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Publication List

  1. Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway
    Daniel Abegg, Martin Tomanik, Nan Qiu, Dany Pechalrieu, Anton Shuster, Bruno Commare, Antonio Togni, Seth B. Herzon, and Alexander Adibekian*
    J. Am. Chem. Soc. 2021 143, 20332-20342

  2. Clinical Antiviral Drug Arbidol Inhibits Infection by SARS-CoV-2 and Variants through Direct Binding to the Spike Protein
    Anton Shuster, Dany Pechalrieu, Cody B. Jackson, Daniel Abegg, Hyeryun Choe, and Alexander Adibekian*
    ACS Chem. Biol. 2021 16, 2845-2851

  3. Dichloro Butendiamides as Irreversible Site-Selective Protein Conjugation Reagent
    Victor Laserna, Daniel Abegg, Cláudia Afonso, Esther Martin, Alexander Adibekian, Peter Ravn, Francisco Corzana, and Gonçalo J. L. Bernardes*
    Angew. Chem. Int. Ed. 2021 60, 23750-23755

  4. Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment
    Peiyuan Zhang,# Xiaohui Liu,# Daniel Abegg, Toru Tanaka, Yuquan Tong, Raphael I. Benhamou, Jared Baisden, Gogce Crynen, Samantha M. Meyer, Michael D. Cameron, Arnab K. Chatterjee, Alexander Adibekian, Jessica L. Childs-Disney, and Matthew D. Disney*
    J. Am. Chem. Soc. 2021 143, 13044-13055

  5. Artemisinin inhibits NRas palmitoylation by targeting the protein acyltransferase ZDHHC6
    Nan Qiu, Daniel Abegg, Mara Guidi, Kerry Gilmore, Peter H. Seeberger, and Alexander Adibekian*
    Cell Chem. Biol. 2021 , in press

  6. A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype
    Hafeez S. Haniff,# Xiaohui Liu,# Yuquan Tong, Samantha M. Meyer, Laurent Knerr, Malin Lemurell, Daniel Abegg, Haruo Aikawa, Alexander Adibekian*, and Matthew D. Disney*
    Cell Chem. Biol. 2021 , in press

  7. Total Synthesis and Target Identification of the Curcusone Diterpenes
    Chengsen Cui,# Brendan G. Dwyer,# Chang Liu, Daniel Abegg, Zhong-Jian Cai, Dominic G. Hoch, Xianglin Yin, Nan Qiu, Jie-Qing Liu, Alexander Adibekian*, and Mingji Dai*
    J. Am. Chem. Soc. 2021 143, 4379-4386

  8. Genetic Ablation of MiR-22 Fosters Diet-Induced Obesity and NAFLD Development
    Monika Gjorgjieva,# Cyril Sobolewski,# Anne-Sophie Ay,# Daniel Abegg, Marta Correia de Sousa, Dorothea Portius, Flavien Berthou, Margot Fournier, Christine Maeder, Pia Rantakari, Fu-Ping Zhang, Matti Poutanen, Didier Picard, Xavier Montet, Serge Nef , Alexander Adibekian, and Michelangelo Foti*
    J. Pers. Med. 2020 10, 170

  9. Chemoproteomics‐Enabled De Novo Discovery of Photoswitchable Carboxylesterase Inhibitors for Optically Controlled Drug Metabolism
    Brendan Dwyer,# Chao Wang,# Daniel Abegg, Brittney Racioppo, Nan Qiu, Zhensheng Zhao, Dany Pechalrieu, Anton Shuster, Dominic Hoch, and Alexander Adibekian*
    Angew. Chem. Int. Ed. 2021 60, 3071-3079

  10. Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions
    Hafeez S. Haniff, Laurent Knerr, Xiaohui Liu, Gogce Crynen, Jonas Boström, Daniel Abegg, Alexander Adibekian, Elizabeth Lekah, Kye Won Wang, Michael D. Cameron, Ilyas Yildirim, Malin Lemurell, and Matthew D. Disney*
    Nature Chemistry 2020 12, 952-961

  11. Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190
    Paige Dickson, Daniel Abegg, Ekaterina Vinogradova, Junichiro Takaya, Hongchan An, Scott Simanski, Benjamin F. Cravatt, Alexander Adibekian, and Thomas Kodadek*
    Cell Chem. Biol. 2020 27, 1371-1382

  12. Concise Chemoenzymatic Total Synthesis and Identification of Cellular Targets of Cepafungin I
    Alexander Amatuni, Anton Shuster, Alexander Adibekian,* and Hans Renata*
    Cell Chem. Biol. 2020 27, 1318-1326

