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Shen Lab Former Members

PhGraduate students

Name

Time

Degree and Current position

Elpidio R. Rafanan

Elpidio

1995-2000

Ph.D. (2000)

Thesis: "Elloramycin biosynthesis in Streptomyces olivaceus Tu2353: genetic and biochemical characterization of the elmGHIJ locus"

Senior Scientist, Bio-Rad Laboratories, Orange County, California

Publications:

1.  Beynon, J.D.; Rafanan Jr., E.R.; Shen, B.; Fisher, A.J. (2000) Crystallization and Preliminary X-ray Analysis of Tetracenomycin A2 Oxygenase: A Flavoprotein Hydroxylase Involved in Polyketide Biosynthesis.  Acta Cryst., D56:1647-1651.
2.  Rafanan Jr., E.R.; Hutchinson, C.R.; Shen, B. (2000) Triple Hydroxylation of Tetracenomycin A2 to Tetracenomycin C Involving Two Molecules of O2 and One Molecule of H2O. Org. Lett., 2:3225-3227.
3.  Rafanan Jr., E.R.; Le, L.; Zhao, L.; Decker, H.; Shen, B. (2001) Cloning, Sequencing, and Heterologous Expression of the elmGHIJ Genes Involved in the Biosynthesis of the Polyketide Antibiotic Elloramycin from Streptomyces olivaceus Tü2353.  J. Nat. Prod., 64:444-449.  (Received the 2001 Best Paper Award of J. Nat. Prod.)

Wen Liu

1996-2000

Ph.D. (2001) (co-advisor)

Thesis title: "Biosynthesis of the novel enediyne antitumor antibiotic C-1027 in Streptomyces globisporus"

Professor, National Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, CAS, Shanghai, China

Publications:

1.  Thorson, J.S.; Shen, B.; Whitwam, R.E.; Liu, W.; Li, Y.; Ahlert, J. (1999) Enediyne Biosynthesis and Self-resistance: A Progress Report.  Bioorg. Chem. 27:172-188.
2.  Liu, W.; Shen, B. (2000) Genes for Production of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus Are Clustered with the cagA Gene That Encodes the C-1027 Apoprotein.  Antimicrob. Agents Chermother. 44:382-392.  (Featured in C & E News, March 13, 2000, pp. 47-49)
3.  Liu, W.; Christenson, S.D.; Standage, S.; Shen, B. (2002) Biosynthesis of the Enediyne Antitumor Antibiotic C-1027.  Science, 297:1170-1173. (Featured in C & E News, August 19, 2002, p12, and various professional and popular media, and selected by C & E News as Chemistry Highlights 2002, December 16, 2002, pp. 35-48)
4. Christenson, S.D.; Liu, W.; Toney, M.D.; Shen, B. (2003) A Novel 4-Methylideneimidazole-5-one-Containing Tyrosine Aminomutase in Enediyne Antitumor Antibiotic C-1027 Biosynthesis.  J. Am. Chem. Soc. 125:6062-6063.
5.  Murrell, J.M.; Liu, W.; Shen, B. (2004) Biochemical Characterization of the SgcA1 α-D-Glucopyranosyl-1-phosphate Thymidylytransferase from the Enediyne Antitumor Antibiotic C-1027 Biosynthetic Pathway and Overexpression of sgcA1 in Streptomyces globisporus to Improve C-1027 Production.  J. Nat. Prod. 67:206-213.
6.  Van Lanen, S.; Dorrestein, P.C.; Christenson, S.D.; Liu, W.; Ju, J.; Kelleher, N.L.; Shen, B. (2005) Biosynthesis of the β-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring β-amnoacyl-S-carrier protein intermediates. J. Am. Chem. Soc. 127:11594-11595.
7.  Shen, B.; Cheng, Y.-Q.; Christenson, S. D.; Jiang, H.; Ju, J.; Kwon, H.-J.; Lim, S.-K.; Liu, W.; Nonaka, K.; Seo, J.-W.; Smith, W. C.; Standage, S.; Tang, G.-L.; Van Lanen, S.; Zhang, J. (2007) Polyketide biosynthesis beyond the type I, II, and III polyketide synthase paradigms: a progress report. In ACS Symposium Series 955: Polyketides: Biosynthesis, Biological Activity, and Engineering, Rimando, A. M.; Baerson, S.R. eds., ACS, Washington DC, pp154-166.

