Publications

(Last update: August 1, 2012)

J. Lenger, M. Schroeder, E. C. Ennemann, B. Mueller, C.-H. Wong, T. Noll, T. Dierks, S. R. Hanson, N. Sewald, "Evaluation of Sulfatase-Directed Quinone Methide Traps for Proteomics," Biooganic and Medicinal Chemistry, 2012, 20(2):622-627.
M.-H. Hsieh, J.-T. Hung, Y.-W. Liw, Y.-J. Lu, C.-H. Wong, A. L.Yu, P.-H. Liang, "Synthesis and Evaluation of Acyl-Chain- and Galactose-6''-Modified Analogues of a-GalCer for NKT Cell Activation," ChemBioChem, 2012, 13(11):1689-1697.
J. L. Price, E. K. Culyba, W. Chen, A. N.Murray, S. R. Hanson, C.-H. Wong, E. T. Powers, J. W. Kelly, "N-glycosylation of Enhanced Aromatic Sequons to Increase Glycoprotein Stability," Biopolymers, 2012, 98(3):195-211.
C.-Y. Huang, H.-W. Shih, L-Y. Lin, Y.-W. Tien, T.-J. R. Cheng, W.-C. Cheng, C.-H. Wong and C. Ma, "Crystal Structure of Staphylococcus aureus Transglycosylase in Complex with a Lipid II Analog and Elucidation of Peptidoglycan Synthesis Mechanism," Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(17):6496-6501.
S.-C. Hung, M. Zulueta, S.-Y. Lin, Y.-T. Lin, C.-J. Huang, C.-C. Wang, C.-C. Ku, Z.-H. Shi, C.-L. Chyan, D. Irene, L.-H. Lim, T.-I. Tsai, Y.-P. Hu, S. Arco, C.-H. Wong, "a-Glycosylation by D-Glucosamine-Derived Donors: Synthesis of Heparosan and Heparin Analogs that Interact with Mycobacterial Heparin-Binding Hemagglutinin," Journal of the American Chemical Society, 2012, 134(21):8988-8995.
Y. Hsu, X.-A. Lu, M. Zulueta, C.-M. Tsai, K.-I. Lin, S.-C. Hung, C.-H. Wong, "Acyl and Silyl Group Effects in Reactivity-based One-pot Glycosylation: Synthesis of Embryonic Stem Cell Surface Carbohydrates Lc4 and IV2Fuc-Lc4," Journal of the American Chemical Society, 2012, 134(10):4549-4552.
S.-H. Chen, D.-R. Hwang, G.-H. Chen, N.-S. Hsu, Y.-T. Wu, T.-L. Li, C.-H. Wong, "Engineering Transaldolase in Pichia stipitis to Improve Bioethanol Production," Chemical Biology, 2012, 7(3):481-486.
D. Punyadarsaniya, C.-H. Liang, C. Winter, H. Petersen, S. Rautenschlein, I. Hennig-Pauka, C. Schwegmann-Wessels, C.-Y. Wu, C.-H. Wong, G. Herrler, "Infection of Differentiated Porcine Airway Epithelial Cells by Influenza Virus: Differential Susceptibility to Infection by Porcine and Avian Viruses," PLoS One, 2011, 6(12):e28429.
C.-H. Hsu, S.-C. Hung, C.-Y. Wu and C.-H. Wong, "Toward Automatic Oligosaccharide Synthesis," Angewandte Chemie, International Edition, 2011, 50(50):11872-11823.
R. Pejchal, K.J. Doores, L.M. Walker, R. Khayat, P.-S. Huang, S.-K. Wang, R.L. Stanfield, J.P. Julien, A. Ramos, M. Crispin, R. Depetris, U. Katpally, A. Marozsan, A. Cupo, S. Maloveste, Y. Liu, R. McBride, Y. Ito, R.W. Sanders, C. Ogohara, J.C. Paulson, T. Feizi, C.N. Scanlan, C.-H. Wong, J.P. Moore, W.C. Olson, A.B. Ward, P. Poignard, W.R. Schief, D.R. Burton, I.A. Wilson, "A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield," Science, 2011, 334(6059):1097-1003.
T.-N. Wu, K.-H. Lin, Y.-J. Chang, J.-R. Huang, J.-Y. Cheng, A. L. Yu, and C.-H. Wong, "Avidity of CD1d-ligand-receptor Ternary Complex Contributes to Th1 Polarization and Anticancer Efficacy," Proceedings of the National Academy of Sciences of the United States of America, 2011, 08(42):17275-17280.
C.-Y. Wu and C.-H. Wong, "Programmable One-Pot Glycosylation," in: Topics in Current Chemistry, Springer-Verlag, 2011, 301:223-252.
13. Y.-F. Shen, Y.-H. Chen, S.-Y. Chu, M.-I. Lin, H.-T. Hsu, P.-Y. Wu, C.-J. Wu, H.-W. Liu, F.-Y. Lin, G. Lin, P.-H. Hsu, A.-S. Yang, Y.-S. E. Cheng, Y.-T. Wu, C.-H. Wong and M.-D. Tsai, "The E339...R416 Salt Bridge of Nucleoprotein as a Feasible Target for Influenza Virus Inhibitors," Proceedings of the National Academy of Sciences of the United States of America, 2011, 108(40):16515-16520.
J.-J. Shie, J.-M. Fang, P.-T. Lai, W.-H. Wen, S.-Y. Wang, Y.-S. Cheng, K.-C. Tsai, A.-S. Yang, C.-H. Wong, "A Practical Synthesis of Zanamivir Phosphonate Congeners with Potent Anti-influenza Activity," Journal of the American Chemical Society, 2011, 133(44):17959-17965.
F.-C. Meng, K.-T. Chen, L.-Y. Huang, H.-W. Shih, H.-H. Chang, F.-Y. Nien, P.-H. Liang, T.-J. Cheng, C.-H. Wong, W.-C. Cheng, "Total Synthesis of Polyprenyl N-Glycolyl Lipid II as a Mycobacterial Transglycosylase Substrate," Organic Letters, 2011, 13(19):5306-5309.
L. M. Walker, M. Huber, K. J. Doores, E. Falkowska, R. Pejchal, J.-P. Julien, S.-K. Wang, P.-Y. Chan-Hui, P. W. Hammond, O. A. Olsen, A. Ramos, P. Phung, T. Wrin, M. D. Simek, S. Fling, C.-H. Wong, S. Phogat, W. C. Koff, I. A. Wilson, D. R. Burton, P. Poignard, "Broad Neutralization Coverage of HIV by Multiple Highly Potent Antibodies," Nature, 2011, 477(7365):466-470.
H.-L. Yen, C.-H. Liang, C.-Y. Wu, H. L. Forrest, A. Ferguson, K.T. Choy, J. Jones, D.D.Y. Wong, P.P.-H. Cheung, C.-H. Hsu, O.T. Li, K.M. Yuen, R.W.Y. Chan, L.L.M. Poon, M.C.W. Chan, J. Nicholls, S. Krauss, C.-H. Wong, Y. Guan, R.G. Webster, R.J. Webby & J.S.M. Peiris, "Hemagglutinin-neuraminidase Balance Confers Respiratory Droplet Transmissibility of the Pandemic H1N1 Influenza Virus in Ferrets," Proceedings of the National Academy of Sciences of the United States of America, 2011, 108(34):14264-14269.
Y. Kinjo, P. Illarionov, J. L. Vela, B. Pei, E. Girardi, X. Li, Y. Li, M. Imamura, Y. Kaneko, Y. Miyazaki, P. Rogers, S. Dahesh, S. Uchiyama, A. Khurana, K. Kawahara, H. Yesilkaya, P. W. Andrew, C.-H. Wong, K. Kawakami, V. Nizet, G. S. Besra, M. Tsuji, D. M. Zajonc, M. Kronenberg, "Invariant NKT Cells Recognize Glycolipids from Pathogenic Gram-positive Bacteria," Nature Immunology, 2011, 12(10):966-974.
K.-C. Chu, C.-T. Ren, C.-P. Lu, C.-H. Hsu, T.-H. Sun, T.-A. Chao, Y.-F. Lin, S.-H. Wu, C.-H. Wong and C.-Y. Wu, "Efficient and Stereoselective Synthesis of ?(2?9) Oligosialic Acids Up to Dodecamer," Angewandte Chemie, International Edition, 2011, 50(40):9391-9395.
J.-R. Chen, C. Ma, C.-H. Wong, "Vaccine design of hemagglutinin glycoprotein against influenza," Trends in Biotechnology, 2011, 29(9):426-434.
C.-Y. Wang, C.-Y. Wu, T.-J. Hung, C.-H. Wong, C.-H. Chen, "Sequence constructive SELEX for screening DNA aptamers binding to Globo H," Nucleic Acids Research, 2011, in press.
K.-C. Liu, P.-S. Lee, S.-Y. Wang, Y.-S. E. Cheng, J.-M. Fang and C.-H. Wong, "Intramolecular Ion-pair Prodrugs of Zanamivir and Guanidino-oseltamivir," Bioorganic and Medicinal Chemistry, 2011, 19(16):4796-4702.
H.-W. Shih, K.-T. Chen, T.-J. Cheng, C.-H. Wong, W.-C. Cheng, "A New Synthetic Approach toward Bacterial Transglycosylase Substrates, Lipid II and Lipid IV," Organic Letters, 2011, 13(17):4600-4603.
Y.-C. Liu, H.-Y. Yen, C.-Y. Chen, C.-H. Chen, P.-F. Cheng, Y.-H. Juan, C.-H. Chen, K.-H. Khoo, C.-J. Yu, P.-C. Yang, T.-L. Hsu, C.-H. Wong, "Sialylation and Fucosylation of Epidermal Growth Factor Receptor Suppress its Dimerization and Activation in Lung Cancer Cells," Proceedings of the National Academy of Sciences of the United States of America, 2011, 108(28):11332-11337.
R. Schmaltz, S. R. Hanson, C.-H. Wong, "Enzymes in the Synthesis of Glycoconjugates," Chemical Reviews, 2011, 111(7):4259-4207.
C.-Y. Wu, C.-H. Wong, "Chemistry and Glycobiology," Chemical Communications, 2011, 47(22):6201-6207.
C.-F. Chang, J.-F. Pan, C.-N. Lin, I.-L. Wu, C.-H. Wong, C.-H. Lin, "Rapid Characterization of Sugar-Binding Specificity by In-Solution Proximity Binding with Photosensitizers," Glycobiology, 2011, 21(7):895-902.
J.-W. Hsu, H.-C. Huang, S.-T. Chen, C.-H. Wong, H.-F. Juan, "Ganoderma lucidum polysaccharides induce macrophage-like differentiation in human leukemia THP-1 cells via caspase and p53 activation," Evidence Based Complementary & Alternative Medicine, Volume 2011, Article ID 358717, 13 pages, 2011.
C.-Y. Chou, T.-P. Ko, K.-J. Wu, K.-F. Huang, C.-H. Lin, C.-H. Wong, A. H.-J. Wang, "Modulation of Substrate Specificities of D-sialic Acid Aldolase through Single Mutations of Val251," Journal of Biological Chemistry, 2011, 286(16):14057-14064.
B.-L. Tsai, J.-L. Han, C.-T. Ren, C.-Y. Wu, C.-H. Wong, "Programmable One-Pot Synthesis of Tumor-Associated Carbohydrate Antigens Lewis X Dimer and KH-1 Epitopes," Tetrahedron Letters, 2011, 52(17), 2132-2135.
M.-W. Chen, H.-Y. Liao, T.-J. R. Cheng, C.-T. Ren, C.-Y. Wu, Y. Huang, D. D. Ho, C.-H. Wong, "Broadly Neutralizing DNA Vaccine with Site Specific Mutation Alters the Antigenicity and Sugar Binding Activities of Influenza Hemagglutinin," Proceedings of the National Academy of Sciences of the United States of America, 2011, 108(9):3510-3515.
E. K. Culyba, J. L. Price, S. R. Hanson, A. Dhar, C.-H. Wong, M. Gruebele, E. T. Powers, J. W. Kelly, "Protein Native-state Stabilization by Placing Aromatic Side Chains in N-glycosylated Reverse Turns," Science, 2011, 331(6017):571-575.
R.-T. Lee, T.-L. Hsu, S.-K. Huang, S.-L. Hsieh, C.-H. Wong, Y.-C. Lee, "Survey of Immune-related, Mannose/fucose-binding C-Type Lectin Receptors Reveals Widely Divergent Sugar-binding Specificities," 2011, Glycobiology, 21(4):512-520.
C.-H. Liang, S.-K. Wang, C.-W. Lin, C.-C. Wang, C.-H. Wong, C.-Y. Wu, "Effects of Neighboring Glycans on Antibody-Carbohydrate Interaction," Angewandte Chemie, International Edition, 2011, 50(7):1608-1612.
W.A. Greenberg, C.-H. Wong, "One-step Synthesis of L-fructose using Rhamnulose-1-phosphate Aldolase in Borate Buffer" in: From Practical Methods for Biocatalysis and Biotransformations, J. Whittall, P. Sutton, Eds., John Wiley & Sons, Inc., New York, NY, pp. 203-205, 2010.
J. C. Lewis, S. M. Mantovani, Y. Fu, C. D. Snow, R. S. Komor, C.-H. Wong, F. H. Arnold, "Combinatorial Alanine Substitution Enables Rapid Optimization of Cytochrome P450BM3 for Selective Hydroxylation of Large Substrates," ChemBioChem, 2010, 11(18):2502-2505.
W.-Y. Chen, W.-B. Yang, C.-H. Wong, D.T.-B. Shih, "Effect of Reishi Polysaccharides on Human Stem/Progenitor Cells," Biooganic and Medicinal Chemistry, 2010, 18(24):8583-8591.
T.-J. R. Cheng, Y.-T. Wu, S.-T. Yang, A. Loh, S.-K. Chen, Y.-H. Chen, W.-I. Huang, C.-H. Yuan, H.-W. Shih, Y.-S. E. Cheng, W.-C. Cheng, C.-H. Wong, "High-Throughput Identification of Antibacterials against Methichillin-Resistant Staphylococcus Aureus (MRSA) and the Transglycosylase," Biooganic and Medicinal Chemistry, 2010, 18(24):8512-8529.
M. Schelwies, D. Brinson, Y.-H. Hong, M. K. Lotz, C.-H. Wong, S. R. Hanson, "GlcN-6-sulfamate Heparan Analogs as Inhibitors of Endosulfatases," ChemBioChem, 2010, 11(17):2393-2397.
C.-Y. Su, T.-J. R. Cheng, M.-I. Lin, S.-Y. Wang, W.-I. Huang, S.-Y. Lin-Chua, Y.-H. Chen, C.-Y. Wu, M. M. C. Lai, W.-C. Cheng, Y.-T. Wu, M.-D. Tsai, Y.-S. E. Cheng, C.-H. Wong, "High-throughput Identification of Compounds Targeting Influenza RNA-dependent RNA Polymerase Activity," Proceedings of the National Academy of Sciences of the United States of America, 2010, 107(45):19151-19156.
H.-Y. Liao, C.-H. Hsu, S.-C. Wang, C.-H. Liang, H.-Y. Yen, C.-Y. Su, J.-T. Jan, C.-T. Ren, T.-J. Cheng, C.-Y. Wu, C.-H. Wong, "Differential Receptor Binding Affinities of Influenza Hemagglutinins on Glycan Arrays," Journal of the American Chemical Society, 2010, 132(42):14849-14856.
S.-H. Chang, J.-L. Han, Susan Y. Tseng, H.-Y. Lee, C.-W. Lin, Y.-C. Lin, W.-Y. Jeng, A. H.-J. Wang, C.-Y. Wu, C.-H. Wong, "Glycan Array on Aluminum Oxide Coated Glass Slides Through Phosphonate Chemistry," Journal of the American Chemical Society, 2010, 132(38):13371-13380.
K.-H. Lin, J.-J. Liang, W.-I. Huang, S.-Y. Lin-Chu, C.-Y. Su, Y.-L. Lee, J.-T. Jan, Y.-L. Lin, Y.-S. E. Cheng, C.-H. Wong, “In Vivo Protection of Bacterial and Viral Infections in Murine Models Using a Synthetic New ?-GalCer Analog,” Antimicrobial Agents and Chemotherapy, 2010, 54(10):4129-4136.
J.-J. Shie, C.-A. Chen, C.-C. Lin, A. F. Ku, T.-J. R. Cheng, J.-M. Fang, C.-H. Wong, “Regioselective Synthesis of Di-C-glycosylflavones Possessing Anti-Inflammation Activities,” Organic & Biomolecular Chemistry, 2010, 8(19):4451-4462.
X. Li, D. Wu, M. Fujio, M. Imamura, S. Vasan, C.-H. Wong, D. D. Ho, M. Tsuji, “Design of a Potent CD1d-binding NKT Cell Ligand as a Vaccine Adjuvant,” Proceedings of the National Academy of Sciences of the United States of America, 2010, 107(29):13010-13015.
C.-S. Tsai, P.-Y. Liu, H.-Y. Yen, T.-L. Hsu, C.-H. Wong, “Development of Trifunctional Probes for Glycoproteomic Analysis,” Chemical Communications, 2010, 46(30):5575-5577.
S. Otsuki, S. Hanson, S. Miyaki, S. Grogan, M. Kinoshita, H. Asahara, C.-H. Wong, M. Lotz, “Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways,” Proceedings of the National Academy of Sciences of the United States of America, 2010, 107(22):10202-10207.
W.-H. Wen, S.-Y. Wang, K.-C. Ysai, Y.-S. E. Cheng, A.-S. Yang, J.-M. Fang, C.-H. Wong, “Analogues of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses,” Bioorganic & Medicinal Chemistry, 2010, 18:4074–4084.
H.-W. Shih, K.-T. Chen, S.-K. Chen, C.-Y. Huang, T.-J. Cheng, C. Ma, C.-H. Wong, W.-C. Cheng, “Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors,” Organic & Biomolecular Chemistry, 2010, 8(11):2586-93.
R. D. Astronomo, E. Kaltgrad, A. K. Udit, S.-K. Wang, R. Pantophlet, C.-Y. Huang, J. C. Paulson, C.-H. Wong, M.G. Finn, D. R. Burton, “Defining Criteria For Oligomannose Immunogens for HIV Using Icosahedral Virus Capsid Scaffolds,” Chemistry & Biology, 2010, 17(4):357-70.
C.-C. Chang, A. F. Ku, Y.-Y. Tseng, W.-B. Yang, J.-M. Fang, C.-H. Wong, “6,8-Di-C-glycosyl flavonoids from Dendrobium huoshanense,” The Journal of Natural Products, 2010, 73(2):229-32.
C.-Y. Liu, C.-W. Guo, Y.-F. Chang, J.-T. Wang, H.-W. Shih, Y.-F. Hsu, C.-W. Chen, S.-K. Chen, Y.-C. Wang, T.-J. Cheng, C. Ma, C.-H. Wong, J.-M. Fang, W.-C. Cheng, “Synthesis and evaluation of a new fluorescent transglycosylase substrate: lipid II-based molecule possessing a dansyl-C20 polyprenyl moiety,” Organic Letters, 2010, 12(7):1608-11.
C.-H. Hsu, K.-C. Chu, Y.-S. Lin, J.-L. Han, Y.-S. Peng, C.-T. Ren, C.-Y. Wu, C.-H. Wong, “Highly Alpha-Selective Sialyl Phosphate Donors for Efficient Preparation of Natural Sialosides,” Chemistry–A European Journal, 2010, 16(6):1754-1760.
R. J. Payne and C.-H. Wong, “Advances in Chemical Ligation Strategies for the Synthesis of Glycopeptides and Glycoproteins,” Chemical Communications, 2010, 46:21-43.
J.-W. Hsu, H.-C. Huang, S.-T. Chen, C.-H. Wong, H.-F. Juan, “Ganoderma lucidum polysaccharides induce macrophage-like differentiation in human leukemia THP-1 cells via caspase and p53 activation,” Evidence Based Complementary and Alternative Medicine, 2010, in press.
T.-L. Hsu, S.-C. Cheng, W.-B. Yang, S.-W. Chin, B.-H. Chen, M.-T. Huang, S.-L. Hsieh, C.-H. Wong, “Profiling Carbohydrate-Receptor Interaction with Recombinant Innate Immunity Receptor-Fc Fusion Proteins,” The Journal of Biological Chemistry, 2009, 284(50):34479-34489.
M.-H. Chuang, S.-H. Chiou, C.-H. Huang, W.-B. Yang and C.-H. Wong, “The lifespan-promoting effect of acetic acid and Reishi polysaccharide,” Bioorganic & Medicinal Chemistry, 2009, 17(22):7831-7840.
Schiefner, M. Fujio, D. Wu, C.-H. Wong and I. A. Wilson, “Structural Evaluation of Potent NKT Cell Agonists: Implications for Design of Novel Stimulatory Ligands,” The Journal of Molecular Biology, 2009, 394(1):71-82.
C.-C. Wang, J.-R. Chen, Y.-C. Tseng, C.-H. Hsu, Y.-F. Hung, S.-W. Chen, C.-M. Chen, K.-H. Khoo, T.-J. Cheng, Y.-S. E. Cheng, J.-T. Jan, C.-Y. Wu, C. Ma, and C.-H. Wong, “Glycans on influenza hemagglutinin affect receptor binding and immune response,” Proceedings of the National Academy of Sciences of the United States of America, 2009, 106(43):18137-18142.
J. C. Lewis, S. Bastian, C. S. Bennett, Y. Fu, Y. Mitsuda, M. M. Chen, W. A. Greenberg, C.-H. Wong, and F. H. Arnold, “Chemoenzymatic Elaboration of Monosaccharides Using Engineered Cytochrome P450BM3 Demethylases,” Proceedings of the National Academy of Sciences of the United States of America, 2009, 106(39):16550-16555.
C.-H. Liang, C.-C. Wang, Y.-C. Lin, C.-H. Chen, C.-H. Wong, C.-Y. Wu, “Iron Oxide/Gold Core/Shell Nanoparticles for Ultrasensitive Detection of Carbohydrate-Protein Interactions,” Analytical Chemistry, 2009, 81(18), 7750-775.
J. C. Lewis, S. Bastian, C. S. Bennett, Y. Fu, Y. Mitsuda, M. M. Chen, W. A. Greenberg, C.-H. Wong, F. H. Arnold, “Chemoenzymatic Elaboration of Monosaccharides Using Engineered Cytochrome P450BM3 Demethylases,”Proceedings of the National Academy of Sciences of the United States of America, 2009, 106(39), 16550-16555.
C.-H. Wong, “Enzymes for Glycoprotein Synthesis,” CHIMA, 2009, 63(6), 318-326.
W.-H. Wen, M. Lin, C.-Y. Su, S.-Y. Wang, Y.-S. E. Cheng, J.-M. Fang and C.-H. Wong, “Synergistic Effect of Zanamivir–Porphyrin Conjugates on Inhibition of Neuraminidase and Inactivation of Influenza Virus," Journal of Medicinal Chemistry 2009, 52(15), 4903-4910.
L. Motiei, S. Rahimipour, D. A. Thayer, C.-H. Wong, M. R. Ghadiri, “Antibacterial cyclic D,L-alpha-glycopeptides,” Chemical Communications, 2009, 7(25), 3693-3695.
Z. Hong, L. Liu, M. Sugiyama, Y. Fu, C.-H. Wong, “Concise Synthesis of Iminocyclitois via Petasis-type Aminocyclization,” Journal of the American Chemical Society, 2009, 131 (24), 8352–8353.
M.-T. Sung, Y.-T. Lai, C.-Y. Huang, L.-Y. Chou, H.-W. Shih, W.-C. Cheng, C.-H. Wong, C. Ma, “Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli,” Proceedings of the National Academy of Sciences of the United States of America 2009, 106(22), 8824-8829.
C.-Y. Wu, P.-H. Liang and C.-H. Wong, “New development of glycan arrays,” Organic & Biomolecular Chemistry, 2009, 7(11), 2247-2254.
S. R. Hanson, E. K. Culyba, T. L. Hsu, C.-H. Wong, J. W. Kelly, E. T. Powers, “The Core Trisaccharide of an N-linked Glycoprotein Intrinsically Accelerates Folding and Enhances Stability,” Proceedings of the National Academy of Sciences of the United States of America, 2009, 106(9), 3131-3136.
S.-Y. Wang, C.-Y. Su, M. Lin, S.-Y. Huang, W.-I. Huang, C.-C. Wang, Y.-T. Wu, T.-J. R. Cheng, H.-M. Yu, C.-T. Ren, C.-Y. Wu, C.-H. Wong, Y.-S. E. Cheng, “HA-pseudotyped retroviral vectors for influenza antagonist screening,” Journal of Biomolecular Screening, 2009, 14(3), 294-302.
E. Tupin, M. R.-E.-I. Benhnia, Y. Kinjo, R. Patsey, C. Lena, M. Haller, M. J. Caimano, M. Imamura, C.-H. Wong, S. Crotty, J. D. Radolf, T. J. Sellati, M. Kronenberg, “NKT cells prevent chronic joint inflammation following infection with Borrelia burgdorferi,” Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(50), 19863-19868.
C. S. Bennett, R. J. Payne, K. M. Koeller, C.-H. Wong, “Synthesis and Applications of Biologically Relevant Glycopeptides,” in Glycoscience (B. Fraser-Reid, K. Tatsuta, J. Thiem, eds.), Springer-Verlag, pp.1795-1858, 2008.
M. J. Giffin, H. Heaslet, A. Brik, Y.-C. Lin, G. Cauvi, C.-H.Wong, D. E. McRee, J. H. Elder, C. D. Stout, B. E. Torbett, “A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant,”Journal of Medicinal Chemistry, 2008, 51(20), 6263-6270.
M.-L. Chen, A. K. Adak, N.-C. Yeh, W.-B. Yang, Y.-J. Chuang, C.-H. Wong, K.-C. Hwang, J.-R. R. Hwu, S.-L. Hsieh, C.-C. Lin, “Fabrication of an Oriented Fc-Fused Lectin Microarray through Boronate Formation,” Angewandte Chemie, International Edition, 2008, 47(45), 8627-8630.
M. W. Chen, T.-J. R. Cheng, Y. Huang, J.-T. Jan, S.-H. Ma, A. L.Yu, C.-H. Wong, D. D. Ho, “A Consensus-Hemagglutinin-Based DNA Vaccine that Protects Mice Against Divergent H5N1 Influenza Viruses,” Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(36), 13538-13543.
C.-S. Shi, G.-Y. Shi, S.-M. Hsiao, Y.-C. Kao, K.-L. Kuo, C.-Y. Ma, C.-H. Kuo, B.-I. Chang, C.-F. Chang, C.-H. Lin, C.-H. Wong, H.-L. Wu, “Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response," Blood, 2008, 112(9), 3661-3670.
S. Y. Tseng, C. C. Wang, C.-W. Lin, C.-L. Chen, W.-Y. Yu, C.-H. Chen, C.-Y. Wu, C.-H. Wong, “Glycan Arrays on Aluminum Coated Glass Slides,” Chemistry--An Asian Journal, 2008, 3(8), 1395-1405.
C. Bennett, S. Dean, R. Payne, S. Ficht, A. Brik, C.-H. Wong, “Sugar-assisted Glycopeptide Ligation with Complex Oligosaccharides: Scope and Limitations,”Journal of the American Chemical Society, 2008, 130(36), 11945-11952.
P.-H. Liang, M. Imamura, X. Li, D. Wu, M. Fujio, R. Guy, B.-C. Wu, M. Tsuji, C.-H. Wong, “Quantitative Microarray Analysis of Intact Glycolipid-CD1d Interaction and Correlation with Cell-based Cytokine Production,” Journal of the American Chemical Society, 2008, 130(37), 12348-12354.
J.-J. Shie, J.-M. Fang, C.-H. Wong, “A Concise and Flexible Synthesis of the Potent Anti-Influenza Agents – Tamiflu and Tamiphosphor,” Angewandte Chemie, International Edition, 2008, 47(31), 5788-5791.
C.-Y. Su, S.-Y. Wang, J.-J. Shie, K.-S. Jeng, N. J. Temperton, J.-M. Fang, C.-H. Wong, Y.-S.E. Cheng, “In vitro evaluation of neuraminidase inhibitors using the neuraminidase-dependent release assay of hemagglutinin-pseudotyped viruses,” Antiviral Research, 2008, 79(3), 199-205.
W.-W. Chang, C. H. Lee, P. Lee, J. Lin, C.-W. Hsu, J.-T. Hung, J.-J. Lin, J.-C. Yu, L. E. Shao, J. Yu, C.-H. Wong, A. L. Yu, “Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 & 2 in Globo H synthesis,” Proceedings of the National Academy of Sciences of the United States of America, 2008, 105, 11667-11672.
C.-C. Wang, Y.-L. Huang, C.-T. Ren, C.-W. Lin, J.-T. Hung, J.-C. Yu, A. Yu, C.-Y. Wu, C.-H. Wong, “Glycan Microarray of Globo H and Related Structures for Quantitative Analysis of Breast Cancer,” Proceedings of the National Academy of Sciences of the United States of America, 2008, 105, 11661-11666.
