The Ron Davis Laboratory at the Scripps Research Institute Florida

Ongoing Support

The National Institute of Neurological Disorders and Stroke

R21 NS095425 (PI: Xu)                                                                     
Astrocytic TrkB in diet-induced obesity
The major goals of this project are to investigate the role of the truncated TrkB receptor expressed in hypothalamic astrocytes and astrogliosis in diet-induced obesity

The National Institute of Diabetes and Digestive and Kidney Diseases

R01 DK089237 (PI: Xu)
Regulation of energy homeostasis by BDNF
The major goals of this project are to elucidate how BDNF controls energy homeostasis by regulating the formation of neural circuits in the hypothalamus using a unique mouse mutant that is deficient in local BDNF synthesis.

R01 DK103335 (PI: Xu)
Unraveling the role of PVH BDNF neurons in energy balance
The major goals of this project are to determine the role of BDNF-expressing neurons in the paraventricular hypothalamus in the control of food intake and energy expenditure and to elucidate the neural circuits linking these neurons.

R01 DK112759 (PI: Yang)                                                                             
Astrocytic target mechanisms in obesity
The major goals of this project are to investigate the role of astrocytes in the control of food intake and energy expenditure by modulating the function of neurons in the arcuate nucleus of the hypothalamus.
Role: co-investigator

The National Institute of Mental Health

R21 MH108046 (PI: Xu)                                                        
Neural basis underlying autistic behaviors
The major goals of this project are to determine whether increasing protein synthesis in neurons or astrocytes leads to autistic-like behaviors in mice.