The Wiseman Lab


The maintenance of cellular protein homeostasis (or proteostasis) in the crowded intracellular environment is a fundamental biological challenge. In order to prevent pathologic disruptions in cellular proteostasis, cells have evolved stress-responsive signaling pathways such as the endoplasmic reticulum unfolded protein response and the cytosolic heat shock response that transcriptionally remodel cellular proteostasis pathways in response to environmental, genetic or aging-related insults. The primary focus of the Wiseman lab is to elucidate the functional implications of stress-responsive signaling on the composition and activity of cellular proteostasis pathways and to evaluate the therapeutic potential for activation of stress-responsive signaling to ameliorate pathologic protein misfolding associated with human disease.


Adapting Cellular Proteostasis through Stress-Responsive Signaling