Y. Kinjo, B. Pei, S. Bufali, R. Raju, S. K. Richardson, M. Imamura, M. Fujio, D. Wu, A. Khurana, K. Kawahara, C.-H. Wong, A. R. Howell, P. H. Seeberger, M. Kronenberg, “Natural Sphingomonas Glycolipids Vary Greatly in their Ability to Activate Natural Killer T Cells,” Chemical Biology, 2008, 15(7), 654-664.
Y. S.-Y. Hsieh, C. Chien, S. K.-S. Liao, S.-F. Liao, W.-T. Hung, W.-B. Yang, C.-C. Lin, T.-J. R. Cheng, C.-C. Chang, J.-M. Fang, C.-H. Wong, “Structure and Bioactivity of the Polysaccharides in Medicinal Plant Dendrobium huoshanense,”Bioorganic & Medicinal Chemistry 2008, 16, 6054-6068.
R. D. Astronomo, H. K. Lee, C. N. Scanlan, R. Pantophlet, C. Y. Huang, I. A. Wilson, O. Blixt, R. A. Dwek, C.-H. Wong, D. R. Burton,“A glycoconjugate antigen based on the recognition motif of a broadly-neutralising human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120,” Journal of Virology, 2008, 82, 6359-68.
N.-Y. Hsu, S.Y. Tseng, C.-Y. Wu, C.-T. Ren, Y.-C. Lee, C.-H. Wong, C.-H. Chen, “Desorption Ionization of Biomolecules on Metals,” Analytical Chemistry, 2008, 80, 5203-5210.
S.-T. Chen, Y.-L. Lin, M.-T. Huang, M.-F. Wu, S.-C. Cheng, H.-Y. Lei, C.-K. Lee, T.-W. Chiou, C.-H. Wong, S.-L. Hsieh, “CLEC5A is Critical for Dengue Virus-Induced Lethal Disease,” Nature, 2008, 453:672-6.
R. Payne, S. Ficht, W.A. Greenberg, C.-H. Wong, “Cysteine-Free Peptide and Glycopeptide Ligation by Direct Aminolysis,” Angewandte Chemie, International Edition, 2008, 47, 4411-4415.
Y.-M. Shao, W.-B. Yang, T.-H. Kuo, K.-C. Tsai, C.-H. Lin, A.-S. Yang, P.-H. Liang, C.-H. Wong, “Design, Synthesis, and Evaluation of Trifluoromethyl Ketones as Inhibitors of SARS-CoV 3CL Protease,” Bioorganic & Medicinal Chemistry, 2008, 16, 4652-4660.
S. Ficht, R. Payne, R. Guy, C.-H. Wong, “Solid-Phase Synthesis of Peptide- and Glycopeptide Thioesters via Side Chain Anchoring Strategies,”Chemistry--An Asian Journal, 2008, 14(12), 3620-3629.
P.-H. Liang, C.-Y. Wu, W. A. Greenberg, C.-H. Wong,“Glycan Arrays: Perspectives in Biological and Medical Applications,” Current Opinion in Chemical Biology, 2008, 12(1), 86-92.
S.-K. Wang, P.-H. Liang, R. Astronomo, T.-L. Hsu, S.-L. Hsieh, D. Burton, C.-H. Wong, “Targeting the Carbohydrates on HIV-1: Interaction of Oligomannose Dendrons with Human Monoclonal Antibody 2G12 and DC-SIGN,”Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(10), 3690-3695.
T. R. Northen, J.-C. Lee, L. Hoang, J. Raymond, D.-R. Hwang, S. M. Yannone, C.-H. Wong, G. Siuzdak, “A Nanostructure-Initiator Mass Spectrometry Based Enzyme Activity Assay,” Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(10), 3678-3683.
D. Wu, M. Fujio, C.-H. Wong, “Glycolipids as Immunostimulating Agents,”Bioorganic & Medicinal Chemistry 2008, 16, 1073–1083.
T.-J. R.Cheng, M.-T. Sung, H.-Y. Liao, Y.-F. Chang, C.-W. Chen, C.-Y.Huang, L.-Y. Chou, Y.-D. Wu, Y.-H. Chen, Y.-S. E. Cheng, C.-H. Wong, C. Ma, W-C Cheng, “Domain Requirement of Moenomycin Binding to Bi-functional Transglycosylases and its Application for High-Throughput Drug Discovery,” Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(2), 431-436.
S. R. Hanson, W.A. Greenberg, C.-H. Wong, “Probing Glycans with the Copper(I)-Catalyzed [3+2] Azide-Alkyne Cycloaddition,” QSAR Combinational Science, 2007, 26, 1243-1252.
K.-C. Cheng, H.-C. Huang, J.-H. Chen, J.-W. Hsu, H.-C. Cheng, C.-H. Ou, W.-B. Yang, S.-T. Chen, C.-H. Wong, H.-F. Juan, “Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction,”BMC, Genomics 2007, 8(1), 411.
M. Sugiyama, Z. Hong, P.-H. Liang, L.J. Whalen, W.A. Greenberg, C.-H. Wong, “D-Fructose-6-Phosphate Aldolase Catalyzed One-Pot Synthesis of Iminocyclitols,”Journal of the American Chemical Society, 2007, 129(47), 14811-14817.
R.J. Payne, S. Ficht, S. Tang, A. Brik, Y.-Y. Yang, D.A. Case, C.-H. Wong, “Extended Sugar-Assisted Ligations: Development, Scope and Applications,”Journal of the American Chemical Society, 2007, 129(44), 13527-13536.
T. Polat, C.-H. Wong, “Anomeric Reactivity-Based One-Pot Synthesis of Heparin-like Oligosaccharides,”Journal of the American Chemical Society, 2007, 129(42),12795-12800.
C. Casey, C.-H. Wong, “Partly Cloudy with a Chance of Showers,” Chemical Biology, 2007, 2(9), 573-576.
J.-J. Shie, J.-M. Fang, S.-Y. Wang, K.-C. Tsai, Y.S.E. Cheng, A.-S. Yang, S.-C. Hsiao, C.Y. Su, C.-H. Wong, “Synthesis of Tamiflu and its Phosphonate Congeners Possessing Potent Anti-Influenza Activity,”Journal of the American Chemical Society, 2007, 129(39), 11892-11893.
K.-F. Hua, H.-Y Hsu, L.K. Chao, S.-T. Chen, W.-B. Yang, J. Hsu, C.H. Wong, “Ganoderma Lucidum Polysaccharides Enhance CD14 Endocytosis of LPS and Promote TLR4 Signal Transduction of Cytokine Expression,” Journal of Cell Physiology, 2007, 212, 537-550.
Y.-M. Shao, W.-B. Yang, H.-P. Peng, M.-F. Hsu, K.-C. Tsai, T.-H. Kuo, A.-S. Yang, A.H.-J. Wang, P.-H. Liang, C.-H. Lin, C.-H. Wong, “Structure-Based Design and Synthesis of Highly Potent SARS-CoV 3CL Protease Inhibitors," ChemBioChem, 2007, 8(14), 1654-1657.
P.-H. Liang, S.-K. Wang, C.-H. Wong, “Quantification of Carbohydrate-Protein Interactions Using Glycan Microarrays: Determination of Surface and Solution Dissociation Constants,”Journal of the American Chemical Society, 2007, 129(36), 11177-11184.
M.-T. Wei, K.-F. Hua, J. Hsu, A. Karmenyan, K.-Y. Tseng, C.-H. Wong, H.-Y. Hsu, A. Chiou, “The Interaction of Lipopolysaccharide with Membrane Receptors on Macrophages Pretreated with Extract of Reishi Polysaccharides Measured by Optical Tweezers,” Optical Society of America, 2007, 15(17), 11020-11032.
E. Kaltgrad, S. Sen Gupta, S. Punna, C.-Y. Huang, A. Chang, C.-H. Wong, M.G. Finn, O. Blixt, “Anti-Carbohydrate Antibodies Elicited by Polyvalent Display on a Viral Scaffold,” ChemBioChem, 2007, 8(12), 1455-1462.
C.S. Bennett, C.-H. Wong, “Chemoenzymatic Approaches to Glycoprotein Synthesis,” Chemical Society Reviews, 2007, 36(8), 1227-1238.
S. Ficht, R.J. Payne, A. Brik, C.-H. Wong, “Second Generation Sugar-Assisted Ligation: An Effective New Method for the Synthesis of Cysteine-Containing Glycopeptides,” Angewandte Chemie, International Edition, 2007, 46(31), 5975-5979.
M. Sugiyama, Z-Y. Hong, W.A. Greenberg, C.-H. Wong, “In vivo selection for the directed evolution of L-rhamnulose aldolase from L-rhamnulose-1-phosphate aldolase (RhaD),”Bioorganic & Medicinal Chemistry, 2007, 15(17), 5905-5911.
S. M. Dean, W.A. Greenberg, C.-H. Wong “Recent Advances in Aldolase-catalyzed Asymmetric Synthesis,”Advanced Synthesis & Catalysis, 2007, 349, 1308-1320.
A. Brik, C.-H. Wong, “Sugar-Assisted Ligation for the Synthesis of Glycopeptides,”Chemistry--An Asian Journal, 2007, 13(20), 5670-5675.
Y.-J. Chang, J.-R. Huang, Y.-C. Tsai, J.-T. Hung, D. Wu, M. Fujio, C.-H. Wong, A. L. Yu, “Potent Immune-modulating and Anti-cancer Effects of Novel NKT Stimulatory Glycolipids,”Proceedings of the National Academy of Sciences of the United States of America, 2007, 104(25), 10299-10304.
Y.-Y. Yang, S. Ficht, A. Brik, C.-H. Wong, “Sugar-Assisted Ligation in Glycoprotein Synthesis,”Journal of the American Chemical Society, 2007, 129(24), 7690-7701.
N.-Y. Hsu, W.-B.Yang, C.-H. Wong, Y.-C. Lee, R.T. Lee, Y.-S. Wang, C.-H. Chen, “Matrix-assisted laser desorption/ionization mass spectrometry of polysaccharides with 20,40,60-trihydroxyacetophenone as matrix,” Rapid Communications in Mass Spectrometry, 2007, 21:2137-2146.
S.R. Hanson, T.L Hsu, E. Weerapana, K. Kishikawa, G.M. Simon, B.F. Cravatt, C.-H. Wong, “Tailored Glycoproteomics and Glycan Site Mapping Using Saccharide-Selective Bioorthogonal Probes,”Journal of the American Chemical Society, 2007, 129(23), 7266-7267.
M.-L. Michel, A.C. Keller, C. Paget, M. Fujio, F. Trottein, P.B. Savage, C.-H. Wong, E. Schneider, M. Dy, & M.C. Leite-de-Moraes, “Identification of an IL-17–producing NK1.1neg iNKT Cell Population Involved in Airway Neutrophilia,” Journal of Experimental Medicine, 2007, 204(5), 995-1001.
C.-H. Wong, W.A. Greenberg, “Asymmetric synthesis using Deoxyribose-5-phosphate Aldolase,” in Asymmetric Synthesis – The Essentials, M. Christmann, S. Brase, ed., Wiley-VCH Verlag GmbH & Co., KGaA, Germany, pp. 217-221, 2007.
T.-L. Hsu, S.R. Hanson, K. Kishikawa, S.-K. Wang, M. Sawa, C.-H. Wong, “Alkynyl Sugar Analogs for the Labeling and Visualization of Glycoconjugates in Cells,” Proceedings of the National Academy of Sciences of the United States of America 2007, 104(8), 2614-2619.
Yu, Z.; Sawkar, A. R.; Whalen, L. J.; Wong, C.-H.; Kelly, J. W., Isofagomine- and 2,5-Anhydro-2,5-imino-D-glucitol-Based Glucocerebrosidase Pharmacological Chaperones for Gaucher Disease Intervention. Journal of Medicinal Chemistry 2007, 50(1), 94-100.
Wu, D.; Zajonc, D. M.; Fujio, M.; Sullivan, B. A.; Kinjo, Y.; Kronenberg, M.; Wilson, I. A.; Wong, C.-H., Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d. Proceedings of the National Academy of Sciences of the United States of America 2006, 103(11), 3972-3977.
Wu, C.-Y.; King, K.-Y.; Kuo, C.-J.; Fang, J.-M.; Wu, Y.-T.; Ho, M.-Y.; Liao, C.-L.; Shie, J.-J.; Liang, P.-H.; Wong, C.-H., Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease. Chemistry & Biology (Cambridge, MA, United States) 2006, 13(3), 261-268.
Wong, C.-H., Reviews and Perspectives. Bioorganic & Medicinal Chemistry 2006, 14, (4), 1274-1276.
Whalem, L. J.; Wong, C.-H., Enzymes in organic synthesis: aldolase-mediated synthesis of iminocyclitols and novel heterocycles. Aldrichimica Acta 2006, 39, (3), 63-71.
Thayer, D. A.; Wong, C.-H., Vancomycin analogues containing monosaccharides exhibit improved antibiotic activity: a combined one-pot enzymatic Glycosylation and chemical diversification strategy. Chemistry--An Asian Journal 2006, 1, (3), 445-452.
Sawa, M.; Hsu, T.-L.; Itoh, T.; Sugiyama, M.; Hanson, S. R.; Vogt, P. K.; Wong, C.-H., Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo. Proceedings of the National Academy of Sciences of the United States of America 2006, 103, (33), 12371-12376.
Sanna, M. G.; Wang, S.-K.; Gonzalez-Cabrera, P. J.; Don, A.; Marsolais, D.; Matheu, M. P.; Wei, S. H.; Parker, I.; Jo, E.; Cheng, W.-C.; Cahalan, M. D.; Wong, C.-H.; Rosen, H., Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nature Chemical Biology 2006, 2, (8), 434-441.
Qiu, H.; Gabrielsen, A.; Agardh, H. E.; Wan, M.; Wetterholm, A.; Wong, C.-H.; Hedin, U.; Swedenborg, J.; Hansson, G. K.; Samuelsson, B.; Paulsson-Berne, G.; Haeggstroem, J. Z., Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability. Proceedings of the National Academy of Sciences of the United States of America 2006, 103, (21), 8161-8166.
Liu, L.; Hong, Z.-Y.; Wong, C.-H., "Convergent glycopeptide synthesis by traceless Staudinger ligation and enzymatic coupling," ChemBioChem 2006, 7, (3), 429-432.
Liu, L.; Bennett, C. S.; Wong, C.-H., "Advances in glycoprotein synthesis. Chemical Communications (Cambridge, United Kingdom) 2006, (1), 21-33.
Liu, H.; Wong, C.-H., Characterization of a transglycosylase domain of Streptococcus pneumoniae PBP1b. Bioorganic & Medicinal Chemistry 2006, 14, (21), 7187-7195.
Lin, Y.-C.; Brik, A.; de Parseval, A.; Tam, K.; Torbett Bruce, E.; Wong, C.-H.; Elder John, H., Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system. Journal of virology 2006, 80, (16), 7832-43.
Lin, Y.-C.; Brik, A.; de Parseval, A.; Tam, K.; Torbett, B. E.; Wong, C.-H.; Elder, J. H., Altered Gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system. Journal of Virology 2006, 80, (16), 7832-7843.
Lin, K.-I.; Kao, Y.-Y.; Kuo, H.-K.; Yang, W.-B.; Chou, A.; Lin, H.-H.; Yu, A. L.; Wong, C.-H., Reishi Polysaccharides Induce Immunoglobulin Production through the TLR4/TLR2-mediated Induction of Transcription Factor Blimp-1. Journal of Biological Chemistry 2006, 281, (34), 24111-24123.
Liang, P.-H.; Cheng, W.-C.; Lee, Y.-L.; Yu, H.-P.; Wu, Y.-T.; Lin, Y.-L.; Wong, C.-H., Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: New structures for antivirals and osteoarthritis. ChemBioChem 2006, 7, (1), 165-173.
Liang, F.-S.; Greenberg, W. A.; Hammond, J. A.; Hoffmann, J.; Head, S. R.; Wong, C.-H., Evaluation of RNA-binding specificity of aminoglycosides with DNA microarrays. Proceedings of the National Academy of Sciences of the United States of America 2006, 103, (33), 12311-12316.
Liang, F.-S.; Brik, A.; Lin, Y.-C.; Elder, J. H.; Wong, C.-H., Epoxide opening in water and screening in situ for rapid discovery of enzyme inhibitors in microtiter plates. Bioorganic & Medicinal Chemistry 2006, 14, (4), 1058-1062.
Lee, J.-C.; Wu, C.-Y.; Apon, J. V.; Siuzdak, G.; Wong, C.-H., Reactivity-based one-pot synthesis of the tumor-associated antigen N3 minor octasaccharide for the development of a photo-cleavable DIOS-MS sugar array. Angewandte Chemie, International Edition 2006, 45, (17), 2753-2757.
Kinjo, Y.; Tupin, E.; Wu, D.; Fujio, M.; Garcia-Navarro, R.; Benhnia, M. R.-E.-I.; Zajonc, D. M.; Ben-Menachem, G.; Ainge, G. D.; Painter, G. F.; Khurana, A.; Hoebe, K.; Behar, S. M.; Beutler, B.; Wilson, I. A.; Tsuji, M.; Sellati, T. J.; Wong, C.-H.; Kronenberg, M., Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nature Immunology 2006, 7, (9), 978-986.
Huang, K.-T.; Wu, B.-C.; Lin, C.-C.; Luo, S.-C.; Chen, C.; Wong, C.-H.; Lin, C.-C., Multi-enzyme one-pot strategy for the synthesis of sialyl Lewis X-containing PSGL-1 glycopeptide. Carbohydrate Research 2006, 341, (12), 2151-2155.
Huang, C.-Y.; Thayer, D. A.; Chang, A. Y.; Best, M. D.; Hoffmann, J.; Head, S.; Wong, C.-H., Carbohydrate microarray for profiling the antibodies interacting with Globo H tumor antigen. Proceedings of the National Academy of Sciences of the United States of America 2006, 103, (1), 15-20.
Hsu, H.-Y.; Hua, K.-F.; Su, Y.-C.; Chu, L.-C.; Su, S.-C.; Chiu, H.-W.; Wong, C.-H.; Chen, S.-T.; Shieh, C.-W.; Yang, S.-S.; Chen, Y.-M.; Chao, L. K., Alkali-Soluble Polysaccharides of Rhizoclonium riparium Alga Induce IL-1 Gene Expression via Protein Kinase Signaling Pathways. Journal of Agricultural and Food Chemistry 2006, 54, (10), 3558-3565.
Hong, Z.; Liu, L.; Hsu, C.-C.; Wong, C.-H., Three-step synthesis of sialic acids and derivatives. Angewandte Chemie, International Edition 2006, 45, (44), 7417-7421.
Hanson, S. R.; Whalen, L. J.; Wong, C.-H., Synthesis and evaluation of general mechanism-based inhibitors of sulfatases based on (difluoro)methyl phenyl sulfate and cyclic phenyl sulfamate motifs. Bioorganic & Medicinal Chemistry 2006, 14, (24), 8386-8395.
Fujio, M.; Wu, D.; Garcia-Navarro, R.; Ho, D. D.; Tsuji, M.; Wong, C.-H., Structure-Based Discovery of Glycolipids for CD1d-Mediated NKT Cell Activation: Tuning the Adjuvant versus Immunosuppression Activity. Journal of the American Chemical Society 2006, 128, (28), 9022-9023.
Chuang, M.-H.; Wu, M.-S.; Lo, W.-L.; Lin, J.-T.; Wong, C.-H.; Chiou, S.-H., The antioxidant protein alkylhydroperoxide reductase of Helicobacter pylori switches from a peroxide reductase to a molecular chaperone function. Proceedings of the National Academy of Sciences of the United States of America 2006, 103, (8), 2552-2557.
Cheng, Y.-S. E.; Lo, K.-H.; Hsu, H.-H.; Shao, Y.-M.; Yang, W.-B.; Lin, C.-H.; Wong, C.-H., Screening for HIV protease inhibitors by protection against activity-mediated cytotoxicity in Escherichia coli. Journal of Virological Methods 2006, 137, (1), 82-87.
Calarese, D.; Scanlan, C.; Lee, H.-K.; Rudd, P.; Wong, C.-H.; Dwek, R.; Burton, D.; Wilson, I. A., Toward a carbohydrate-based HIV-1 vaccine. ACS Symposium Series 2006, 932, (Carbohydrate Drug Design), 161-185, 4 plates.
Brik, A.; Yang, Y.-Y.; Ficht, S.; Wong, C.-H., Sugar-Assisted Glycopeptide Ligation. Journal of the American Chemical Society 2006, 128, (17), 5626-5627.
Brik, A.; Wu, C.-Y.; Wong, C.-H., Microtiter plate based chemistry and in situ screening: a useful approach for rapid inhibitor discovery. Organic & Biomolecular Chemistry 2006, 4, (8), 1446-1457.
Brik, A.; Ficht, S.; Yang, Y.-Y.; Bennett, C. S.; Wong, C.-H., Sugar-Assisted Ligation of N-Linked Glycopeptides with Broad Sequence Tolerance at the Ligation Junction. Journal of the American Chemical Society 2006, 128, (46), 15026-15033.
Brik, A.; Ficht, S.; Wong, C.-H., Strategies for the preparation of homogenous glycoproteins. Current Opinion in Chemical Biology 2006, 10, (6), 638-644.
Brigl, M.; Van den Elzen, P.; Chen, X.; Meyers, J. H.; Wu, D.; Wong, C.-H.; Reddington, F.; Illarianov, P. A.; Besra, G. S.; Brenner, M. B.; Gumperz, J. E., Conserved and Heterogeneous Lipid Antigen Specificities of CD1d-Restricted NKT Cell Receptors. Journal of Immunology 2006, 176, (6), 3625-3634.
Zajonc, D. M.; Maricic, I.; Wu, D.; Halder, R.; Roy, K.; Wong, C.-H.; Kumar, V.; Wilson, I. A., Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. Journal of Experimental Medicine 2005, 202, (11), 1517-1526.
Xing, G.-W.; Wu, D.; Poles, M. A.; Horowitz, A.; Tsuji, M.; Ho, D. D.; Wong, C.-H., Synthesis and human NKT cell stimulating properties of 3-O-sulfo-a/b-galactosylceramides. Bioorganic & Medicinal Chemistry 2005, 13, (8), 2907-2916.
Wu, D.; Xing, G.-W.; Poles, M. A.; Horowitz, A.; Kinjo, Y.; Sullivan, B.; Bodmer-Narkevitch, V.; Plettenburg, O.; Kronenberg, M.; Tsuji, M.; Ho, D. D.; Wong, C.-H., Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells. Proceedings of the National Academy of Sciences of the United States of America 2005, 102, (5), 1351-1356.
Wu, C.-Y.; Brik, A.; Wang, S.-K.; Chen, Y.-H.; Wong, C.-H., Tetrabutylammonium fluoride-mediated rapid alkylation reaction in microtiter plates for the discovery of enzyme inhibitors in situ. ChemBioChem 2005, 6, (12), 2176-2180.
Wong, C.-H.; Editor, Symposium-in-Print: Chemistry and Biology of Natural Products - Tetrahedron Prize for Creativity in Organic Chemistry 2004. (A Special Issue Dedicated to Professor Koji Nakanishi's Work from 28 August 2001 to September 2005.) [In: Bioorg. Med. Chem.; 2005, 13(17)]. 2005; p 350 pp.
Wong, C.-H., Protein glycosylation: New challenges and opportunities. Journal of Organic Chemistry 2005, 70, (11), 4219-4225.
Wong, C.-H., A wide range of strategies yields new enzymatic reactions and processes. Advanced Synthesis & Catalysis 2005, 347, (7+8), 901.
Wong, C.-H., Reviews and Perspectives. Bioorganic & Medicinal Chemistry 2005, 13, (15), 4789-4790.
Wei, S. H.; Rosen, H.; Matheu, M. P.; Sanna, M. G.; Wang, S.-K.; Jo, E.; Wong, C.-H.; Parker, I.; Cahalan, M. D., Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nature Immunology 2005, 6, (12), 1228-1235.
Tolbert, T. J.; Franke, D.; Wong, C.-H., A new strategy for glycoprotein synthesis: ligation of synthetic glycopeptides with truncated proteins expressed in E. coli as TEV protease cleavable fusion protein. Bioorganic & Medicinal Chemistry 2005, 13, (3), 909-915.
Thayer, D. A.; Yu, H. N.; Galan, M. C.; Wong, C.-H., A general strategy toward S-linked glycopeptides. Angewandte Chemie, International Edition 2005, 44, (29), 4596-4599.
Sinchaikul, S.; Pan, F.-M.; Cheng, C.-W.; Wong, C.-H.; Fang, J.-M.; Tseng, M.-J.; Chen, S.-T., Protein microarray using a-amino acids as metal tags on chips. Bioorganic & Medicinal Chemistry Letters 2005, 15, (5), 1413-1416.
Shie, J.-J.; Fang, J.-M.; Kuo, T.-H.; Kuo, C.-J.; Liang, P.-H.; Huang, H.-J.; Wu, Y.-T.; Jan, J.-T.; Cheng, Y.-S. E.; Wong, C.-H., Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic a,b-unsaturated esters. Bioorganic & Medicinal Chemistry 2005, 13, (17), 5240-5252.
Shie, J.-J.; Fang, J.-M.; Kuo, C.-J.; Kuo, T.-H.; Liang, P.-H.; Huang, H.-J.; Yang, W.-B.; Lin, C.-H.; Chen, J.-L.; Wu, Y.-T.; Wong, C.-H., Discovery of Potent Anilide Inhibitors against the Severe Acute Respiratory Syndrome 3CL Protease. Journal of Medicinal Chemistry 2005, 48, (13), 4469-4473.
Scanlan, C.; Calarese, D.; Lee, H.-K.; Blixt, O.; Wong, C.-H.; Wilson, I.; Burton, D.; Dwek, R.; Rudd, P., Antibody recognition of a carbohydrate epitope: a template for HIV vaccine design. Advances in experimental medicine and biology 2005, 564, 7-8.
Sawkar, A. R.; Adamski-Werner, S. L.; Cheng, W.-C.; Wong, C.-H.; Beutler, E.; Zimmer, K.-P.; Kelly, J. W., Gaucher Disease-Associated Glucocerebrosidases Show Mutation-Dependent Chemical Chaperoning Profiles. Chemistry & Biology (Cambridge, MA, United States) 2005, 12, (11), 1235-1244.
Nyffeler, P. T.; Duron, S. G.; Burkart, M. D.; Vincent, S. P.; Wong, C.-H., Selectfluor: Mechanistic insight and applications. Angewandte Chemie, International Edition 2005, 44, (2), 192-212.
Numa, M. M. D.; Lee, L. V.; Hsu, C.-C.; Bower, K. E.; Wong, C.-H., Identification of novel anthrax lethal factor inhibitors generated by combinatorial Pictet-Spengler reaction followed by screening in situ. ChemBioChem 2005, 6, (6), 1002-1006.
Mocharla, V. P.; Colasson, B.; Lee, L. V.; Roeper, S.; Sharpless, K. B.; Wong, C.-H.; Kolb, H. C., In situ click chemistry: Enzyme-generated inhibitors of carbonic anhydrase II. Angewandte Chemie, International Edition 2005, 44, (1), 116-120.
Kinjo, Y.; Wu, D.; Kim, G.; Xing, G.-W.; Poles, M. A.; Ho, D. D.; Tsuji, M.; Kawahara, K.; Wong, C.-H.; Kronenberg, M., Recognition of bacterial glycosphingolipids by natural killer T cells. Nature (London, United Kingdom) 2005, 434, (7032), 520-525.
Hsu, C.-C.; Hong, Z.; Wada, M.; Franke, D.; Wong, C.-H., Directed evolution of D-sialic acid aldolase to L-3-deoxy-manno-2-octulosonic acid (L-KDO) aldolase. Proceedings of the National Academy of Sciences of the United States of America 2005, 102, (26), 9122-9126.
Ganem, B.; Wasserman, H. H.; Wong, C.-H., Tetrahedron Prize for Creativity in Organic Chemistry. Bioorganic & Medicinal Chemistry 2005, 13, (17), 4983.
