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The Taffe Laboratory

Opioids

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 A surge in the non-medical use of prescription opioids developed over the ~2004-2012 interval in the US, this was followed by a rise in the use of heroin. In more recent years, starting around 2015 a large increase in the availability of potent, fentanyl-derivative drugs on the illicit market was observed.

The Taffe laboratory studies on opioids were initiated to determine the behavioral and neurological consequences of oxycodone use. Oxycodone, the active opioid in Oxycontin and Percoset. This work includes a major focus on the role of the endogenous opioid dynorphin and it's receptor, the kappa opioid receptor. In addition, the Lab is pursuing research on potential therapy for oxycodone addiction including the development of anti-oxycodone vaccination strategies and synergistic effects of cannabinoids such as THC.

 

Publications

Nguyen*, J.D., Hwang*, C.S., Grant, Y., Janda, K.D.. and Taffe, M.A. Prophylactic vaccination protects against the development of oxycodone self-administration.  Neuropharmacology, 2018, 138:292-303. [ Publisher Link ][ PubMed ]

 [* authors contributed equally]

Preprints

 

Nguyen, J.D., Grant, Y., Creehan, K.M., Hwang, C.S., Vandewater, S.A., Janda, K.D., Cole, M. and Taffe, M.A. Δ9-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions. bioRχiv, 2017, Posted December 23, 2017 doi: 

Nguyen, J.D., Hwang, C.S., Grant, Y., Janda, K.D.. and Taffe, M.A. Prophylactic vaccination protects against the development of oxycodone addiction. bioRχiv, 2017, Posted October 27, 2017  [Accepted for publication 06/21/18; Neuropharmacology]

Nguyen, J.D., Kirson, D., Steinman, M.Q., Patel, R., Khom, S., Varodayan, F.P., Hedges, D.M., Oleata, C.S., Grant, Y., Roberto, M. and Taffe, M.A.Withdrawal-induced escalated oxycodone self-administration is mediated by kappa opioid receptor function. bioRχiv, 2017, Posted August 18, 2017 doihttps://doi.org/10.1101/177899

Opioid research in the Taffe Laboratory is supported by USPHS Grant R01 DA035281.