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Publications


  • Witham, E. Comunian, C., Ratanpal, H., Skora, S., Zimmer, M., Srinivasan, S. (2016) C. elegans Body Cavity Neurons are Homeostatic Sensors that Integrate Fluctions in Oxygen Availability and Internal Nutrient Reserves. Cell Reports 14(7):1641-54. 
  • Noble, T., Stieglitz,  J., Srinivasan,  S. (2013) An Integrated  Serotonin  and Octopamine  Neuronal  Circuit Directs  the Release  of an Endocrine  Signal  to Control  C. elegans  Body Fat  Cell Metabolism  18:  672-84.  PMID: 24120942; PMCID: In Process
  • Behl, M., Rao, D., Aagaard, K., Davidson, T., Levin, E., Slotkin, T., Srinivasan, S., Wallinga, D., White, M., Walker, V., Thayer, K. and Holloway, A. (2013) Evaluation of the association between maternal smoling, childhood obesity and metabolic disorders: A National Toxicology Program Workshop Review. Environmental Health Perspectives 121(2): 170-180. PMID: 23232494; PMCID: In Process
  • Cunningham, K.A., Hua, Z., Srinivasan, S., Liu, J., Lee, B.H., Edwards, R. H. and Ashrafi, K. (2012)   AMP- activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegansCell Metabolism 16: 113-121.  PMID: 22768843; PMCID: PMC3413480
  • Lee BH, Liu J, Wong D, Srinivasan S, Ashrafi K. Hyperactive Neuroendocrine Secretion Causes Size, Feeding, and Metabolic Defects of C. elegans Bardet-Biedl Syndrome Mutants. PLoS Biol. 2011;9(12):e1001219.
  • Srinivasan S, Sadegh L, Elle IC, Christensen AG, Faergeman NJ, Ashrafi K. Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms. Cell Metab. 2008;7(6):533-44.
  • Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL. Engineering GPCR signaling pathways with RASSLs. Nat Methods. 2008;5(8):673-8.
  • Srinivasan S, Santiago P, Lubrano C, Vaisse C, Conklin BR. Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo. PLoS One. 2007;2(7):e668.
  • Govaerts C, Srinivasan S, Shapiro A, Zhang S, Picard F, Clement K, Lubrano-Berthelier C, Vaisse C. Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function. Peptides. 2005;26(10):1909-19.
  • Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C. Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. J Clin Invest. 2004;114(8):1158-64.
  • Srinivasan S, Vaisse C, Conklin BR. Engineering the melanocortin-4 receptor to control G(s) signaling in vivo. Ann N Y Acad Sci. 2003;994):225-32.
  • Alexander S, Srinivasan S, Alexander H. Proteomics opens doors to the mechanisms of developmentally regulated secretion. Mol Cell Proteomics. 2003;2(11):1156-63.
  • Srinivasan S, Traini M, Herbert B, Sexton D, Harry J, Alexander H, Williams KL, Alexander S. Proteomic analysis of a developmentally regulated secretory vesicle. Proteomics. 2001;1(9):1119-27.
  • Srinivasan S, Griffiths KR, McGuire V, Champion A, Williams KL, Alexander S. The cellulose-binding activity of the PsB multiprotein complex is required for proper assembly of the spore coat and spore viability in Dictyostelium discoideum. Microbiology. 2000;146 ( Pt 8)):1829-39.
  • Srinivasan S, Alexander H, Alexander S. The Dictyostelium fruiting body - a structure of cells and cellulose. Trends Cell Biol. 2000;10(8):315.
  • Srinivasan S, Alexander H, Alexander S. Crossing the finish line of development: regulated secretion of Dictyostelium proteins. Trends Cell Biol. 2000;10(6):215-9.
  • Mreyen M, Champion A, Srinivasan S, Karuso P, Williams KL, Packer NH. Multiple O-glycoforms on the spore coat protein SP96 in Dictyostelium discoideum. Fuc(alpha1-3)GlcNAc-alpha-1-P-Ser is the major modification. J Biol Chem. 2000;275(16):12164-74.
  • Srinivasan S, Alexander H, Alexander S. The prespore vesicles of Dictyostelium discoideum. Purification, characterization, and developmental regulation. J Biol Chem. 1999;274(50):35823-31.

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