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Scripps Laboratories for tRNA Synthetase Research

Zhongying Mo, Ph.D.

Contact: zhongymo@scripps.edu

Photo of Zhongying Mo, Ph.D.

Education:
B.S., Biotechnology, Wuhan University, 2004
Ph.D., Biochemistry and Molecular Biology, Wuhan University, 2009

Current Research Focus:
Mutations in Glycyl-tRNA Synthetase (GlyRS) have been discovered in Charcot-Marie-Tooth (CMT-2D) patients and the etiology remains unclear. My current research focus is to elucidate novel functions of GlyRS and explore their connections with CMT-2D.

Selected Publications:
Y Shi, X Xu, Q Zhang, G Fu, Z Mo, GS Wang, S Kishi, XL Yang (2014). tRNA synthetase counteracts c-Myc to develop functional vasculature. eLife Jun 17;3:e02349. doi: 10.7554/eLife.02349.

ZY Mo, YZ Zhu, HL Zhu, JB Fan, J Chen, Y Liang (2009). Low micromolar zinc accelerates the fibrillization of human Tau via bridging of Cys-291 and Cys-322. J Biol Chem. Dec 11;284(50):34648-57.          

Y Tang, J Dai, L Zhang, Z Mo, Y Wang, Y Li, S Ji, C Fang, C Zheng (2009). Dyadobacter alkalitolerans sp. nov., isolated from desert sand. Int J Syst Evol Microbiol. Jan;59(Pt 1):60-4. 

JM Liao, ZY Mo, LJ Wu, J Chen, Y Liang (2008). Binding of calcium ions to Ras promotes Ras guanine nucleotide exchange under emulated physiological conditions. Biochim Biophys Acta. Nov;1784(11):1560-9.

F Du, Z Zhou, ZY Mo, JZ Shi, J Chen, Y Liang (2006). Mixed macromolecular crowding accelerates the refolding of rabbit muscle creatine kinase: Implications for protein folding in physiological environments. J Mol Biol. Dec 1;364(3):469-82.

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