Fridman, M.; Belakhov, V.; Lee, L. V.; Liang, F.-S.; Wong, C.-H.; Baasov, T., Dual effect of synthetic amino-glycosides: Antibacterial activity against Bacillus anthracis and inhibition of anthrax lethal factor. Angewandte Chemie, International Edition 2005, 44, (3), 447-452.
Fan, G.-T.; Pan, Y.-s.; Lu, K.-C.; Cheng, Y.-P.; Lin, W.-C.; Lin, S.; Lin, C.-H.; Wong, C.-H.; Fang, J.-M.; Lin, C.-C., Synthesis of a-galactosyl ceramide and the related glycolipids for evaluation of their activities on mouse splenocytes. Tetrahedron 2005, 61, (7), 1855-1862.
Calarese, D. A.; Lee, H.-K.; Huang, C.-Y.; Best, M. D.; Astronomo, R. D.; Stanfield, R. L.; Katinger, H.; Burton, D. R.; Wong, C.-H.; Wilson, I. A., Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12. Proceedings of the National Academy of Sciences of the United States of America 2005, 102, (38), 13372-13377.
Brik, A.; Wu, C.-Y.; Best, M. D.; Wong, C.-H., Tetrabutylammonium fluoride-assisted rapid N9-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ. Bioorganic & Medicinal Chemistry 2005, 13, (15), 4622-4626.
Brik, A.; Alexandratos, J.; Lin, Y.-C.; Elder, J. H.; Olson, A. J.; Wlodawer, A.; Goodsell, D. S.; Wong, C.-H., 1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors. ChemBioChem 2005, 6, (7), 1167-1169.
Zhang, Z.; Gildersleeve, J.; Yang, Y.-Y.; Xu, R.; Loo, J. A.; Uryu, S.; Wong, C.-H.; Schultz, P. G., A new strategy for the synthesis of glycoproteins. Science (Washington, DC, United States) 2004, 303, (5656), 371-373.
Yu, H. N.; Furukawa, J.; Ikeda, T.; Wong, C.-H., Novel Efficient Routes to Heparin Monosaccharides and Disaccharides Achieved via Regio- and Stereoselective Glycosidation. Organic Letters 2004, 6, (5), 723-726.
Xu, R.; Hanson, S. R.; Zhang, Z.; Yang, Y.-Y.; Schultz, P. G.; Wong, C.-H., Site-specific incorporation of the mucin-type N-acetylgalactosamine-a-O-threonine into protein in Escherichia coli. Journal of the American Chemical Society 2004, 126, (48), 15654-15655.
Wu, C.-Y.; Jan, J.-T.; Ma, S.-H.; Kuo, C.-J.; Juan, H.-F.; Cheng, Y.-S. E.; Hsu, H.-H.; Huang, H.-C.; Wu, D.; Brik, A.; Liang, F.-S.; Liu, R.-S.; Fang, J.-M.; Chen, S.-T.; Liang, P.-H.; Wong, C.-H., Small molecules targeting severe acute respiratory syndrome human coronavirus. Proceedings of the National Academy of Sciences of the United States of America 2004, 101, (27), 10012-10017.
Tolbert, T. J.; Wong, C.-H., Conjugation of glycopeptide thioesters to expressed protein fragments: semisynthesis of glycosylated interleukin-2. Methods in Molecular Biology (Totowa, NJ, United States) 2004, 283, (Bioconjugation Protocols), 255-266.
Tolbert, T. J.; Wong, C.-H., Subtilisin-catalyzed glycopeptide condensation. Methods in Molecular Biology (Totowa, NJ, United States) 2004, 283, (Bioconjugation Protocols), 267-279.
Tolbert, T. J.; Wong, C.-H., Carbohydrate chains: enzymatic and chemical synthesis. Encyclopedia of Biological Chemistry 2004, 1, 307-313.
Nyffeler Paul, T.; Duron Sergio, G.; Burkart Michael, D.; Vincent Stephane, P.; Wong, C.-H., Selectfluor: mechanistic insight and applications. Angewandte Chemie (International ed. in English) 2004, 44, (2), 192-212.
Nyffeler Paul, T.; Boyle Nicholas, A.; Eltepu, L.; Wong, C.-H.; Eschenmoser, A.; Lerner Richard, A.; Wentworth, P., Jr., Dihydrogen trioxide (HOOOH) is generated during the thermal reaction between hydrogen peroxide and ozone. Angewandte Chemie (International ed. in English) 2004, 43, (35), 4656-9.
Noyori, R.; Buchwald, S.; Burk, M. J.; Jacobsen, E. N.; Kobayashi, S.; Pfaltz, A.; Wong, C.-H., Happy birthday. Advanced Synthesis & Catalysis 2004, 346, (7), 707.
Mocharla Vani, P.; Colasson, B.; Lee Lac, V.; Roper, S.; Sharpless, K. B.; Wong, C.-H.; Kolb Hartmuth, C., In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II. Angewandte Chemie (International ed. in English) 2004, 44, (1), 116-20.
Liu, J.; Numa, M. M. D.; Liu, H.; Huang, S.-J.; Sears, P.; Shikhman, A. R.; Wong, C.-H., Synthesis and high-throughput screening of N-acetyl-b-hexosaminidase inhibitor libraries targeting osteoarthritis. Journal of Organic Chemistry 2004, 69, (19), 6273-6283.
Liu, J.; Hsu, C.-C.; Wong, C.-H., Sequential aldol condensation catalyzed by DERA mutant Ser238Asp and a formal total synthesis of atorvastatin. Tetrahedron Letters 2004, 45, (11), 2439-2441.
Lin, H.; Thayer, D. A.; Wong, C.-H.; Walsh, C. T., Macrolactamization of Glycosylated Peptide Thioesters by the Thioesterase Domain of Tyrocidine Synthetase. Chemistry & Biology 2004, 11, (12), 1635-1642.
Liang, F.-S.; Wang, S.-K.; Nakatani, T.; Wong, C.-H., Targeting RNAs with tobramycin analogues. Angewandte Chemie, International Edition 2004, 43, (47), 6496-6500.
Lee, L. V.; Bower, K. E.; Liang, F.-S.; Shi, J.; Wu, D.; Sucheck, S. J.; Vogt, P. K.; Wong, C.-H., Inhibition of the Proteolytic Activity of Anthrax Lethal Factor by Aminoglycosides. Journal of the American Chemical Society 2004, 126, (15), 4774-4775.
Lee, H.-K.; Scalan, C. N.; Huang, C.-Y.; Chang, A. Y.; Calarese, D. A.; Dwek, R. A.; Rudd, P. M.; Burton, D. R.; Wilson, I. A.; Wong, C.-H., Reactivity-based one-pot synthesis of oligo-mannoses: Defining antigens recognized by 2G12, a broadly neutralizing anti-HIV-1 antibody. Angewandte Chemie, International Edition 2004, 43, (8), 1000-1003.
Klostermeier, D.; Sears, P.; Wong, C.-H.; Millar, D. P.; Williamson, J. R., A three-fluorophore FRET assay for high-throughput screening of small-molecule inhibitors of ribosome assembly. Nucleic Acids Research 2004, 32, (9), 2707-2715.
Hsu, H.-Y.; Hua, K.-F.; Lin, C.-C.; Lin, C.-H.; Hsu, J.; Wong, C.-H., Extract of Reishi Polysaccharides Induces Cytokine Expression via TLR4-Modulated Protein Kinase Signaling Pathways. Journal of Immunology 2004, 173, (10), 5989-5999.
Heine, A.; Luz, J. G.; Wong, C.-H.; Wilson, I. A., Analysis of the Class I Aldolase Binding Site Architecture Based on the Crystal Structure of 2-Deoxyribose-5-phosphate Aldolase at 0.99.ANG. Resolution. Journal of Molecular Biology 2004, 343, (4), 1019-1034.
Heck, M.-P.; Vincent, S. P.; Murray, B. W.; Bellamy, F.; Wong, C.-H.; Mioskowski, C., Cyclic Amidine Sugars as Transition-State Analogue Inhibitors of Glycosidases: Potent Competitive Inhibitors of Mannosidases. Journal of the American Chemical Society 2004, 126, (7), 1971-1979.
Hanson, S. R.; Best, M. D.; Wong, C.-H., Enzyme chemistry: Sulfatases: structure, mechanism, biological activity, inhibition, and synthetic utility. Angewandte Chemie, International Edition 2004, 43, (43), 5736-5763.
Hanson, S.; Best, M.; Bryan, M. C.; Wong, C.-H., Chemoenzymatic synthesis of oligosaccharides and glycoproteins. Trends in Biochemical Sciences 2004, 29, (12), 656-663.
Franke, D.; Hsu, C.-C.; Wong, C.-H., Directed evolution of aldolases. Methods in Enzymology 2004, 388, (Protein Engineering), 224-238.
Fazio, F.; Bryan, M. C.; Lee, H.-K.; Chang, A.; Wong, C.-H., Assembly of sugars on polystyrene plates: a new facile microarray fabrication technique. Tetrahedron Letters 2004, 45, (12), 2689-2692.
Duron, S. G.; Polat, T.; Wong, C.-H., N-(Phenylthio)-e-caprolactam: A New Promoter for the Activation of Thioglycosides. Organic Letters 2004, 6, (5), 839-841.
Chou, C.-H.; Wu, C.-S.; Chen, C.-H.; Lu, L.-D.; Kulkarni, S. S.; Wong, C.-H.; Hung, S.-C., Regioselective Glycosylation of Neamine Core: A Facile Entry to Kanamycin B Related Analogues. Organic Letters 2004, 6, (4), 585-588.
Chien, C. M.; Cheng, J.-L.; Chang, W.-T.; Tien, M.-H.; Tsao, C.-M.; Chang, Y.-H.; Chang, H.-Y.; Hsieh, J.-F.; Wong, C.-H.; Chen, S.-T., Polysaccharides of Ganoderma lucidum alter cell immunophenotypic expression and enhance CD56+ NK-cell cytotoxicity in cord blood. Bioorganic & Medicinal Chemistry 2004, 12, (21), 5603-5609.
Cheng, T.-J.; Brik, A.; Wong, C.-H.; Kan, C.-C., Model system for high-throughput screening of novel human immunodeficiency virus protease inhibitors in Escherichia coli. Antimicrobial Agents and Chemotherapy 2004, 48, (7), 2437-2447.
Cheng, C.-W.; Lin, K.-C.; Pan, F.-M.; Sinchaikul, S.; Wong, C.-H.; Su, W.-C.; Hsu, C.-H.; Chen, S.-T., Facile synthesis of metal-chelating peptides on chip for protein array. Bioorganic & Medicinal Chemistry Letters 2004, 14, (8), 1987-1990.
Chen, J.-H.; Chang, Y.-W.; Yao, C.-W.; Chiueh, T.-S.; Huang, S.-C.; Chien, K.-Y.; Chen, A.; Chang, F.-Y.; Wong, C.-H.; Chen, Y.-J., Plasma proteome of severe acute respiratory syndrome analyzed by two-dimensional gel electrophoresis and mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America 2004, 101, (49), 17039-17044.
Chen, H.-S.; Tsai, Y.-F.; Lin, S.; Lin, C.-C.; Khoo, K.-H.; Lin, C.-H.; Wong, C.-H., Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides. Bioorganic & Medicinal Chemistry 2004, 12, (21), 5595-5601.
Chapman, E.; Best, M. D.; Hanson, S. R.; Wong, C.-H., Sulfotransferases: Structure, mechanism, biological activity, inhibition, and synthetic utility. Angewandte Chemie, International Edition 2004, 43, (27), 3526-3548.
Chang, C.-F.; Ho, C.-W.; Wu, C.-Y.; Chao, T.-A.; Wong, C.-H.; Lin, C.-H., Discovery of Picomolar Slow Tight-Binding Inhibitors of a-Fucosidase. Chemistry & Biology 2004, 11, (11), 1595.
Bryan, M. C.; Wong, C.-H., Aminoglycoside array for the high-throughput analysis of small molecule-RNA interactions. Tetrahedron Letters 2004, 45, (18), 3639-3642.
Bryan, M. C.; Lee, L. V.; Wong, C.-H., High-throughput identification of fucosyltransferase inhibitors using carbohydrate microarrays. Bioorganic & Medicinal Chemistry Letters 2004, 14, (12), 3185-3188.
Bryan, M. C.; Fazio, F.; Lee, H.-K.; Huang, C.-Y.; Chang, A.; Best, M. D.; Calarese, D. A.; Blixt, O.; Paulson, J. C.; Burton, D.; Wilson, I. A.; Wong, C.-H., Covalent display of oligosaccharide arrays in microtiter plates. Journal of the American Chemical Society 2004, 126, (28), 8640-8641.
Blixt, O.; Head, S.; Mondala, T.; Scanlan, C.; Huflejt, M. E.; Alvarez, R.; Bryan, M. C.; Fazio, F.; Calarese, D.; Stevens, J.; Razi, N.; Stevens, D. J.; Skehel, J. J.; van Die, I.; Burton, D. R.; Wilson, I. A.; Cummings, R.; Bovin, N.; Wong, C.-H.; Paulson, J. C., Printed covalent glycan array for ligand profiling of diverse glycan binding proteins. Proceedings of the National Academy of Sciences of the United States of America 2004, 101, (49), 17033-17038.
Best, M. D.; Brik, A.; Chapman, E.; Lee, L. V.; Cheng, W.-C.; Wong, C.-H., Rapid discovery of potent sulfotransferase inhibitors by diversity-oriented reaction in microplates followed by in situ screening. ChemBioChem 2004, 5, (6), 811-819.
Agnelli, F.; Sucheck, S. J.; Marby, K. A.; Rabuka, D.; Yao, S.-L.; Sears, P. S.; Liang, F.-S.; Wong, C.-H., Dimeric aminoglycosides as antibiotics. Angewandte Chemie, International Edition 2004, 43, (12), 1562-1566.
Wu, C.-Y.; Chang, C.-F.; Chen, J. S.-Y.; Wong, C.-H.; Lin, C.-H., Rapid diversity-oriented synthesis in microtiter plates for in situ screening: Discovery of potent and selective a-fucosidase inhibitors. Angewandte Chemie, International Edition 2003, 42, (38), 4661-4664.
Wong, C.-H.; Liang, F.-S., Surface plasmon resonance study of RNA-aminoglycoside interactions. Methods in Enzymology 2003, 362, (Recognition of Carbohydrates in Biological Systems, Part A), 340-353.
Wong, C.-H.; Editor, Carbohydrate-Based Drug Discovery, Volume 2. 2003; p 947 pp.
Wong, C.-H.; Editor, Carbohydrate-Based Drug Discovery, Volume 1. 2003; p 459 pp.
Wong, C.-H.; Bryan, M. C.; Nyffeler, P. T.; Liu, H.; Chapman, E., Synthesis of carbohydrate-based antibiotics. Pure and Applied Chemistry 2003, 75, (2-3), 179-186.
Wong, C.-H.; Bryan, M. C., Sugar arrays in microtiter plates. Methods in Enzymology 2003, 362, (Recognition of Carbohydrates in Biological Systems, Part A), 218-225.
Wong, C.-H., Editorial. Bioorganic & Medicinal Chemistry 2003, 11, (1), 7.
Wong, C.-H., New developments in biocatalysis. Advanced Synthesis & Catalysis 2003, 345, (6+7), 651.
Wada, M.; Hsu, C.-C.; Franke, D.; Mitchell, M.; Heine, A.; Wilson, I.; Wong, C.-H., Directed evolution of N-acetylneuraminic acid aldolase to catalyze enantiomeric aldol reactions. Bioorganic & Medicinal Chemistry 2003, 11, (9), 2091-2098.
Silvestri, M. G.; Desantis, G.; Mitchell, M.; Wong, C.-H., Asymmetric aldol reactions using aldolases. Topics in Stereochemistry 2003, 23, 267-342.
Ritter, T. K.; Wong, C.-H., Carbohydrate-based drug discovery in the battle against bacterial infections: new opportunities arising from programmable one-pot oligosaccharide synthesis. Carbohydrate-Based Drug Discovery 2003, 2, 899-932.
Ritter, T. K.; Mong, K.-K. T.; Liu, H.; Nakatani, T.; Wong, C.-H., A programmable one-pot oligosaccharide synthesis for diversifying the sugar domains of natural products: A case study of vancomycin. Angewandte Chemie, International Edition 2003, 42, (38), 4657-4660.
Mong, T. K.-K.; Lee, H.-K.; Duron, S. G.; Wong, C.-H., Reactivity-based one-pot total synthesis of fucose GM1 oligosaccharide: A sialylated antigenic epitope of small-cell lung cancer. Proceedings of the National Academy of Sciences of the United States of America 2003, 100, (3), 797-802.
Mong, T. K. K.; Lee, L. V.; Brown, J. R.; Esko, J. D.; Wong, C.-H., Synthesis of N-acetyllactosamine derivatives with variation in the aglycon moiety for the study of inhibition of sialyl Lewisx expression. ChemBioChem 2003, 4, (9), 835-840.
Mong, T. K. K.; Huang, C.-Y.; Wong, C.-H., A New Reactivity-Based One-Pot Synthesis of N-Acetyllactosamine Oligomers. Journal of Organic Chemistry 2003, 68, (6), 2135-2142.
Mak, C. C.; Brik, A.; Lerner, D. L.; Elder, J. H.; Morris, G. M.; Olson, A. J.; Wong, C.-H., Design and synthesis of broad-based mono- and bi- cyclic inhibitors of FIV and HIV proteases. Bioorganic & Medicinal Chemistry 2003, 11, (9), 2025-2040.
Liu, H.; Wang, L.; Brock, A.; Wong, C.-H.; Schultz, P. G., A method for the generation of glycoprotein mimetics. Journal of the American Chemical Society 2003, 125, (7), 1702-1703.
Liu, H.; Ritter, T. K.; Sadamoto, R.; Sears, P. S.; Wu, M.; Wong, C.-H., Acceptor specificity and inhibition of the bacterial cell-wall glycosyltransferase MurG. ChemBioChem 2003, 4, (7), 603-609.
Lee, L. V.; Mitchell, M. L.; Huang, S.-J.; Fokin, V. V.; Sharpless, K. B.; Wong, C.-H., A Potent and Highly Selective Inhibitor of Human a-1,3-Fucosyltransferase via Click Chemistry. Journal of the American Chemical Society 2003, 125, (32), 9588-9589.
Franke, D.; Machajewski, T.; Hsu, C.-C.; Wong, C.-H., One-Pot Synthesis of L-Fructose Using Coupled Multienzyme Systems Based on Rhamnulose-1-phosphate Aldolase. Journal of Organic Chemistry 2003, 68, (17), 6828-6831.
Feizi, T.; Fazio, F.; Chai, W.; Wong, C.-H., Carbohydrate microarrays - a new set of technologies at the frontiers of glycomics. Current Opinion in Structural Biology 2003, 13, (5), 637-645.
Fazio, F.; Wong, C.-H., RuCl3-promoted amide formation from azides and thio-acids. Tetrahedron Letters 2003, 44, (51), 9083-9085.
DeSantis, G.; Liu, J.; Clark, D. P.; Heine, A.; Wilson, I. A.; Wong, C.-H., Structure-based mutagenesis approaches toward expanding the substrate specificity of D-2-Deoxyribose-5-phosphate aldolase. Bioorganic & Medicinal Chemistry 2003, 11, (1), 43-52.
Chapman, E.; Bryan, M. C.; Wong, C.-H., Mechanistic studies of b-arylsulfotransferase IV. Proceedings of the National Academy of Sciences of the United States of America 2003, 100, (3), 910-915.
Brik, A.; Wong, C.-H., HIV-1 protease: mechanism and drug discovery. Organic & Biomolecular Chemistry 2003, 1, (1), 5-14.
Brik, A.; Muldoon, J.; Lin, Y.-c.; Elder, J. H.; Goodsell, D. S.; Olson, A. J.; Fokin, V. V.; Sharpless, K. B.; Wong, C.-h., Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors. ChemBioChem 2003, 4, (11), 1246-1248.
Zhang, Z.; Wong, C.-H., Regioselective benzoylation of sugars mediated by excessive Bu2SnO: observation of temperature promoted migration. Tetrahedron 2002, 58, (32), 6513-6519.
Zhang, Z.; Niikura, K.; Huang, X.-F.; Wong, C.-H., A strategy for the one-pot synthesis of sialylated oligosaccharides. Canadian Journal of Chemistry 2002, 80, (8), 1051-1054.
Wong, C.-H., Hydrolysis and formation of glycosidic bonds. Enzyme Catalysis in Organic Synthesis (2nd Edition) 2002, 2, 609-653.
Wong, C.-H., Formation of C-C bonds. Enzyme Catalysis in Organic Synthesis (2nd Edition) 2002, 2, 931-974.
Wang, Y.-Y.; Khoo, K.-H.; Chen, S.-T.; Lin, C.-C.; Wong, C.-H.; Lin, C.-H., Studies on the immuno-Modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-Containing glycoprotein fraction responsible for the activities. Bioorganic & Medicinal Chemistry 2002, 10, (4), 1057-1062.
Tolbert, T. J.; Wong, C.-H., New methods for proteomic research: preparation of proteins with N-terminal cysteines for labeling and conjugation. Angewandte Chemie, International Edition 2002, 41, (12), 2171-2174.
Thunnissen, M. M. G. M.; Andersson, B.; Samuelsson, B.; Wong, C.-H.; Haeggstroem, J. Z., Crystal structures of leukotriene A4 hydrolase in complex with captopril and two competitive tight-binding inhibitors. FASEB Journal 2002, 16, (12), 1648-1650, 10 1096/fj 01-1017fje.
Sears, P.; Wong, C.-H., Strategies for creating the diversity of oligosaccharides. Handbook of Combinatorial Chemistry 2002, 2, 706-722.
Sawkar, A. R.; Cheng, W.-C.; Beutler, E.; Wong, C.-H.; Balch, W. E.; Kelly, J. W., Chemical chaperones increase the cellular activity of N370S b-glucosidase: a therapeutic strategy for Gaucher disease. Proceedings of the National Academy of Sciences of the United States of America 2002, 99, (24), 15428-15433.
Sadamoto, R.; Niikura, K.; Sears, P. S.; Liu, H.; Wong, C.-H.; Suksomcheep, A.; Tomita, F.; Monde, K.; Nishimura, S., Cell-wall engineering of living bacteria. Journal of the American Chemical Society 2002, 124, (31), 9018-9019.
Plettenburg, O.; Mui, C.; Bodmer-Narkevitch, V.; Wong, C.-H., Rapid preparation of glycolipid libraries by cross metathesis. Advanced Synthesis & Catalysis 2002, 344, (6+7), 622-626.
Plettenburg, O.; Bodmer-Narkevitch, V.; Wong, C.-H., Synthesis of a-Galactosyl Ceramide, a Potent Immunostimulatory Agent. Journal of Organic Chemistry 2002, 67, (13), 4559-4564.
Nyffeler, P. T.; Liang, C.-H.; Koeller, K. M.; Wong, C.-H., The Chemistry of Amine-Azide Interconversion: Catalytic Diazo transfer and Regioselective Azide Reduction. Journal of the American Chemical Society 2002, 124, (36), 10773-10778.
Mong, K.-K. T.; Wong, C.-H., Reactivity-based one-pot synthesis of a Lewis Y carbohydrate hapten: a colon-rectal cancer antigen determinant. Angewandte Chemie, International Edition 2002, 41, (21), 4087-4090.
Mitchell, M. L.; Tian, F.; Lee, L. V.; Wong, C.-H., Synthesis and evaluation of transition-state analogue inhibitors of a-1,3-fucosyltransferase. Angewandte Chemie, International Edition 2002, 41, (16), 3041-3044.
Mitchell, M. L.; Lee, L. V.; Wong, C.-H., Synthesis and evaluation of six-membered GDP-iminocyclitol. Tetrahedron Letters 2002, 43, (32), 5691-5693.
Liu, J.; Wong, C.-H., Aldolase-catalyzed asymmetric synthesis of novel pyranose synthons as a new entry to heterocycles and epothilones. Angewandte Chemie, International Edition 2002, 41, (8), 1404-1407.
Liu, J.; Wong, C.-H., Selectfluor-mediated allylstannation of aldehydes and imines. Tetrahedron Letters 2002, 43, (21), 3915-3917.
Liu, J.; Wong, C.-H., An efficient method for the cleavage of p-methoxybenzylidene (PMP), tetrahydropyranyl (THP) and 1,3-dithiane protecting groups by Selectfluor. Tetrahedron Letters 2002, 43, (22), 4037-4039.
Liu, J.; Huang, C.-Y.; Wong, C.-H., An efficient method for the preparation of 2-hydroxy- and 2-aminoglycals from glycosyl sulfoxides. Tetrahedron Letters 2002, 43, (18), 3447-3448.
Liu, J.; DeSantis, G.; Wong, C.-H., Structure-based rationalization of aldolase-catalyzed asymmetric synthesis. Canadian Journal of Chemistry 2002, 80, (6), 643-645.
Kanemitsu, T.; Wong, C.-H.; Kanie, O., Solid-Phase Synthesis of Oligosaccharides and On-Resin Quantitative Monitoring Using Gated Decoupling 13C NMR. Journal of the American Chemical Society 2002, 124, (14), 3591-3599.
Guo, C.-T.; Sun, X.-L.; Kanie, O.; Shortridge, K. F.; Suzuki, T.; Miyamoto, D.; Hidari, K. I. P. J.; Wong, C.-H.; Suzuki, Y., An O-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses. Glycobiology 2002, 12, (3), 183-190.
Fazio, F.; Bryan, M. C.; Blixt, O.; Paulson, J. C.; Wong, C.-H., Synthesis of Sugar Arrays in Microtiter Plate. Journal of the American Chemical Society 2002, 124, (48), 14397-14402.
Demura, M.; Noda, M.; Kajimoto, T.; Uchiyama, T.; Umemoto, K.; Wong, C.-H.; Asakura, T., Solution structure of sialyl Lewis X mimics studied by two-dimensional NMR. Journal of Molecular Structure 2002, 602-603, 215-222.
Chapman, E.; Wong, C.-H., A pH sensitive colorimetric assay for the high-throughput screening of enzyme inhibitors and substrates. A case study using kinases. Bioorganic & Medicinal Chemistry 2002, 10, (3), 551-555.
Chapman, E.; Ding, S.; Schultz, P. G.; Wong, C.-H., A Potent and Highly Selective Sulfotransferase Inhibitor. Journal of the American Chemical Society 2002, 124, (49), 14524-14525.
Bryan, M. C.; Plettenburg, O.; Sears, P.; Rabuka, D.; Wacowich-Sgarbi, S.; Wong, C.-H., Saccharide Display on Microtiter Plates. Chemistry & Biology 2002, 9, (6), 713-720.
Brik, A.; Lin, Y.-C.; Elder, J.; Wong, C.-H., A Quick Diversity-Oriented Amide-Forming Reaction to Optimize P-Subsite Residues of HIV Protease Inhibitors. Chemistry & Biology 2002, 9, (8), 891-896.
Yu, C.-S.; Niikura, K.; Lin, C.-C.; Wong, C.-H., The thioglycoside and glycosyl phosphite of 5-azido sialic acid: excellent donors for the a-glycosylation of primary hydroxy groups. Angewandte Chemie, International Edition 2001, 40, (15), 2900-2903.
