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The Sun Lab

Publications

Sun P, Schoderbek WE and Maurer RA. 1992. Phosphorylation of Cyclic Adenosine 3’, 5’ -Monophosphate (cAMP) Response Element-Binding Protein Isoforms by the cAMP-Dependent Protein Kinase. Molecular Endocrinology 6:1858-1866.

Sun P, Enslen H, Myung PS and Maurer RA, 1994. Differential Activation of CREB by Ca2+/Calmodulin-dependent Protein Kinases Type II and IV Involves Phosphorylation of a Site That Negatively Regulates Activity. Genes Dev. 8:2527-2539.

Enslen H, Sun P, Brickey D, Soderling SH, Klamo E and Soderling TR. 1994. Characterization of Ca2+/Calmodulin-dependent Protein Kinase IV. J. Biol. Chem. 269:15520-15527.

Sun P and Maurer RA, 1995. An inactivating Point Mutation Demonstrates that Interaction of CREB with the CREB Binding Protein (CBP) is not sufficient for Transcriptional Activation. J. Biol. Chem. 270:7041-7044

Sun P, Lou L and Maurer RA, 1996. Regulation of Activating Transcription Factor-1 and the cAMP Response Element-binding Protein by Ca2+/Calmodulin-dependent Protein Kinases Type I, II, and IV. J. Biol. Chem. 271:3066-3073.

Sun P, Dong P, Dai K, Hannon GJ and Beach D, 1998. The p53-Independent Role of MDM2 in TGF-β Resistance in Tumors. Science 282:2270-2272.

Hannon GJ, Sun P, Carnero A, Xie LY, Maestro R, Conklin DS and Beach D, 1999. MaRX: An Approach to Genetics in Mammalian Cells. Science 283:1129-1130.

Wang WJ, Chen X, Liao R, Deng Q, Zhou JJ, Huang S and Sun P, 2002. Sequential Activation of the MEK-Extracellular Signal-Regulated Kinase and MKK3/6-p38 Mitogen-Activated Protein Kinase Pathways Mediates Oncogenic ras-Induced Premature Senescence. Mol. Cell Biol. 22:3389-3403.

Li X, Zhao Q, Liao R, Sun P, Wu X, 2003. The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. J Biol Chem. 278:30854-8

Deng Q, Liao R, Wu BL and Sun P, 2004. High-intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts. J. Biol. Chem. 279:1050-9 (Epub 2003 Oct. 29).

Bian D, Su S, Mahanivong C, Chen RK, Han Q, Pan ZK, Sun P and Huang H, 2004. Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway. Cancer Res. 64:4209-17.

de Parseval A, Ngo S, Sun P and Elder JH, 2004. Factors that increase the effective concentration of CXCR4 dictate feline immunodeficiency virus tropism and kinetics of replication. J Virol. 78:9132-43.

de Parseval A, Chatterji U, Sun P and Elder JH, 2004. Feline immunodeficiency virus targets activated CD4+ T cells by using CD134 as a binding receptor. Proc. Natl. Acad. Sci. 101:13044-9.

de Parseval A, Chatterji U, Morris G, Sun P, Olson AJ and Elder JH, 2005. Structural mapping of CD134 residues critical for interaction with feline immunodeficiency virus. Nat. Struct. Mol. Biol. 12:60-6.

Deng Q, Li Y, Tedesco D, Liao R, Fuhrmann G and Sun P. 2005. The Ability of E1A to Rescue ras-induced Premature Senescence and Confer Transformation Relies on Inactivation of both p300/CBP and Rb Family Proteins. Cancer Res. 65:8298-307.

Lin S, Xiao R, Sun P, Xu X. and Fu X, 2005. Dephosphorylation-Dependent Sorting of SR Splicing Factors during mRNP Maturation. Mol. Cell 20:413-25.

Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong M, Frangou CG, Yates, JR III, Wright PE and Han J, 2007. PRAK Mediates a Novel Pathway Essential for Oncogenic ras-Induced Senescence and Tumor Suppression. Cell 128:295-308.

Kannemeier C, Liao R and Sun P, 2007. The RING Finger Domain is Essential for MDM2-mediated TGF-β Resistance. Mol. Biol. Cell 18:2367-2377.

Han J. and Sun P, 2007. The Pathways to Tumor Suppression via Route p38. Trends Biochem. Sci. 32:364-371.

Wang K, Cheng C, Li L, Liu H, Huang Q, Xia CH, Yao K, Sun P, Horwitz J, Gong X, 2007. γD-Crystallin Associated Protein Aggregation and Lens Fiber Cell Denucleation. Invest. Ophthalmol. Vis. Sci. 48:3719-3728.

