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The Sundrud Laboratory

Selected publications

* Co-corresponding authorship

Primary Research

Ramesh R, Kozhaya L, McKevitt K, Djuretic IM, Carlson TJ, Quintero, McCauley JL, Abreu MT, Unutmaz D, Sundrud MS. "Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids." J Exp Med. 2014. Jan 6; 211(1): 89-104.

Carlson TJ, Pellerin A, Djuretic IM, Trivigno C, Koralov SB, Rao A, Sundrud MS. 2014. "Halofuginone-induced amino acid starvation regulates Stat3-dependent Th17 effector function and reduces established autoimmune inflammation." J Immunol. 2014.  In press.

Keller TL, Zocco D, Sundrud MS, Hendrick M, Edenius M, Yum J, Kim YJ, Lee HK, Cortese JF, Wirth DF, Dignam JD, Rao A, Yeo CY, Mazitschek R, Whitman M. "Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase." Nat Chem Biol. 2012. 8(3):311-7. PMCID: PMC3281520 [PubMed]

Wan Q, Kozhaya L, ElHed A, Ramesh R, Carlson TJ, Djuretic IM, Sundrud MS*, Unutmaz D*. "Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+ human memory T cells." J Exp Med. 2011. 208(9):1875-87. PMCID: PMC3171088 [PubMed]

Ghosh S, Koralov SB, Stevanovic I, Sundrud MS, Sasaki Y, Rajewsky K, Rao A, Müller MR. "Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis." Proc Natl Acad Sci USA. 2010. 107(34):15169-74. PMCID: PMC2930568 [PubMed]

Koh KP, Sundrud MS, Rao A. "Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3." PLoS One. 2009. 4(12):e8109. PMCID: PMC2779587 [PubMed]

Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A. "Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response." Science. 2009. 324(5932):1334-8. PMCID: PMC2803727 [PubMed]

Sundrud MS, Vancompernolle SE, Eger KA, Bruno TC, Subramaniam A, Mummidi S, Ahuja SK, Unutmaz D. "Transcription factor GATA-1 potently represses the expression of the HIV-1 coreceptor CCR5 in human T cells and dendritic cells." Blood. 2005. 106(10):3440-8. PMCID: PMC1895046 [PubMed]

Sundrud MS, Torres VJ, Unutmaz D, Cover TL. "Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion." Proc Natl Acad Sci USA. 2004. 101(20):7727-32. PMCID: PMC419674 [PubMed]

Sundrud MS, Grill SM, Ni D, Nagata K, Alkan SS, Subramaniam A, Unutmaz D. "Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation." J Immunol. 2003. 171(7):3542-9. [PubMed]

Books and Reviews

Sundrud MS, Trivigno C. "Identity crisis of Th17 cells: many forms, many functions, many questions." Semin Immunol. 2013.  Nov. 15; 25(4):263-72.

Sundrud MS, Nolan MA. "Synergistic and combinatorial control of T cell activation and differentiation by transcription factors." Curr Opin Immunol. 2010. 22(3):286-92. [PubMed]

Sundrud MS, Koralov SB. Chapter: "Negative regulation of Th17 differentiation." In: Quesniaux V, Ryffel B, Padova F, editors. "TH17 Cells in Health and Disease." New York: Springer Press. 2010. [Publisher's Link]

Sundrud MS, Rao A. "New twists of T cell fate: control of T cell activation and tolerance by TGF-beta and NFAT." Curr Opin Immunol. 2007. 19(3):287-93. [PubMed]

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