The Sun Lab

Publications

Sun P, Schoderbek WE and Maurer RA. 1992. Phosphorylation of Cyclic Adenosine 3’, 5’ -Monophosphate (cAMP) Response Element-Binding Protein Isoforms by the cAMP-Dependent Protein Kinase. Molecular Endocrinology 6:1858-1866.

Sun P, Enslen H, Myung PS and Maurer RA, 1994. Differential Activation of CREB by Ca2+/Calmodulin-dependent Protein Kinases Type II and IV Involves Phosphorylation of a Site That Negatively Regulates Activity. Genes Dev. 8:2527-2539.

Enslen H, Sun P, Brickey D, Soderling SH, Klamo E and Soderling TR. 1994. Characterization of Ca2+/Calmodulin-dependent Protein Kinase IV. J. Biol. Chem. 269:15520-15527.

Sun P and Maurer RA, 1995. An inactivating Point Mutation Demonstrates that Interaction of CREB with the CREB Binding Protein (CBP) is not sufficient for Transcriptional Activation. J. Biol. Chem. 270:7041-7044

Sun P, Lou L and Maurer RA, 1996. Regulation of Activating Transcription Factor-1 and the cAMP Response Element-binding Protein by Ca2+/Calmodulin-dependent Protein Kinases Type I, II, and IV. J. Biol. Chem. 271:3066-3073.

Sun P, Dong P, Dai K, Hannon GJ and Beach D, 1998. The p53-Independent Role of MDM2 in TGF-β Resistance in Tumors. Science 282:2270-2272.

Hannon GJ, Sun P, Carnero A, Xie LY, Maestro R, Conklin DS and Beach D, 1999. MaRX: An Approach to Genetics in Mammalian Cells. Science 283:1129-1130.

Wang WJ, Chen X, Liao R, Deng Q, Zhou JJ, Huang S and Sun P, 2002. Sequential Activation of the MEK-Extracellular Signal-Regulated Kinase and MKK3/6-p38 Mitogen-Activated Protein Kinase Pathways Mediates Oncogenic ras-Induced Premature Senescence. Mol. Cell Biol. 22:3389-3403.

Li X, Zhao Q, Liao R, Sun P, Wu X, 2003. The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. J Biol Chem. 278:30854-8

Deng Q, Liao R, Wu BL and Sun P, 2004. High-intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts. J. Biol. Chem. 279:1050-9 (Epub 2003 Oct. 29).

Bian D, Su S, Mahanivong C, Chen RK, Han Q, Pan ZK, Sun P and Huang H, 2004. Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway. Cancer Res. 64:4209-17.

de Parseval A, Ngo S, Sun P and Elder JH, 2004. Factors that increase the effective concentration of CXCR4 dictate feline immunodeficiency virus tropism and kinetics of replication. J Virol. 78:9132-43.

de Parseval A, Chatterji U, Sun P and Elder JH, 2004. Feline immunodeficiency virus targets activated CD4+ T cells by using CD134 as a binding receptor. Proc. Natl. Acad. Sci. 101:13044-9.

de Parseval A, Chatterji U, Morris G, Sun P, Olson AJ and Elder JH, 2005. Structural mapping of CD134 residues critical for interaction with feline immunodeficiency virus. Nat. Struct. Mol. Biol. 12:60-6.

Deng Q, Li Y, Tedesco D, Liao R, Fuhrmann G and Sun P. 2005. The Ability of E1A to Rescue ras-induced Premature Senescence and Confer Transformation Relies on Inactivation of both p300/CBP and Rb Family Proteins. Cancer Res. 65:8298-307.

Lin S, Xiao R, Sun P, Xu X. and Fu X, 2005. Dephosphorylation-Dependent Sorting of SR Splicing Factors during mRNP Maturation. Mol. Cell 20:413-25.

Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong M, Frangou CG, Yates, JR III, Wright PE and Han J, 2007. PRAK Mediates a Novel Pathway Essential for Oncogenic ras-Induced Senescence and Tumor Suppression. Cell 128:295-308.

Kannemeier C, Liao R and Sun P, 2007. The RING Finger Domain is Essential for MDM2-mediated TGF-β Resistance. Mol. Biol. Cell 18:2367-2377.

Han J. and Sun P, 2007. The Pathways to Tumor Suppression via Route p38. Trends Biochem. Sci. 32:364-371.

Wang K, Cheng C, Li L, Liu H, Huang Q, Xia CH, Yao K, Sun P, Horwitz J, Gong X, 2007. γD-Crystallin Associated Protein Aggregation and Lens Fiber Cell Denucleation. Invest. Ophthalmol. Vis. Sci. 48:3719-3728.

Liu E, Lee A, Chiba T, Olson . Sun P and Wu X. 2007 ATR-mediated S-phase checkpoint prevents DNA rereplication in mammalian cells when the licensing control is disrupted. Journal of Cell Biology. 179:643-57.

Kwong J, Hong L, Liao R, Deng Q, Han J and Sun P. 2009 p38α and p38γ Mediate oncogenic RAS-induced senescence through differential mechanisms. J. Biol.Chem. 284:11237-46. PMID:19251701 PMCID: PMC2670128

Ren JL, Pan JS, Lu YP, Sun P, Han J. 2009 Inflammatory signaling and cellular senescence. Cell Signal. 21:378-83. PMID: 18992324 PMCID: PMC2870712

Wu C-C, Wu X, Han J, and Sun P. 2010 p38γ Regulates UV-Induced Checkpoint Signaling and Repair of UV-Induced DNA Damage. Protein Cell 1:573-583. PMID:21170151 PMCID: PMC3002048

Hong L, Lai M, Chen M, Xie C, Liao R, Kang YL, Xiao C, Hu W-Y, Han J, and Sun P. 2010. The miR-17-92 Cluster of microRNAs Confers Tumorigenicity by Inhibiting Oncogene-Induced Senescence. Cancer Res. 70:8547-57. Epub 2010 Sep 17. PMID: 20851997 PMCID: PMC2970743

Zheng M, Wang YH, Wu XN, Wu SQ, Lu BJ, Dong MQ, Zhang H, Sun P, Lin SC, Guan KL, Han J. Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppressionof mTORC1. Nat Cell Biol. 2011 Mar;13(3):263-72. Epub 2011 Feb 20. PMID: 21336308 PMID:21336308 PMCID: PMC3070924