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Publications

Narayan KM, N Agrawal, SX Du, JE Muranaka, K Bauer, DP Leaman, P Phung, K Limoli, H Chen, RI Boenig, T Wrin, MB Zwick*, RG Whalen. Prime-boost immunization of rabbits with HIV-1 gp120 elicits potent neutralization activity against a primary viral isolate. PLoS ONE. (In press.)

Gach JS, Leaman DP, Zwick MB. (2011) Targeting HIV-1 gp41 in close proximity to the membrane using antibody and other molecules. Curr Top Med Chem. 11:2997-3021.

Stanfield RL, Julien JP, Pejchal R, Gach JS, Zwick MB, Wilson IA. (2011) Structure-based design of a protein immunogen that displays an HIV-1 gp41 neutralizing epitope. J Mol Biol. 414:460-76.

Agrawal N, Leaman DP, Rowcliffe E, Kinkead H, Nohria R, Akagi J, Bauer K, Du SX, Whalen RG, Burton DR, Zwick MB. (2011) Functional stability of unliganded envelope glycoprotein spikes among isolates of human immunodeficiency virus type 1 (HIV-1). PLoS One. 6:e21339.

Du SX, Xu L, Zhang W, Tang S, Boenig RI, Chen H, Mariano EB, Zwick MB, Parren PW, Burton DR, Wrin T, Petropoulos CJ, Ballantyne JA, Chambers M, Whalen RG. (2011) A directed molecular evolution approach to improved immunogenicity of the HIV-1 envelope glycoprotein. PLoS One. 6:e20927. 

Ingale S, Gach JS, Zwick MB, Dawson PE. (2010) Synthesis and analysis of the membrane proximal external region epitopes of HIV-1. J Pept Sci. 16:716-22.

Walker LM, Simek MD, Priddy F, Gach JS, Wagner D, Zwick MB, Phogat SK, Poignard P, Burton DR. (2010) A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals. PLoS Pathog. 6:e1001028.

Murray EJ, Leaman DP, Pawa N, Perkins H, Pickford C, Perros M, Zwick MB, Butler SL. (2010) A low molecular weight entry inhibitor of both CCR5- and CXCR4-tropic strains of human immunodeficiency virus type 1 (HIV-1) targets a novel site on gp41. J Virol. In Press.

Nakamura KJ, Gach JS, Jones L, Semrau K, Walter J, Bibollet-Ruche F, Decker JM, Heath L, Decker WD, Sinkala M, Kankasa C, Thea D, Mullins J, Kuhn L, Zwick MB, Aldrovandi GM. (2010) 4E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphisms. PLoS One. 5:e9786.

Leaman DP, Kinkead H, Zwick MB. (2010) In-solution virus capture assay helps deconstruct heterogeneous antibody recognition of human immunodeficiency virus type 1. J Virol. 84:3382-95.

Scherer EM, Leaman DP, Zwick MB, McMichael AJ, Burton DR. (2010) Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions. Proc Natl Acad Sci U S A. 107:1529-34.

Ofek G, McKee K, Yang Y, Yang ZY, Skinner J, Guenaga FJ, Wyatt R, Zwick MB, Nabel GJ, Mascola JR, Kwong PD. (2010) Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region. J Virol. 84:2955-62.

Pejchal R, Gach JS, Brunel FM, Cardoso RM, Stanfield RL, Dawson PE, Burton DR, Zwick MB, Wilson IA. (2009) A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies. J Virol. 83:8451-62.

Song L, Sun ZY, Coleman KE, Zwick MB, Gach JS, Wang JH, Reinherz EL, Wagner G, Kim M. (2009) Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface. Proc Natl Acad Sci U S A. 106:9057-62.

Reynolds MR, Weiler AM, Weisgrau KL, Piaskowski SM, Furlott JR, Weinfurter JT, Kaizu M, Soma T, León EJ, MacNair C, Leaman DP, Zwick MB, Gostick E, Musani SK, Price DA, Friedrich TC, Rakasz EG, Wilson NA, McDermott AB, Boyle R, Allison DB, Burton DR, Koff WC, Watkins DI. (2008) Macaques vaccinated with live-attenuated SIV control replication of heterologous virus. J Exp Med. 205:2537-50.

Zwick MB, Gach JS, Burton DR. (2008) A welcome burst of human antibodies. Nat Biotechnol. 26:886-7.

Crooks ET, Jiang P, Franti M, Wong S, Zwick MB, Hoxie JA, Robinson JE, Moore PL, Binley JM. (2008) Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization. Virology. 377:364-78.

Nelson JD, Kinkead H, Brunel FM, Leaman D, Jensen R, Louis JM, Maruyama T, Bewley CA, Bowdish K, Clore GM, Dawson PE, Frederickson S, Mage RG, Richman DD, Burton DR, Zwick MB. (2008) Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics. Virology. 377:170-83.

