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Recent Lab Publications


Kern A, Mavrikaki M, Ullrich C, Albarran-Zeckler R, Brantley AF, Smith RG.  Cell. 2015 Nov 19;163(5):1176-90.  Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor.

Engel JA, Jerlhag E, Svensson L, Smith RG, Egecioglu E.  Psychopharmacology (Berl). 2015 Dec;232(23):4285-92.  Blockade of growth hormone secretagogue receptor 1A signaling by JMV 2959 attenuates the NMDAR antagonist, phencyclidine-induced impairments in prepulse inhibition.

Garcia JM, Chen JA, Guillory B, Donehower LA, Smith RG, Lamb DJ.  Biol Reprod. 2015 Jul;93(1):24. doi: 10.1095/biolreprod.115.129759. Epub 2015 May 27.  Ghrelin Prevents Cisplatin-Induced Testicular Damage by Facilitating Repair of DNA Double Strand Breaks Through Activation of p53 in Mice.

Whirledge SD, Garcia JM, Smith RG, Lamb DJ.  Biol Reprod. 2015 Mar;92(3):76.  Ghrelin partially protects against cisplatin-induced male murine gonadal toxicity in a GHSR-1a-dependent manner.


Girardet C, Mavrikaki M, Southern MR, Smith RG, Butler AA.  Endocrinology. 2014 Dec;155(12):4843-55.  Assessing interactions between Ghsr and Mc3r reveals a role for AgRP in the expression of food anticipatory activity in male mice.

Kern A, Grande C, Smith RG. Front Endocrinol (Lausanne). 2014 Aug 18;5:129. doi: 10.3389/fendo.2014.00129. eCollection 2014. Review.  Apo-Ghrelin Receptor (apo-GHSR1a) Regulates Dopamine Signaling in the Brain.

Delhanty PJ, van der Velde M, van der Eerden BC, Sun Y, Geminn JM, van der Lely AJ, Smith RG, van Leeuwen JP.  Endocrinology. 2014 Nov;155(11):4287-95.  Genetic manipulation of the ghrelin signaling system in male mice reveals bone compartment specificity of acylated and unacylated ghrelin in the regulation of bone remodeling.

George SR, Kern A, Smith RG, Franco R.  Prog Brain Res. 2014;211:183-200.  Dopamine receptor heteromeric complexes and their emerging functions.

Alvarez-Garcia O, Rogers NH, Smith RG, Lotz MK. Arthritis Rheumatol. 2014 Jul;66(7):1779-88.  Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1.

Tannour-Louet M, Lewis SK, Louet JF, Stewart J, Addai JB, Sahin A, Vangapandu HV, Lewis AL, Dittmar K, Pautler RG, Zhang L, Smith RG, Lamb DJ. FASEB J. 2014 Jan;28(1):364-72. doi:10.1096/fj.13-236109. Epub 2013 Sep 30.   Increased expression of CYP24A1 correlates with advanced stages of prostate cancer and can cause resistance to vitamin D3-based therapies.


Garcia JM, Scherer T, Chen JA, Guillory B, Nassif A, Papusha V, Smiechowska J, Asnicar M, Buettner C, Smith RG.  Endocrinology. 2013 Sep;154(9):3118-29. doi: 10.1210/en.2013-1179. Epub 2013 Jul 5.  Inhibition of cisplatin-induced lipid catabolism and weight loss by ghrelin in male mice.

Albarrán-Zeckler RG, Smith RG. Endocr Dev. 2013;25:5-15. doi: 10.1159/000346042. Epub 2013 Apr 25. Review.  The ghrelin receptors (GHS-R1a and GHS-R1b).

Porporato PE, Filigheddu N, Reano S, Ferrara M, Angelino E, Gnocchi VF, Prodam F, Ronchi G, Fagoonee S, Fornaro M, Chianale F, Baldanzi G, Surico N, Sinigaglia F, Perroteau I, Smith RG, Sun Y, Geuna S, Graziani A.  J Clin Invest. 2013 Feb;123(2):611-22. doi: 10.1172/JCI39920. Epub 2013 Jan 2.  Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice

Rogers NH, Smith RG. Aging (Albany NY). 2012 Nov;4(11):728-9. Review.  Brown-to-white transition in subcutaneous fat: linking aging and disease.

Rogers Nicole H, Landa Alejandro, Park Seongjoon, Smith Roy G (2012)  Aging Leads to a Programmed Loss of Brown Adipocytes in Murine Subcutaneous White Adipose Tissue.  Aging Cell (2012) Dec;11 (6):1074-83.

Park S, Jiang H, Zhang H, Smith RG. (2012).  Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release.  Proc Natl Acad Sci U S A. 2012 Oct 29.

van der Velde M, van der Eerden BCJ, Sun Y, Almering JMM, van der Lely AJ, Delhanty PJD, Smith RG, van Leeuwen JPTM.  (2012) Age-dependent interaction with leptin unmasks ghrelin’s bone-protective effects.  Endocrinology.  2012 Aug; 153(8): 3593-602.

Albarran-Zeckler RG, Brantley AF, Smith RG.  (2012) Growth Hormone Secretagogue Receptor (GHS-R1a) Knockout Mice Exhibit Improved Spatial Memory and Deficits in Contextual Memory.  Behavioural Brain Research, PMCID: PMC3361606.

Kern A, Albarran-Zeckler R, Walsh HE, Smith RG. Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism.  Neuron. 2012 Jan 26; 73(2):317-32.  PMCID: PMC3269786.

Albarran-Zeckler RG, Sun Y, Smith RG (2011) Physiological roles revealed by ghrelin and ghrelin receptor deficient mice. Peptides 2011 Nov; 32 (11) : 2229-35. Epub 2011 Jul 12.  PMCID: PMC3221867.

Szentirmai, E., Kapás, Sun, Y., Smith, RG, Krueger, JM (2010) Restricted feeding-induced sleep, activity, and body temperature changes in normal and preproghrelin-deficient mice.  Am J Physiol Regul Integr Comp Physiol 298 R467-R477.  PMCID: PMC282818

Szentirmai, E., Kapas, L., Sun, Y., Smith, R.G., and Krueger, J.M. (2009)  The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice.  Proc Natl Acad Sci USA 106(33):14069-74.  PMCID: PMC272902.

Hill J. T., Mastracci T. L., Vinton C., Doyle M. L. Anderson K. R,, Loomis Z. L, Schrunk J. M., Minic A. D., Pugliese A., Sun Y., Smith R. G., and Sussel L. (2009) Ghrelin is dispensable for embryonic pancreatic islet development and differentiation. Regulatory Peptides 157:51-56.  PMCID: PMC2828774.

Yang H, Dixit V. D., Patel K, Vandanmagsar B., Collins G., Sun Y., Smith R. G., and Taub D.D. (2008) Reduction in hypophyseal growth hormone and prolactin expression due to deficiency in ghrelin receptor signaling is associated with Pit-1 suppression: Relevance to the immune system.  Brain Behav Immun. (2008) 22:1138-1145. PMCID: PMC2783985.

Garcia J. M, Cata J. P., Dougherty P. M., and Smith R. G. (2008) Ghrelin prevents cisplatin-induced mechanical hyperalgesia and cachexia. Endocrinology 149(2):455-460.  PMCID: PMC2219295.

Sun Y, Butte N. F., Garcia J. M, and Smith R. G. (2008) Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance.  Endocrinology 149(2):843-850.  PMCID: PMC2219310.

Smith, R.G., Betancourt, L., Sun, Y. (2005) Molecular endocrinology and physiology of the aging central nervous system.  Endocrine Reviews 26:203-250.