Ye, X.-S.; Huang, X.; Wong, C.-H., Conversion of the carboxy group of sialic acid donors to a protected hydroxymethyl group yields an efficient reagent for the synthesis of the unnatural beta-linkage. Chemical Communications (Cambridge, United Kingdom) 2001, (11), 974-975.
Wong, C.-H., Programmed one-pot oligosaccharide synthesis. Abstracts of Papers, 221st ACS National Meeting, San Diego, CA, United States, April 1-5, 2001 2001, CARB-025.
Wong, C.-H., Editorial commentary. Advanced Synthesis & Catalysis 2001, 343, (6+7), 495.
Simanek, E. E.; Wong, C.-H., Carbohydrate libraries in solution using thioglycosides: from multistep synthesis to programmable, one-pot synthesis. Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries 2001, 213-238.
Silvestri, M. G.; Wong, C.-H., Opening of Thiiranes: Preparation of Orthogonal Protected 2-Thioglyceraldehyde. Journal of Organic Chemistry 2001, 66, (3), 910-914.
Sears, P.; Wong, C.-H., Toward automated synthesis of oligosaccharides and glycoproteins. Science (Washington, DC, United States) 2001, 291, (5512), 2344-2350.
Sears, P.; Tolbert, T.; Wong, C.-H., Enzymatic approaches to glycoprotein synthesis. Genetic Engineering (New York, NY, United States) 2001, 23, 45-68.
Saotome, C.; Wong, C.-H.; Kanie, O., Combinatorial library of five-membered iminocyclitol and the inhibitory activities against glyco-enzymes. Chemistry & Biology 2001, 8, (11), 1061-1070.
Ritter, T. K.; Wong, C.-H., Carbohydrate-based antibiotics: a new approach to tackling the problem of resistance. Angewandte Chemie, International Edition 2001, 40, (19), 3508-3533.
Mitchell, M.; Qaio, L.; Wong, C.-H., Chemical-enzymatic synthesis of iminocyclitol phosphonic acids. Advanced Synthesis & Catalysis 2001, 343, (6+7), 596-599.
Liu, H.; Sadamoto, R.; Sears, P. S.; Wong, C.-H., An Efficient Chemoenzymatic Strategy for the Synthesis of Wild-Type and Vancomycin-Resistant Bacterial Cell-Wall Precursors: UDP-N-acetylmuramyl-peptides. Journal of the American Chemical Society 2001, 123, (40), 9916-9917.
Kozlov, I. A.; Mao, S.; Xu, Y.; Huang, X.; Lee, L.; Sears, P. S.; Gao, C.; Coyle, A. R.; Janda, K. D.; Wong, C.-H., Synthesis of solid-supported mirror-image sugars: A novel method for selecting receptors for cellular-surface carbohydrates. ChemBioChem 2001, 2, (10), 741-746.
Koeller, K. M.; Wong, C.-H., Enzymes for chemical synthesis. Nature (London) 2001, 409, (6817), 232-240.
Koeller, K. M.; Wong, C.-H., Synthesis and applications of biologically relevant glycopeptides. Glycoscience 2001, 3, 2305-2352.
Izumi, M.; Wong, C.-H., Microbial sialyltransferases for carbohydrate synthesis. Trends in Glycoscience and Glycotechnology 2001, 13, (72), 345-360.
Izumi, M.; Shen, G.-J.; Wacowich-Sgarbi, S.; Nakatani, T.; Plettenburg, O.; Wong, C.-H., Microbial Glycosyltransferases for Carbohydrate Synthesis: a-2,3-Sialyltransferase from Neisseria gonorrheae. Journal of the American Chemical Society 2001, 123, (44), 10909-10918.
Huang, X.; Witte, K. L.; Bergbreiter, D. E.; Wong, C.-H., Homogenous enzymatic synthesis using a thermo-responsive water-soluble polymer support. Advanced Synthesis & Catalysis 2001, 343, (6+7), 675-681.
Heine, A.; DeSantis, G.; Luz, J. G.; Mitchell, M.; Wong, C.-H.; Wilson, I. A., Observation of covalent intermediates in an enzyme mechanism at atomic resolution. Science (Washington, DC, United States) 2001, 294, (5541), 369-374.
Heine, A.; DeSantis, G.; Luz, J. G.; Mitchell, M.; Wong, C.-H.; Wilson, I. A., Observation of covalent intermediates in an enzyme mechanism at atomic resolution. [Erratum to document cited in CA135:354605]. Science (Washington, DC, United States) 2001, 294, (5549), No pp given.
Burkhart, F.; Zhang, Z.; Wacowich-Sgarbi, S.; Wong, C.-H., Synthesis of the Globo H hexasaccharide using the programmable reactivity-based one-pot strategy. Angewandte Chemie, International Edition 2001, 40, (7), 1274-1277.
Buhler, B.; Lin, Y.-C.; Morris, G.; Olson, A. J.; Wong, C.-H.; Richman, D. D.; Elder, J. H.; Torbett, B. E., Viral evolution in response to the broad-based retroviral protease inhibitor TL-3. Journal of Virology 2001, 75, (19), 9502-9508.
Buchwald, S. L.; Burk, M. J.; Jacobsen, E. N.; Kobayashi, S.; Pfaltz, A.; Wong, C.-H., Nobel Prizes in chemistry 2001; congratulations from the Editors. Advanced Synthesis & Catalysis 2001, 343, (8), 755.
Zhang, Z.; Wong, C.-H., Glycosylation methods: use of phosphites. Carbohydrates in Chemistry and Biology 2000, 1, 117-134.
Ye, X.-S.; Wong, C.-H., Anomeric Reactivity-Based One-Pot Oligosaccharide Synthesis: A Rapid Route to Oligosaccharide Libraries. Journal of Organic Chemistry 2000, 65, (8), 2410-2431.
Wong, C.-H.; Koeller, K. M., Recycling of sugar nucleotides in enzymatic glycosylation. Carbohydrates in Chemistry and Biology 2000, 2, 663-684.
Wong, C.-H., Handbook of Enzyme Inhibitors. Part A/1+2, Part B/1+2. edited by Helmward Zollner. 2000; Vol. 39, p 1700.
Wong, C.-H., From sequence-specific RNA binders to bifunctional antibiotics. Abstracts of Papers, 220th ACS National Meeting, Washington, DC, United States, August 20-24, 2000 2000, MEDI-014.
Wittmann, V.; Datta, A. K.; Koeller, K. M.; Wong, C.-H., Chemoenzymatic synthesis and fluorescent visualization of cell-surface selectin-bound Sialyl Lewis X derivatives. Chemistry--A European Journal 2000, 6, (1), 162-171.
Vincent, S. P.; Schleyer, A.; Wong, C.-H., Asymmetric Strecker Synthesis of C-Glycopeptide. Journal of Organic Chemistry 2000, 65, (14), 4440-4443.
Tolbert, T. J.; Wong, C.-H., Intein-Mediated Synthesis of Proteins Containing Carbohydrates and Other Molecular Probes. Journal of the American Chemical Society 2000, 122, (23), 5421-5428.
Takayanagi, M.; Flessner, T.; Wong, C.-H., A Strategy for the Solution-Phase Parallel Synthesis of N-(Pyrrolidinylmethyl)hydroxamic Acids. Journal of Organic Chemistry 2000, 65, (12), 3811-3815.
Sun, X.-L.; Kanie, Y.; Guo, C.-T.; Kanie, O.; Suzuki, Y.; Wong, C.-H., Syntheses of C-3-modified sialyl-glycosides as selective inhibitors of influenza hemagglutinin and neuraminidase. European Journal of Organic Chemistry 2000, (14), 2643-2653.
Sucheck, S. J.; Wong, C.-H., RNA as a target for small molecules. Current Opinion in Chemical Biology 2000, 4, (6), 678-686.
Sucheck, S. J.; Wong, A. L.; Koeller, K. M.; Boehr, D. D.; Draker, K.-a.; Sears, P.; Wright, G. D.; Wong, C.-H., Design of Bifunctional Antibiotics that Target Bacterial rRNA and Inhibit Resistance-Causing Enzymes. Journal of the American Chemical Society 2000, 122, (21), 5230-5231.
Sucheck, S. J.; Greenberg, W. A.; Tolbert, T. J.; Wong, C.-H., Design of small molecules that recognize RNA: development of aminoglycosides as potential antitumor agents that target oncogenic RNA sequences. Angewandte Chemie, International Edition 2000, 39, (6), 1080-1084.
Shibata, K.; Hiruma, K.; Kanie, O.; Wong, C.-H., Synthesis of 1,1-Linked Galactosyl Mannosides Carrying a Thiazine Ring as Mimetics of Sialyl Lewis X Antigen: Investigation of the Effect of Carboxyl Group Orientation on P-Selectin Inhibition. Journal of Organic Chemistry 2000, 65, (8), 2393-2398.
Sheppard, T. L.; Wong, C.-H.; Joyce, G. F., Nucleoglycoconjugates: design and synthesis of a new class of DNA - carbohydrate conjugates. Angewandte Chemie, International Edition 2000, 39, (20), 3660-3663.
Romero, A.; Wong, C.-H., Chemo-Enzymatic Total Synthesis of 3-Epiaustraline, Australine, and 7-Epialexine. Journal of Organic Chemistry 2000, 65, (24), 8264-8268.
Nishide, K.; Shibata, K.; Fujita, T.; Kajimoto, T.; Wong, C.-H.; Node, M., An asymmetric total synthesis of a potent immunosuppressant, mycestericins D and F, through an aldol reaction using L-threonine aldolase. Heterocycles 2000, 52, (3), 1191-1201.
Machajewski, T. D.; Wong, C.-H.; Lerner, R. A., The catalytic asymmetric aldol reaction. Angewandte Chemie, International Edition 2000, 39, (8), 1352-1374.
Lin, Y.-C.; Beck, Z.; Lee, T.; Le, V.-D.; Morris, G. M.; Olson, A. J.; Wong, C.-H.; Elder, J. H., Alteration of substrate and inhibitor specificity of feline immunodeficiency virus protease. Journal of Virology 2000, 74, (10), 4710-4720.
Li, M.; Morris, G. M.; Lee, T.; Laco, G. S.; Wong, C.-H.; Olson, A. J.; Elder, J. H.; Wlodawer, A.; Gustchina, A., Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease. Proteins: Structure, Function, and Genetics 2000, 38, (1), 29-40.
Le, V.-D.; Wong, C.-H., Synthesis of 2-Substituted Polyhydroxytetrahydropyrimidines (N-Hydroxy Cyclic Guanidino-Sugars): Transition-State Mimics of Enzymatic Glycosidic Cleavage. Journal of Organic Chemistry 2000, 65, (8), 2399-2409.
Kreutter, K. D.; Wong, C.-H., Enzyme inhibitors. Stimulating Concepts in Chemistry 2000, 355-368.
Koeller, K. M.; Wong, C.-H., Chemoenzymatic synthesis of sialyl-trimeric-Lewis X. Chemistry--A European Journal 2000, 6, (7), 1243-1251.
Koeller, K. M.; Wong, C.-H., Emerging themes in medicinal glycoscience. Nature Biotechnology 2000, 18, (8), 835-841.
Koeller, K. M.; Wong, C.-H., Synthesis of Complex Carbohydrates and Glycoconjugates: Enzyme-Based and Programmable One-Pot Strategies. Chemical Reviews (Washington, D. C.) 2000, 100, (12), 4465-4493.
Koeller, K. M.; Wong, C.-H., Complex carbohydrate synthesis tools for glycobiologists: enzyme-based approach and programmable one-pot strategies. Glycobiology 2000, 10, (11), 1157-1169.
Koeller, K. M.; Smith, M. E. B.; Wong, C.-H., Tyrosine Sulfation on a PSGL-1 Glycopeptide Influences the Reactivity of Glycosyltransferases Responsible for Synthesis of the Attached O-Glycan. Journal of the American Chemical Society 2000, 122, (4), 742-743.
Koeller, K. M.; Smith, M. E. B.; Wong, C.-H., Chemoenzymatic synthesis of a tyrosine sulfated PSGL-1 glycopeptide. Abstracts of Papers, 220th ACS National Meeting, Washington, DC, United States, August 20-24, 2000 2000, ORGN-357.
Koeller, K. M.; Smith, M. E. B.; Huang, R.-F.; Wong, C.-H., Chemoenzymatic synthesis of a PSGL-1 N-terminal glycopeptide containing tyrosine sulfate and a-O-linked sialyl Lewis X. Journal of the American Chemical Society 2000, 122, (17), 4241-4242.
Kanie, O.; Grotenbreg, G.; Wong, C.-H., Removal of benzyl protecting groups from solid-supported compounds by hydrogenolysis using palladium nanoparticles. Angewandte Chemie, International Edition 2000, 39, (24), 4545-4547.
Fong, S.; Machajewski, T. D.; Mak, C. C.; Wong, C.-H., Directed evolution of D-2-keto-3-deoxy-6-phosphogluconate aldolase to new variants for the efficient synthesis of D- and L-sugars. Chemistry & Biology 2000, 7, (11), 873-883.
Flessner, T.; Wong, C.-H., Efficient synthesis of triazoles from D-arabinose and L-fucose. Tetrahedron Letters 2000, 41, (41), 7805-7808.
Burkart, M. D.; Izumi, M.; Chapman, E.; Lin, C.-H.; Wong, C.-H., Regeneration of PAPS for the Enzymatic Synthesis of Sulfated Oligosaccharides. Journal of Organic Chemistry 2000, 65, (18), 5565-5574.
Zhang, Z.; Ollmann, I. R.; Ye, X.-S.; Wischnat, R.; Baasov, T.; Wong, C.-H., Programmable One-Pot Oligosaccharide Synthesis. Journal of the American Chemical Society 1999, 121, (4), 734-753.
Zhang, X.; Rosenthal, P. B.; Formanowski, F.; Fitz, W.; Wong, C.-H.; Meier-Ewert, H.; Skehel, J. J.; Wiley, D. C., X-ray crystallographic determination of the structure of the influenza C virus haemagglutinin-esterase-fusion glycoprotein. Acta Crystallographica, Section D: Biological Crystallography 1999, D55, (5), 945-961.
Yuasa, H.; Hashimoto, H.; Abe, Y.; Kajimoto, T.; Wong, C.-H., Studies on the unusual stability of cis-2,5-diethoxy-2,5-bis(hydroxymethyl)-1,4-dioxane. Tetrahedron 1999, 55, (8), 2193-2204.
Wu, W.-g.; Pasternack, L.; Huang, D.-H.; Koeller, K. M.; Lin, C.-C.; Seitz, O.; Wong, C.-H., Structural study on O-glycopeptides: glycosylation-induced conformational changes of O-GlcNAc, O-LacNAc, O-Sialyl-LacNAc, and O-Sialyl-Lewis-X peptides of the Mucin domain of MAdCAM-1. Journal of the American Chemical Society 1999, 121, (11), 2409-2417.
Wong, C.-H., Mimics of Complex Carbohydrates Recognized by Receptors. Accounts of Chemical Research 1999, 32, (4), 376-385.
Wong, C.-H., Design and synthesis of carbohydrate mimetics: a new strategy for tackling the problem of carbohydrate-mediated biological recognition. Journal of the Chinese Chemical Society (Taipei) 1999, 46, (3), 271-281.
Weitz-Schmidt, G.; Gong, K. W.; Wong, C.-H., Selectin/Glycoconjugate Binding Assays for the Identification and Optimization of Selectin Antagonists. Analytical Biochemistry 1999, 273, (1), 81-88.
Vincent, S. P.; Burkart, M. D.; Tsai, C.-Y.; Zhang, Z.; Wong, C.-H., Electrophilic Fluorination-Nucleophilic Addition Reaction Mediated by Selectfluor: Mechanistic Studies and New Applications. Journal of Organic Chemistry 1999, 64, (14), 5264-5279.
Takebayashi, M.; Hiranuma, S.; Kanie, Y.; Kajimoto, T.; Kanie, O.; Wong, C.-H., A Versatile Synthetic Strategy for the Preparation and Discovery of New Iminocyclitols as Inhibitors of Glycosidases. Journal of Organic Chemistry 1999, 64, (14), 5280-5291.
Takayama, S.; Lee, S. T.; Hung, S.-C.; Wong, C.-H., Designing enzymic resolution of amines. Chemical Communications (Cambridge) 1999, (2), 127-128.
Takayama, S.; Chung, S. J.; Igarashi, Y.; Ichikawa, Y.; Sepp, A.; Lechler, R. I.; Wu, J.; Hayashi, T.; Siuzdak, G.; Wong, C.-H., Selective inhibition of b-1,4- and a-1,3-galactosyltransferases: donor sugar-nucleotide based approach. Bioorganic & Medicinal Chemistry 1999, 7, (2), 401-409.
Shen, G.-J.; Datta, A. K.; Izumi, M.; Koeller, K. M.; Wong, C.-H., Expression of a2,8/2,9-polysialyltransferase from Escherichia coli K92. Characterization of the enzyme and its reaction products. Journal of Biological Chemistry 1999, 274, (49), 35139-35146.
Sears, P.; Wong, C.-H., Carbohydrate mimetics: a new strategy for tackling the problem of carbohydrate-mediated biological recognition. Angewandte Chemie, International Edition 1999, 38, (16), 2301-2324.
Sears, P.; Witte, K.; Wong, C.-H., Synthesis of glycopeptides and glycoproteins. Collection Symposium Series 1999, 1, (Future Aspects in Peptide Chemistry), 211-216.
Mao, S.; Gao, C.; Lo, C.-H. L.; Wirsching, P.; Wong, C.-H.; Janda, K. D., Phage-display library selection of high-affinity human single-chain antibodies to tumor-associated carbohydrate antigens sialyl Lewisx and Lewisx. Proceedings of the National Academy of Sciences of the United States of America 1999, 96, (12), 6953-6958.
Machajewski, T. D.; Wong, C.-H., Chemoenzymic synthesis of key epothilone fragments. Synthesis 1999, (Spec. Iss.), 1469-1472.
Lin, C.-C.; Moris-Varas, F.; Weitz-Schmidt, G.; Wong, C.-H., Synthesis of sialyl Lewis x mimetics as selectin inhibitors by enzymic aldol condensation reactions. Bioorganic & Medicinal Chemistry 1999, 7, (3), 425-433.
Lee, T.; Le, V.-D.; Lim, D.; Lin, Y.-C.; Morris, G. M.; Wong, A. L.; Olson, A. J.; Elder, J. H.; Wong, C.-H., Development of a New Type of Protease Inhibitors, Efficacious against FIV and HIV Variants. Journal of the American Chemical Society 1999, 121, (6), 1145-1155.
Koeller, K. M.; Wong, C.-H., Synthesis of biologically active glycopeptides. Journal of the Chinese Chemical Society (Taipei) 1999, 46, (5), 659-685.
Kidd, R. D.; Sears, P.; Huang, D.-H.; Witte, K.; Wong, C.-H.; Farber, G. K., Breaking the low barrier hydrogen bond in a serine protease. Protein Science 1999, 8, (2), 410-417.
Kanemitsu, T.; Kanie, O.; Wong, C.-H., Quantitative monitoring of solid-phase synthesis using gated decoupling 13C NMR spectroscopy with a 13C-enriched protecting group and an internal standard in the synthesis of sialyl Lewisx tetrasaccharide. Angewandte Chemie, International Edition 1999, 37, (24), 3415-3418.
Huwe, C. M.; Woltering, T. J.; Jiricek, J.; Weitz-Schmidt, G.; Wong, C.-H., Design, synthesis and biological evaluation of aryl-substituted sialyl Lewis X mimetics prepared via cross-metathesis of C-fucopeptides. Bioorganic & Medicinal Chemistry 1999, 7, (5), 773-788.
Hiranuma, S.; Kanie, O.; Wong, C.-H., Formation of the 1,2,6-orthoester of mannose and its utilization in the glycosylation reaction. Tetrahedron Letters 1999, 40, (35), 6423-6426.
Hendrix, M.; Wong, C.-H., Enzymatic synthesis of carbohydrates. Bioorganic Chemistry: Carbohydrates 1999, 198-243, 569-575.
Greenberg, W. A.; Priestley, E. S.; Sears, P. S.; Alper, P. B.; Rosenbohm, C.; Hendrix, M.; Hung, S.-C.; Wong, C.-H., Design and Synthesis of New Amino Glycoside Antibiotics Containing Neamine as an Optimal Core Structure: Correlation of Antibiotic Activity with in Vitro Inhibition of Translation. Journal of the American Chemical Society 1999, 121, (28), 6527-6541.
Depre, D.; Duffels, A.; Green, L. G.; Lenz, R.; Ley, S. V.; Wong, C.-H., Synthesis of glycans from the glycodelins: two undeca-, two deca-, three nona-, an octa- and a heptasaccharide. Chemistry--A European Journal 1999, 5, (11), 3326-3340.
Burkart, M. D.; Wong, C.-H., A Continuous Assay for the Spectrophotometric Analysis of Sulfotransferases Using Aryl Sulfotransferase IV. Analytical Biochemistry 1999, 274, (1), 131-137.
Burkart, M. D.; Vincent, S. P.; Wong, C.-H., An efficient synthesis of CMP-3-fluoroneuraminic acid. Chemical Communications (Cambridge) 1999, (16), 1525-1526.
Burkart, M. D.; Izumi, M.; Wong, C.-H., Enzymatic regeneration of 3'-phosphoadenosine-5'-phosphosulfate using aryl sulfo-transferase for the preparative enzymatic synthesis of sulfated carbohydrates. Angewandte Chemie, International Edition 1999, 38, (18), 2747-2750.
Wong, C.-H.; Ye, X.-S.; Zhang, Z., Assembly of Oligosaccharide Libraries with a Designed Building Block and an Efficient Orthogonal Protection-Deprotection Strategy. Journal of the American Chemical Society 1998, 120, (28), 7137-7138.
Wong, C.-H.; Hendrix, M.; Priestley, E. S.; Greenberg, W. A., Specificity of aminoglycoside antibiotics for the A-site of the decoding region of ribosomal RNA. Chemistry & Biology 1998, 5, (7), 397-406.
Wong, C.-H.; Hendrix, M.; Manning, D. D.; Rosenbohm, C.; Greenberg, W. A., A Library Approach to the Discovery of Small Molecules That Recognize RNA: Use of a 1,3-Hydroxyamine Motif as Core. Journal of the American Chemical Society 1998, 120, (33), 8319-8327.
Wittmann, V.; Takayama, S.; Gong, K. W.; Weitz-Schmidt, G.; Wong, C.-H., Ligand Recognition by E- and P-Selectin: Chemoenzymic Synthesis and Inhibitory Activity of Bivalent Sialyl Lewis x Derivatives and Sialyl Lewis x Carboxylic Acids. Journal of Organic Chemistry 1998, 63, (15), 5137-5143.
Witte, K.; Skolnick, J.; Wong, C.-H., A Synthetic Retrotransition (Backward Reading) Sequence of the Right-Handed Three-Helix Bundle Domain (10-53) of Protein A Shows Similarity in Conformation as Predicted by Computation. Journal of the American Chemical Society 1998, 120, (50), 13042-13045.
Witte, K.; Seitz, O.; Wong, C.-H., Solution- and Solid-Phase Synthesis of N-Protected Glycopeptide Esters of the Benzyl Type as Substrates for Subtilisin-Catalyzed Glycopeptide Couplings. Journal of the American Chemical Society 1998, 120, (9), 1979-1989.
Wischnat, R.; Martin, R.; Wong, C.-H., Synthesis of a New Class of N-Linked Lewis and LacNAc Analogs as Potential Inhibitors of Human Fucosyltransferases: A General Method for the Incorporation of an Iminocyclitol as a Transition-State Mimetic of the Donor Sugar to the Acceptor. Journal of Organic Chemistry 1998, 63, (23), 8361-8365.
Wischnat, R.; Martin, R.; Takayama, S.; Wong, C.-H., Chemoenzymic synthesis of iminocyclitol derivatives: a useful library strategy for the development of selective fucosyltransfer enzymes inhibitors. Bioorganic & Medicinal Chemistry Letters 1998, 8, (23), 3353-3358.
Wasserman, H. H.; Wong, C.-H., Preface. Bioorganic & Medicinal Chemistry 1998, 6, (8), vii.
Wasserman, H. H.; Wong, C.-H., Tetrahedron Prize for Creativity in Organic Chemistry. [In: Bioorg. Med. Chem., 1998; 6(8)]. 1998; p 274 pp.
Vassilev, V. P.; Wood, M. R.; Wong, C.-H., Enzymic synthesis of a chiral gelator with remarkably low molecular weight. Chemical Communications (Cambridge) 1998, (17), 1865-1866.
Tsai, C.-Y.; Park, W. K. C.; Weitz-Schmidt, G.; Ernst, B.; Wong, C.-H., Synthesis of sialyl Lewis X mimetics using the Ugi four-component reaction. Bioorganic & Medicinal Chemistry Letters 1998, 8, (17), 2333-2338.
Simanek, E. E.; McGarvey, G. J.; Jablonowski, J. A.; Wong, C.-H., Selectin-Carbohydrate Interactions: From Natural Ligands to Designed Mimics. Chemical Reviews (Washington, D. C.) 1998, 98, (2), 833-862.
Simanek, E. E.; Huang, D.-H.; Pasternack, L.; Machajewski, T. D.; Seitz, O.; Millar, D. S.; Dyson, H. J.; Wong, C.-H., Glycosylation of Threonine of the Repeating Unit of RNA Polymerase II with b-Linked N-Acetylglucosamine Leads to a Turnlike Structure. Journal of the American Chemical Society 1998, 120, (45), 11567-11575.
Sears, P.; Wong, C.-H., Mechanism-based inhibition of carbohydrate-mediated biological recognitions. Chemical Communications (Cambridge) 1998, (11), 1161-1170.
Sears, P.; Witte, K.; Wong, C.-H., Chemo-enzymatic synthesis of carbohydrates and glycoconjugates. Synthesis and Applications of Isotopically Labelled Compounds 1997, Proceedings of the International Symposium, 6th, Philadelphia, PA, United States, Sept. 14-18, 1997 1998, 33-40.
Rosenthal, P. B.; Zhang, X.; Formanowski, F.; Fitz, W.; Wong, C.-H.; Meier-Ewert, H.; Skehel, J. J.; Wiley, D. C., Structure of the hemagglutinin-esterase-fusion glycoprotein of influenza C virus. Nature (London) 1998, 396, (6706), 92-96.
