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Welcome to the Strosberg Lab

The Strosberg laboratory has two main interests:

Virology:

We study the role of protein-protein interactions in host–pathogen relation, in particular for the Hepatitis C and Human Immunodeficiency viruses. Our results show that inhibitors of dimerization of core, the HCV capsid protein, block viral particle assembly without affecting entry or replication of the virus. Small molecules active at nanomolar concentrations have been developed with the help of chemists from Boston University and Scripps Florida. Furthermore, we have established that the interaction of core with the viral helicase depends on core dimerization. Assays were also developed to discover inhibitors of the HIV capsid protein p24. We have thus established that the viral capsid proteins constitute novel targets for drug development. Our goal is now to explore the role of viral non structural and host cell proteins in the budding of the particle.

Cell Biology:

We have previously developed the unique PAZ6 human brown pre-adipocyte cell line which we are now evaluating as a model to study potential markers and pathways in stem cell-derived brown adipocytes. We have already confirmed that the PAZ6 cells express most of the markers identified in primary brown adipocytes. Our goal is to better understand human brown adipocyte differentiation and thermogenesis in order to develop novel treatments for metabolic diseases.

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