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Zorrilla Lab Publications

All     Highlights    Obesity    Addiction     Stress/Anxiety/Depression      Reviews     Patents/Chapters

All (as of 7/16/2012)

Behavioral, biological and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism.
Zorrilla EP, Heilig M, deWit H, Shaham Y.
Drug Alcohol Depend. 2013 Jan 4. [Epub ahead of print]
[ABSTRACT] [PUBLISHER LINK]

Effects of CB1 and CRF1 receptor antagonists on binge-like eating in rats with limited access to a sweet fat diet: Lack of withdrawal-like responses.
Parylak SL, Cottone P, Sabino V, Rice KC, Zorrilla EP.
Physiol Behav. 2012 Jul 6. [Epub ahead of print]
[ABSTRACT] [PUBLISHER LINK]

Stress history increases alcohol intake in relapse: Relation to phosphodiesterase 10A
Addict Biol, 2012 Jun doi: 10.1111/j.1369-1600.2012.00460.x
Logrip, M. L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats
Addict Biol 17, 300-308, (2012)
Zorrilla, E. P., Wee, S., Zhao, Y., Specio, S., Boutrel, B., Koob, G. F., Weiss, F.
[ABSTRACT]  [PUBLISHER LINK] [PUBMED CENTRAL]

Oligoclonal antibody targeting ghrelin increases energy expenditure and reduces food intake in fasted mice
Mol Pharm 9, 281-289, (2012)
Zakhari, J. S., Zorrilla, E. P., Zhou, B., Mayorov, A. V., Janda, K. D.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats
J Neurosci 32, 7563-7571, (2012)
Vendruscolo, L. F., Barbier, E., Schlosburg, J. E., Misra, K. K., Whitfield, T. W., Jr., Logrip, M. L., Rivier, C., Repunte-Canonigo, V., Zorrilla, E. P., Sanna, P. P., Heilig, M., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Stress modulation of drug self-administration: implications for addiction comorbidity with post-traumatic stress disorder
Neuropharmacology 62, 552-564, (2012)
Logrip, M. L., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Update on corticotropin-releasing factor pharmacotherapy for psychiatric disorders: a revisionist view
Neuropsychopharmacology 37, 308-309, (2012)
Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Systemic kappa-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats
Addict Biol 16, 116-119, (2011)
Walker, B. M., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Activation of sigma-receptors induces binge-like drinking in Sardinian alcohol-preferring rats
Neuropsychopharmacology 36, 1207-1218, (2011)
Sabino, V., Cottone, P., Blasio, A., Iyer, M. R., Steardo, L., Rice, K. C., Conti, B., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

The dark side of food addiction
Physiol Behav 104, 149-156, (2011)
Parylak, S. L., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention
CNS Drugs 25, 271-287, (2011)
Logrip, M. L., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (sigmaR1)
Invest Ophthalmol Vis Sci 52, 7749-7760, (2011)
Ha, Y., Saul, A., Tawfik, A., Williams, C., Bollinger, K., Smith, R., Tachikawa, M., Zorrilla, E., Ganapathy, V., Smith, S. B.
[ABSTRACT] [PUBLISHER LINK]

Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress
Br J Pharmacol 164, 1959-1975, (2011)
Fekete, E. M., Zhao, Y., Szucs, A., Sabino, V., Cottone, P., Rivier, J., Vale, W. W., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Progress in corticotropin-releasing factor-1 antagonist development
Drug Discov Today 15, 371-383, (2010)
Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence
Biol Psychiatry 67, 831-839, (2010)
Roberto, M., Cruz, M. T., Gilpin, N. W., Sabino, V., Schweitzer, P., Bajo, M., Cottone, P., Madamba, S. G., Stouffer, D. G., Zorrilla, E. P., Koob, G. F., Siggins, G. R., Parsons, L. H.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Genome-wide gene expression analysis identifies K-ras as a regulator of alcohol intake
Brain Res 1339, 1-10, (2010)
Repunte-Canonigo, V., van der Stap, L. D., Chen, J., Sabino, V., Wagner, U., Zorrilla, E. P., Schumann, G., Roberts, A. J., Sanna, P. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Pattern of maternal circulating CRH in laboratory-housed squirrel and owl monkeys
Am J Primatol 72, 1004-1012, (2010)
Power, M. L., Williams, L. E., Gibson, S. V., Schulkin, J., Helfers, J., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: Focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin
Brain Res 1314, 145-161, (2010)
Martin-Fardon, R., Zorrilla, E. P., Ciccocioppo, R., Weiss, F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor
Curr Opin Investig Drugs 11, 63-71, (2010)
Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBMED CENTRAL]

