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Zorrilla Lab Publications

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Obesity (as of 7/16/2012)

Effects of CB1 and CRF1 receptor antagonists on binge-like eating in rats with limited access to a sweet fat diet: Lack of withdrawal-like responses.
Parylak SL, Cottone P, Sabino V, Rice KC, Zorrilla EP.
Physiol Behav. 2012 Jul 6. [Epub ahead of print]
[ABSTRACT] [PUBLISHER LINK]

Oligoclonal antibody targeting ghrelin increases energy expenditure and reduces food intake in fasted mice
Mol Pharm 9, 281-289, (2012)
Zakhari, J. S., Zorrilla, E. P., Zhou, B., Mayorov, A. V., Janda, K. D.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

The dark side of food addiction
Physiol Behav 104, 149-156, (2011)
Parylak, S. L., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress
Br J Pharmacol 164, 1959-1975, (2011)
Fekete, E. M., Zhao, Y., Szucs, A., Sabino, V., Cottone, P., Rivier, J., Vale, W. W., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

 

Consummatory, anxiety-related and metabolic adaptations in female rats with alternating access to preferred food
Psychoneuroendocrinology 34, 38-49, (2009)
Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

 

CRF system recruitment mediates dark side of compulsive eating
Proc Natl Acad Sci U S A 106, 20016-20020, (2009)
Cottone, P., Sabino, V., Roberto, M., Bajo, M., Pockros, L., Frihauf, J. B., Fekete, E. M., Steardo, L., Rice, K. C., Grigoriadis, D. E., Conti, B., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance
Swiss Med Wkly 138, 665-673, (2008)
Osborn, O., Gram, H., Zorrilla, E. P., Conti, B., Bartfai, T.
[ABSTRACT] [PUBLISHER LINK]

Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice
Proc Natl Acad Sci U S A 105, 17487-17492, (2008)
Mayorov, A. V., Amara, N., Chang, J. Y., Moss, J. A., Hixon, M. S., Ruiz, D. I., Meijler, M. M., Zorrilla, E. P., Janda, K. D.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food
Neuropsychopharmacology 33, 524-535, (2008)
Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats
Am J Physiol Regul Integr Comp Physiol 295, R1066-1076, (2008)
Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency
Proc Natl Acad Sci U S A 104, 11097-11102, (2007)
Zorrilla, E. P., Sanchez-Alavez, M., Sugama, S., Brennan, M., Fernandez, R., Bartfai, T., Conti, B.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge
Physiol Behav 91, 479-485, (2007)
Zorrilla, E. P., Brennan, M., Sabino, V., Lu, X., Bartfai, T.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis
Eur J Neurosci 26, 2303-2314, (2007)
Tabarin, A., Diz-Chaves, Y., Consoli, D., Monsaingeon, M., Bale, T. L., Culler, M. D., Datta, R., Drago, F., Vale, W. W., Koob, G. F., Zorrilla, E. P., Contarino, A.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats
J Pharmacol Exp Ther 320, 180-193, (2007)
O'Dell, L. E., Chen, S. A., Smith, R. T., Specio, S. E., Balster, R. L., Paterson, N. E., Markou, A., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs
Front Neuroendocrinol 28, 1-27, (2007)
Fekete, E. M., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval
Neuropsychopharmacology 32, 1052-1068, (2007)
Fekete, E. M., Inoue, K., Zhao, Y., Rivier, J. E., Vale, W. W., Szucs, A., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability
Neuropsychopharmacology 32, 1069-1081, (2007)
Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Feeding microstructure in diet-induced obesity susceptible versus resistant rats: central effects of urocortin 2
J Physiol 583, 487-504, (2007)
Cottone, P., Sabino, V., Nagy, T. R., Coscina, D. V., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Vaccination against weight gain
Proc Natl Acad Sci U S A 103, 13226-13231, (2006)
Zorrilla, E. P., Iwasaki, S., Moss, J. A., Chang, J., Otsuji, J., Inoue, K., Meijler, M. M., Janda, K. D.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Transgenic mice with a reduced core body temperature have an increased life span
Science 314, 825-828, (2006)
Conti, B., Sanchez-Alavez, M., Winsky-Sommerer, R., Morale, M. C., Lucero, J., Brownell, S., Fabre, V., Huitron-Resendiz, S., Henriksen, S., Zorrilla, E. P., de Lecea, L., Bartfai, T.
[ABSTRACT] [PUBLISHER LINK]

Unlimited access to heroin self-administration: independent motivational markers of opiate dependence
Neuropsychopharmacology 31, 2692-2707, (2006)
Chen, S. A., O'Dell, L. E., Hoefer, M. E., Greenwell, T. N., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior
J Neurosci 26, 5500-5510, (2006)
Chen, A., Zorrilla, E., Smith, S., Rousso, D., Levy, C., Vaughan, J., Donaldson, C., Roberts, A., Lee, K. F., Vale, W.
[ABSTRACT] [PUBLISHER LINK]

Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat
Psychopharmacology (Berl) 177, 324-335, (2005)
Zorrilla, E. P., Inoue, K., Valdez, G. R., Tabarin, A., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Measuring meals: structure of prandial food and water intake of rats
Am J Physiol Regul Integr Comp Physiol 288, R1450-1467, (2005)
Zorrilla, E. P., Inoue, K., Fekete, E. M., Tabarin, A., Valdez, G. R., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene"
Diabetes 54, 3510-3516, (2005)
Tabarin, A., Diz-Chaves, Y., Carmona Mdel, C., Catargi, B., Zorrilla, E. P., Roberts, A. J., Coscina, D. V., Rousset, S., Redonnet, A., Parker, G. C., Inoue, K., Ricquier, D., Penicaud, L., Kieffer, B. L., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity
J Pharmacol Exp Ther 310, 1027-1034, (2004)
Zorrilla, E. P., Reinhardt, L. E., Valdez, G. R., Inoue, K., Rivier, J. E., Vale, W. W., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Reduction of anxiety after restricted feeding in the rat: implication for eating disorders
Biol Psychiatry 55, 1075-1081, (2004)
Inoue, K., Zorrilla, E. P., Tabarin, A., Valdez, G. R., Iwasaki, S., Kiriike, N., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Nibbling at CRF receptor control of feeding and gastrocolonic motility
Trends Pharmacol Sci 24, 421-427, (2003)
Zorrilla, E. P., Tache, Y., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Human urocortin II, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat
J Pharmacol Exp Ther 305, 385-393, (2003)
Inoue, K., Valdez, G. R., Reyes, T. M., Reinhardt, L. E., Tabarin, A., Rivier, J., Vale, W. W., Sawchenko, P. E., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]