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Shen Lab Research: Project 5

(v) Microbial natural product isolation and structural elucidation for anticancer and antiinfective drug discovery

1. Establishment of the steroechemistry of dorrigocin A, dorrigocin B, and iso-migrastatin and isolation and structural elucidation of 13-epi-dorrigocin from Streptomyces platensis NRRL18993 (J. Am. Chem. Soc., 2005, 127, 1662-1663)

Diagram of Dorrigocin A and B

2. Isolation and structural elucidation of eight new congeners of iso-migrastatin from Streptomyces platensis NRRL18993 (J. Am. Chem. Soc., 2005, 127, 11930-11931)

Diagram of iso-Migrastatin

3. Isolation and structural elucidation of zorbamycin from Streptomyces flavoviridis ATCC21892 (J. Nat. Prod., 2007, 70: in press)

Diagram of Zorbamycin

4. Isolation and structural elucidation of new congeners of lactimodomycin from Streptomyces amphibiosporus (Org. Lett., 2007, 9, 5183-5186)

Diagram of congeners of lactimodomycin

5. Isolation and structural elucidation of fredericamycin E from Streptomyces griseus (J. Nat. Prod., 2008, 71, 431-437)

Diagram of fredericamycin E

6. Isolation and structural elucidation of new erythromycin analogues erythronolides H and I from Actinopolyspora sp. YIM90600 (Org. Lett., 2009, 11, 1353-1356)

Diagram of elucidation of new erythromycin analogues erythronolides H and I

7. Isolation, structural elucidation, and discovery of novel estrogen receptor heterodimering actinopolymorphol A from Actinopolymorpha rutilus YIM45725 (Org. Lett., 2010, 12, 3525-3527; Biochem. Pharmacol. 2010, 80, 1221-1229)

Diagram of Actinopolymorphol A, B, and C

8. Isolation and structural elucidation of new bafilomycins from an endophytic actinomycete Streptomyces sp. YIM56209 (J. Antibiot., 2011, 64, 159-162)

Diagram of actinomycete

9. Isolation and structural elucidation of new cycloheximides from endophytic actinomycete Streptomyces sps. YIM56132 and YIM56141 (J. Antibiot., 2011, 64, 163-166)

Diagram of new cycloheximides