  13. Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex
    Dominic G. Hoch,# Daniel Abegg,# J. Thomas Hannich, Dany Pechalrieu, Anton Shuster, Brendan Dwyer, Chao Wang, Xiaojin Zhang, Qidong You, Howard Riezman, and Alexander Adibekian*
    Cell Chem. Biol. 2020 27, 586-597

  14. Ethynylation of Cysteines from Peptides to Proteins in Living Cells
    Romain Tessier, Raj Kumar Nandi, Brendan G. Dwyer, Daniel Abegg, Charlotte Sornay, Javier Ceballos, Stephane Erb, Sarah Cianferani, Alain Wagner, Guilhem Chaubet*, Alexander Adibekian*, and Jerome Waser*
    Angew. Chem. Int. Ed. 2020 59, 10961-10970

  15. Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands
    Xiaohui Liu, Hafeez S. Haniff, Jessica L. Childs-Disney, Anton Shuster, Haruo Aikawa, Alexander Adibekian, and Matthew D. Disney*
    J. Am. Chem. Soc. 2020 142, 6970-6982

  16. Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer
    Matthew G. Costales, Haruo Aikawa, Yue Li, Jessica L. Childs-Disney, Daniel Abegg, Dominic G. Hoch, Sai Pradeep Velagapudi, Yoshio Nakai, Tanya Khan, Kye Won Wang, Ilyas Yildirim, Alexander Adibekian, Eric T. Wang, and Matthew D. Disney*
    Proc. Natl. Acad. Sci. 2020 117, 2406-2411

  17. S100A11/ANXA2 belongs to a tumour suppressor/oncogene network deregulated early with steatosis and involved in inflammation and hepatocellular carcinoma development
    Cyril Sobolewski, Daniel Abegg, Flavien Berthou, Dobrochna Dolicka, Nicolas Calo, Christine Sempoux, Margot Fournier, Christine Maeder, Anne-Sophie Ay, Pierre-Alain Clavien, Bostjan Humar, Jean-François Dufour, Alexander Adibekian, and Michelangelo Foti*
    Gut 2020

  18. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA
    Peiyuan Zhang, Hye-Jin Park, Jie Zhang, Eunsung Junn, Ryan J. Andrews, Sai Pradeep Velagapudi, Daniel Abegg, Kamalakannan Vishnu, Matthew G. Costales, Jessica L. Childs-Disney, Alexander Adibekian, Walter N. Moss, M. Maral Mouradian, and Matthew D. Disney*
    Proc. Natl. Acad. Sci. 2020 117, 1457-1467

  19. 1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding
    J. Thomas Hannich, A. Galih Haribowo, Sébastien Gentina, Melanie Paillard, Ludovic Gomez, Bruno Pillot, Hélène Thibault, Daniel Abegg, Nicolas Guex, Andreas Zumbuehl, Alexander Adibekian, Michel Ovize, Jean-Claude Martinou, and Howard Riezman*
    Nat. Metab. 2019, 1, 996-1008

  20. Discovery and Evaluation of Novel Activity-Based Probes for Serine Hydrolases
    Chao Wang, Daniel Abegg, Brendan G. Dwyer,* and Alexander Adibekian*
    ChemBioChem 2019, 20, 2212-2216

  21. A designed precision small molecule inhibiting a noncoding RNA sensitizes HER2 negative cancer to Herceptin
    Matthew G. Costales, Dominic G. Hoch, Daniel Abegg, Jessica L. Childs-Disney, Sai Pradeep Velagapudi, Alexander Adibekian, and Matthew D. Disney*
    J. Am. Chem. Soc. 2019, 141, 2960-2974

  22. Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids
    Dexter C. Davis,# Dominic G. Hoch,# Li Wu, Daniel Abegg, Brandon S. Martin, Zhong-Yin Zhang,* Alexander Adibekian,* and Mingji Dai*
    J. Am. Chem. Soc. 2018, 140, 17465-17473

  23. Cysteine-reactive probes and their use in chemical proteomics
    Dominic G. Hoch, Daniel Abegg, and Alexander Adibekian*
    Chem. Commun. 2018, 54, 4501-4512

  24. The SAGA complex, together with transcription factors and the endocytic protein Rvs167p, coordinate the reprofiling of gene expression in response to changes in sterol composition in Saccharomyces cerevisiae
    Gisèle Dewhurst-Maridor, Daniel Abegg, Fabrice P.A. David, Jacques Rougemont, Cameron C. Scott, Alexander Adibekian, and Howard Riezman*
    Mol. Biol. Cell 2017, 28, 2637-2649