Daniel J. Edwards

dan edwards

1996-2001

Thesis title: “Bleomycin biosynthesis: insights into a hybrid nonribosomal peptide synthetase/polyketide synthase system”

Associate Professor, Depatment of Chemistry and Biochemistry, California State University at Chico, Chico, California; Tel: 530-898-5226; Email: djedwards@csuchico.edu

Publications:

1.  Shen, B.; Du, L.; Sanchez, C.; Chen, M.; Edwards, D.J. (1999) Bleomycin Biosynthesis in Streptomyces verticillus ATCC15003: A Model of Hybrid Peptide and Polyketide Biosynthesis” Bioorg. Chem. 27:155-171.
2.  Du, L.; Sanchez, C.; Chen, M.; Edwards, D.J.; Shen, B. (2000) The Biosynthetic Gene Cluster for the Antitumor Drug Bleomycin from Streptomyces verticillus ATCC15003 Supporting Functional Interactions between Nonribosomal Peptide Synthetases and a Polyketide Synthase.  Chem. Biol. 7:623-642.  (Featured in C & E News, August 12, 2000, p32)
3.  Sanchez, C.; Du, L.; Edwards, D.J.; Toney, M.D,; Shen, B.  (2001) Cloning and Characterization of a Phosphopantetheinyl Transferase from Streptomyces  verticillus ATCC15003, the Producer of the Hybrid Peptide-Polyketide Antitumor Drug Bleomycin.  Chem. Biol., 8:725-738.
4. Shen, B.; Du, L.; Sanchez, C.; Chen, M.; Edwards, D.J.; Chen, M.; Murrell, J.M.  (2001) The Biosynthetic Gene Cluster for the Anticancer Drug Bleomycin from Streptomyces verticillus ATCC15003 as a Model for Hybrid Peptide-Polyketide Natural Product Biosynthesis.  J. Ind. Microbiol. Biotechnol., 27:378-385.
5. Shen, B.; Du, L.; Sanchez, C.; Chen, M.; Edwards, D.J.; Chen, M.; Murrell, J.M.  (2002) Cloning and Characterization of the Bleomycin Biosynthetic Gene Cluster from Streptomyces verticillus ATCC15003.  J. Nat. Prod. 65:422-531.
6.  Shen, B.; Chen, M.; Cheng, Y.-Q.; Du, L.; Edwards, D.J.; George, N.P.; Huang, Y.; Oh, T.; Sanchez, C.; Tang, G.-L.; Wendt-Pienkowski, E.; Yi, F. (2005) “Prerequisites for combinatorial biosynthesis: evolution of hybrid NRPS-PKS gene clusters” in Biocombinatorial Approaches for Drug Finding, The Ernst Schering Research Foundation Workshop 51, Springer-Verlag, Berlin, 2005, pp107-126.

Wyatt C. Smith

wyatt smith

1996-2002

Ph.D. (2002)

Thesis title: "Molecular and biochemical characterization of the macrotetrolide biosynthesis cluster from Streptomyces griseus DSM40695"

Scientist II, Department of Biochemistry, Genencor/DuPont, 925 Page Mill Rd., Palo Alto, California 04304; Tel. 650-846-5890; Email: wsmith@genencor.com

Publications:

1.  Smith, W. C.; Xiang, L.; Shen, B. (2000) Genetic Localization and Molecular Characterization of the nonS Gene Required for Macrotetrolide Biosynthesis in Streptomyces griseus DSM40695. Antimicrob. Agents Chermother. 44:1943-1953.
2.  Kwon, H.-J.; Smith, W.C.; Xiang, L.; Shen, B. (2001) Cloning and Heterologous Expression of the Macrotetrolide Biosynthetic Gene Cluster Revealed a Novel Polyketide Synthase That Lacks an Acyl Carrier Proteine.  J. Am. Chem. Soc., 123:3385-3386.
3.  Kwon, H.-J.; Smith, W.C.; Scharon, A.J.; Hwang S.H.; Kurth, M.J.; Shen, B. (2002) C—O Bond Formation by Polyketide Synthases.  Science, 297:1327-1330. (Featured in Science in “This Week in Science”, 297:1233, 2002)
4.  Zhao, C.; Ju, J.; Christenson, S. D.; Smith, W. C.; Song, D.; Zhou, X.; Shen, B.; Deng, Z. (2006) Utilization of the methoxymalony-acyl carrier protein biosynthetic locus for the cloning of the oxazolomycin biosynthetic gene cluster from Streptomyces albus.  J. Bacteriol. 198:4141-4147.
5.  Shen, B.; Cheng, Y.-Q.; Christenson, S. D.; Jiang, H.; Ju, J.; Kwon, H.-J.; Lim, S.-K.; Liu, W.; Nonaka, K.; Seo, J.-W.; Smith, W. C.; Standage, S.; Tang, G.-L.; Van Lanen, S.; Zhang, J. (2007) Polyketide biosynthesis beyond the type I, II, and III polyketide synthase paradigms: a progress report. In ACS Symposium Series 955: Polyketides: Biosynthesis, Biological Activity, and Engineering, Rimando, A. M.; Baerson, S.R. eds., ACS, Washington DC, pp154-166.