Urocortin 2 protects against retinal degeneration following bilateral common carotid artery occlusion in the rat
Neurosci Lett 455, 42-45, (2009)
Szabadfi, K., Atlasz, T., Reglodi, D., Kiss, P., Danyadi, B., Fekete, E. M., Zorrilla, E. P., Tamas, A., Szabo, K., Gabriel, R.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist
Psychopharmacology (Berl) 205, 327-335, (2009)
Sabino, V., Cottone, P., Zhao, Y., Steardo, L., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking
Neuropsychopharmacology 34, 1482-1493, (2009)
Sabino, V., Cottone, P., Zhao, Y., Iyer, M. R., Steardo, L., Jr., Steardo, L., Rice, K. C., Conti, B., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Sigma-1 receptor knockout mice display a depressive-like phenotype
Behav Brain Res 198, 472-476, (2009)
Sabino, V., Cottone, P., Parylak, S. L., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Presynaptic CRF1 receptors mediate the ethanol enhancement of GABAergic transmission in the mouse central amygdala
ScientificWorldJournal 9, 68-85, (2009)
Nie, Z., Zorrilla, E. P., Madamba, S. G., Rice, K. C., Roberto, M., Siggins, G. R.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration
Pharmacol Biochem Behav 91, 295-302, (2009)
Greenwell, T. N., Walker, B. M., Cottone, P., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats
Addict Biol 14, 130-143, (2009)
Greenwell, T. N., Funk, C. K., Cottone, P., Richardson, H. N., Chen, S. A., Rice, K. C., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis
J Neurosci 29, 5389-5401, (2009)
Francesconi, W., Berton, F., Repunte-Canonigo, V., Hagihara, K., Thurbon, D., Lekic, D., Specio, S. E., Greenwell, T. N., Chen, S. A., Rice, K. C., Richardson, H. N., O'Dell, L. E., Zorrilla, E. P., Morales, M., Koob, G. F., Sanna, P. P.
[ABSTRACT] [PUBLISHER LINK]

Increased perioculomotor urocortin 1 immunoreactivity in genetically selected alcohol preferring rats
Alcohol Clin Exp Res 33, 1956-1965, (2009)
Fonareva, I., Spangler, E., Cannella, N., Sabino, V., Cottone, P., Ciccocioppo, R., Zorrilla, E. P., Ryabinin, A. E.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Social defeat stress activates medial amygdala cells that express type 2 corticotropin-releasing factor receptor mRNA
Neuroscience 162, 5-13, (2009)
Fekete, E. M., Zhao, Y., Li, C., Sabino, V., Vale, W. W., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Consummatory, anxiety-related and metabolic adaptations in female rats with alternating access to preferred food
Psychoneuroendocrinology 34, 38-49, (2009)
Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

CRF system recruitment mediates dark side of compulsive eating
Proc Natl Acad Sci U S A 106, 20016-20020, (2009)
Cottone, P., Sabino, V., Roberto, M., Bajo, M., Pockros, L., Frihauf, J. B., Fekete, E. M., Steardo, L., Rice, K. C., Grigoriadis, D. E., Conti, B., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats
Psychopharmacology (Berl) 196, 473-482, (2008)
Specio, S. E., Wee, S., O'Dell, L. E., Boutrel, B., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist
Pharmacol Biochem Behav 88, 497-510, (2008)
Richardson, H. N., Zhao, Y., Fekete, E. M., Funk, C. K., Wirsching, P., Janda, K. D., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance
Swiss Med Wkly 138, 665-673, (2008)
Osborn, O., Gram, H., Zorrilla, E. P., Conti, B., Bartfai, T.
[ABSTRACT] [PUBLISHER LINK]

Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice
Proc Natl Acad Sci U S A 105, 17487-17492, (2008)
Mayorov, A. V., Amara, N., Chang, J. Y., Moss, J. A., Hixon, M. S., Ruiz, D. I., Meijler, M. M., Zorrilla, E. P., Janda, K. D.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests
Neuropeptides 42, 387-397, (2008)
Lu, X., Ross, B., Sanchez-Alavez, M., Zorrilla, E. P., Bartfai, T.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food
Neuropsychopharmacology 33, 524-535, (2008)
Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats
Am J Physiol Regul Integr Comp Physiol 295, R1066-1076, (2008)
Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency
Proc Natl Acad Sci U S A 104, 11097-11102, (2007)
Zorrilla, E. P., Sanchez-Alavez, M., Sugama, S., Brennan, M., Fernandez, R., Bartfai, T., Conti, B.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge
Physiol Behav 91, 479-485, (2007)
Zorrilla, E. P., Brennan, M., Sabino, V., Lu, X., Bartfai, T.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Remission and resurgence of anxiety-like behavior across protracted withdrawal stages in ethanol-dependent rats
Alcohol Clin Exp Res 31, 1505-1515, (2007)
Zhao, Y., Weiss, F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Subtype-selective corticotropin-releasing factor receptor agonists exert contrasting, but not opposite, effects on anxiety-related behavior in rats
J Pharmacol Exp Ther 323, 846-854, (2007)
Zhao, Y., Valdez, G. R., Fekete, E. M., Rivier, J. E., Vale, W. W., Rice, K. C., Weiss, F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis
Eur J Neurosci 26, 2303-2314, (2007)
Tabarin, A., Diz-Chaves, Y., Consoli, D., Monsaingeon, M., Bale, T. L., Culler, M. D., Datta, R., Drago, F., Vale, W. W., Koob, G. F., Zorrilla, E. P., Contarino, A.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

14-Methoxymetopon, a highly potent mu opioid agonist, biphasically affects ethanol intake in Sardinian alcohol-preferring rats
Psychopharmacology (Berl) 192, 537-546, (2007)
Sabino, V., Cottone, P., Steardo, L., Schmidhammer, H., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats
J Pharmacol Exp Ther 320, 180-193, (2007)
O'Dell, L. E., Chen, S. A., Smith, R. T., Specio, S. E., Balster, R. L., Paterson, N. E., Markou, A., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats
Proc Natl Acad Sci U S A 104, 17198-17203, (2007)
George, O., Ghozland, S., Azar, M. R., Cottone, P., Zorrilla, E. P., Parsons, L. H., O'Dell, L. E., Richardson, H. N., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats
Biol Psychiatry 61, 78-86, (2007)
Funk, C. K., Zorrilla, E. P., Lee, M. J., Rice, K. C., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs
Front Neuroendocrinol 28, 1-27, (2007)
Fekete, E. M., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval
Neuropsychopharmacology 32, 1052-1068, (2007)
Fekete, E. M., Inoue, K., Zhao, Y., Rivier, J. E., Vale, W. W., Szucs, A., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability
Neuropsychopharmacology 32, 1069-1081, (2007)
Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Feeding microstructure in diet-induced obesity susceptible versus resistant rats: central effects of urocortin 2
J Physiol 583, 487-504, (2007)
Cottone, P., Sabino, V., Nagy, T. R., Coscina, D. V., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout
Pharmacol Biochem Behav 86, 813-821, (2007)
Chu, K., Koob, G. F., Cole, M., Zorrilla, E. P., Roberts, A. J.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Vaccination against weight gain
Proc Natl Acad Sci U S A 103, 13226-13231, (2006)
Zorrilla, E. P., Iwasaki, S., Moss, J. A., Chang, J., Otsuji, J., Inoue, K., Meijler, M. M., Janda, K. D.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats
Psychopharmacology (Berl) 189, 175-186, (2006)
Sabino, V., Cottone, P., Koob, G. F., Steardo, L., Lee, M. J., Rice, K. C., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Exposure to repetitive versus varied stress during prenatal development generates two distinct anxiogenic and neuroendocrine profiles in adulthood
Endocrinology 147, 2506-2517, (2006)
Richardson, H. N., Zorrilla, E. P., Mandyam, C. D., Rivier, C. L.
[ABSTRACT] [PUBLISHER LINK]