  25. Epidithiodiketopiperazines: Strain-Promoted Thiol-Mediated Cellular Uptake at Highest Tension
    Lili Zong,# Eline Bartolami,# Daniel Abegg, Alexander Adibekian, Naomi Sakai, and Stefan Matile*
    ACS Cent. Sci. 2017, 3, 449-453

  26. Strained Cyclic Disulfides Enable Cellular Uptake by Reacting with the Transferrin Receptor
    Daniel Abegg, Giulio Gasparini, Dominic G. Hoch, Anton Shuster, Eline Bartolami, Stefan Matile*, and Alexander Adibekian*
    J. Am. Chem. Soc. 2017, 139, 231-238

  27. Cysteine-specific Chemical Proteomics: From Target Identification to Drug Discovery
    Dominic G. Hoch, Daniel Abegg, Chao Wang, Anton Shuster, Alexander Adibekian*
    Chimia 2016, 70, 764-767

  28. Divergent Synthesis and Identification of the Cellular Targets of Deoxyelephantopins
    Roman Lagoutte,# Christelle Serba,# Daniel Abegg,# Dominic G. Hoch, Alexander Adibekian,* Nicolas Winssinger*
    Nat. Commun. 2016, 7, 12470

  29. Cutting Edge Chemical Biology: Report from the 2016 International Symposium on Chemical Biology
    Alexander Adibekian*, Pierre Stallforth*
    ACS Chem. Biol. 2016, 11, 816–820

  30. Chemoproteomics-Enabled Discovery of a Potent and Selective Inhibitor of the DNA-Repair Protein MGMT
    Chao Wang,# Daniel Abegg,# Dominic G. Hoch, Alexander Adibekian*
    Angew. Chem. Int. Ed. 2016, 55, 2911-2915

  31. Proteome-Wide Profiling of Targets of Cysteine-reactive Small Molecules by using Ethynyl Benziodoxolone Reagents
    Daniel Abegg, Reto Frei, Luca Cerato, Durga Prasad Hari, Chao Wang, Jerome Waser, Alexander Adibekian*
    Angew. Chem. Int. Ed. 2015, 54, 10852-10857

  32. Conference Report on the 50th EUCHEM Conference on Stereochemistry (Bürgenstock Conference)
    Alexander Adibekian*, Thomas Magauer*
    Chimia 2015, 69, 485-487

  33. Identification of Covalent Bromodomain Binders through DNA Display of Small Molecules
    Jean-Pierre Daguer, Claudio Zambaldo, Daniel Abegg, Sofia Barluenga, Cynthia Tallant, Susanne Müller, Alexander Adibekian, Nicolas Winssinger*
    Angew. Chem. Int. Ed. 2015, 54, 6057-6061

  34. Mechanistic Effects of Protein Palmitoylation and the Cellular Consequences Thereof
    Sanja Blaskovic, Alexander Adibekian, Mathieu Blanc, Gisou van der Goot*
    Chemistry and Physics of Lipids 2014, 180, 44-52

  35. Characterisation of a Serine Hydrolase Targeted by Acyl Protein Thioesterase Inhibitors in Toxoplasma gondii
    Louise Kemp, Marion Rusch, Alexander Adibekian, Hayley E. Bullen, Arnault Graindorge, Céline Freymond, Matthias Rottmann, Catherine Braun-Breton, Stefan Baumeister, Arthur T. Porfetye, Ingrid R. Vetter, Christian Hedberg, Dominique Soldati-Favre*
    J. Biol. Chem. 2013, 288, 27002-27018

Previous Research:

  1. Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation
    Yuta Shimanaka, Nozomu Kono, Yoshitaka Taketomi, Makoto Arita, Yoshimichi Okayama, Yuki Tanaka, Yasumasa Nishito, Tatsuki Mochizuki, Hiroyuki Kusuhara, Alexander Adibekian, Benjamin F Cravatt, Makoto Murakami*, and Hiroyuki Arai*
    Nat. Med. 2017, 23, 1287-1297

  2. A semisynthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice
    Cavallari M, Stallforth P, Kalinichenko A, Rathwell DC, Gronewold TM, Adibekian A, Mori L, Landmann R, Seeberger PH, De Libero G*
    Nat. Chem. Biol. 2014, 10, 950-956

  3. Diced Electrophoresis Gel Assay for Screening Enzymes with Specified Activities
    Toru Komatsu, Kenjiro Hanaoka, Alexander Adibekian, Takuya Terai, Tasuku Ueno, Mitsuyasu Kawaguchi, Benjamin F. Cravatt, Tetsuo Nagano*
    J. Am. Chem. Soc. 2013, 135, 6002-6005

