Wolan Laboratory

The Scripps Research Institute Departments of Molecular and Experimental Medicine and Chemical Physiology
10550 North Torrey Pines
Mail Stop MEM-L43
La Jolla, CA 92037

Lab: 858.784.7946
Office: 858.784.7936
wolan@scripps.edu

Selected Publications

Wolan Lab

Gonzalez, G.E. and Wolan, D.W. 2012. "Ultrahigh and high resolution structures and mutational analysis of monomeric Streptococcus pyogenes SpeB reveal a functional role for the glycine-rich C-terminal loop." Journal of Biological Chemistry, 287, 24412-24426.

Postdoctorate

Wolan, D.W., Zorn, J.A., Gray, D. and Wells, J.A. 2009. “Small molecule activators of a proenzyme.” Science 326, 853-858.

Publication highlighted in the following articles:

Graduate

Cheong, C.G., Wolan, D.W., Greasley, S.E., Horton, P.A., Beardsley, G.P. and Wilson, I.A. 2004. “Crystal structures of human bifunctional enzyme ATIC in complex with potent sulfonyl-containing antifolates.” Journal of Biological Chemistry 17, 18034-18045.

Wolan, D.W., Cheong, C.G., Greasley, S.E. and Wilson, I.A. 2004. “Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with bound XMP inhibitor.” Biochemistry 43, 1171-1183.

Wolan, D.W., Greasley, S.E., Wall, M.J., Benkovic, S.J. and Wilson, I.A. 2003. “Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor β-DADF identifies the folate binding site.” Biochemistry 42, 10904-10914.

Wolan, D.W., Greasley, S.E., Beardsley, G.P. and Wilson, I.A. 2002. “Structural insights into the avian AICAR transformylase mechanism.” Biochemistry 41, 15505-15513.

Wolan, D.W., Teyton L., Rudolph, M.G., Villmow, B., Bauer, S., Busch, D.H. and Wilson, I.A. 2001. “Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 Å.” Nature Immunology 2, 248-254.