Miura, T.; Kajimoto, T.; Jimbo, M.; Yamagishi, K.; Inokuchi, J.-C.; Wong, C.-H., Synthesis and evaluation of morpholino- and pyrrolidinosphingolipids as inhibitors of glucosylceramide synthase. Bioorganic & Medicinal Chemistry 1998, 6, (9), 1481-1489.
Martin, R.; Witte, K. L.; Wong, C.-H., The synthesis and enzymic incorporation of sialic acid derivatives for use as tools to study the structure, activity, and inhibition of glycoproteins and other glycoconjugates. Bioorganic & Medicinal Chemistry 1998, 6, (8), 1283-1292.
Lee, T.; Laco, G. S.; Torbett, B. E.; Fox, H. S.; Lerner, D. L.; Elder, J. H.; Wong, C.-H., Analysis of the S3 and S3' subsite specificities of feline immunodeficiency virus (FIV) protease: development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo. Proceedings of the National Academy of Sciences of the United States of America 1998, 95, (3), 939-944.
Lampe, T. F. J.; Weitz-Schmidt, G.; Wong, C.-H., Parallel synthesis of sialyl Lewis X mimetics on a solid phase: access to a library of fucopeptides. Angewandte Chemie, International Edition 1998, 37, (12), 1707-1711.
Kanie, Y.; Kirsch, A.; Kanie, O.; Wong, C.-H., Enzymic assay of galactosyltransferase by capillary electrophoresis. Analytical Biochemistry 1998, 263, (2), 240-245.
Kamitakahara, H.; Suzuki, T.; Nishigori, N.; Suzuki, Y.; Kanie, O.; Wong, C.-H., A lysoganglioside/poly-L-glutamic acid conjugate as a picomolar inhibitor of influenza hemagglutinin. Angewandte Chemie, International Edition 1998, 37, (11), 1524-1528.
Jones, J. B.; Wong, C.-H., Biocatalysis and biotransformation exploiting nature's magic. Current Opinion in Chemical Biology 1998, 2, (1), 67-69.
Hogg, J. H.; Ollmann, I. R.; Wetterholm, A.; Blomster Andberg, M.; Haeggstrom, J.; Samuelsson, B.; Wong, C.-H., Probing the activities and mechanisms of leukotriene A4 hydrolase with synthetic inhibitors. Chemistry--A European Journal 1998, 4, (9), 1698-1713.
Hiruma, K.; Kanie, O.; Wong, C.-H., Synthesis of analogs of 1,1-linked galactosyl mannoside as mimetics of sialyl Lewis X tetrasaccharide. Tetrahedron 1998, 54, (52), 15781-15792.
Guo, C.-T.; Wong, C.-H.; Kajimoto, T.; Miura, T.; Ida, Y.; Juneja, L. R.; Kim, M.-J.; Masuda, H.; Suzuki, T.; Suzuki, Y., Synthetic sialylphosphatidylethanolamine derivatives bind to human influenza A viruses and inhibit viral infection. Glycoconjugate Journal 1998, 15, (11), 1099-1108.
Chung, S. J.; Takayama, S.; Wong, C.-H., Acceptor substrate-based selective inhibition of galactosyltransferases. Bioorganic & Medicinal Chemistry Letters 1998, 8, (23), 3359-3364.
Alper, P. B.; Hendrix, M.; Sears, P.; Wong, C.-H., Probing the Specificity of Aminoglycoside-Ribosomal RNA Interactions with Designed Synthetic Analogs. Journal of the American Chemical Society 1998, 120, (9), 1965-1978.
Wu, J.; Takayama, S.; Wong, C.-H.; Siuzdak, G., Quantitative electrospray mass spectrometry for the rapid assay of enzyme inhibitors. Chemistry & Biology 1997, 4, (9), 653-657.
Wong, C.-H.; Moris-Varas, F.; Hung, S.-C.; Marron, T. G.; Lin, C.-C.; Gong, K. W.; Weitz-Schmidt, G., Small Molecules as Structural and Functional Mimics of Sialyl Lewis X in Selectin Inhibition: A Remarkable Enhancement of Inhibition by Additional Negative Charge and/or Hydrophobic Group. Journal of the American Chemical Society 1997, 119, (35), 8152-8158.
Wong, C.-H., Recent research at the interface of bioorganic and synthetic chemistry: a chemo-enzymic approach to the study of carbohydrate recognition in biological systems. Youji Huaxue 1997, 17, (1), 47-52.
Wong, C.-H., A chemo-enzymic approach to the study of carbohydrate-based biological recognitions. Pure and Applied Chemistry 1997, 69, (3), 419-422.
Wittmann, V.; Wong, C.-H., 1H-Tetrazole as Catalyst in Phosphoromorpholidate Coupling Reactions: Efficient Synthesis of GDP-Fucose, GDP-Mannose, and UDP-Galactose. Journal of Organic Chemistry 1997, 62, (7), 2144-2147.
Witte, K.; Sears, P.; Wong, C.-H., Enzymic Glycoprotein Synthesis: Preparation of Ribonuclease Glycoforms via Enzymic Glycopeptide Condensation and Glycosylation. Journal of the American Chemical Society 1997, 119, (9), 2114-2118.
Wang, R.; Steensma, D. H.; Takaoka, Y.; Yun, J. W.; Kajimoto, T.; Wong, C.-H., A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases. Bioorganic & Medicinal Chemistry 1997, 5, (4), 661-672.
Takayama, S.; Wong, C.-H., Chemo-enzymic approach to carbohydrate recognition and selectin inhibition. Current Organic Chemistry 1997, 1, (2), 109-126.
Takayama, S.; McGarvey, G. J.; Wong, C.-H., Microbial aldolases and transketolases: new biocatalytic approaches to simple and complex sugars. Annual Review of Microbiology 1997, 51, 285-310.
Takayama, S.; McGarvey, G. J.; Wong, C.-H., Enzymes in organic synthesis: recent developments in aldol reactions and glycosylations. Chemical Society Reviews 1997, 26, (6), 407-415.
Takayama, S.; Martin, R.; Wu, J.; Laslo, K.; Siuzdak, G.; Wong, C.-H., Chemoenzymic Preparation of Novel Cyclic Imine Sugars and Rapid Biological Activity Evaluation Using Electrospray Mass Spectrometry and Kinetic Analysis. Journal of the American Chemical Society 1997, 119, (35), 8146-8151.
Seitz, O.; Wong, C.-H., Chemoenzymic solution- and solid-phase synthesis of O-glycopeptides of the Mucin domain of MAdCAM-1. A general route to O-LacNAc, O-Sialyl-LacNAc, and O-Sialyl-Lewis-X peptides. Journal of the American Chemical Society 1997, 119, (38), 8766-8776.
Murray, B. W.; Wittmann, V.; Burkart, M. D.; Hung, S.-C.; Wong, C.-H., Mechanism of Human a-1,3-Fucosyltransferase V: Glycosidic Cleavage Occurs Prior to Nucleophilic Attack. Biochemistry 1997, 36, (4), 823-831.
Moree, W. J.; Sears, P.; Kawashiro, K.; Witte, K.; Wong, C.-H., Exploitation of Subtilisin BPN' as Catalyst for the Synthesis of Peptides Containing Noncoded Amino Acids, Peptide Mimetics and Peptide Conjugates. Journal of the American Chemical Society 1997, 119, (17), 3942-3947.
McGarvey, G. J.; Wong, C. H., Chemical, enzymic, and structural studies in molecular glycobiology. Liebigs Annalen/Recueil 1997, (6), 1059-1074.
Lin, C.-H.; Murray, B. W.; Ollmann, I. R.; Wong, C.-H., Why is CMP-Ketodeoxyoctonate Highly Unstable? Biochemistry 1997, 36, (4), 780-785.
Lin, C.-C.; Lin, C.-H.; Wong, C.-H., Sialic acid aldolase-catalyzed condensation of pyruvate and N-substituted mannosamine: a useful method for the synthesis of N-substituted sialic acids. Tetrahedron Letters 1997, 38, (15), 2649-2652.
Koketsu, M.; Nitoda, T.; Sugino, H.; Juneja, L. R.; Kim, M.; Yamamoto, T.; Abe, N.; Kajimoto, T.; Wong, C.-H., Synthesis of a Novel Sialic Acid Derivative (Sialylphospholipid) as an Antirotaviral Agent. Journal of Medicinal Chemistry 1997, 40, (21), 3332-3335.
Kimura, T.; Vassilev, V. P.; Shen, G.-J.; Wong, C.-H., Enzymic Synthesis of b-Hydroxy-a-amino Acids Based on Recombinant D- and L-Threonine Aldolases. Journal of the American Chemical Society 1997, 119, (49), 11734-11742.
Kim, M.-J.; Lim, I. T.; Kim, H.-J.; Wong, C.-H., Enzymic single aldol reactions of remote dialdehydes. Tetrahedron: Asymmetry 1997, 8, (9), 1507-1509.
Kaneko, M.; Kanie, O.; Kajimoto, T.; Wong, C.-H., Toward a transition state analog inhibitor of N-acetylglucosaminyl transferase V. Bioorganic & Medicinal Chemistry Letters 1997, 7, (21), 2809-2812.
Janda, K. D.; Lo, L.-C.; Lo, C.-H. L.; Sim, M.-M.; Wang, R.; Wong, C.-H.; Lerner, R. A., Chemical selection for catalysis in combinatorial antibody libraries. Science (Washington, D. C.) 1997, 275, (5302), 945-948.
Ikeda, T.; Kajimoto, T.; Kondo, H.; Wong, C.-H., Design and synthesis of an a-mannosyl terpenoid as selective inhibitor of P-selectin. Bioorganic & Medicinal Chemistry Letters 1997, 7, (19), 2485-2490.
Hung, S.-C.; Lin, C.-C.; Wong, C.-H., One-pot synthesis of 1-allyl- and 1-allenyl-6-O-acetyl-2,3,4-tri-O-benzyl-a-D-glycosides from Methyl tetra-O-benzyl-a-D-glycosides. Tetrahedron Letters 1997, 38, (31), 5419-5422.
Hendrix, M.; Priestley, E. S.; Joyce, G. F.; Wong, C.-H., Direct Observation of Aminoglycoside-RNA Interactions by Surface Plasmon Resonance. Journal of the American Chemical Society 1997, 119, (16), 3641-3648.
Hendrix, M.; Alper, P. B.; Priestley, E. S.; Wong, C.-H., Hydroxyamines as a new motif for the molecular recognition of phosphodiesters: implications for aminoglycoside-RNA interactions. Angewandte Chemie, International Edition in English 1997, 36, (1/2), 95-98.
Hayashi, T.; Murray, B. W.; Wang, R.; Wong, C.-H., A chemoenzymic synthesis of UDP-(2-deoxy-2-fluoro)galactose and evaluation of its interaction with galactosyltransferase. Bioorganic & Medicinal Chemistry 1997, 5, (3), 497-500.
Fitz, W.; Wong, C.-H., Oligosaccharide synthesis by enzymic glycosidation. Preparative Carbohydrate Chemistry 1997, 485-504.
Cappi, M. W.; Moree, W. J.; Qiao, L.; Marron, T. G.; Weitz-Schmidt, G.; Wong, C.-H., Synthesis of novel 6-amido-6-deoxy-L-galactose derivatives as sialyl Lewis X mimetics. Bioorganic & Medicinal Chemistry 1997, 5, (7), 1453.
Burkart, M. D.; Zhang, Z.; Hung, S.-C.; Wong, C.-H., A New Method for the Synthesis of Fluoro-Carbohydrates and Glycosides Using Selectfluor. Journal of the American Chemical Society 1997, 119, (49), 11743-11746.
Wu, S.-H.; Shimazaki, M.; Lin, C.-C.; Qiao, L.; Moree, W. J.; Weitz-Schmidt, G.; Wong, C.-H., Synthesis of fucopeptides as sialyl Lewisx mimetics. Angewandte Chemie, International Edition in English 1996, 35, (1), 88-90.
Wong, C.-H., Biotransformations in Organic Chemistry (2nd ed.) by Kurt Faber. 1996; Vol. 3, p 29-30.
Wong, C.-H., Chemoenzymic synthesis: application to the study of carbohydrate recognition. Acta Chemica Scandinavica 1996, 50, (3), 211-18.
Wong, C.-H., Practical synthesis of oligosaccharides based on glycosyltransferases and glycosylphosphites. Frontiers in Natural Product Research 1996, 1, (Modern Methods in Carbohydrate Synthesis), 467-491.
Woltering, T. J.; Weitz-Schmidt, G.; Wong, C.-H., C-Fucopeptides as selection antagonists: attachment of lipid moieties enhances the activity. Tetrahedron Letters 1996, 37, (50), 9033-9036.
Wang, R.; Wong, C.-H., Synthesis of sialyl Lewis X mimetics: Use of O-a-fucosyl-(1R,2R)-2-aminocyclohexanol as core structure. Tetrahedron Letters 1996, 37, (31), 5427-5430.
Uchiyama, T.; Woltering, T. J.; Wong, W.; Lin, C.-C.; Kajimoto, T.; Takebaashi, M.; Weitz-Schmidt, G.; Asakura, T.; Noda, M.; Wong, C.-H., Design and synthesis of C-linked fucosides as inhibitors of E-selectin. Bioorganic & Medicinal Chemistry 1996, 4, (7), 1149-1165.
Takayama, S.; Shimazaki, M.; Qiao, L.; Wong, C.-H., Synthesis of lactosamine derivatives using b-D-galactosidase from Bacillus circulans. Bioorganic & Medicinal Chemistry Letters 1996, 6, (10), 1123-1126.
Takayama, S.; Moree, W. J.; Wong, C.-H., Enzymic resolution of amines and amino alcohols using pent-4-enoyl derivatives. Tetrahedron Letters 1996, 37, (35), 6287-6290.
Takayama, S.; Livingston, P. O.; Wong, C.-H., Synthesis of the melanoma-associated ganglioside 9-O-acetyl GD3 through regioselective enzymic acetylation of GD3 using subtilisin. Tetrahedron Letters 1996, 37, (52), 9271-9274.
Shibata, K.; Shingu, K.; Vassilev, V. P.; Nishide, K.; Fujita, T.; Node, M.; Kajimoto, T.; Wong, C.-H., Kinetic and thermodynamic control of L-threonine aldolase catalyzed reaction and its application to the synthesis of mycestericin D. Tetrahedron Letters 1996, 37, (16), 2791-4.
Sears, P.; Wong, C.-H., Engineering Enzymes for Bioorganic Synthesis: Peptide Bond Formation. Biotechnology Progress 1996, 12, (4), 423-433.
Sears, P.; Wong, C.-H., Intervention of carbohydrate recognition by proteins and nucleic acids. Proceedings of the National Academy of Sciences of the United States of America 1996, 93, (22), 12086-12093.
Qiao, L.; Murray, B. W.; Shimazaki, M.; Schultz, J.; Wong, C.-H., Synergistic Inhibition of Human a-1,3-Fucosyltransferase V. Journal of the American Chemical Society 1996, 118, (33), 7653-7662.
Qian, X.; Moris-Varas, F.; Wong, C.-H., Synthesis of C2-symmetrical polyhydroxyazepanes as inhibitors of glycosidases. Bioorganic & Medicinal Chemistry Letters 1996, 6, (10), 1117-1122.
Qian, X.; Moris-Varas, F.; Fitzgerald, M. C.; Wong, C.-H., C2-symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and HIV/FIV proteases. Bioorganic & Medicinal Chemistry 1996, 4, (12), 2055-2069.
Patterson, J. E.; Ollmann, I. R.; Cravatt, B. F.; Boger, D. L.; Wong, C. H.; Lerner, R. A., Inhibition of Oleamide Hydrolase Catalyzed Hydrolysis of the Endogenous Sleep-Inducing Lipid cis-9-Octadecenamide. Journal of the American Chemical Society 1996, 118, (25), 5938-5945.
Park, W. K. C.; Auer, M.; Jaksche, H.; Wong, C.-H., Rapid Combinatorial Synthesis of Amino Glycoside Antibiotic Mimetics: Use of a Polyethylene Glycol-Linked Amine and a Neamine-Derived Aldehyde in Multiple Component Condensation as a Strategy for the Discovery of New Inhibitors of the HIV RNA Rev Responsive Element. Journal of the American Chemical Society 1996, 118, (42), 10150-10155.
Orsat, B.; Alper, P. B.; Moree, W.; Mak, C.-P.; Wong, C.-H., Homocarbonates as Substrates for the Enantioselective Enzymic Protection of Amines. Journal of the American Chemical Society 1996, 118, (3), 712-13.
Murray, B. W.; Takayama, S.; Schultz, J.; Wong, C.-H., Mechanism and specificity of human a-1,3-fucosyltransferase V. Biochemistry 1996, 35, (34), 11183-11195.
Moris-Varas, F.; Qian, X.-H.; Wong, C.-H., Enzymic/Chemical Synthesis and Biological Evaluation of Seven-Membered Imino Cyclitols. Journal of the American Chemical Society 1996, 118, (33), 7647-7652.
Marron, T. G.; Woltering, T. J.; Weitz-Schmidt, G.; Wong, C.-H., C-Mannose derivatives as potent mimics of sialyl Lewis X. Tetrahedron Letters 1996, 37, (50), 9037-9040.
Lin, C.-C.; Kimura, T.; Wu, S.-H.; Weitz-Schmidt, G.; Wong, C.-H., Liposome-like fucopeptides as sialyl Lewis X mimetics. Bioorganic & Medicinal Chemistry Letters 1996, 6, (22), 2755-2760.
Kimura, T.; Takayama, S.; Huang, H.; Wong, C.-H., A practical method for the synthesis of N-Acetyl-D-lactosamine derivatives by the tandem use of galactose oxidase and b-galactosidase. Angewandte Chemie, International Edition in English 1996, 35, (20), 2348-2350.
Kidd, R. D.; Yennawar, H. P.; Sears, P.; Wong, C.-H.; Farber, G. K., A Weak Calcium Binding Site in Subtilisin BPN' Has a Dramatic Effect on Protein Stability. Journal of the American Chemical Society 1996, 118, (7), 1645-50.
Jeong, J.-H.; Murray, B. W.; Takayama, S.; Wong, C.-H., Cyclic Guanidino-Sugars with Low pKa as Transition-State Analog Inhibitors of Glycosidases: Neutral Instead of Charged Species Are the Active Forms. Journal of the American Chemical Society 1996, 118, (18), 4227-34.
Hung, S.-C.; Wong, C.-H., Synthesis of glycosyl chlorides with acid-labile protecting groups. Tetrahedron Letters 1996, 37, (28), 4903-4906.
Hung, S.-C.; Wong, C.-H., Samarium diiodide mediated coupling of glycosyl phosphates with carbon radical or anion acceptors - preparation of C-glycosides. Angewandte Chemie, International Edition in English 1996, 35, (22), 2671-2674.
Hiruma, K.; Kajimoto, T.; Weitz-Schmidt, G.; Ollmann, I.; Wong, C.-H., Rational Design and Synthesis of a 1,1-Linked Disaccharide That Is 5 Times as Active as Sialyl Lewis X in Binding to E-Selectin. Journal of the American Chemical Society 1996, 118, (39), 9273-9278.
Hendrix, M.; Wong, C.-H., A chemoenzymic approach to carbohydrate-mediated cell adhesion. Pure and Applied Chemistry 1996, 68, (11), 2081-2087.
Hendrix, M.; Wong, C.-H., A chemo-enzymic approach to the study of carbohydrate recognition in biological system. Enantiomer 1996, 1, (4-6), 305-310.
Gijsen, H. J. M.; Qiao, L.; Fitz, W.; Wong, C.-H., Recent Advances in the Chemoenzymic Synthesis of Carbohydrates and Carbohydrate Mimetics. Chemical Reviews (Washington, D. C.) 1996, 96, (1), 443-73.
Fitz, W.; Rosenthal, P. B.; Wong, C.-H., Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the x-ray structure determination of 9-O-acetylsialic acid esterase from influenza C virus. Bioorganic & Medicinal Chemistry 1996, 4, (8), 1349-1353.
De Luca, C.; Lansing, M.; Crescenzi, F.; Martini, I.; Shen, G.-J.; O'Regan, M.; Wong, C.-H., Overexpression, one-step purification and characterization of UDP-glucose dehydrogenase and UDP-N-acetylglucosamine pyrophosphorylase. Bioorganic & Medicinal Chemistry 1996, 4, (1), 131-42.
Alper, P. B.; Hung, S.-C.; Wong, C.-H., Metal catalyzed diazo transfer for the synthesis of azides from amines. Tetrahedron Letters 1996, 37, (34), 6029-6032.
Wong, C.-H.; Whitesides, G. M., Enzymes in synthetic organic chemistry. 1995; Vol. 8, p 201-2.
Wong, C.-H.; Provencher, L.; Porco, J. A., Jr.; Jung, S.-H.; Wang, Y.-F.; Chen, L.; Wang, R.; Steensma, D. H., Synthesis and Evaluation of Homoaza Sugars as Glycosidase Inhibitors. Journal of Organic Chemistry 1995, 60, (6), 1492-501.
Wong, C.-H.; Halcomb, R. L.; Ichikawa, Y.; Kajimoto, T., Enzymes in organic synthesis: application to the problems of carbohydrate recognition. Part 1. Angewandte Chemie, International Edition in English 1995, 34, (4), 412-32.
Wong, C.-H.; Halcomb, R. L.; Ichikawa, Y.; Kajimoto, T., Enzymes in organic synthesis: application to the problems of carbohydrate recognition. Part 2. Angewandte Chemie, International Edition in English 1995, 34, (5), 521-46.
Wong, C.-H.; Garcia-Junceda, E.; Chen, L.; Blanco, O.; Gijsen, H. J. M.; Steensma, D. H., Recombinant 2-Deoxyribose-5-phosphate Aldolase in Organic Synthesis: Use of Sequential Two-Substrate and Three-Substrate Aldol Reactions. Journal of the American Chemical Society 1995, 117, (12), 3333-9.
Wong, C.-H.; Alajarin, R.; Moris-Varas, F.; Blanco, O.; Garcia-Junceda, E., Enzymic Synthesis of L-Fucose and Analogs. Journal of Organic Chemistry 1995, 60, (22), 7360-3.
Wong, C. H.; Whitesides, G. M., Enzymes in synthetic organic chemistry. 1995; Vol. 12, p 347.
Wong, C.-H., Intervention of carbohydrate-mediated biological recognitions. RIKEN Review 1995, 8, 3-4.
Wong, C.-H., Enzymic and chemo-enzymic synthesis of carbohydrates. Pure and Applied Chemistry 1995, 67, (10), 1609-16.
Wetterholm, A.; Haeggstroem, J. Z.; Samuelsson, B.; Yuan, W.; Munoz, B.; Wong, C.-H., Potent and selective inhibitors of leukotriene A4 hydrolase: effects on purified enzyme and human polymorphonuclear leukocytes. Journal of Pharmacology and Experimental Therapeutics 1995, 275, (1), 31-7.
Wang, P. G.; Fitz, W.; Wong, C.-H., Making complex carbohydrates via enzymic routes. An immense variety of stereospecific structures can be assembled from a few monosaccharide building blocks. Modifying these with proteins and lipids leads to biologically active compounds. Chemtech 1995, 25, (4), 22-32.
Vassilev, V. P.; Uchiyama, T.; Kajimoto, T.; Wong, C.-H., L-Threonine aldolase in organic synthesis: preparation of novel b-hydroxy-a-amino acids. Tetrahedron Letters 1995, 36, (23), 4081-84.
Vassilev, V. P.; Uchiyama, T.; Kajimoto, T.; Wong, C.-H., An efficient chemoenzymic syntheses of a-amino-b-hydroxy-g-butyrolactone. Tetrahedron Letters 1995, 36, (28), 5063-4.
Vassilev, V. P.; Kajimoto, T.; Wong, C.-H., Applications of L-allo-threonine aldolase in synthesis of glycoconjugate precursors. RIKEN Review 1995, 8, 25-6.
Uchiyama, T.; Vassilev, V. P.; Kajimoto, T.; Wong, W.; Lin, C.-C.; Huang, H.; Wong, C.-H., Design and Synthesis of Sialyl Lewis X Mimetics. Journal of the American Chemical Society 1995, 117, (19), 5395-6.
Sugai, T.; Lin, C.-H.; Shen, G.-J.; Wong, C.-H., CMP-KDO synthetase: overproduction and application to the synthesis of CMP-KDO and analogs. Bioorganic & Medicinal Chemistry 1995, 3, (3), 313-20.
Stura, E. A.; Ghosh, S.; Garcia-Junceda, E.; Chen, L.; Wong, C.-H.; Wilson, I. A., Crystallization and preliminary crystallographic data for class I deoxyribose-5-phosphate aldolase from Escherichia coli: an application of reverse screening. Proteins: Structure, Function, and Genetics 1995, 22, (1), 67-72.
Slee, D. H.; Laslo, K. L.; Elder, J. H.; Ollmann, I. R.; Gustchina, A.; Kervinen, J.; Zdanov, A.; Wlodawer, A.; Wong, C.-H., Selectivity in the Inhibition of HIV and FIV Protease: Inhibitory and Mechanistic Studies of Pyrrolidine-Containing a-Keto Amide and Hydroxyethylamine Core Structures. Journal of the American Chemical Society 1995, 117, (48), 11867-78.
Shibata, K.; Nishide, K.; Node, M.; Vasilev, V. P.; Uchiyama, T.; Shingu, K.; Kajimoto, T.; Wong, C.-H., Synthesis of a sialyl Lewis X mimic and mycestericin D by using L-threonine aldolase from Candida humicola (AKU 4586). Tennen Yuki Kagobutsu Toronkai Koen Yoshishu 1995, 37th, 162-7.
Ollmann, I. R.; Hogg, J. H.; Munoz, B.; Haeggstroem, J. Z.; Samuelsson, B.; Wong, C.-H., Investigation of the inhibition of leukotriene A4 hydrolase. Bioorganic & Medicinal Chemistry 1995, 3, (7), 969-95.
Lin, C.-H.; Shimazaki, M.; Wong, C.-H.; Koketsu, M.; Juneja, L. R.; Kim, M., Enzymic synthesis of a sialyl Lewis X dimer from egg yolk as an inhibitor of E-selectin. Bioorganic & Medicinal Chemistry 1995, 3, (12), 1625-30.
Lin, C.-H.; Shen, G.-J.; Garcia-Junceda, E.; Wong, C.-H., Enzymic Synthesis and Regeneration of 3'-Phosphoadenosine 5'-Phosphosulfate (PAPS) for Regioselective Sulfation of Oligosaccharides. Journal of the American Chemical Society 1995, 117, (30), 8031-2.
Kajimoto, T.; Wong, C.-H., Transition-state analog inhibitors for N-acetylglucosaminyltransfer enzymes. RIKEN Review 1995, 8, 13-14.
Ikeda, T.; Kajimoto, T.; Wong, C.-H., Oligosaccharides components in traditional Chinese medicines and the liposome carrying these oligosaccharides. RIKEN Review 1995, 8, 21-2.