Jeffrey M. Murrell

jeffmurrel

1998-2003

Ph.D. (2003)

Thesis title: "Investigation of sugar biosynthesis pathways of antitumor antibiotics C-1027 and bleomycin"

Director or Research, StaVin, Inc., P.O. Box 1693, Sausalito, CA 94966-1693; Tel. 707-225-4794

Publications:
1.  Murrell, J.M.; Liu, W.; Shen, B. (2004) Biochemical Characterization of the SgcA1 α-D-Glucopyranosyl-1-phosphate Thymidylytransferase from the Enediyne Antitumor Antibiotic C-1027 Biosynthetic Pathway and Overexpression of sgcA1 in Streptomyces globisporus to Improve C-1027 Production.  J. Nat. Prod. 67:206-213.

Steven D. Christenson

S Christianson

1997-2003

Ph.D. (2003)

Thesis title: "Genetic and biochemical characterization of C-1027 enediyne biosynthesis cluster from Streptomyces globisporus"

Professor, Department of Biology, Brigham Young University-Idaho, Rexburg, Idaho; Tel. 208-496-4609;
Email: christensons@byui.edu

Publications:

1.  Liu, W.; Christenson, S.D.; Standage, S.; Shen, B. (2002) Biosynthesis of the Enediyne Antitumor Antibiotic C-1027.  Science, 297:1170-1173. (Featured in C & E News, August 19, 2002, p12, and various professional and popular media, and selected by C & E News as Chemistry Highlights 2002, December 16, 2002, pp. 35-48)
2. Christenson, S.D.; Liu, W.; Toney, M.D.; Shen, B. (2003) A Novel 4-Methylideneimidazole-5-one-Containing Tyrosine Aminomutase in Enediyne Antitumor Antibiotic C-1027 Biosynthesis.  J. Am. Chem. Soc. 125:6062-6063.
3.  Christenson, S.D.; Wu, W.; Shen, B.; Toney, M.D (2003) Kinetic Analysis of the 4-Methylideneimidazole-5-one-Containing Tyrosine Aminomutase in Enediyne Antitumor Antibiotic C-1027 Biosynthesis. Biochemistry 42:12708-12718.
4.  Liu, W.; Nonaka, K.; Nie, P.; Zhang, J.; Christenson, S.D.; Bae, J.; Van Lanen, S.G.; Zazopoulos, E.; Farnet, C.M.; Yang, C.F.; Shen, B. (2005) The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC15944 involving two iterative type I polyketide synthase. Chem. Biol. 12:293-302.
5.  Van Lanen, S.; Dorrestein, P.C.; Christenson, S.D.; Liu, W.; Ju, J.; Kelleher, N.L.; Shen, B. (2005) Biosynthesis of the β-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring β-amnoacyl-S-carrier protein intermediates. J. Am. Chem. Soc. 127:11594-11595.
6.  Zhao, C.; Ju, J.; Christenson, S. D.; Smith, W. C.; Song, D.; Zhou, X.; Shen, B.; Deng, Z. (2006) Utilization of the methoxymalony-acyl carrier protein biosynthetic locus for the cloning of the oxazolomycin biosynthetic gene cluster from Streptomyces albus.  J. Bacteriol. 198:4141-4147.
7.  Shen, B.; Cheng, Y.-Q.; Christenson, S. D.; Jiang, H.; Ju, J.; Kwon, H.-J.; Lim, S.-K.; Liu, W.; Nonaka, K.; Seo, J.-W.; Smith, W. C.; Standage, S.; Tang, G.-L.; Van Lanen, S.; Zhang, J. (2007) Polyketide biosynthesis beyond the type I, II, and III polyketide synthase paradigms: a progress report. In ACS Symposium Series 955: Polyketides: Biosynthesis, Biological Activity, and Engineering, Rimando, A. M.; Baerson, S.R. eds., ACS, Washington DC, pp154-166.

Bensheng Li

2001-2003

M.S. (2003)

Thesis title: "Cloning and molecular characterization of seven genes of the fredericamycin biosynthetic cluster from Streptomyces griseus"

Ph.D. program at the Department of Chemistry, UC-Davis, Davis, California

Publications:

1.  Wendt-Pienkowski, E.; Huang, Y.; Zhang, J.; Li, B.; Jiang, H.; Kwon, H.-J.; Hutchinson, C.R.; Shen, B. (2005) Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus. J. Am. Chem. Soc. 127:16442-16452.

Fan Yi

2001-2003

M.S. (2003)

Thesis title: "Cloning and localization of the antitumor antibiotic phleomycin biosynthetic gene cluster from Streptomyces flavoviridis ATCC21892"

Ph.D. program at the Department of Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin

Publications:

1.  Galm, U.; Wendt-Pienkowski, E.; Wang, L.; George, N. P.; Oh, T.-J.; Yi, F.; Tao, M.; Coughlin, J. M; Shen, B. (2009) The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC21892.  Mol. BioSyst. 4:77-90.