Scherer EM, Zwick MB, Teyton L, Burton DR. (2007) Difficulties in eliciting broadly neutralizing anti-HIV antibodies are not explained by cardiolipin autoreactivity. AIDS. 21:2131-9.
Zwick MB, Burton DR. (2007) HIV-1 neutralization: mechanisms and relevance to vaccine design. Curr HIV Res. 5:608-24.

Saphire EO, Montero M, Menendez A, van Houten NE, Irving MB, Pantophlet R, Zwick MB, Parren PW, Burton DR, Scott JK, Wilson IA. (2007) Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies. J Mol Biol. 369(3):696-709.

Zhou T, Xu L, Dey B, Hessell AJ, Van Ryk D, Xiang SH, Yang X, Zhang MY, Zwick MB, Arthos J, Burton DR, Dimitrov DS, Sodroski J, Wyatt R, Nabel GJ, Kwong PD. (2007) Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature. 445:732-7.

Nelson JD, Brunel FM, Jensen R, Crooks ET, Cardoso RM, Wang M, Hessell A, Wilson IA, Binley JM, Dawson PE, Burton DR, Zwick MB. (2007) An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10.J Virol. 81:4033-43.

Bowley DR, Labrijn AF, Zwick MB, Burton DR. (2007) Antigen selection from an HIV-1 immune antibody library displayed on yeast yields many novel antibodies compared to selection from the same library displayed on phage. Protein Eng Des Sel. 20:81-90.

Cardoso RM, FM Brunel, S Ferguson, MB Zwick, DR Burton, PE Dawson, IA Wilson. (2007) Structural Basis of Enhanced Binding of Extended and Helically Constrained Peptide Epitopes of the Broadly Neutralizing HIV-1 Antibody 4E10. J Mol Biol. 365:1533-44.

Yuste E, HB Sanford, J Carmody, J Bixby, S Little, MB Zwick, T Greenough, DR Burton, DD Richman, RC Desrosiers, WE Johnson. (2006) Simian immunodeficiency virus engrafted with human immunodeficiency virus type 1 (HIV-1)-specific epitopes: replication, neutralization, and survey of HIV-1-positive plasma. J Virol. 80:3030-41.

van Houten NE, MB Zwick, A Menendez, JK Scott. (2006) Filamentous phage as an immunogenic carrier to elicit focused antibody responses against a synthetic peptide. Vaccine. 24:4188-200.

Moore PL, Crooks ET, Porter L, Zhu P, Cayanan CS, Grise H, Corcoran P, Zwick MB, Franti M, Morris L, Roux KH, Burton DR, Binley JM. (2006) Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1. J Virol. 80(5):2515-28.
Brunel FM, Zwick MB, Cardoso RM, Nelson JD, Wilson IA, Burton DR, Dawson PE. (2006) Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody. J Virol. 80(4):1680-7.

Zwick MB. (2005) The membrane-proximal external region of HIV-1 gp41: a vaccine target worth exploring. AIDS. 19:1725-37.

Cardoso RM, MB Zwick, RL Stanfield, R Kunert, JM Binley, H Katinger, DR Burton, IA Wilson. (2005) Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41. Immunity. 22:163-73.

Ho J, RA Uger, MB Zwick, MA Luscher, BH Barber, KS MacDonald. (2005) Conformational constraints imposed on a pan-neutralizing HIV-1 antibody epitope result in increased antigenicity but not neutralizing response. Vaccine. 23:1559-73.

Zwick MB, R Jensen, S Church, M Wang, G Stiegler, R Kunert, H Katinger, DR Burton. (2005) Anti-human immunodeficiency virus type 1 (HIV-1) antibodies 2F5 and 4E10 require surprisingly few crucial residues in the membrane-proximal external region of glycoprotein gp41 to neutralize HIV-1. J Virol. 79:1252-61.

Binley JM, T Wrin, B Korber, MB Zwick, M Wang, C Chappey, G Stiegler, R Kunert, S Zolla-Pazner, H Katinger, CJ Petropoulos, DR Burton. (2004) Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies. J Virol. 78:13232-52.

Zwick MB, HK Komori, RL Stanfield, S Church, M Wang, PWHI Parren, R Kunert, H Katinger, IA Wilson, DR Burton. (2004) The long third complementarity-determining region of the heavy chain is important in the activity of the broadly neutralizing anti-HIV-1 antibody 2F5. J Virol. 78:3155-61.

Zwick MB, EO Saphire, DR Burton. (2004) gp41: HIV's shy protein. Nat Med. 10:133-4.

Zhang M-Y, Y Shu, D Rudolph, P Prabakaran, AF Labrijn, MB Zwick, RB Lal, DS Dimitrov. (2004) Improved breadth and potency of an HIV-1-neutralizing human single-chain antibody by random mutagenesis and sequential antigen panning. J Mol Biol. 335:209-19.

