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Transhydrogenase

Transhydrogenase Image
Superposition of three copies of the co-crystal structure of soluble TH domains. The lare membrane component of the intact enzyme resides below the soluble domains in this view.

Major effort is focused on transhydrogenase (TH), a mitochondrial enzyme and large integral membrane protein.  Structure determination will elucidate the mechanism by which TH transduces the proton motive force generated by respiration into the chemistry required to maintain a reducing environment.  Understanding of TH function is relevant to type 2 diabetes and neurodegenerative diseases.