Ikeda, T.; Kajimoto, T.; Nohara, T.; Kinjo, J.; Wong, C. H., Preparation of a neoglycolipid carrying the oligosaccharide component of saponin from Albizzia julibrissin. Tetrahedron Letters 1995, 36, (9), 1509-10.
Huang, H.; Wong, C.-H., Synthesis of Biologically Active Sialyl Lewis X Mimetics. Journal of Organic Chemistry 1995, 60, (10), 3100-6.
Hogg, J. H.; Ollmann, I. R.; Haeggstroem, J. Z.; Wetterholm, A.; Samuelsson, B.; Wong, C.-H., Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase. Bioorganic & Medicinal Chemistry 1995, 3, (10), 1405-15.
Hiranuma, S.; Vassilev, V. P.; Kajimoto, T.; Wong, C.-H., Design of oligosaccharide mimetics with higher stability and simpler structures than parent oligosaccharides. RIKEN Review 1995, 8, 19-20.
Hiranuma, S.; Shimizu, T.; Nakata, T.; Kajimoto, T.; Wong, C.-H., Synthesis and inhibition analysis of five-membered homoaza sugars from D-arabinofuranose via an SN2 reaction of the chloromethylsulfonate. Tetrahedron Letters 1995, 36, (45), 8247-50.
Gijsen, H. J. M.; Wong, C.-H., Sequential One-Pot Aldol Reactions Catalyzed by 2-Deoxyribose-5-phosphate Aldolase and Fructose-1,6-diphosphate Aldolase. Journal of the American Chemical Society 1995, 117, (10), 2947-8.
Gijsen, H. J. M.; Wong, C.-H., Sequential Three- and Four-Substrate Aldol Reactions Catalyzed by Aldolases. Journal of the American Chemical Society 1995, 117, (29), 7585-91.
Gijsen, H. J. M.; Wong, C.-H., Synthesis of a cyclitol via a tandem enzymic aldol-intramolecular Horner-Wadsworth-Emmons reaction. Tetrahedron Letters 1995, 36, (39), 7057-60.
Garcia-Junceda, E.; Shen, G.-J.; Sugai, T.; Wong, C.-H., A new strategy for the cloning, overexpression and one step purification of three DHAP-dependent aldolases: rhamnulose-1-phosphate aldolase, fuculose-1-phosphate aldolase and tagatose-1,6-diphosphate aldolase. Bioorganic & Medicinal Chemistry 1995, 3, (7), 945-53.
Garcia-Junceda, E.; Shen, G.-J.; Alajarin, R.; Wong, C.-H., Cloning and overexpression of rhamnose isomerase and fucose isomerase. Bioorganic & Medicinal Chemistry 1995, 3, (10), 1349-55.
Fitz, W.; Schwark, J.-R.; Wong, C.-H., Aldotetroses and C(3)-Modified Aldohexoses as Substrates for N-Acetylneuraminic Acid Aldolase: A Model for the Explanation of the Normal and the Inversed Stereoselectivity. Journal of Organic Chemistry 1995, 60, (12), 3663-70.
Fang, J.-M.; Lin, C.-H.; Bradshaw, C. W.; Wong, C.-H., Enzymes in organic synthesis: oxidoreductions. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry 1995, (13), 1781.
DeFrees, S. A.; Kosch, W.; Way, W.; Paulson, J. C.; Sabesan, S.; Halcomb, R. L.; Huang, D.-H.; Ichikawa, Y.; Wong, C.-H., Ligand Recognition by E-Selectin: Synthesis, Inhibitory Activity and Conformational Analysis of Bivalent Sialyl Lewis x Analogs. Journal of the American Chemical Society 1995, 117, (1), 66-79.
De Luca, C.; Lansing, M.; Martini, I.; Crescenzi, F.; Shen, G.-J.; O'Regan, M.; Wong, C.-H., Enzymic synthesis of hyaluronic acid with regeneration of sugar nucleotides. Journal of the American Chemical Society 1995, 117, (21), 5869-70.
Chou, W.-C.; Fotsch, C.; Wong, C.-H., Synthesis of Nitrocyclitols Based on Enzymic Aldol Reaction and Intramolecular Nitroaldol Reaction. Journal of Organic Chemistry 1995, 60, (9), 2916-17.
Alajarin, R.; Garcia-Junceda, E.; Wong, C.-H., A Short Enzymic Synthesis of L-Glucose from Dihydroxyacetone Phosphate and L-Glyceraldehyde. Journal of Organic Chemistry 1995, 60, (13), 4294-5.
Yuasa, H.; Kajimoto, T.; Wong, C.-H., Synthesis of iminothiasugar as a potential transition-state analog inhibitor of glycosyltransfer reactions. Tetrahedron Letters 1994, 35, (44), 8243-6.
Wang, Y.-F.; Takaoka, Y.; Wong, C.-H., Remarkable stereoselectivity in the inhibition of a-galactosidase from coffee beans by a new polyhydroxypyrrolidine inhibitor. Angewandte Chemie 1994, 106, (12), 1343-5 (See also Angew Chem , Int Ed Engl , 1994, 33(12), 1242-4).
Sears, P.; Schuster, M.; Wang, P.; Witte, K.; Wong, C.-H., Engineering Subtilisin for Peptide Coupling: Studies on the Effects of Counterions and Site-Specific Modifications on the Stability and Specificity of the Enzyme. Journal of the American Chemical Society 1994, 116, (15), 6521-30.
Schuster, M.; Wang, P.; Paulson, J. C.; Wong, C.-H., Solid-Phase Chemical-Enzymic Synthesis of Glycopeptides and Oligosaccharides. Journal of the American Chemical Society 1994, 116, (3), 1135-6.
Provencher, L.; Steensma, D. H.; Wong, C.-H., Five-membered ring aza sugars as potent inhibitors of a-L-rhamnosidase (naringinase) from Penicillium decumbens. Bioorganic & Medicinal Chemistry 1994, 2, (11), 1179-88.
Munoz, B.; Giam, C.-Z.; Wong, C.-H., a-Ketoamide Phe-Pro isostere as a new core structure for the inhibition of HIV protease. Bioorganic & Medicinal Chemistry 1994, 2, (10), 1085-90.
Marquardt, J. L.; Brown, E. D.; Lane, W. S.; Haley, T. M.; Ichikawa, Y.; Wong, C.-H.; Walsh, C. T., Kinetics, Stoichiometry, and Identification of the Reactive Thiolate in the Inactivation of UDP-GlcNAc Enolpyruvoyl Transferase by the Antibiotic Fosfomycin. Biochemistry 1994, 33, (35), 10646-51.
Kondo, H.; Aoki, S.; Ichikawa, Y.; Halcomb, R. L.; Ritzen, H.; Wong, C.-H., Glycosyl Phosphites as Glycosylation Reagents: Scope and Mechanism. Journal of Organic Chemistry 1994, 59, (4), 864-77.
Jung, S.-H.; Jeong, J.-H.; Miller, P.; Wong, C.-H., An Efficient Multigram-Scale Preparation of Dihydroxyacetone Phosphate. Journal of Organic Chemistry 1994, 59, (23), 7182-4.
Ichikawa, Y.; Wong, C.-H., Topochemistry and inhibition of selectin-mediated cell adhesion: Chemical-enzymic synthesis of inhibitors related to E-selectin recognition. Alfred Benzon Symposium 1994, 36, (COMPLEX CARBOHYDRATES IN DRUG RESEARCH), 118-33.
Ichikawa, Y.; Wang, R.; Wong, C.-H., Regeneration of sugar nucleotide for enzymic oligosaccharide synthesis. Methods in Enzymology 1994, 247, (Neoglycoconjugates, Pt. B), 107-27.
Ichikawa, Y.; Halcomb, R. L.; Wong, C. H., Sticky solutions. Chemistry in Britain 1994, 30, (2), 117-18, 120-1.
Hiranuma, S.; Kajimoto, T.; Wong, C.-H., A facile synthesis of 1-thiopentofuranoside. Tetrahedron Letters 1994, 35, (29), 5257-60.
Herrmann, G. F.; Wang, P.; Shen, G.-J.; Wong, C.-H., Recombinant whole cells as catalysts for enzymic synthesis of oligosaccharides and glycopeptides. Angewandte Chemie 1994, 106, (12), 1346-7 (See also Angew Chem , Int Ed Engl , 1994, 33(12), 1241-2).
Herrmann, G. F.; Wang, P.; Shen, G.-J.; Garcia-Junceda, E.; Khan, S. H.; Matta, K. L.; Wong, C.-H., Large scale production of recombinant a-1,2-mannosyltransferase from E. coli for the study of acceptor specificity and use of the recombinant whole cells in synthesis. Journal of Organic Chemistry 1994, 59, (21), 6356-62.
Henderson, I.; Sharpless, K. B.; Wong, C. H., Synthesis of carbohydrates via tandem use of the osmium-catalyzed asymmetric dihydroxylation and enzyme-catalyzed aldol addition reactions. Journal of the American Chemical Society 1994, 116, (2), 558-61.
Henderson, I.; Laslo, K.; Wong, C. H., Chemoenzymic synthesis of homoazasugars. Tetrahedron Letters 1994, 35, (3), 359-62.
Halcomb, R. L.; Wong, C.-H., Asymmetric synthesis based on enzymes. Stereocontrolled Organic Synthesis 1994, 413-434.
Halcomb, R. L.; Huang, H.; Wong, C.-H., Solution- and Solid-Phase Synthesis of Inhibitors of H. pylori Attachment and E-Selectin-Mediated Leukocyte Adhesion. Journal of the American Chemical Society 1994, 116, (25), 11315-22.
Halcomb, R. L.; Fitz, W.; Wong, C.-H., Enzymic synthesis of 7-deoxy-N-acetylneuraminic acid and 7-O-methyl-N-acetylneuraminic acid. Tetrahedron: Asymmetry 1994, 5, (12), 2437-42.
Gijsen, H. J. M.; Wong, C.-H., Unprecedented Asymmetric Aldol Reactions with Three Aldehyde Substrates Catalyzed by 2-Deoxyribose-5-phosphate Aldolase. Journal of the American Chemical Society 1994, 116, (18), 8422-3.
Fotsch, C. H.; Wong, C.-H., Synthesis of a guanidino-sugar as a glycosyl cation mimic. Tetrahedron Letters 1994, 35, (21), 3481-4.
Fitz, W.; Wong, C.-H., Combined Use of Subtilisin and N-Acetylneuraminic Acid Aldolase for the Synthesis of a Fluorescent Sialic Acid. Journal of Organic Chemistry 1994, 59, (26), 8279-80.
Fang, J.-M.; Wong, C.-H., Enzymes in organic synthesis: alteration of reversible reactions to irreversible processes. Synlett 1994, (6), 393-402.
Chou, W.-C.; Chen, L.; Fang, J.-M.; Wong, C.-H., A New Route to Deoxythio sugars Based on Aldolases. Journal of the American Chemical Society 1994, 116, (14), 6191-4.
Aoki, S.; Kondo, H.; Wong, C.-H., Glycosyl phosphites as glycosylation reagents. Methods in Enzymology 1994, 247, (Neoglycoconjugates, Pt. B), 193-211.
Yuan, W.; Munoz, B.; Wong, C. H.; Haeggstroem, J. Z.; Wetterholm, A.; Samuelsson, B., Development of selective tight-binding inhibitors of leukotriene A4 hydrolase. Journal of Medicinal Chemistry 1993, 36, (2), 211-20.
Wong, C. H.; Schuster, M.; Wang, P.; Sears, P., Enzymic synthesis of N- and O-linked glycopeptides. Journal of the American Chemical Society 1993, 115, (14), 5893-901.
Wong, C. H.; Ichikawa, Y.; Kajimoto, T.; Liu, K. K. C.; Shen, G. J.; Lin, C. H.; Wang, Y. F.; Dumas, D. P.; Lin, Y. C.; et al., Practical synthesis of carbohydrates based on aldolases and glycosyltransferases. Pure and Applied Chemistry 1993, 65, (4), 803-8.
Wong, C. H., Development of enzymes for chemoenzymic synthesis. Chimia 1993, 47, (4), 127-32.
Wang, Y. F.; Dumas, D. P.; Wong, C. H., Chemoenzymic synthesis of five-membered aza sugars as inhibitors of fucosidase and fucosyltransferase: an issue regarding the stereochemistry discrimination at transition states. Tetrahedron Letters 1993, 34, (3), 403-6.
Wang, Y. F.; Dumas, D. P.; Wong, C. H., Chemoenzymic synthesis of five-membered aza sugars as inhibitors of fucosidase and fucosyltransferase: an issue regarding the stereochemistry discrimination at transition states. [Erratum to document cited in CA118(25):255233a]. Tetrahedron Letters 1993, 34, (8), 1228.
Wang, P.; Shen, G. J.; Wang, Y. F.; Ichikawa, Y.; Wong, C. H., Enzymes in oligosaccharide synthesis: active-domain overproduction, specificity study, and synthetic use of an a-1,2-mannosyltransferase with regeneration of GDP-Man. Journal of Organic Chemistry 1993, 58, (15), 3985-90.
Wang, P.; Schuster, M.; Wang, Y. F.; Wong, C. H., Synthesis of phospholipid-inhibitor conjugates by enzymic transphosphatidylation with phospholipase D. Journal of the American Chemical Society 1993, 115, (23), 10487-91.
Takaoka, Y.; Kajimoto, T.; Wong, C. H., Inhibition of N-acetylglucosaminyl transfer enzymes: chemical-enzymic synthesis of new five-membered acetamido azasugars. Journal of Organic Chemistry 1993, 58, (18), 4809-12.
Sugai, T.; Shen, G. J.; Ichikawa, Y.; Wong, C. H., Synthesis of 3-deoxy-D-manno-2-octulosonic acid (KDO) and its analogs based on KDO aldolase-catalyzed reactions. Journal of the American Chemical Society 1993, 115, (2), 413-21.
Sugai, T.; Ritzen, H.; Wong, C. H., Towards the chemoenzymic synthesis of lipid A. Tetrahedron: Asymmetry 1993, 4, (5), 1051-8.
Siuzdak, G.; Ichikawa, Y.; Caulfield, T. J.; Munoz, B.; Wong, C. H.; Nicolaou, K. C., Evidence of calcium(2+)-dependent carbohydrate association through ion spray mass spectrometry. Journal of the American Chemical Society 1993, 115, (7), 2877-81.
Sim, M. M.; Kondo, H.; Wong, C. H., Synthesis of dibenzyl glycosyl phosphites using dibenzyl N,N-diethylphosphoramidite as phosphitylating reagent: an effective route to glycosyl phosphates, nucleotides, and glycosides. Journal of the American Chemical Society 1993, 115, (6), 2260-7.
Look, G. C.; Ichikawa, Y.; Shen, G. J.; Cheng, P. W.; Wong, C. H., A combined chemical and enzymatic strategy for the construction of carbohydrate-containing antigen core units. Journal of Organic Chemistry 1993, 58, (16), 4326-30.
Look, G. C.; Fotsch, C. H.; Wong, C. H., Enzyme-catalyzed organic synthesis: practical routes to aza sugars and their analogs for use as glycoprocessing inhibitors. Accounts of Chemical Research 1993, 26, (4), 182-90.
Ichikawa, Y.; Look, G. C.; Shen, G.-J.; Sears, P.; Wang, P.; Wong, C.-H., Recent developments in enzymic synthesis of oligosaccharides and glycopeptides. Frontiers in Biomedicine and Biotechnology 1993, 1, (CARBOHYDRATES AND CARBOHYDRATE POLYMERS), 2-16.
Herrmann, G. F.; Ichikawa, Y.; Wandrey, C.; Gaeta, F. C. A.; Paulson, J. C.; Wong, C. H., A new multi-enzyme system for a one-pot synthesis of sialyl oligosaccharides: combined use of b-galactosidase and a(2,6)-sialyltransferase coupled with regeneration in situ of CMP-sialic acid. Tetrahedron Letters 1993, 34, (19), 3091-4.
Halcomb, R. L.; Wong, C. H., Synthesis of oligosaccharides, glycopeptides, and glycolipids. Current Opinion in Structural Biology 1993, 3, (5), 694-700.
DeFrees, S. A.; Gaeta, F. C. A.; Lin, Y. C.; Ichikawa, Y.; Wong, C. H., Ligand recognition by E-selectin: analysis of conformation and activity of synthetic monomeric and bivalent sialyl Lewis X analogs. Journal of the American Chemical Society 1993, 115, (16), 7549-50.
Yuan, W.; Wong, C. H.; Haeggstroem, J. Z.; Wetterholm, A.; Samuelsson, B., Novel tight-binding inhibitors of leukotriene A4 hydrolase. Journal of the American Chemical Society 1992, 114, (16), 6552-3.
Wong, C. H.; Wang, R.; Ichikawa, Y., Regeneration of sugar nucleotide for enzymic oligosaccharide synthesis: use of Gal-1-phosphate uridyltransferase in the regeneration of UDP-galactose, UDP-2-deoxygalactose, and UDP-galactosamine. Journal of Organic Chemistry 1992, 57, (16), 4343-4.
Wong, C. H.; Liu, K. K. C.; Kajimoto, T.; Chen, L.; Zhong, Z.; Ichikawa, Y.; Shen, G. J., Developing better enzymes for organic synthesis. Annals of the New York Academy of Sciences 1992, 672, (Enzyme Engineering XI), 343-51.
Wong, C. H.; Liu, K. K. C.; Kajimoto, T.; Chen, L.; Zhong, Z.; Dumas, D. P.; Liu, J. L. C.; Ichikawa, Y.; Shen, G. J., Enzymes for carbohydrate and peptide syntheses. Pure and Applied Chemistry 1992, 64, (8), 1197-202.
Wong, C. H.; Kajimoto, T.; Liu, K. K. C.; Zhong, Z.; Ichikawa, Y., Engineering enzymes for the synthesis of carbohydrates and peptides. Harnessing Biotechnol. 21st Century, Proc. Int. Biotechnol. Symp. Expo., 9th 1992, 168-71.
Wong, C. H.; Ichikawa, Y.; Kajimoto, T.; Liu, K. K. C.; Dumas, D. P.; Lin, Y. C.; Look, G. C., Chemical-enzymic synthesis of carbohydrates. NATO ASI Series, Series C: Mathematical and Physical Sciences 1992, 381, (Microbial Reagents in Organic Synthesis), 35-42.
Wong, C. H.; Dumas, D. P.; Ichikawa, Y.; Koseki, K.; Danishefsky, S. J.; Weston, B. W.; Lowe, J. B., Specificity, inhibition, and synthetic utility of a recombinant human a-1,3-fucosyltransferase. Journal of the American Chemical Society 1992, 114, (18), 7321-2.
Wong, C. H., Engineering enzymes for chemoenzymatic synthesis. Part I: practical routes to aza-sugars and complex carbohydrates. Trends in Biotechnology 1992, 10, (10), 337-41.
Wong, C. H., Engineering enzymes for chemoenzymic synthesis. Part 2: Modifying proteases for peptide synthesis. Trends in Biotechnology 1992, 10, (11), 378-81.
Shen, G. J.; Liu, J. L. C.; Wong, C. H., Cloning and overexpression of a tagged CMP-N-acetylneuraminic acid synthetase from E. coli using a lambda phage system and application of the enzyme to the synthesis of CMP-N-acetylneuraminic acid. Biocatalysis 1992, 6, (1), 31-42.
Look, G. C.; Wong, C. H., A facile enzymic synthesis of Galb(1,3)Glucal a key intermediate for the synthesis of Lea and sialyl Lea. Tetrahedron Letters 1992, 33, (30), 4253-6.
Liu, K. K. C.; Wong, C. H., Enzymic halohydration of glycals. Journal of Organic Chemistry 1992, 57, (13), 3748-50.
Liu, K. K. C.; Wong, C. H., A new strategy for the synthesis of nucleoside analogs based on enzyme-catalyzed aldol reactions. Journal of Organic Chemistry 1992, 57, (18), 4789-91.
Liu, J. L. C.; Shen, G. J.; Ichikawa, Y.; Rutan, J. F.; Zapata, G.; Vann, W. F.; Wong, C. H., Overproduction of CMP-sialic acid synthetase for organic synthesis. Journal of the American Chemical Society 1992, 114, (10), 3901-10.
Lin, Y. C.; Hummel, C. W.; Huang, D. H.; Ichikawa, Y.; Nicolaou, K. C.; Wong, C. H., Conformational studies of sialyl Lewis X in aqueous solution. Journal of the American Chemical Society 1992, 114, (13), 5452-4.
Lin, C. H.; Sugai, T.; Halcomb, R. L.; Ichikawa, Y.; Wong, C. H., Unusual stereoselectivity in sialic acid aldolase-catalyzed aldol condensations: synthesis of both enantiomers of high-carbon monosaccharides. Journal of the American Chemical Society 1992, 114, (26), 10138-45.
Kondo, H.; Ichikawa, Y.; Wong, C. H., b-Sialyl phosphite and phosphoramidite: synthesis and application to the chemoenzymic synthesis of CMP-sialic acid and sialyl oligosaccharides. Journal of the American Chemical Society 1992, 114, (22), 8748-50.
Ichikawa, Y.; Sim, M. M.; Wong, C. H., Efficient chemical synthesis of GDP-fucose. Journal of Organic Chemistry 1992, 57, (10), 2943-6.
Ichikawa, Y.; Look, G. C.; Wong, C. H., Enzyme-catalyzed oligosaccharide synthesis. Analytical Biochemistry 1992, 202, (2), 215-38.
Ichikawa, Y.; Look, G. C.; Wong, C. H., Synthesis of oligosaccharides using glycosyltransferases. Yuki Gosei Kagaku Kyokaishi 1992, 50, (5), 441-50.
Fu, H.; Kondo, H.; Ichikawa, Y.; Look, G. C.; Wong, C. H., Chloroperoxidase-catalyzed asymmetric synthesis: enantioselective reactions of chiral hydroperoxides with sulfides and bromohydroxylation of glycals. Journal of Organic Chemistry 1992, 57, (26), 7265-70.
Fernholz, E.; Schloeder, D.; Liu, K. K. C.; Bradshaw, C. W.; Huang, H.; Janda, K.; Lerner, R. A.; Wong, C. H., Specificity of antibody-catalyzed transesterifications using enol esters: a comparison with lipase reactions. Journal of Organic Chemistry 1992, 57, (17), 4756-61.
Dumas, D. P.; Kajimoto, T.; Liu, K. K. C.; Wong, C. H.; Berkowitz, D. B.; Danishefsky, S. J., Azasugar and glycal inhibitors of a-L-fucosidase. Bioorganic & Medicinal Chemistry Letters 1992, 2, (1), 33-6.
Danishefsky, S. J.; Gervay, J.; Peterson, J. M.; McDonald, F. E.; Koseki, K.; Oriyama, T.; Griffith, D. A.; Wong, C. H.; Dumas, D. P., Remarkable regioselectivity in the chemical glycosylation of glycal acceptors: a concise solution to the synthesis of sialyl-Lewis X glycal. Journal of the American Chemical Society 1992, 114, (21), 8329-31.
Chen, L.; Dumas, D. P.; Wong, C. H., Deoxyribose 5-phosphate aldolase as a catalyst in asymmetric aldol condensation. Journal of the American Chemical Society 1992, 114, (2), 741-8.
Bradshaw, C. W.; Lalonde, J. J.; Wong, C. H., Enzymic synthesis of (R)- and (S)-1-deuteriohexanol. Applied Biochemistry and Biotechnology 1992, 33, (1), 15-24.
Bradshaw, C. W.; Hummel, W.; Wong, C. H., Lactobacillus kefir alcohol dehydrogenase: a useful catalyst for synthesis. Journal of Organic Chemistry 1992, 57, (5), 1532-6.
Bradshaw, C. W.; Fu, H.; Shen, G. J.; Wong, C. H., A Pseudomonas sp. alcohol dehydrogenase with broad substrate specificity and unusual stereospecificity for organic synthesis. Journal of Organic Chemistry 1992, 57, (5), 1526-32.
Zhong, Z. Z.; Wong, C. H., Development of new enzymic catalysts for peptide synthesis in aqueous and organic solvents. Biomedica Biochimica Acta 1991, 50, (10-11), S9-S14.
Zhong, Z.; Liu, J. L. C.; Dinterman, L. M.; Finkelman, M. A. J.; Mueller, W. T.; Rollence, M. L.; Whitlow, M.; Wong, C. H., Engineering subtilisin for reaction in dimethylformamide. Journal of the American Chemical Society 1991, 113, (2), 683-4.
Zhong, Z.; Bibbs, J. A.; Yuan, W.; Wong, C. H., Active-site-directed modification of subtilisin. Journal of the American Chemical Society 1991, 113, (6), 2259-63.
Yuan, W.; Zhong, Z.; Wong, C. H.; Haeggstroem, J. Z.; Wetterholm, A.; Samuelsson, B., Probing the inhibition of leukotriene A4 hydrolase based on its aminopeptidase activity. Bioorganic & Medicinal Chemistry Letters 1991, 1, (10), 551-6.
Wong, C. H.; Krach, T.; Gautheron-Le Narvor, C.; Ichikawa, Y.; Look, G. C.; Gaeta, F.; Thompson, D.; Nicolaou, K. C., Synthesis of novel disaccharides based on glycosyltransferases: b-1,4-galactosyltransferase. Tetrahedron Letters 1991, 32, (37), 4867-70.
Wong, C. H.; Ichikawa, Y.; Krach, T.; Gautheron-Le Narvor, C.; Dumas, D. P.; Look, G. C., Probing the acceptor specificity of b-1,4-galactosyltransferase for the development of enzymatic synthesis of novel oligosaccharides. Journal of the American Chemical Society 1991, 113, (21), 8137-45.
Shen, G. J.; Wang, Y. F.; Bradshaw, C.; Wong, C. H., A new NAD-dependent alcohol dehydrogenase with opposite facial selectivity useful for asymmetric reduction and cofactor regeneration [Erratum to document cited in CA113(13):111902s]. Journal of the Chemical Society, Chemical Communications 1991, (12), 835.
Pederson, R. L.; Esker, J.; Wong, C. H., An improved synthesis of dihydroxyacetone phosphate. Tetrahedron 1991, 47, (14-15), 2643-8.
Liu, K. K. C.; Pederson, R. L.; Wong, C. H., Fructose 1,6-diphosphate aldolase-catalyzed stereoselective carbon-carbon bond formation. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) 1991, (11), 2669-73.
Liu, K. K. C.; Kajimoto, T.; Chen, L.; Zhong, Z.; Ichikawa, Y.; Wong, C. H., Use of dihydroxyacetone phosphate-dependent aldolases in the synthesis of deoxy aza sugars. Journal of Organic Chemistry 1991, 56, (22), 6280-9.
Kajimoto, T.; Liu, K. K. C.; Pederson, R. L.; Zhong, Z.; Ichikawa, Y.; Porco, J. A., Jr.; Wong, C. H., Enzyme-catalyzed aldol condensation for asymmetric synthesis of azasugars: synthesis, evaluation, and modeling of glycosidase inhibitors. Journal of the American Chemical Society 1991, 113, (16), 6187-96.