Transgenic mice with a reduced core body temperature have an increased life span
Science 314, 825-828, (2006)
Conti, B., Sanchez-Alavez, M., Winsky-Sommerer, R., Morale, M. C., Lucero, J., Brownell, S., Fabre, V., Huitron-Resendiz, S., Henriksen, S., Zorrilla, E. P., de Lecea, L., Bartfai, T.
[ABSTRACT] [PUBLISHER LINK]

Unlimited access to heroin self-administration: independent motivational markers of opiate dependence
Neuropsychopharmacology 31, 2692-2707, (2006)
Chen, S. A., O'Dell, L. E., Hoefer, M. E., Greenwell, T. N., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior
J Neurosci 26, 5500-5510, (2006)
Chen, A., Zorrilla, E., Smith, S., Rousso, D., Levy, C., Vaughan, J., Donaldson, C., Roberts, A., Lee, K. F., Vale, W.
[ABSTRACT] [PUBLISHER LINK]

Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat
Psychopharmacology (Berl) 177, 324-335, (2005)
Zorrilla, E. P., Inoue, K., Valdez, G. R., Tabarin, A., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Measuring meals: structure of prandial food and water intake of rats
Am J Physiol Regul Integr Comp Physiol 288, R1450-1467, (2005)
Zorrilla, E. P., Inoue, K., Fekete, E. M., Tabarin, A., Valdez, G. R., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Homeostasis within the corticotropin-releasing factor system via CRF2 receptor activation: a novel approach for the treatment of anxiety
Drug Development Research 65, 205-215, (2005)
Valdez, G. R., Zorrilla, E. P., Koob, G. F.
[PUBLISHER LINK]

Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene"
Diabetes 54, 3510-3516, (2005)
Tabarin, A., Diz-Chaves, Y., Carmona Mdel, C., Catargi, B., Zorrilla, E. P., Roberts, A. J., Coscina, D. V., Rousset, S., Redonnet, A., Parker, G. C., Inoue, K., Ricquier, D., Penicaud, L., Kieffer, B. L., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats
Neuropsychopharmacology 30, 90-98, (2005)
Stinus, L., Cador, M., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity
J Pharmacol Exp Ther 310, 1027-1034, (2004)
Zorrilla, E. P., Reinhardt, L. E., Valdez, G. R., Inoue, K., Rivier, J. E., Vale, W. W., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

The therapeutic potential of CRF1 antagonists for anxiety
Expert Opin Investig Drugs 13, 799-828, (2004)
Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Reduction of anxiety after restricted feeding in the rat: implication for eating disorders
Biol Psychiatry 55, 1075-1081, (2004)
Inoue, K., Zorrilla, E. P., Tabarin, A., Valdez, G. R., Iwasaki, S., Kiriike, N., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Nibbling at CRF receptor control of feeding and gastrocolonic motility
Trends Pharmacol Sci 24, 421-427, (2003)
Zorrilla, E. P., Tache, Y., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

CRF1 receptor antagonists for anxiety
European Neuropsychopharmacology 13, s130-s131, (2003)
Zorrilla, E., Fekete, E., Mason, B. J., Wirsching, P., Janda, K. D., Koob, G. F.
[PUBLISHER LINK]

Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence
Alcohol 29, 55-60, (2003)
Valdez, G. R., Zorrilla, E. P., Roberts, A. J., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Locomotor suppressive and anxiolytic-like effects of urocortin 3, a highly selective type 2 corticotropin-releasing factor agonist
Brain Res 980, 206-212, (2003)
Valdez, G. R., Zorrilla, E. P., Rivier, J., Vale, W. W., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Human urocortin II, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat
J Pharmacol Exp Ther 305, 385-393, (2003)
Inoue, K., Valdez, G. R., Reyes, T. M., Reinhardt, L. E., Tabarin, A., Rivier, J., Vale, W. W., Sawchenko, P. E., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat
Brain Res 952, 188-199, (2002)
Zorrilla, E. P., Valdez, G. R., Nozulak, J., Koob, G. F., Markou, A.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors
Brain Res 952, 200-210, (2002)
Zorrilla, E. P., Schulteis, G., Ormsby, A., Klaassen, A., Ling, N., McCarthy, J. R., Koob, G. F., De Souza, E. B.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor
Alcohol Clin Exp Res 26, 1494-1501, (2002)
Valdez, G. R., Roberts, A. J., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Human urocortin II: mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide
Brain Res 943, 142-150, (2002)
Valdez, G. R., Inoue, K., Koob, G. F., Rivier, J., Vale, W., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Time-dependent induction of anxiogenic-like effects after central infusion of urocortin or corticotropin-releasing factor in the rat
Psychopharmacology (Berl) 160, 113-121, (2002)
Spina, M. G., Merlo-Pich, E., Akwa, Y., Balducci, C., Basso, A. M., Zorrilla, E. P., Britton, K. T., Rivier, J., Vale, W. W., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Changes in levels of regional CRF-like-immunoreactivity and plasma corticosterone during protracted drug withdrawal in dependent rats
Psychopharmacology (Berl) 158, 374-381, (2001)
Zorrilla, E. P., Valdez, G. R., Weiss, F.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Performance-enhancing effects of CRF-BP ligand inhibitors
Neuroreport 12, 1231-1234, (2001)
Zorrilla, E. P., Schulteis, G., Ling, N., Koob, G. F., De Souza, E. B.
[ABSTRACT]  [REQUEST PDF]

The relationship of depression and stressors to immunological assays: a meta-analytic review
Brain Behav Immun 15, 199-226, (2001)
Zorrilla, E. P., Luborsky, L., McKay, J. R., Rosenthal, R., Houldin, A., Tax, A., McCorkle, R., Seligman, D. A., Schmidt, K.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors
Ann N Y Acad Sci 937, 1-26, (2001)
Weiss, F., Ciccocioppo, R., Parsons, L. H., Katner, S., Liu, X., Zorrilla, E. P., Valdez, G. R., Ben-Shahar, O., Angeletti, S., Richter, R. R.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Behavioral effects of central administration of the novel CRF antagonist astressin in rats
Neuropsychopharmacology 22, 230-239, (2000)
Spina, M. G., Basso, A. M., Zorrilla, E. P., Heyser, C. J., Rivier, J., Vale, W., Merlo-Pich, E., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Altered amygdalar CRF release and increased anxiety-like behavior in Sardinian alcohol-preferring rats: a microdialysis and behavioral study
Alcohol Clin Exp Res 24, 1765-1772, (2000)
Richter, R. M., Zorrilla, E. P., Basso, A. M., Koob, G. F., Weiss, F.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Leukocyte differentials predict short-term clinical outcome following antipsychotic treatment in schizophrenia
Biol Psychiatry 43, 887-896, (1998)
Zorrilla, E. P., Cannon, T. D., Kessler, J., Gur, R. E.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Multiparous species present problems (and possibilities) to developmentalists
Dev Psychobiol 30, 141-150, (1997)
Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Affiliative trust-mistrust and immunity in depressed patients receiving supportive-expressive psychotherapy
Psychotherapy Research 7, 249-260, (1997)
McKay, J. R., Luborsky, L., Barber, J. P., Kabasakalian-McKay, R., Zorrilla, E. P., Cacciola, J. S.
[PUBLISHER LINK]

