The Wüthrich Laboratory

Samit Kumar Dutta, Ph.D.

Research Associate

samit@scripps.edu

Research interest

Being a part of the NMR core of The Joint Center for Structural Genomics (JCSG), the focus of my research is to determine solution structures of protein targets using highly automated approaches. The goal is to explore the expanding horizon of the protein universe which provides an opportunity to tackle new challenges and contribute significantly to the emerging areas of biology, chemistry and medicine.

Curriculum Vitae

Apr 2011 – present: Post Doctoral Research Associate in Prof Kurt Wüthrich lab in The Scripps Research Institute.

Sept 2010 – Mar 2011: NMR Application Specialist in Varian (presently part of Agilent Technologies).

Nov 2009 – Feb 2010: EMBO short term project at Ernst-Moritz-Arndt-University of Greifswald, Germany.

2005 – 2009: Doctoral research work under the supervision of Dr. A. C. Kunwar (Director Grade Scientist), at Indian Institute of Chemical Technology, Hyderabad, India.

 2002 – 2004: M.Sc., (Organic Chemistry), Jadavpur University, Kolkata, India.

1999 – 2002: B.Sc., [Chemistry (honours), Mathematics and Physics] Jadavpur University, Kolkata, India.

Publications:

1. Sanchita Roy, Sharmistha Guha, Samit Kumar Dutta, and Sanjay Bhar.
   Synthetic Communications 2006, 36, 1919-1922.
   Preparation of Aryl-Substituted E-Homoallylic Bromides from Cyclopropylcarbinol and PBr₃.
2. Tushar Kanti Chakraborty, Sandip P. Udawant, Saumya Roy, Bajjuri Krishna Mohan, Kolla Srinivasa Rao, Samit Kumar Dutta, and Ajit Chand Kunwar.
   Tetrahedron Letters 2006, 47, 4631-4634.
   Synthesis and characterization of Boc-protected 4-amino- and 5-amino-pyrrole-2-carboxylic acid methyl esters.
3. Tushar K. Chakraborty, Saumya Roy, Dipankar Koley, Samit Kumar Dutta, and A. C. Kunwar.
   Journal of Organic Chemistry 2006, 71, 6240-6243.
   Conformational Analysis of Some C₂-Symmetric Cyclic Peptides Containing Tetrahydrofuran Amino Acids.
4. Subhash Ghosh, J. Shashidhar, and Samit Kumar Dutta.
   Tetrahedron Letters 2006, 47, 6041-6044.
   A general strategy for the stereoselective synthesis of L-1-deoxyallonojirimycin and D-1-deoxygulonojirimycin.
5. Gowravaram Sabitha, Chittapragada Maruthi, Erigala Venkata Reddy, Chitti Srinivas, Jhillu S. Yadav, Samit K. Dutta, and Ajit C. Kunwar.
   Helvetica Chemica Acta 2006, 89, 2728-2731.
   Intramolecular Hetero-Diels-Alder Reactions Catalyzed by BiCl₃: Stereo-selective Synthesis of Benzo-Annelated Decahydrofuro[3,2-h][1,6] – naphthyridine Derivatives.
6. J.S. Yadav, Sipak Joyasawal, S.K. Dutta and A.C. Kunwar.
   Tetrahedron Letters 2007, 48, 5335-5340.
   Stereoselective synthesis of the ABCD ring framework of azaspiracids.
7. Subhash Ghosh, Chapala Nageswara Rao, Samit Kumar Dutta.
   Synlett 2007, 9, 1464-1466.
   Stereoselective Total Synthesis of (+)-Goniothalesdiol and (+)-2,5-epi-Goniothalesdiol from D-Mannitol.
8. G. V. M. Sharma, V. Manohar, Samit K. Dutta, V. Subash and Ajit C. Kunwar.
   Journal of Organic Chemistry 2008, 73, 3689-3698.
   Design of a ‘New Motif’ with β-Amino Acids and α-Aminoxy Acids: Synthesis of Hybrid Peptides with 12/10-Helix.
9. Gangavaram V. M. Sharma, Vennampalli Manohar, Samit Kumar Dutta, Bojja Sridhar, Venna Ramesh, Ragampeta Srinivas and Ajit Chand Kunwar.
   Journal of Organic Chemistry 2010, 75, 1087-1094.
   Self Assembling Cyclic Tetrapeptide from Alternating C-Linked Carbo-β-Amino Acid [(S)-β-Caa] and α-Aminoxy Acid [(R)-Ama]: A Selective Chloride Ion Receptor.
10. Tushar Kanti Chakraborty, N. V. Suresh Kumar, Saumya Roy, Samit Kumar Dutta, Ajit Chand Kunwar, Balasubramanian Sridhar, Harjinder Singh.
Journal of Physical Organic Chemistry, In press, doi: 10.1002/poc.1818.
Stereochemical Control in the Structures of Linear δ,α-Hybrid Tripeptides Containing Tetrahydrofuran Amino Acids.
11. G. V. M. Sharma, K. Srinivas Reddy, Samit K. Dutta, Subhash Velaparthi, Kongari Narasimulu and Ajit Chand Kunwar. 
Folding Propensities of b-Peptides: Induction of Helicity in Oligomers of b-hGly. (Communicated for publication)