Kajimoto, T.; Chen, L.; Liu, K. K. C.; Wong, C. H., Palladium-mediated stereocontrolled reductive amination of azido sugars prepared from enzymic aldol condensation: a general approach to the synthesis of deoxy aza sugars. Journal of the American Chemical Society 1991, 113, (17), 6678-80.
Kajimoto, T.; Chen, L.; Liu, K. K. C.; Wong, C. H., Palladium-mediated stereocontrolled reductive amination of azido sugars prepared from enzymic aldol condensation: a general approach to the synthesis of deoxy aza sugars [Erratum to document cited in CA115(13):136547j]. Journal of the American Chemical Society 1991, 113, (23), 9009.
Ichikawa, Y.; Liu, J. L. C.; Shen, G. J.; Wong, C. H., A highly efficient multienzyme system for the one-step synthesis of a sialyl trisaccharide: in situ generation of sialic acid and N-acetyllactosamine coupled with regeneration of UDP-glucose, UDP-galactose and CMP-sialic acid. Journal of the American Chemical Society 1991, 113, (16), 6300-2.
Gautheron-Le Narvor, C.; Wong, C. H., Glycosyltransferase-catalyzed stereoselective glycosidation of monosaccharide-based glycosidase inhibitors: a new approach to the synthesis of sequence-specific glycosidase inhibitors. Journal of the Chemical Society, Chemical Communications 1991, (16), 1130-1.
Gautheron-Le Narvor, C.; Ichikawa, Y.; Wong, C. H., A complete change of stereoselectivity in sialic acid aldolase reactions: a novel synthetic route to the KDO type of nine-carbon L-sugars. Journal of the American Chemical Society 1991, 113, (20), 7816-18.
Fu, H.; Shen, G. J.; Wong, C. H., Asymmetric epoxidation of allyl alcohol derivatives by w-hydroxylases from Pseudomonas oleovorans. Recueil des Travaux Chimiques des Pays-Bas 1991, 110, (05), 167-70.
Fu, H.; Newcomb, M.; Wong, C. H., Pseudomonas oleovorans monooxygenase-catalyzed asymmetric epoxidation of allyl alcohol derivatives and hydroxylation of a hypersensitive radical probe with the radical ring-opening rate exceeding the oxygen-rebound rate. Journal of the American Chemical Society 1991, 113, (15), 5878-80.
Fu, H.; Look, G. C.; Zhang, W.; Jacobsen, E. N.; Wong, C. H., Mechanistic study of a synthetically useful monooxygenase model using the hypersensitive probe trans-2-phenyl-1-vinylcyclopropane. Journal of Organic Chemistry 1991, 56, (23), 6497-500.
Dumas, D. P.; Ichikawa, Y.; Wong, C. H.; Lowe, J. B.; Nair, R. P., Enzymic synthesis of sialyl Lex and derivatives based on a recombinant fucosyltransferase. Bioorganic & Medicinal Chemistry Letters 1991, 1, (8), 425-8.
Drueckhammer, D. G.; Hennen, W. J.; Pederson, R. L.; Barbas, C. F., III; Gautheron, C. M.; Krach, T.; Wong, C. H., Enzyme catalysis in synthetic carbohydrate chemistry. Synthesis 1991, (7), 499-525.
Barbas, C. F., III; Wong, C. H., Overexpression and substrate specificity studies of phosphodeoxyribomutase and thymidine phosphorylase. Bioorganic Chemistry 1991, 19, (3), 261-9.
Wong, C. H.; Chen, S. T.; Hennen, W. J.; Bibbs, J. A.; Wang, Y. F.; Liu, J. L. C.; Pantoliano, M. W.; Whitlow, M.; Bryan, P. N., Enzymes in organic synthesis: use of subtilisin and a highly stable mutant derived from multiple site-specific mutations. Journal of the American Chemical Society 1990, 112, (3), 945-53.
Wong, C. H., Aldolases in organic synthesis. Biocatalysis 1990, 319-35.
West, J. B.; Hennen, W. J.; Lalonde, J. L.; Bibbs, J. A.; Zhong, Z.; Meyer, E. F., Jr.; Wong, C. H., Enzymes as synthetic catalysts: mechanistic and active-site considerations of natural and modified chymotrypsin. Journal of the American Chemical Society 1990, 112, (13), 5313-20.
Von der Osten, C. H.; Gioannetti, C.; Barbas, C.; Pederson, R. L.; Wang, Y. F.; Wong, C. H.; Ozaki, A.; Toone, E.; Whitesides, G. M.; Sinskey, A. J., Molecular cloning of aldolases for synthetic applications. Annals of the New York Academy of Sciences 1990, 613, (Enzyme Eng. 10), 771-5.
Shen, G. J.; Wang, Y. F.; Bradshaw, C.; Wong, C. H., A new NAD-dependent alcohol dehydrogenase with opposite facial selectivity useful for asymmetric reduction and cofactor regeneration. Journal of the Chemical Society, Chemical Communications 1990, (9), 677-9.
Pederson, R. L.; Liu, K. K. C.; Rutan, J. F.; Chen, L.; Wong, C. H., Enzymes in organic synthesis: synthesis of highly enantiomerically pure 1,2-epoxy aldehydes, epoxy alcohols, thiirane, aziridine, and glyceraldehyde 3-phosphate. Journal of Organic Chemistry 1990, 55, (16), 4897-901.
Liu, K. K. C.; Nozaki, K.; Wong, C. H., Problems of acyl migration in lipase-catalyzed enantioselective transformation of meso-1,3-diol systems. Biocatalysis 1990, 3, (1-2), 169-77.
Hsu, S. H.; Wu, S. S.; Wang, Y. F.; Wong, C. H., Lipase-catalyzed irreversible transesterification using enol esters: XAD-8 immobilized lipoprotein lipase-catalyzed resolution of secondary alcohols. Tetrahedron Letters 1990, 31, (44), 6403-6.
Bibbs, J. A.; Zhong, Z.; Wong, C. H., Modification of proteases for peptide synthesis. Materials Research Society Symposium Proceedings 1990, 174, (Mater. Synth. Util. Biol. Processes), 223-8.
Barbas, C. F., III; Wang, Y. F.; Wong, C. H., Deoxyribose-5-phosphate aldolase as a synthetic catalyst. Journal of the American Chemical Society 1990, 112, (5), 2013-14.
Babiak, K. A.; Ng, J. S.; Dygos, J. H.; Weyker, C. L.; Wang, Y. F.; Wong, C. H., Lipase-catalyzed irreversible transesterification using enol esters: resolution of prostaglandin synthons 4-hydroxy-2-alkyl-2-cyclopentenones and inversion of the 4S enantiomer to the 4R enantiomer. Journal of Organic Chemistry 1990, 55, (10), 3377-81.
Wang, Y. F.; Wong, C. H., Enantioselective syntheses of platelet-activating factor and a phospholipase A2 inhibitor from chiral synthons prepared enzymatically. Journal of the Chinese Chemical Society (Taipei, Taiwan) 1989, 36, (5), 463-8.
Wang, Y. F.; Chen, S. T.; Liu, K. K. C.; Wong, C. H., Lipase-catalyzed irreversible transesterification using enol esters: resolution of cyanohydrins and syntheses of ethyl (R)-2-hydroxy-4-phenylbutyrate and (S)-propranolol. Tetrahedron Letters 1989, 30, (15), 1917-20.
Von der Osten, C. H.; Sinskey, A. J.; Barbas, C. F., III; Pederson, R. L.; Wang, Y. F.; Wong, C. H., Use of a recombinant bacterial fructose-1,6-diphosphate aldolase in aldol reactions: preparative syntheses of 1-deoxynojirimycin, 1-deoxymannojirimycin, 1,4-dideoxy-1,4-imino-D-arabinitol, and fagomine. Journal of the American Chemical Society 1989, 111, (11), 3924-7.
Pederson, R. L.; Wong, C. H., Enzymic aldol condensation as a route to heterocycles: synthesis of 1,4-dideoxy-1,4-imino-D-arabinitol, fagomine, 1-deoxynojirimycin and 1-deoxymannojirimycin. Heterocycles 1989, 28, (1), 477-80.
Hennen, W. J.; Wong, C. H., A new method for the enzymic synthesis of nucleosides using purine nucleoside phosphorylase. Journal of Organic Chemistry 1989, 54, (19), 4692-5.
Drueckhammer, D. G.; Durrwachter, J. R.; Pederson, R. L.; Crans, D. C.; Daniels, L.; Wong, C. H., Reversible and in situ formation of organic arsenates and vanadates as organic phosphate mimics in enzymatic reactions: mechanistic investigation of aldol reactions and synthetic applications. Journal of Organic Chemistry 1989, 54, (1), 70-7.
Chen, S. T.; Wong, C. H., Studies on angiotensin-converting enzyme inhibitors: protease catalyzed resolution of aryl 3-mercapto-2-methylpropionic ester. Journal of the Chinese Chemical Society (Taipei, Taiwan) 1989, 36, (5), 451-8.
West, J. B.; Scholten, J.; Stolowich, N. J.; Hogg, J. L.; Scott, A. I.; Wong, C. H., Modification of proteases to esterases for peptide synthesis: methylchymotrypsin. Journal of the American Chemical Society 1988, 110, (11), 3709-10.
Wang, Y. F.; Wong, C. H., Lipase-catalyzed irreversible transesterification for preparative synthesis of chiral glycerol derivatives. Journal of Organic Chemistry 1988, 53, (13), 3127-9.
Wang, Y. F.; Lalonde, J. J.; Momongan, M.; Bergbreiter, D. E.; Wong, C. H., Lipase-catalyzed irreversible transesterifications using enol esters as acylating reagents: preparative enantio- and regioselective syntheses of alcohols, glycerol derivatives, sugars and organometallics. Journal of the American Chemical Society 1988, 110, (21), 7200-5.
Pederson, R. L.; Kim, M. J.; Wong, C. H., A combined chemical and enzymic procedure for the synthesis of 1-deoxynojirimycin and 1-deoxymannojirimycin. Tetrahedron Letters 1988, 29, (37), 4645-8.
Kim, M. J.; Hennen, W. J.; Sweers, H. M.; Wong, C. H., Enzymes in carbohydrate synthesis: N-acetylneuraminic acid aldolase catalyzed reactions and preparation of N-acetyl-2-deoxy-D-neuraminic acid derivatives. Journal of the American Chemical Society 1988, 110, (19), 6481-6.
Hennen, W. J.; Sweers, H. M.; Wang, Y. F.; Wong, C. H., Enzymes in carbohydrate synthesis. Lipase-catalyzed selective acylation and deacylation of furanose and pyranose derivatives. Journal of Organic Chemistry 1988, 53, (21), 4939-45.
Durrwachter, J. R.; Wong, C. H., Fructose 1,6-diphosphate aldolase-catalyzed stereoselective synthesis of C-alkyl and N-containing sugars: thermodynamically controlled C-C bond formations. Journal of Organic Chemistry 1988, 53, (18), 4175-81.
Drueckhammer, D. G.; Barbas, C. F., III; Nozaki, K.; Wong, C. H.; Wood, C. Y.; Ciufolini, M. A., Chemoenzymic synthesis of chiral furan derivatives: useful building blocks for optically active structures. Journal of Organic Chemistry 1988, 53, (8), 1607-11.
Barbas, C. F., III; Wong, C. H., One-pot tripeptide syntheses from three single amino acid derivatives catalyzed by papain. Tetrahedron Letters 1988, 29, (24), 2907-10.
Barbas, C. F., III; Matos, J. R.; West, J. B.; Wong, C. H., A search for peptide ligase: cosolvent-mediated conversion of proteases to esterases for irreversible synthesis of peptides. Journal of the American Chemical Society 1988, 110, (15), 5162-6.
Wong, C. H., Nicotinamide cofactor-requiring enzymic synthesis in organic solvent-water biphasic systems. Studies in Organic Chemistry (Amsterdam) 1987, 29, (Biocatal. Org. Media), 197-208.
West, J. B.; Wong, C.-H., Use of nonproteases in peptide synthesis. Tetrahedron Letters 1987, 28, (15), 1629-32.
Matos, J. R.; Wong, C. H., S-Adenosylmethionine: stability and stabilization. Bioorganic Chemistry 1987, 15, (1), 71-80.
Matos, J. R.; West, J. B.; Wong, C. H., Lipase catalyzed synthesis of peptides: preparation of a penicillin G precursor and other peptides. Biotechnology Letters 1987, 9, (4), 233-6.
Matos, J. R.; Raushel, F. M.; Wong, C. H., S-Adenosylmethionine: studies on chemical and enzymic synthesis. Biotechnology and Applied Biochemistry 1987, 9, (1), 39-52.
Crans, D. C.; Kazlauskas, R. J.; Hirschbein, B. L.; Wong, C. H.; Abril, O.; Whitesides, G. M., Enzymic regeneration of adenosine 5'-triphosphate: acetyl phosphate, phosphoenolpyruvate, methoxycarbonyl phosphate, dihydroxyacetone phosphate, 5-phospho-a-D-ribosyl pyrophosphate, uridine-5'-diphosphoglucose. Methods in Enzymology 1987, 136, (Immobilized Enzymes Cells, Pt. C), 263-80.
Barbas, C. F., III; Wong, C. H., Papain-catalyzed peptide synthesis. Control of amidase activity and the introduction of unusual amino acids. Journal of the Chemical Society, Chemical Communications 1987, (8), 533-4.
Wong, C. H., Aldolases as catalysts in organic synthesis. NATO ASI Series, Series C: Mathematical and Physical Sciences 1986, 178, (Enzymes Catal. Org. Synth.), 199-216.
West, J. B.; Wong, C. H., Enzyme-catalyzed irreversible formation of peptides containing D-amino acids. Journal of Organic Chemistry 1986, 51, (14), 2728-35.
West, J. B.; Wong, C. H., Enzyme-catalyzed synthesis of peptides containing D-amino acids. Journal of the Chemical Society, Chemical Communications 1986, (5), 417-18.
Sweers, H. M.; Wong, C. H., Enzyme-catalyzed regioselective deacylation of protected sugars in carbohydrate synthesis. Journal of the American Chemical Society 1986, 108, (20), 6421-2.
Matos, J. R.; Wong, C. H., Biphasic one-pot synthesis of two useful and separable compounds using cofactor-requiring enzymatic reactions: glutamate dehydrogenase catalyzed synthesis of L-a-aminoadipate coupled with alcohol dehydrogenase catalyzed synthesis of a chiral lactone. Journal of Organic Chemistry 1986, 51, (12), 2388-9.
Durrwachter, J. R.; Sweers, H. M.; Nozaki, K.; Wong, C. H., Enzymatic aldol reaction/isomerization as a route to unusual sugars. Tetrahedron Letters 1986, 27, (11), 1261-4.
Durrwachter, J. R.; Drueckhammer, D. G.; Nozaki, K.; Sweers, H. M.; Wong, C. H., Enzymic aldol condensation/isomerization as a route to unusual sugar derivatives. Journal of the American Chemical Society 1986, 108, (24), 7812-18.
Chen, S. T.; Wang, K. T.; Wong, C. H., Chirally selective hydrolysis of D,L-amino acid esters by alkaline protease. Journal of the Chemical Society, Chemical Communications 1986, (20), 1514-16.
Wong, C. H.; Matos, J. R., Enantioselective oxidation of 1,2-diols to L-a-hydroxy acids using co-immobilized alcohol and aldehyde dehydrogenases as catalysts. Journal of Organic Chemistry 1985, 50, (11), 1992-4.
Wong, C. H.; Drueckhammer, D. G., Enzymic synthesis of chiral hydroxy compounds using immobilized glucose dehydrogenase from Bacillus cereus for NAD(P)H regeneration. Bio/Technology 1985, 3, (7), 649-51.
Whitesides, G. M.; Wong, C. H., Enzymes in organic synthesis. Angewandte Chemie 1985, 97, (8), 617-38.
Root, R. L.; Durrwachter, J. R.; Wong, C. H., Enzymic synthesis of unusual sugars: galactose oxidase-catalyzed stereospecific oxidation of polyols. Journal of the American Chemical Society 1985, 107, (10), 2997-9.
Matos, J. R.; Smith, M. B.; Wong, C. H., Enantioselectivity of alcohol dehydrogenase-catalyzed oxidation of 1,2-diols and amino alcohols. Bioorganic Chemistry 1985, 13, (2), 121-30.
Drueckhammer, D. G.; Wong, C. H., FMN reductase catalyzed regeneration of NAD(P) for use in enzymic synthesis. Journal of Organic Chemistry 1985, 50, (25), 5387-9.
Drueckhammer, D. G.; Wong, C. H., Chemoenzymic syntheses of fluoro sugar phosphates and analogs. Journal of Organic Chemistry 1985, 50, (26), 5912-13.
Wong, C. H.; Whitesides, G. M., Enzyme-catalyzed organic synthesis: regeneration of deuterated nicotinamide cofactors for use in large-scale enzymatic synthesis of deuterated substances. Journal of the American Chemical Society 1983, 105, (15), 5012-14.
Wong, C. H.; Whitesides, G. M., Synthesis of sugars by aldolase-catalyzed condensation reactions. Journal of Organic Chemistry 1983, 48, (19), 3199-205.
Wong, C. H.; Mazenod, F. P.; Whitesides, G. M., Chemical and enzymatic syntheses of 6-deoxyhexoses. Conversion to 2,5-dimethyl-4-hydroxy-2,3-dihydrofuran-3-one (Furaneol) and analogs. Journal of Organic Chemistry 1983, 48, (20), 3493-7.
Wong, C. H.; Haynie, S. L.; Whitesides, G. M., Preparation of a mixture of nucleoside triphosphates from yeast RNA: use in enzymic synthesis requiring nucleoside triphosphate regeneration and conversion to nucleoside diphosphate sugars. Journal of the American Chemical Society 1983, 105, (1), 115-17.
Whitesides, G. M.; Wong, C. H., Enzymes as catalysts in organic synthesis. Aldrichimica Acta 1983, 16, (2), 27-34.
Wong, C. H.; Whitesides, G. M., Enzyme-catalyzed transhydrogenation between nicotinamide cofactors and its application in organic synthesis. Journal of the American Chemical Society 1982, 104, (12), 3542-4.
Wong, C. H.; Whitesides, G. M., Enzyme-catalyzed organic synthesis: NAD(P)H cofactor regeneration using ethanol/alcohol dehydrogenase/aldehyde dehydrogenase and methanol/alcohol dehydrogenase/aldehyde dehydrogenase/formate dehydrogenase. Journal of Organic Chemistry 1982, 47, (14), 2816-18.
Wong, C. H.; Pollak, A.; McCurry, S. D.; Sue, J. M.; Knowles, J. R.; Whitesides, G. M., Synthesis of ribulose 1,5-bisphosphate: routes from glucose 6-phosphate (via 6-phosphogluconate) and from adenosine monophosphate (via ribose 5-phosphate). Methods in Enzymology 1982, 89, (Carbohydr. Metab., Pt. D), 108-21.
Wong, C. H.; Haynie, S. L.; Whitesides, G. M., Enzyme-catalyzed synthesis of N-acetyllactosamine with in situ regeneration of uridine 5'-diphosphate glucose and uridine 5'-diphosphate galactose. Journal of Organic Chemistry 1982, 47, (27), 5416-18.
Whitesides, G. M.; Wong, C. H.; Pollak, A., Asymmetric synthesis using cofactor-requiring enzymes. ACS Symposium Series 1982, 185, (Asymmetric React. Processes Chem.), 205-18.
Wong, C.-H.; Whitesides, G. M., Enzyme-catalyzed organic synthesis: NAD(P)H cofactor regeneration by using glucose-6-phosphate and the glucose-5-phosphate dehydrogenase from Leuconostoc mesenteroides. Journal of the American Chemical Society 1981, 103, (16), 4890-9.
Wong, C.-H.; Daniels, L.; Orme-Johnson, W. H.; Whitesides, G. M., Enzyme-catalyzed organic synthesis: NAD(P)H regeneration using dihydrogen and the hydrogenase from Methanobacterium thermoautotrophicum. Journal of the American Chemical Society 1981, 103, (20), 6227-8.
Wong, C. H.; Gordon, J.; Cooney, C. L.; Whitesides, G. M., Regeneration of NAD(P)H using glucose-6-sulfate and glucose-6-phosphate dehydrogenase. Journal of Organic Chemistry 1981, 46, (23), 4676-9.
DiCosimo, R.; Wong, C.-H.; Daniels, L.; Whitesides, G. M., Enzyme-catalyzed organic synthesis: electrochemical regeneration of NAD(P)H from NAD(P) using methyl viologen and flavoenzymes. Journal of Organic Chemistry 1981, 46, (22), 4622-3.
Wong, C.-H.; McCurry, S. D.; Whitesides, G. M., Practical enzymic syntheses of ribulose 1,5 bisphosphate and ribose 5-phosphate. Journal of the American Chemical Society 1980, 102, (27), 7938-9.
Wong, C.-H.; Ho, C.-L.; Wang, K.-T., The status of methionine in cobra cardiotoxin. Journal of the Chinese Biochemical Society 1980, 9, (1), 25-9.
Wong, C.-H.; Chen, S.-T.; Wang, K.-T., Enzymic synthesis of opioid peptides. Biochimica et Biophysica Acta, Protein Structure 1979, 576, (1), 247-9.
Wong, C.-H., The resolution of RS-mandelic acid. Journal of the Chinese Chemical Society (Taipei, Taiwan) 1979, 26, (2), 75-8.
Tseng, M.-J.; Chen, S.-T.; Wong, C.-H.; Wang, K.-T., Enzymic synthesis of oligopeptide. III. The optimal condition of papain-catalyzed peptide bond formation. Proceedings of the National Science Council, Republic of China 1979, 3, (1), 42-5.
Chou, S.-H.; Wong, C.-H.; Chen, S.-T.; Wang, K.-T., Enzymic synthesis of oligopeptide. Part II. Synthesis of bis(N-protected amino acid) hydrazides by papain. Journal of the Chinese Chemical Society (Taipei, Taiwan) 1979, 26, (1), 11-15.
Wong, C.-H.; Wang, K.-T., Electrochemistry in organic synthesis. I. Large-scale preparation of cysteine from cystine. Journal of the Chinese Chemical Society (Taipei, Taiwan) 1978, 25, (3), 149-51.
Wong, C.-H.; Wang, K.-T., Mutual resolution of (+-)-ephedrine and Z-DL-amino acid induced by seeding chiral salt. Tetrahedron Letters 1978, (40), 3813-16.
Wong, C.-H.; Wang, K.-T., The mutual resolution of DL-ephedrine and N-(benzyloxycarbonyl)-DL-amino acids. Journal of the Chinese Chemical Society (Taipei, Taiwan) 1978, 25, (4), 209-14.
Wong, C.-H.; Ho, M.-F.; Wang, K.-T., Preparation of optically pure N-tert-butyloxycarbonyl-O-benzyl-L-serine and its antipode. Journal of Organic Chemistry 1978, 43, (18), 3604.
Wong, C.-H.; Ho, C.-L.; Wang, K.-T., Purification of synthetic cardiotoxin by affinity chromatography. Journal of Chromatography 1978, 154, (1), 25-32.
Wong, C.-H.; Chen, Y.-H.; Hung, M.-C.; Wang, K.-T.; Ho, C.-L.; Lo, T.-B., Renaturation of a reduced Taiwan cobra cardiotoxin. Biochimica et Biophysica Acta, Protein Structure 1978, 533, (1), 105-11.
Wong, C.-H.; Chen, S.-W.; Ho, C.-L.; Wang, K.-T., Synthesis of cobra neurotoxin. Proceedings of the National Science Council, Republic of China 1978, 2, (2), 149-53.
Wong, C.-H.; Chen, S.-T.; Ho, C.-L.; Wang, K.-T., Synthesis of a fully active snake venom cardiotoxin by fragment condensation on solid polymer. Biochimica et Biophysica Acta, Protein Structure 1978, 536, (2), 376-89.
Hsiao, S.-L.; Hung, M.-C.; Wong, C.-H.; Wang, K.-T., Solid phase synthesis of C-terminal disulfide loop of Taiwan cobra cardiotoxin and its immunochemical and conformational studies. Proceedings of the National Science Council, Republic of China 1978, 2, (4), 346-51.
Chou, S.-H.; Chen, S.-T.; Wong, C.-H.; Wang, K.-T., Enzymic synthesis of oligopeptides. Part I. Papain-catalyzed synthesis of dipeptides, tripeptides, and a tetrapeptide. Journal of the Chinese Chemical Society (Taipei, Taiwan) 1978, 25, (4), 215-18.
Wong, C.-H.; Chen, S.-T.; Wang, K.-T., The resolution of amino acids by enzymes. Part 1: Proteolytic enzyme bromelain for hydrolysis of L-amino acid methyl esters. Journal of the Chinese Chemical Society (Taipei, Taiwan) 1977, 24, (3), 129-33.
Wong, C.-H.; Wang, K.-T., Synthesis of polypeptide corresponding to Tqiwan cobra (Naja naja atra) venom cardiotoxin. Journal of the Chinese Biochemical Society 1976, 5, (1), 1-6.
Kong, F.-T.; Lin, T.-C.; Wong, C.-H.; Wang, K.-T., Synthesis of Taiwan cobra venom cardiotoxin II. Synthesis of protected hexapeptide, sequence 44-49 and protected tripeptide, sequence 50-52. Journal of the Chinese Chemical Society (Taipei, Taiwan) 1976, 23, (3), 155-64.
Wong, C.-H.; Wang, K.-T., Synthesis of Taiwan cobra venom cardiotoxin I. Synthesis of sequence 53-60 octapeptide. Journal of the Chinese Biochemical Society 1975, 4, (1), 24-35.
Wong, C.-H.; Hsiao, M.-H.; Wang, K.-T., Liquid-phase synthesis of pure peptides without intermediated purifications. Journal of the Chinese Biochemical Society 1973, 2, (2), 64-9.

