Publications

Note: Underlined names indicate first authors.

  • Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway CA, Ghosh S. (1999) "ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway." Genes & Development 13: 2059-2071.
  • Xiao C, Shim JH, Kluppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S. (2003) "Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis." Genes & Development 17: 2933-2949.
  • Monticelli S, Ansel KM, Xiao C, Socci ND, Krichevsky AM, Thai TH, Rajewsky N, Marks DS, Sander C, Rajewsky K, Rao A, Kosik KS. (2005) "MicroRNA profiling of the murine hematopoietic system." Genome Biology 6(8): R71.
  • Shim JH, Xiao C, Paschal AE, Bailey ST, Rao P, Hayden MS, Lee KY, Bussey C, Steckel M, Tanaka N, Yamada G, Akira S, Matsumoto K, Ghosh S. (2005) "TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo." Genes & Development 19: 2668-2681.
  • Xiao C, Ghosh S. (2005) "NF-kappaB, an evolutionarily conserved mediator of immune and inflammatory responses." Advances in Experimental Medicine and Biology 560: 41-45.
  • Shim JH, Xiao C, Hayden MS, Lee KY, Trombetta ES, Pypaert M, Nara A, Yoshimori T, Wilm B, Erdjument-Bromage H, Tempst P, Hogan BL, Mellman I, Ghosh S. (2006) "CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis." Journal of Cell Biology 172: 1045-1056.
  • Xiao C, Calado DP, Galler G, Thai TH, Patterson HC, Wang J, Rajewsky N, Bender TP, Rajewsky K. (2007) "MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb." Cell 131: 146-159. corrigendum
  • Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K. (2007) "Regulation of the germinal center response by microRNA-155." Science 316: 604-608.
  • Xiao C, Srinivasan L, Calado DP, Patterson HC, Zhang B, Wang J, Henderson JM, Kutok JL, Rajewsky K. (2008) "Lymphoproliferative disease and autoimmunity in mice with elevated miR-17-92 expression in lymphocytes." Nature Immunology 9: 405-14.
  • Xiao C and Rajewsky K. (2009) "MicroRNA Control in the Immune System: Basic Principles. Cell 136: 26-36. PMID: 19135886
  • Hong L, Lai M, Chen M, Xie C, Liao R, Kang YJ, Xiao C, Hu WY, Han J, Sun P. (2010) "The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence." Cancer Res. 70:8547-57.. PMCID: PMC2970743
  • Yoshizuka N, Lai M, Liao R, Cook R, Xiao C, Han J, Sun P. (2012) "PRAK suppresses oncogenic ras-induced hematopoietic cancer development by antagonizing the JNK pathway." Mol Cancer Res. 10:810-20. PMCID: PMC3378811
  • Adams BD, Guo S, Bai H, Guo Y, Megyola CM, Cheng J, Heydari K, Xiao C, Reddy EP, Lu J. (2012) "An in vivo functional screen uncovers miR-150-mediated regulation of hematopoietic injury response." Cell Rep. 2:1048-60. PMCID: PMC3487471
  • Kang SG, Liu WH, Lu P, Jin HY, Lim HW, Shepherd J, Fremgen D, Verdin E, Oldstone MBA, Qi H, Teijaro JR, Xiao C (2013) "MiR-17~92 family microRNAs are critical regulators of T follicular helper cell differentiation." Nature Immunology 14:849-57. PMID: 23812097
  • Jin HY, Oda H, Lai M, Skalsky RL, Bethel K, Shepherd J, Kang SG, Liu WH, Sabouri-Ghomi M, Cullen BR, Rajewsky K, Xiao C (2013) "MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways." The EMBO J. 32:2377-91. PMID: 23921550
  • Shim EJ, Bang BR, Kang SG, Ma J, Otsuka M, Kang J, Stahl M, Han J, Xiao C, Vallance BA, Kang YJ (2013) "Activation of p38a in T Cells Regulates the Intestinal Host Defense against Attaching and Effacing Bacterial Infections." J Immunol. 191:2764-70. PMID: 23918973
  • Jin HY, Lai M, Xiao C (2014) "microRNA-17~92 is a powerful cancer driver and a therapeutic target." Cell Cycle 13:495-6. PMID: 24419145
  • Wang H, Geng J, Wen X, Bi E, Kossenkov AV, Wolf AI, Tas J, Choi YS, Takata H, Day TJ, Chang LY, Sprout SL, Becker EK, Willen J, Tian L, Wang X, Xiao C, Jiang P, Crotty S, Victora GD, Showe LC, Tucker HO, Erikson J, Hu H (2014) "The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells. Nature Immunology 15:667-75. PMID: 24859450
  • Lai M, Xiao C (2015) "Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation." Int Immunopharmacol. 28:854-8. PMID: 25870038
  • Siegemund S, Shepherd J, Xiao C, Sauer K (2015) "hCD2-iCre and Vav-iCre mediated gene recombination patterns in murine hematopoietic cells." PLoS One 10:e0124661. PMID: 25884630
  • Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E (2015) "SIRT1 deacetylates RORγt and enhances Th17 cell generation." J Exp Med. 212:607-17. PMID: 25918343
  • Greenblatt MB, Park KH, Oh H, Kim JM, Shin DY, Lee JM, Lee JW, Singh A, Lee KY, Hu D, Xiao C, Charles JF, Penninger JM, Lotinun S, Baron R, Ghosh S, Shim JH (2015) "CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts." J Exp Med. 212:1283-301. PMID: 26195726
  • Jin HY, Xiao C (2015) "MicroRNA Mechanisms of Action: What have We Learned from Mice?" Front Genet. 6:328. PMID: 26635864
  • Jin HY, Gonzalez-Martin A, Miletic AV, Lai M, Knight S, Sabouri-Ghomi M, Head SR, Macauley MS, Rickert RC, Xiao C (2015) "Transfection of microRNA Mimics Should Be Used with Caution." Front Genet. 6:340. PMID: 26697058
  • Gonzalez-Martin A, Adams BD, Lai M, Shepherd J, Salvador-Bernaldez M, Salvador JM, Lu J, Nemazee D, Xiao C (2016) "The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity." Nature Immunology 2016 Feb 22. doi: 10.1038/ni.3385. [Epub ahead of print] PMID: 26901150