The Ron Davis Laboratory at the Scripps Research Institute Florida

Ongoing Support

The National Institute of Neurological Disorders and Stroke

R01 NS073930 (6/15/11 – 5/31/16)
Distinct roles of somatically and dendritically synthesized BDNF in spine morphogenesis
The major goals of this project are to determine whether somatically and dendritically synthesized BDNF have distinct roles in spine morphogenesis, to dissect the signaling cascades that mediate these distinct effects of BDNF on spine morphogenesis, and to establish an animal model to investigate the functional consequence of a human SNP that impairs dendritic BDNF synthesis.

R21 NS095425 (9/15/15 – 8/31/17)                                                               
Astrocytic TrkB in diet-induced obesity
The major goals of this project are to investigate the role of the truncated TrkB receptor expressed in hypothalamic astrocytes and astrogliosis in diet-induced obesity

The National Institute of Diabetes and Digestive and Kidney Diseases

R01 DK103335 (4/1/15 – 1/31/19)
Unraveling the role of PVH BDNF neurons in energy balance
The major goals of this project are to determine the role of BDNF-expressing neurons in the paraventricular hypothalamus in the control of food intake and energy expenditure and to elucidate the neural circuits linking these neurons.

R01 DK105954 (04/01/16 – 02/28/20)
TrkB neurons in the control of energy balance
The major goals of this project are to investigate the role of TrkB-expressing neurons in the paraventricular hypothalamus and the dorsomedial hypothalamus in the regulation of food intake and energy expenditure, to elucidate the neural circuits linked to these neurons, and to molecularly characterize these neurons.

The National Institute of Mental Health

R21 MH108046 (8/1/15 – 4/30/17)                                                     
Neural basis underlying autistic behaviors
The major goals of this project are to determine whether increasing protein synthesis in neurons or astrocytes leads to autistic-like behaviors in mice.