The Taffe Laboratory

Cannabis

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The Scripps Center for Cannabis Addiction Neurobiology (SCCAN)

 
Marijuana

The Primate Neurobehavioral Laboratory participated under Project #3 (Consequences of chronic exposure to Δ⁹-tetrahydrocannabinol in monkeys) of the Center.

The goal of this project was to determine the cognitive effects ofactute and chronic exposure to delta-9-tetrahydrocannabinol (THC), the primary psychoactive compound in smoked cannabis.

Publications

Wright, Jr, M.J., Vandewater, S.A., Parsons, L.H. and Taffe, M.A. Δ⁹tetrahydrocannabinol impairs reversal learning but not extra-dimensional shifts in rhesus macaques. Neurosci, 2013, 235:51-58 [ PubMed ][ Publisher Link ]

Taffe, M.A. Δ⁹-Tetrahydrocannabinol impairs visuo-spatial associative learning and spatial working memory in rhesus macaques, J Psychopharmacol, 2012, Oct; 26(10):1299-306. Epub 2012 Apr 22[ PubMed Abstract ][ Publisher Link ][ RequestPDF ]

Taffe, M.A. Δ⁹-Tetrahydrocannabinol attenuates MDMA-induced hyperthermia in rhesus monkeys, Neuroscience, 2012, 201:125-133 Nov 29 2011 [Epub ahead of print] [ PubMed Abstract ] [ Publisher Link ] [ RequestPDF ]

Cannabis research in The Primate Neurobehavioral Laboratory was supported by USPHS Grant P20 DA024194 (Taffe, PI Proj#3; 09/30/07-6/30/11).