Patents

(Last updated: October 20, 2009)

C.-H. Wong, “Methods for manufacturing vaccines against viral infection,” US Provisional Patent Application (2009).

C.-H. Wong, “Methods and compositions for immunization against flavivirus,” US Provisional Patent Application (2009).

C.-H. Wong, “Methods and compositions for immunization against human immunodeficiency virus,” US Provisional Patent Application (2009).

C.-H. Wong, “Methods and compositions for immunization against influenza,” US Provisional Patent Application (2009).

C.-H. Wong, “A New Alpha-Selective Sialyation Donor For Primary And Secondary Hydroxyls and Its Use In Preparation of Glycan Assay for Profiling the Specificity of Influenza Hemagglutinin,” US Provisional Patent Application (2009).

C.-H. Wong, C.-Y. Wu, S. Y. Tseng, “Glycan arrays on PTFE-like aluminum coated glass slides and related methods,” PCT Patent Application No. PCT/US09/50754 (2009), US Patent Application No. 12/503,797 (2009).

Brik, Y.-Y. Yang, S. Ficht, and C.-H. Wong, “Method of Preparing Glycopeptides,” PCT Patent Application No. PCT/US07/07410 (2007), US Patent Application No. 12/293,793 (2008), European Patent Application No. 7753745.4 (2008), Japanese Patent Application (2008).

C.-H. Wong, C. Ma, T.-J. Cheng, W.-C. Cheng, “Crystal structure of bifunctional transglycosylase pbp1b from E. coli and inhibitors thereof,” PCT Patent Application No. PCT/US2009/004246 (2009), US Patent Application No. 12/506,982 (2009).

C.-H. Wong, S.-K. Wang, P.-H. Liang, “Methods and compositions for the treatment or prevention of human immunodeficiency virus infection,” US Patent Application No. 12/338,987 (2009).

C.-H. Wong, P.-H. Liang, “Glycan microarray for quantitative analysis of carbohydrate-protein intercations,” US Patent Application No. 12/423,733 (2009).

C.-H. Wong, C.-Y. Wu, A. Yu, J. Yu “Globo H and related anti-cancer vaccines with novel glycolipid adjuvants,” PCT Patent Application No. PCT/US2009/004519 (2009), US Patent Application No. 12/537,129 (2009), Taiwan Patent Application No. 098127948 (2009).

C.-H. Wong, A. Y., J. Yu, “Compositions for inducing immune responses specific to GloboH and SSEA3 and uses thereof in cancer treatment,” US Patent Application No. 12/485,546 (2009), PCT Patent Application No. PCT/US09/47537 (2009).

C.-H. Wong, C.-Y. Wu, C.-C. Wang, “Cancer diagnosis based on levels of antibodies against Globo H and its fragments,” US Patent Application No. 12/485,516 (2009), PCT Patent Application No. PCT/US09/47532 (2009).

C.-H. Wong, P.-H. Liang, “Quantitative Microarray of Intact Glycolipid CD1d Interaction and Correlation with Cell-Based Cytokine Production,” US Patent Application No. 12/423,728 (2009).

C.-H. Wong, M.-H. Chuang, W.-B. Yang, S.-H. Chiou, “Longevity-Promoting Effects of Acetic Acid and Reishi Polysaccharide,” US Patent Application No. 12/425,319 (2009), PCT Patent Application No. PCT/US09/40879 (2009).

C.-H. Wong, J.-M. Fang, W.-B. Yang, T.-J. R. Cheng, Y. S.-Y. Hsieh, C. Chien, C.-C. Lin, H.-Y. Wen, “Structure and Bioactivity of the Polysaccharides in Medicinal Plant Dendrobium huoshanense,” US Patent Application No. 12/378,263 (2009), PCT Patent Application No. PCT/US2009/033940 (2009), Taiwan Patent Application No. 098104560 (2009).

C.-H. Wong, J.-M. Fang, J.-J. Shie, Y.-S. Cheng, J.-T. Jan, “Synthesis of oseltamivir containing phosphonate congeners with anti-influenza activity,” US Patent Application No. 12/201,955 (2008), PCT Patent Application No. PCT/US2008/074914 (2008).

C.-H. Wong, T.-J. Cheng, C. Ma, W.-C. Cheng, “Antibiotic compositions and related screening methods,” US Patent Application No. 12/354,717 (2009).

C.-H. Wong, T.-J. Cheng, C. Ma, W.-C. Cheng, “Expression of penicillin-binding proteins and application for high-throughput discovery of antibiotics thereof,” Taiwan Patent Application No. 097125469 (2008), Japanese Patent Application No. 2008178187.

C.-H. Wong, Y.-S. Cheng, H.-M. Yu, T.-J. Cheng, C.-Y. Wu, J.-M. Fang, “Compositions and methods for treating inflammation and inflammation-related disorders by plectranthus amboinicus extract,” US Patent Application No. 12/212,607 (2008), PCT Patent Application No. PCT/US2008/076735 (2008).

C.-H. Wong, T.-L. Hsu, S. Hanson, “Tailored Glycoproteomic Methods for The Sequencing, Mapping and Identification of Cellular Glycoproteins,” US Patent Application No. 12/079,157 (2008).

C.-H. Wong, T.-L. Hsu, S. Hanson, “Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells,” US Patent Application No. 12/079,226 (2008).

C.-H. Wong, T.-L. Hsu, S. Hanson, M. Sawa, “Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo,” US Patent Application No. 12/079,228 (2008).

D. Ho, Y. Hung, M.-W. Chen, R. T. J. Cheng, C.-H. Wong, A. Yu, “Flu vaccines and methods of use thereof,” US Patent Application No. 12/011,032 (2008), PCT Patent Application No. PCT/US2008/00919 (2008), Taiwan Patent Application No. 097102598 (2008), US Patent Application No. 12/417,556 (2009).

C.-H. Wong, A. Yu, Y.-J. Chang, K.-H. Lin, J.-T. Hung, “Alpha-galactosyl ceramide analogs and their use as immunotherapies,” US Patent Application No. 12/218,082 (2008), PCT Patent Application (2009).

C.-H. Wong, A. Yu, Y.-J. Chang, “Alpha-galactosyl ceramide analogs and their use as immunotherapies,” US Patent Application No. 12/082,751 (2008), PCT Patent Application No. PCT/US2008/060275 (2008), Taiwan Patent Application No. 097113475 (2008).

P.-H. Liang, Y.-L. Lin, C.-H. Wong, “Novel Five-Membered Iminocyclitol Derivatives as Selective and Potent Glycosidase Inhibitors: New Structures for Antivirals and Osteoarthritis Therapeutics,” PCT Patent Application No. PCT/US2006/046348 (2006).

D. T.-B. Shih, W.-Y. Chen, C.-H. Wong, “Reishi-mediated enhancement of human tissue progenitor cell adhesion and differentiation,” US Patent Application No. 11/859,738 (2007), PCT Patent Application No. PCT/US2007/020628 (2007), Japanese Patent Application (2009), European Patent Application (2009).

Yu, C.-H. Wong, J. T. Jan, Y.-S. E. Cheng, “Anti-viral effect of an extract of Ganoderma Lucidum,” US Patent Application No. 11/859,729 (2007).

Yu, J. Yu, K.-I. Lin, W.-B. Yang, C.-H. Wong, “Fungal immunostimulatory compositions,” US Patent Application No. 11/549,215 (2006), Taiwan Patent Application No. 095137640 (2006).

K.-F. Hua, H.-Y. Hsu, C.-H. Wong, “Methods and compositions associated with administration of an extract of Ganoderma Lucidum,” US Patent Application No. 11/534,204 (2006).

C.-H. Wong, H.-Y. Hsu, K.-F. Hua, C.-H. Lin, J. Hsu, S.-T. Chen, K.-I. Lin, W.-B. Yang, J. Yu, A. Yu, “Methods and compositions associated with administration of an extract of Ganoderma Lucidum,” PCT Patent Application No. PCT/US2005/036961, Taiwan Patent Application No. 095131055 (2006), Japanese Patent Application No. 2007536927 (2007), European Patent Application No. 05810080.1 (2007).

Y.-Y Wang, K.-H. Khoo, S.-T. Chen, C.-C. Lin, C.-H. Wong, C.-H. Lin, H.-S. Chen, Y.-F. Tsai, “Immuno-modulating antitumor activities of Ganoderma lucidum (Reishi) polysaccharides,” US Patent No. 7,135,183 (2006), US Patent No. 7,323,176 (2008), US Patent No. 7,560,114 (2009), Taiwan Patent No. 091117677.

“Anti-coronavirus compounds,” PCT Patent Application No. PCT/US2005/015227, Indonesia Patent Application No. W-00200603110, China Patent Application No. 200580014309.50, NZ Patent Application No. 550945, Japanese Patent Application No. 2007-511484, AU Patent Application No. 2005323435, US Patent Application No. 11/121,314, Thailand Patent Application No. 100127, Taiwan Patent Application No. 094114468, India Patent Application No. 1413/MUMNP/2006.

C.-H. Wong, M. Fuji, D. Wu, D. Ho, M. Tsuji “Glycolipids and analogs thereof as antigens for NKT cells” Application Serial Number-11/317,900, US Patent Application filed December 28, 2005.

F.W. Okumu, Y. Ichikawa, S.-B. Huang, M. Lotz, Y.-K. Shue, N.K. Orida, C.-H. Wong, “Treatment of degenerative cartilage conditions in a mammal with glycosidase inhibitors,” US Patent Application filed January 13, 2004.

C.-H. Wong, R. Xu, S. R. Hanson, Z. Zhang, Y.-Y. Yang, P.G. Schultz, “Site-specific incorporation of mucin-type N-acetylgalactosamine a-O-threonine into protein in E. coli,” TRSI 16886-CH, US Patent Application filed October 10, 2004.

C.-H. Wong, “Arrays with cleavable linkers,” TSRI 1052, US Patent Application filed June 24, 2004.

C.-H. Wong, S.J. Sucheck, P. Sears, “Bifunctional antibiotics,” TSRI 757.1, US Patent (Allowed).

C.-H. Wong, J. Liu, “Iminocyclitol inhibitors of hexoaminidase and glycosidase,” TSRI 696.1, US Patent No. 6,774,140B1 (2004).

C.-H. Wong, “Programmable one-pot oligosaccharide synthesis,” US Patent No. 6,538,117 (2003).

C.-H. Wong, M.D. Burkart, “Enzymatic sulfation of biomolecules,” US Patent No. 6,255,088 B1 (2001).

C.-H. Wong, “Inhibition of human fucosyltransferases with N-linked Lewis-x and LacNAc analogs,” U.S. Patent No. 6,232,450 (2001).

T. Lee, J.H. Elder, C.-H. Wong, “HIV/FIV protease inhibitors with small P3 residues,” TSRI 609.1, WO99/29311 (1999), US Patent No. 6,803,466 (2004).

C.-H. Wong, F. Moris-Varas, “Hydroxyazepanes as inhibitors of glycosidases and HIV protease,” US Patent Number 6,462,143 (2002); US Patent No. 6,462,193B1 (2002).

C.-H. Wong, M. Hendrix, P. Alper, S. Priestley, “Nucleic acid binders having an hydroxyamine motif,” US Patent No. 6,120,997 (2000).

C.-H. Wong, C.-C. Lin, T. Woltering, “Liposomic sialyl Lewis X mimetics,” US Patent (Allowed).

C.-H. Wong, D. Slee, K. Laslo, “HIV protease inhibitors,” US Patent (Allowed). EP0873519 (1999).

C.-H. Wong, “Enzymatic synthesis of l-fucose and l-fucose analogs,” US Patent No. 6,713,287 (2004).

C.-H. Wong, C.-H. Lin, “Ketoaldonic acids having formed stereogenic centers of R configuration: Methods and Compositions,” US Patent No. 6,080,563 (2000).

C.-H. Wong, “Mannosyl transfer with regeneration of GDP-mannose,” US Patent No. 6,485,930 (2002).

C.-H. Wong, Y. Ichikawa, G.-J. Shen, “Production of fucosylated carbohydrates by enzymatic fucosylation; synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose,” US Patent No. 6319695B1 (2001). Russian Patent No. 2125092 (1999).

C.-H. Wong, S. Takayama, B. Orsat, W. Moree, “Enantioselective enzymatic protection of amines,” US Patent No. 5981267 (1999).

C.-H. Wong, C.C. Lin,T. Kajimoto “Sialyl Lewis x mimetics incorporating fucopeptides,” US Patent No. 5,962,660 (1999).

R.A. Lerner, C.-H. Wong, D.L. Boger, S.J. Henriksen, “Inhibitors of oleamide hydrolase,” US Patent No. 5,856,537 (1999) and CC 6,096,784 (2000).

C.-H. Wong, C.-H. Lin, G.-J. Shen, “One-pot enzymatic sulfation process using 3¢-phosphoadenosine-5¢-phosphosulfate and recycled phosphorylated adenosine intermediates,” US Patent No. 5,919673 (1999).

C.-H. Wong, T. Sugai, G.-J. Shen, “Biologically pur culture of Aureobacterium barkeri: KDO-37-2,” US Patent No. 5, 869,316 (1999).

C.-H. Wong, T. Kimura, “Transglycosylation reactions employing a-galactosidase,” US Patent No. 5,876,981 (1999).

C.-H. Wong, Hiro Kondo, “Glycosylation of peptides using glycosyl phosphite reagents,” US Patent No. 5854391 (1998).

C.-H. Wong, F. Moris-Varas, C.-C. Lin, “Inhibitors of E-, P-, and L-selectin binding,” US Patent No. 5,830,871 (1998).

C.-H. Wong, T.G. Marron, T.J. Woltering, G. Weitz-Schmidt, “Sialyl Lewis x mimetics incorporating mannopeptides,” US Patent No. 5,837,862 (1998).

C.-H. Wong, H. J.M. Gijsen, “Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives,” US Patent No. 5,795,749 (1998).

C.-H. Wong, S. Takayama, “Synthesis of 9-0-acetyl N-acetyl-neuraminic acid oligosaccharides,” US Patent No. 5,766,887 (1998) C.-H. Wong, T. Hayashi, “Process for preparing nucleoside inhibitors of glycosyltransferases,” US Patent No. 5,770,407 (1998).

C.-H. Wong, “Method for synthesizing 2-ketoaldonic acids,” US Patent No. 5,759,825 (1998).

C.-H. Wong, Y. Ichikawa, G.-J. Shen, “Oligosaccharide enzyme substrates and inhibitors: methods and compositions,” US Patent No. 5,593,887 (1997), 5,759,823 (1998) and 6, 168, 934 (2001). EP0576592 (2000).

C.-H. Wong, G.C. Look, “A facile enzymatic synthesis of galactosyl-b-1,3-glycals,” Australian Patent No. 672029 (1997); Canadian Patent Number 2,139,506 (1998).

C.-H. Wong, T. Kajimoto, K.C. Liu, L. Chen, “Omega-deoxy-azasugars,” US Patent No. 5,596,005 (1997).

C.-H. Wong, “Sialyl Lewis x mimetics incorporating fucopeptides,” US Patent No. 5,614,615 (1997).

C.-H. Wong, T. Kajimoto, “Sialyl Lewis X mimetics,” US Patent No. 5,599,915 (1997). Canada #2,414,107.

C.-H. Wong, Hiro Kondo, “Carbon Linked Glycosyl Compounds,” US Patent No. 5,597,906 (1997).

C.-H. Wong, Hiro Kondo, “Thio Linked Glycosyl Compounds,” US Patent No. 5,514,784 (1996).

C.-H. Wong, J.R. Durrwachter, R.L. Pederson, “Aldolase catalyzed stereoselective synthesis of arabinohexulose, xyloheptulose, threohexulose and xylohexulose,” US Patent No. 5,576,426 (1996).

C.-H. Wong, W.J. Hennen, “2-Deoxyderivatives of N-acetylneuraminic acid and their preparation,” US Patent No. 5,554,771 (1996).

C.-H. Wong, R.L. Pederson, Y.-F. Wang, “Azido diacetal propane derivatives,” US Patent No. 5,565,585 (1996).

C.-H. Wong, Y.-F. Wang, W.J. Hennen, “Enantio- and regio-selective synthesis of organic compounds using enol esters as irreversible transacylation reagents,” US Patent No. 5,585,252 (1996).

C.-H. Wong, “N-Acetylgalactosaminyl or N-acetylglucosaminyl transfer using N-acetylglucosaminyl-1-phosphate or N-acetylgalactosaminyl-1-phosphate as precursor and glycosyl-nucleotide regeneration,” US Patent No. 5, 516, 665 (1996).

C.-H. Wong, Y. Ichikawa, “Oligosaccharide enzyme substrates and inhibitors: Methods and composition,” US Patent No. 5,461,143 (1995), Australian Patent No. 668505 (1996), Canadian Patent No. 2106301 (1999).

C.-H. Wong, K.K.-C. Liu, “Fructosyl C-glycoside nucleoside analogs,” US Patent No. 5,393,879 (1995).

C.-H. Wong, C.W. Bradshaw, “Lactobacillus kefir alcohol dehydrogenase,” US Patent No. 5,342,767 (1995).

C.W. Bradshaw, C.-H. Wong, G.-J. Shen, “Pseudomonas sp. ATCC 49794 PED alcohol dehydrogenase,” US Patent No. 5,385,833 (1995).

W. Yuan, C.-H. Wong, B. Samuelsson, “Novel tight-binding inhibitors of leukotriene A4 hydrolase,” US Patent No. 5,455,271 (1995).

C.-H. Wong, G.C. Look, “Enzymatic process for producing a galactosyl b-1,3-glycal disaccharide using b-galactosidase,” US Patent No. 5,403,726 (1995).

C.-H. Wong, M. Schuster, “Process for solid-phase glycopeptide synthesis,” US Patent No. 5,369,017 (1994).

C.-H. Wong, F. Gaeta, “Combined use of b-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one-pot synthesis of oligosaccharides,” US Patent No. 5,374,541 (1994).

C.-H. Wong, T. Sugai, G.-J. Shen, “KDO aldolase and condensation reactions employed therewith,” US Patent No. 5,358,859 (1994).

C.-H. Wong, K.K.-C. Liu, “Aldolase enzyme process for making 5-azido-5-deoxy-hexulose-1-phosphate, US Patent No. 5,352,591 (1994).

C.-H. Wong, T. Kajimoto, K.K.-C. Liu, Lihren Chen, “Process for forming Omega-deoxy-azasugars,” US Patent No. 5,276,120 (1994).

C.-H. Wong, G.-J. Shen, Y. Ichikawa, “A method and composition for synthesizing sialylated glycosyl compounds,” US Patent No. 5,278,299 (1994).

C.-H. Wong, C.W. Bradshaw, “Lactobacillus kefir alcohol dehydrogenase,” US Patent No. 5,225,339 (1993).

C.-H. Wong, K.K.-C. Liu, “2-Methyl-5-hydroxylmethyl and 2,5-dimethyl-3,4-dihydroxypyrrolidines,” US Patent No. 5,229,523 (1993).

C.-H. Wong, W.J. Hennen, “2-Deoxy Derivatives of N-Acetyl Neuraminic Acid and Their Preparation,” US Patent No. 5,239,091 (1993).

C.-H. Wong, “l-Isomeric sugars having formed stereogenic centers of (R)-configuration: Methods and compositions,” US Patent No. 5,162,513 (1992).

P.N. Bryan, M. Pantoliano, M.L. Rollence, C.-H. Wong, “Biosynthetic uses of thermostable proteases,” US Patent No. 5,116,741 (1992).

C.-H. Wong, J.R. Durrwachter, R.L. Pederson, “Fructose-1,6-diphosphate Aldolase Catalyzed Stereoselective Synthesis of Sugars,” US Patent No. 5,143,831 (1992).

C.-H. Wong, Y.-F. Wang, W.J. Hennen, “Enantio- and Regioselective Synthesis of Organic Compounds Using Enol Esters as Irreversible Transacylation Reagents,” US Patent No, 5196750 (1992).

C.-H. Wong, W.J. Hennen, “Process for the enzymatic synthesis of nucleosides,” US Patent No. 5075225 (1991).

G.M. Whitesides, P.F. Mazenod, C.-H. Wong, “Preparation of 6-Deoxy-d-Fructose and 6-deoxy-L-Sorbose,” US Patent No. 4,440,854 (1984).

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