  4. De Novo Chemoenzymatic Synthesis of Sialic Acid
    Pierre Stallforth, Stefan Matthies, Alexander Adibekian, Dennis G. Gillingham, Donald Hilvert, Peter H. Seeberger*
    Chem. Commun. 2012, 48, 11987-11989

  5. DAGLβ Inhibition Perturbs a Lipid Network Involved in Macrophage Inflammatory Responses
    Ku-Lung Hsu, Katsunori Tsuboi, Alexander Adibekian, Holly Pugh, Kim Masuda, Benjamin F. Cravatt*
    Nat. Chem. Biol. 2012, 8, 999-1007

  6. New Substituted Triazole Compounds are Serine Hydrolase Enzyme Inhibitors, Useful for Treating e.g. Obesity, Metabolic Disorders, Vomiting or Nausea, Neuropathy, Amyotrophic Lateral Sclerosis, Epilepsy and Sleep Disorders
    Benjamin F. Cravatt, Alexander Adibekian, Katsunori Tsuboi, Ku-Lung Hsu
    U.S. Patent No. WO2012138877-A1 (2012)

  7. Confirming Target Engagement of Reversible Inhibitors in vivo by Kinetically Tuned Activity-based Probes
    Alexander Adibekian, Brent R. Martin, Jae Won Chang, Ku-Lung Hsu, Katsunori Tsuboi, Daniel A. Bachovchin, Anna E. Speers, Steven J. Brown, Timothy Spicer, Virneliz Fernandez-Vega, Jill Ferguson, Peter S. Hodder, Hugh Rosen, Benjamin F. Cravatt*
    J. Am. Chem. Soc. 2012, 134, 10345-10348

  8. Global profiling of dynamic protein palmitoylation
    Brent R. Martin, Chu Wang, Alexander Adibekian, Sarah E. Tully, Benjamin F. Cravatt*
    Nat. Methods 2011, 9, 84-89

  9. A Possible Oligosaccharide-Conjugate Vaccine Candidate for Clostridium difficile is Antigenic and Immunogenic
    Matthias Oberli, Marie-Lyn Hecht, Pascal Bindschädler, Thomas Adam, Alexander Adibekian, Peter H. Seeberger*
    Chem. Biol. 2011, 18, 580-588

  10. Comparative Bioinformatics Analysis of the Mammalian and Bacterial Glycomes
    Alexander Adibekian, Pierre Stallforth, Marie-Lyn Hecht, Daniel B. Werz, Pascal Gagneux, Peter H. Seeberger*
    Chem. Sci. 2011, 2, 337-344

  11. Click-Chemistry Generated Triazole Ureas as Ultrapotent, in vivo-Active Serine Hydrolase Inhibitors
    Alexander Adibekian, Brent R. Martin, Chu Wang, Ku-Lung Hsu, Daniel A. Bachovchin, Sherry Niessen, Heather Hoover, Benjamin F. Cravatt*
    Nat. Chem. Biol. 2011, 7, 469-478

  12. Supefamily-wide Portrait of Serine Hydrolase Inhibition Achieved by Library-versus-Library Screening
    Daniel A. Bachovchin, Tianyang Ji, Weiwei Li, Gabriel M. Simon, Jacqueline L. Blankman, Alexander Adibekian, Heather Hoover, Sherry Niessen, Benjamin F. Cravatt*
    Proc. Natl. Acad. Sci. 2010, 107, 20941-20946

  13. Molecular Analysis of Carbohydrate-Antibody Interactions: Case Study Using a Bacillus anthracis Tetrasaccharide
    Matthias Oberli, Marco Tamborrini, Yu-Hsuan Tsai, Daniel B. Werz, Tim Horlacher, Alexander Adibekian, Dominik Gauss, Heiko M. Möller, Gerd Pluschke, Peter H. Seeberger*
    J. Am. Chem. Soc. 2010, 132, 10239-10241

  14. Towards the Synthesis of a Yersinia Pestis Cell Wall Polysaccharide: Enantioselective Synthesis of L-glycero-D-manno-heptose Building Blocks
    Takafumi Ohara, Alexander Adibekian, Davide Esposito, Pierre Stallforth, Peter H. Seeberger*
    Chem. Commun. 2010, 46, 4106-4108

  15. Facile Synthesis of Size Dependent Ru(II)- Carbohydrate Dendrimers via Click Chemistry
    Kikkeri Raghavendra, Xinyu Liu, Alexander Adibekian, Yu-Hsuan Tsai, Peter H. Seeberger*
    Chem. Commun. 2010, 46, 2197-2199