Sexually dimorphic effects of maternal adrenalectomy on hypothalamic corticotrophin-releasing factor, glucocorticoid receptor and anterior pituitary POMC mRNA levels in rat neonates
Brain Res Dev Brain Res 100, 198-204, (1997)
Halasz, I., Rittenhouse, P. A., Zorrilla, E. P., Redei, E.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Relation of stressors and depressive symptoms to clinical progression of viral illness
Am J Psychiatry 153, 626-635, (1996)
Zorrilla, E. P., McKay, J. R., Luborsky, L., Schmidt, K.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Leukocytes and organ-nonspecific autoantibodies in schizophrenics and their siblings: markers of vulnerability or disease?
Biol Psychiatry 40, 825-833, (1996)
Zorrilla, E. P., Cannon, T. D., Gur, R. E., Kessler, J.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

High self-esteem, hardiness and affective stability are associated with higher basal pituitary-adrenal hormone levels
Psychoneuroendocrinology 20, 591-601, (1995)
Zorrilla, E. P., DeRubeis, R. J., Redei, E.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Relative lymphocyte deficit in schizophrenics and their siblings
Schizophrenia Research 15, 52, (1995)
Zorrilla, E. P., Cannon, T. D., Gur, R. E., Kessler, J., Borricella, M.
[PUBLISHER LINK]

Reduced cytokine levels and T-cell function in healthy males: relation to individual differences in subclinical anxiety
Brain Behav Immun 8, 293-312, (1994)
Zorrilla, E. P., Redei, E., DeRubeis, R. J.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Patents

Koob, G.F., Zorrilla, E.P., Mason, B., Wirsching, P., Janda, K.D., MPZP: A small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist, PCT/US2010/0249138 [September 22, 2008].

Zorrilla, E.P., Meijler, M.M., Janda, K.D., Vaccines and methods for controlling adiposity, PCT/US2010/0021487 [originally filed August 1, 2007].

Monographs and Book Chapters

Parylak, S.L., Cottone, P., Zorrilla, E.P., Eating Disorders: Animal Models. In Encyclopedia of Psychopharmacology. Ed. Stolerman, I.,Springer, Berlin, 2010.

Frihauf, J.B., Fekete, E., Zorrilla, E.P., CNS Control of food intake. In Encyclopedia of Behavioral Neuroscience. Eds. Koob GF, Thompson RF, LeMoal M,  Elsevier, London, 2010.

Zorrilla, E.P., Zhao, Y., Koob, G.F., 2007. CRF receptor antagonists, In (Ed.) Fink, G., Encyclopedia of Stress, Vol. 4, Oxford: Academic Press, 206-214.

Fekete, E.M., Zorrilla, E.P., 2007. Urocortins, In (Ed.) Fink, G., Encyclopedia of Stress, Vol. 3, Oxford: Academic Press, 804-811 

Zorrilla, E.P., and Koob, G.F., 2007. Peptides, In (Ed.) Fink, G., Encyclopedia of Stress, Vol. 3, Oxford: Academic Press, 91-96.

Zorrilla, E.P. and Koob, G.F., The roles of urocortins 1, 2 and 3 in the brain. In Steckler, T., Kalin, N.H. and Reul, J.M.H.M. (Eds.), Handbook of Stress, Immunology and Behaviour, (series title: Techniques in the Behavioral and Neural Sciences, vol. 15), Elsevier Science, New York, 2005, pp. 179-203.

Zorrilla, E.P., Koob, G.F., 2000. Urocortin, In (Ed.) Fink, G., Encycopledia of Stress, Vol. 3, San Diego: Academic Press, 637-641.

Zorrilla, E.P., Koob, G.F., 2000. Peptides, In (Ed.) Fink, G., Encycopledia of Stress, Vol. 3, San Diego: Academic Press, 138-141.

Zorrilla, E.P., 1997. Neonatal rodent handling: Potential relevance to human post traumatic stress disorder. Dissertation Abstracts International: Section B: The Sciences & Engineering. Vol. 57(7B), 4773.