Saphire EO, RL Stanfield, MD Crispin, G Morris, MB Zwick, RA Pantophlet, PW Parren, PM Rudd, RA Dwek, DR Burton, IA Wilson. (2003) Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design. Adv Exp Med Biol. 535:55-66.

Labrijn AF, P Poignard, A Raja, MB Zwick, K Delgado, M Franti, J Binley, V Vivona, C Grundner, CC Huang, M Venturi, CJ Petropoulos, T Wrin, DS Dimitrov, J Robinson, PD Kwong, RT Wyatt, J Sodroski, DR Burton. (2003) Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1. J Virol. 77:10557-65.

Choe H, W Li, PL Wright, N Vasilieva, M Venturi, CC Huang, C Grundner, T Dorfman, MB Zwick, L Wang, ES Rosenberg, PD Kwong, DR Burton, JE Robinson, JG Sodroski, M Farzan. (2003) Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120. Cell. 114:161-70.

Calarese DA, CN Scanlan, MB Zwick, S Deechongkit, Y Mimura, R Kunert, P Zhu, MR Wormald, RL Stanfield, KH Roux, JW Kelly, PM Rudd, RA Dwek, H Katinger, DR Burton, IA Wilson. (2003) Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science. 300:2065-71.

Zwick MB, R Kelleher, R Jensen, AF Labrijn, M Wang, GV Quinnan Jr, PWHI Parren, DR Burton. (2003) A novel human antibody against human immunodeficiency virus type 1 gp120 is V1, V2, and V3 loop dependent and helps delimit the epitope of the broadly neutralizing antibody immunoglobulin G1 b12. J Virol. 77:6965-78.

Zwick MB, PWHI Parren, EO Saphire, S Church, M Wang, JK Scott, PE Dawson, IA Wilson, DR Burton. (2003) Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120. J Virol. 77:5863-76.

Zwick, MB, M Wang, P Poignard, G Stiegler, H Katinger, DR Burton and PWHI Parren (2001) Neutralization synergy of human immunodeficiency virus type 1 primary isolates by cocktails of broadly neutralizing antibodies J Virol 75:12198-12208.

Zwick, MB, AF Labrijn, M Wang, C Spenlehauer, EO Saphire, JM Binley, JP Moore, G Stiegler, H Katinger, DR Burton and PWHI Parren (2001) Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41. J Virol 75:10892-905.

Saphire, EO, PWHI Parren, R Pantophlet, MB Zwick, GM Morris, PM Rudd, RA Dwek, RL Stanfield, DR Burton and IA Wilson (2001) Crystal structure of a neutralizing human IgG against HIV-1: a template for vaccine design. Science 293:1155-9.

Zwick, MB, LL Bonnycastle, A Menendez, MB Irving, CF Barbas (III), PWHI Parren, DR Burton and JK Scott (2001) Identification and characterization of a peptide that specifically binds the human, broadly neutralizing anti-HIV-1 antibody b12. J Virol 75:6692-9.

Zwick, MB, J Shen, and JK Scott (2000) Homodimeric peptides displayed by the major coat protein of filamentous phage. J Mol Biol 300:307-20

Zwick, MB, LLC Bonnycastle, KA Noren, S Venturini, E Leong, CF Barbas (III), CJ Noren, and JK Scott (1998) The Maltose Binding Protein as a Scaffold for Monovalent Display of Peptides Derived From Phage Libraries Anal Biochem 264:87-97.

Zwick, MB, J Shen, and JK Scott (1998) Phage-displayed peptide libraries (Review) Curr Opin Biotechnol 9:427-36

Harris, SL, L Craig, JS Mehroke, M Rashed, MB Zwick, K Kenar, EJ Toone, N Greenspan, F-I Auzanneau, J-R Marino-Albernas, BM Pinto, and JK Scott (1997) Exploring the basis of peptide-carbohydrate crossreactivity: Evidence for discrimmination by peptides between closely related anti-carbohydrate antibodies Proc Natl Acad Sci USA 94:2454-9

Stein, MA, KY Leung, M Zwick, F Garcia-del Portillo and BB Finlay (1996) Identification of a Salmonella virulence gene required for formation of filamentous structures containing lysosomal membrane glycoproteins within epithelial cells Molec Micro 20(1):151-64.

Garcia-del Portillo, F, MB Zwick, KY Leung and BB Finlay (1993) Intracellular replication of Salmonella within epithelial cells is associated with filamentous structures containing lysosomal membrane glycoproteins J Inf Agent Dis 2(4):227-31.

Garcia-del Portillo, F, MB Zwick, KY Leung and BB Finlay (1993) Salmonella induces the formation of filamentous structures containing lysosomal membrane glycoproteins in epithelial cells Proc Natl Acad Sci USA 90(12):10544-8.