Liu E, Lee A, Chiba T, Olson . Sun P and Wu X. 2007 ATR-mediated S-phase checkpoint prevents DNA rereplication in mammalian cells when the licensing control is disrupted. Journal of Cell Biology. 179:643-57.

Kwong J, Hong L, Liao R, Deng Q, Han J and Sun P. 2009 p38α and p38γ Mediate oncogenic RAS-induced senescence through differential mechanisms. J. Biol.Chem. 284:11237-46. PMID:19251701 PMCID: PMC2670128

Ren JL, Pan JS, Lu YP, Sun P, Han J. 2009 Inflammatory signaling and cellular senescence. Cell Signal. 21:378-83. PMID: 18992324 PMCID: PMC2870712

Wu C-C, Wu X, Han J, and Sun P. 2010 p38γ Regulates UV-Induced Checkpoint Signaling and Repair of UV-Induced DNA Damage. Protein Cell 1:573-583. PMID:21170151 PMCID: PMC3002048

Hong L, Lai M, Chen M, Xie C, Liao R, Kang YL, Xiao C, Hu W-Y, Han J, and Sun P. 2010. The miR-17-92 Cluster of microRNAs Confers Tumorigenicity by Inhibiting Oncogene-Induced Senescence. Cancer Res. 70:8547-57. Epub 2010 Sep 17. PMID: 20851997 PMCID: PMC2970743

Zheng M, Wang YH, Wu XN, Wu SQ, Lu BJ, Dong MQ, Zhang H, Sun P, Lin SC, Guan KL, Han J.2011  Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppressionof mTORC1. Nat Cell Biol. 2011 Mar;13(3):263-72. Epub 2011 Feb 20. PMID: 21336308 PMID:21336308 PMCID: PMC3070924

Yoshizuka N, Chen RM, Xu Z, Liao R, Hong L, Hu W-Y, Yu G, Han J, Chen L, Sun P. 2012. A Novel Function of p38-Regulated/Activated Kinase (PRAK) In Endothelial Cell Migration and Tumor Angiogenesis. Mol Cell Biol. 32(3):606-18. 2012 Feb;32(3):606-18 Epub 2011 Nov 28. PMCID: PMC3266605

Yoshizuka N, Lai M, Liao R, Cook R, Xiao C, Han J, Sun P. 2012. PRAK suppresses oncogenic ras-induced hematopoietic cancer development by antagonizing the JNK pathway. Mol Cancer Res. Jun;10(6):810-20. Epub 2012 Jun 4 PMCID: PMC3378811

Kolesnichenko M, Hong L, Liao R, Vogt PK, Sun P. 2012 Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence. Cell Cycle. 2012 Jun 15; 11 (12) PMID: 22627671 PMCID: PMC3383597

Zheng H, Seit-Nebi A, Han X, Aslanian A, Tat J, Liao R, Yates JR III, Sun P. 2013. A posttranslational modification cascade involving p38, Tip60 and PRAK mediates oncogene-induced senescence. Molecular Cell 50:699-710. PMCID:PMC3679363

Kwong J, Chen M, Lv D, Luo N, Xiang R and Sun P. 2013. Induction of p38d expression plays an essential role in oncogenic ras-induced senescence. Mol. Cell. Biol. 33:3780-3794. PMCID: PMC3811880

Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan KL, Zheng ZM, Newton AC, Sun P, Zhou H, Fu XD. Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Mol Cell. 2014 May 8;54(3):378-91. PubMed PMID: 24703948; PMCID: PMC4019712

Xu Y, Li N, Xiang R, Sun P. Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence. Trends Biochem Sci. 2014 Jun;39(6):268-76. PMID: 24818748;

Sun P. Contact inhibition against senescence. Oncotarget. 2014 Sep 15;5(17):7212-3. PMID: 25277173; PMCID: PMC4202117  

Jansma AL, Martinez-Yamout MA, Liao R, Sun P, Dyson HJ, Wright PE. The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb. J Mol Biol. 2014 Dec 12;426(24):4030-48. PubMed PMID: 25451029; PMCID: PMC4258470

Xu Y, Liao R, Li N, Xiang R, Sun P. Phosphorylation of Tip60 by p38α regulates p53-mediated PUMA induction and apoptosis in response to DNA damage. Oncotarget. 2014 Dec 30;5(24):12555-72. PMID: 25544752

Li YW, Shen H, Frangou C, Yang N, Guo J, Xu B, Bshara W, Shepherd L, Zhu Q, Wang J, Hu Q, Liu S, Morrison CD, Sun P, Zhang J. Characterization of TAZ domains important for the induction of breast cancer stem cell properties and tumorigenesis. Cell Cycle. 2015;14(1):146-56. PMID: 25602524