134-139. (PubMed).
Tandon, A., Bannykh, S.I., Kowalchyk, J.A., Banerjee, A., Martin, T.F.J., Balch, W.E. (1998) Differential regulation of exocytosis by calcium and CAPS in semi-intact synaptosomes.  Neuron  21:147-154. (PubMed).
Bannykh, S.I., Balch, W.E. (1998) Selective transport of cargo between the endoplasmic reticulum and Golgi compartments.  Histochem109:463-475 .(PubMed).
Aridor, M., Weissman, J., Bannykh, S.I., Nuoffer, C. and Balch, W.E. (1998) Cargo selection by the COPII budding machinery during export from the endoplasmic reticulum.  J. Cell Biol.  141:61-70.  (PubMed).
Rowe, T., Dascher, C., Bannykh, S.I, Plutner, H. and Balch, W.E. (1998) Role of vesicle-associated syntaxin 5 in the assembly of pre-Golgi intermediates.  Science  279:696-700.  (PubMed).
Bannykh, S.I., Nishimura, N. and Balch, W.E. (1998) Getting into the Golgi.  Trends in Cell Biology  8:21-25. (PubMed).
Nishimura, N. and Balch, W.E. (1997) A di-acidic signal required for selective export from the endoplasmic reticulum.  Science  277: 556-558. (PubMed).
Rowe, T. and Balch, W.E. (1997) Membrane fusion. Bridging the gap by AAA ATPases.  Nature  388: 20-21. (PubMed).
Nuoffer, C., S.K. Wu, Dascher, C. and Balch, W.E. (1997) MSS4 does not function as an exchange factor for Rab in endoplasmic reticulum to Golgi transport.  Mol. Biol. Cell  8: 1305-1316.  (PubMed).
Bannykh, S.I. and Balch, W.E. (1997) Membrane dynamics at the endoplasmic reticulum-Golgi interface.  J Cell Biol.,  138:  1-4. (PubMed).
Turner, M.D., Plutner, H. and Balch, W.E. (1997) A rab GTPase is required for homotypic assembly of the endoplasmic reticulum.  J. Biol. Chem., 272:13479-13483. (PubMed).
Tisdale, E.J., Plutner, H. Matteson, J., and Balch, W.E. (1997) p53/58: p53/58 binds COPI and is required for selective transport through the early secretory pathway.  J. Cell Biol.137:581-593 .(PubMed).
Aridor, M. and Balch, W.E. (1996) Timing is everything.  Nature  383: 220-221.
Rowe, T., Aridor, M., McCaffery, J.M., Plutner, H. and Balch, W.E. (1996) COPII vesicles derived from mammalian endoplasmic reticulum (ER) microsomes recruit COPI.  J. Cell Biol.135:895-911. (PubMed).
Traub, L.M. ,  S.I. Bannykh, J.E. Rodel, M. Aridor, W.E. Balch and Kornfeld, S. (1996) AP-2-containing clathrin coats assemble on mature lysosomes. J. Cell Biol.  135:1801-1814 .   (PubMed).
Bannykh, S., Rowe, T. and Balch, W.E. (1996) The organization of endoplasmic reticulum export complexes.  J. Cell Biol.135:19-35.  (PubMed).
Tisdale, E.J. and Balch, W.E. (1996) Rab2 is essential for the assembly of pre-Golgi intermediates.  J. Biol. Chem.271:29372-29379. (PubMed).
Wu, S.-K., Zeng, K., Wilson, I.A., Balch, W.E. (1996) The GDI-CHM/REP connection: structural insights into the Rab GTPase cycle.  Trends Biochem. Sci.21:472-476.  (PubMed).
Aridor, M., Balch, W.E. (1996) Principles of selective transport: coat complexes hold the key.  Trends Cell Biol.  6:315.
Bannykh, S., Aridor, M., Plutner, H., Rowe, T. and Balch, W.E. (1995) Regulated export of cargo from the endoplasmic reticulum of mammalian cells.  Cold Spring Harbor Lab. Press,  60:127.  (PubMed).
Dascher, C. and Balch, W.E. (1996) Mammalian Sly1 regulates syntaxin 5 function in endoplasmic reticulum (ER) to Golgi transport.  J. Biol. Chem.  271:15866-15869 .(PubMed).
Schalk, I., Zeng, K., Wu, S.-K., Stura, E.A., Matteson, J., Huang, M., Tandon, A., Wilson, I.A. and Balch, W.E. (1995) Structure and mutational analysis of Rab GDP-dissociation inhibitor.  Nature  381:42-48.  (PubMed).
Aridor, M., Bannykh, S.I., Rowe, T. and Balch, W.E. (1995) Sequential coupling between COPII and COPI vesicle coats in endoplasmic reticulum (ER) to Golgi transport.  J. Cell Biol.  131:875-893.  (PubMed).
Simpson, J.C., Dascher, C., Roberts, L.M., Lord, J.M. and Balch, W.E. (1995) Ricin cytotoxicity is sensitive to recycling between the endoplasmic reticulum and the Golgi complex.  J. Biol. Chem.  270:20078-20083. (PubMed).
Brown, W.J., Emr, S.D., Plutner , H. and Balch, W.E. (1995) Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells.  J. Cell Biol.  130:781-796 .  (PubMed).
Balch, W.E. and Farquhar, M.G. (1995) Beyond bulk flow.  Trends in Cell Biol5:16-19.
Peter, F., Rowe, T., Nuoffer, C., Tisdale, E.J., Dascher, C., Schalk, E., Balch, W.E. (1995) Purification of His6-tagged Rab1 proteins using bacterial and insect cell expression systems, Expression and purification of mammalian Sar1a, Expression and purification of recombinant His6-tagged guanine nucleotide dissociation inhibitor and formation of Rab1 complex, Transient expression of small GTPases to study protein transport along secretory pathwa in vivo using recombinant T7 vaccinia virus system, Preparation of recombinant vaccinia virus for expression of small GTPases.  In: Methods in Enzymology. Balch, W.E., Der, C., Hall, A. (Eds.). Academic Press, San Diego, p. 3, 49, 80, 165, 174.