  16. De Novo Synthesis of Differentially Protected L Iduronic Acid Glycosylating Agents
    Pascal Bindschädler, Alexander Adibekian, Dan Grünstein, Peter H. Seeberger*
    Carbohydr. Res. 2010, 345, 948-955

  17. Chemoenzymatic Synthesis of Differentially Protected 3-Deoxysugars
    Dennis G. Gillingham, Pierre Stallforth, Alexander Adibekian, Peter H. Seeberger, Donald Hilvert*
    Nat. Chem. 2010, 2, 102-105

  18. Characterization of Tunable Piperidine and Piperazine Carbamates as Inhibitors of Endocannabinoid Hydrolases
    Jonathan Z. Long, Xin Jin, Alexander Adibekian, Weiwei Li, Benjamin F. Cravatt*
    J. Med. Chem. 2010, 53, 1830-1842

  19. In Vitro Imaging and In Vivo Liver Targeting with Carbohydrate Capped Quantum Dots
    Kikkeri Raghavendra, Bernd Lepenies, Alexander Adibekian, Paola Laurino, Peter H. Seeberger*
    J. Am. Chem. Soc. 2009, 131, 2110-2112

  20. Recent Advances in Carbohydrate-based Vaccines
    Marie-Lyn Hecht, Pierre Stallforth, Daniel V. Silva, Alexander Adibekian, Peter H. Seeberger*
    Curr. Opin. Chem. Biol. 2009, 13, 354-359

  21. Carbohydrates: A Frontier in Medicinal Chemistry
    Pierre Stallforth, Bernd Lepenies, Alexander Adibekian, Peter H. Seeberger*
    J. Med. Chem. 2009, 52, 5561-5577

  22. Stereocontrolled Synthesis of Fully Functionalized D-Glucosamine Monosaccharides via a Domino Nitro-Michael/Henry Reaction
    Alexander Adibekian, Mattie S. M. Timmer, Pierre Stallforth, Jimmy van Rijn, Daniel B. Werz, Peter H. Seeberger*
    Chem. Commun. 2008, 3549-3551

  23. De Novo Synthesis of a D-Galacturonic Acid Thioglycoside as Key to the Total Synthesis of a Glycosphingolipid from Sphingomonas yanoikuyae
    Pierre Stallforth, Alexander Adibekian, Peter H. Seeberger*
    Org. Lett. 2008, 10, 1573-1576

  24. Exploring the Structural Diversity of Mammalian Carbohydrates (“Glycospace”) by Statistical Databank Analysis
    Daniel B. Werz, Rene Ranzinger, Stephan Herget, Alexander Adibekian, Claus Wilhelm von der Lieth, Peter H. Seeberger*
    ACS Chem. Biol. 2007, 2, 685-691

  25. Convergent Synthesis of Carbohydrate Building Blocks
    Peter H. Seeberger, Alexander Adibekian, Mattie S.M. Timmer
    International Patent No. WO/2007/099392 (2007)

  26. De Novo Synthesis of Uronic Acid Building Blocks for Assembly of Heparin Oligosaccharides
    Alexander Adibekian, Pascal Bindschädler, Mattie S. M. Timmer, Christian Noti, Nina Schützenmeister, Peter H. Seeberger*
    Chem. Eur. J. 2007, 13, 4510-4522

  27. Synthesis of a Spore Surface Pentasaccharide of Bacillus anthracis
    Daniel B. Werz, Alexander Adibekian, Peter H. Seeberger*
    Eur. J. Org. Chem. 2007, 1976-1982

  28. Total Synthesis of Cyclic Diterpene Tonantzitlolone Based on a Highly Stereoselective Substrate-Controlled Aldol Reaction and Ring-Closing Metathesis
    Christian Jasper, Alexander Adibekian, Torsten Busch, Monika Quitschalle, Rüdiger Wittenberg, Andreas Kirschning*
    Chem. Eur. J. 2006, 12, 8719-8734

  29. Short De Novo Synthesis of Fully Functionalized Uronic Acid Monosaccharides
    Mattie S.M. Timmer, Alexander Adibekian, Peter H. Seeberger*
    Angew. Chem. Int. Ed. 2005, 44, 7605-7607

  30. Practical TEMPO-mediated Oxidations of Alcohols using Different Polymer-Bound Co-Oxidants
    Katrin Kloth, Marco Brünjes, Eike Kunst, Thomas Jöge, Florian Gallier, Alexander Adibekian, Andreas Kirschning*
    Adv. Synth. Catal. 2005, 347, 1423-1434