Ju-Yun Bae

2002-2004

M.S. (2004)

Thesis title: "Cloning and characterization of neocarzinostatin gene cluster from Streptomyces carzinostaticus"

Ph.D. program at the Molecular and Environmental Toxicology Center, UW-Madison, Madison, Wisconsin

Publications:

1.  Liu, W.; Nonaka, K.; Nie, P.; Zhang, J.; Christenson, S.D.; Bae, J.; Van Lanen, S.G.; Zazopoulos, E.; Farnet, C.M.; Yang, C.F.; Shen, B. (2005) The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC15944 involving two iterative type I polyketide synthase. Chem. Biol. 12:293-302.

Yong (Victor) Huang

2001-2007

Ph.D. (2007)

Thesis title: "Biosynthesis and engineering of anticancer antibiotics fredericamycin from Streptomtces griseus and leinamycin from Streptomyces atroolivaceus"

Professional Scientific Collaborator, The Scripps Research Institute, Scripps Florida, Jupiter, Florida; Tel. 561-228-2470; Email yhuang@scripps.edu

Publications:

1. Du, L.; Cheng, Y.Q.; Ingenhorst, G.; Tang, G.-L.; Huang, Y.; Shen, B. (2003) Hybrid Peptide-Polyketide Natural Products: Biosynthesis and Prospects towards Engineering Novel Molecules in Genetic Engineering, Vol. 25, Setlow, J. K. ed., Kluwer Academic/Plenum Publishers, pp. 227-267.
2.  Wendt-Pienkowski, E.; Huang, Y.; Zhang, J.; Li, B.; Jiang, H.; Kwon, H.-J.; Hutchinson, C.R.; Shen, B. (2005) Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus. J. Am. Chem. Soc. 127:16442-16452.
3.  Huang, Y.; Wendt-Pienkowski, E.; Shen, B. (2006) A dedicated phosphopantetheinyl transferase for the fredericamycin polyketide synthase from Streptomyces griseus. J. Biol. Chem. 281:29660-29668.

Jian Zhang

2001-2007

Ph.D. (2007)

Thesis title: "In vivo and in vitro study of enediyne biosynthesis and engineering of drug carrier protein for tumor targeting drug delivery"

Research Scientist II at Bristol-Myers Squibb, Hopewell, NJ

Publications:

1.  Liu, W.; Nonaka, K.; Nie, P.; Zhang, J.; Christenson, S.D.; Bae, J.; Van Lanen, S.G.; Zazopoulos, E.; Farnet, C.M.; Yang, C.F.; Shen, B. (2005) The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC15944 involving two iterative type I polyketide synthase. Chem. Biol. 12:293-302.
2.  Wendt-Pienkowski, E.; Huang, Y.; Zhang, J.; Li, B.; Jiang, H.; Kwon, H.-J.; Hutchinson, C.R.; Shen, B. (2005) Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus. J. Am. Chem. Soc. 127:16442-16452.
3.  Shen, B.; Cheng, Y.-Q.; Christenson, S. D.; Jiang, H.; Ju, J.; Kwon, H.-J.; Lim, S.-K.; Liu, W.; Nonaka, K.; Seo, J.-W.; Smith, W. C.; Standage, S.; Tang, G.-L.; Van Lanen, S.; Zhang, J. (2007) Polyketide biosynthesis beyond the type I, II, and III polyketide synthase paradigms: a progress report. In ACS Symposium Series 955: Polyketides: Biosynthesis, Biological Activity, and Engineering, Rimando, A. M.; Baerson, S.R. eds., ACS, Washington DC, pp154-166.
4.  Zhang, J.; Van Lanen, S. G.; Ju, J.; Liu, W.; Dorrestein, P. C.; Li, W.; Kelleher, N. L.; Shen, B. (2008) A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 105:1460-1465.

Jane M. Coughlin

2003-2008

Ph.D. (2008)

Thesis title: "Hybrid peptide-polyketide natural product biosynthesis : resistance to the bleomycin family of antitumor antibiotics, beta-amino acid activating adenylation domains, and oxazolomycin polyketide synthases that require discrete aclytransferases for two distinct extender units"

Publications:

1.  Tao, M.; Wang, L.; Wendt-Pienkowski, E.; George, N. P.; Galm, U.; Zhang, G.; Coughlin, J. M.; Shen, B. (2007) The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics. Mol. BioSyst. 3:60-74.
2.  Wang, L.; Yun, B.-S.; George, N. P.; Wendt-Pienkowski, E.; Galm, U.; Oh, T.-J.; Coughlin, J. M.; Zhang, G.; Tao, M.; Shen, B. (2007) The glycopeptide antitumor antibiotic zorbamycin from Streptomyces flavoviridis ATCC 21892: strain improvement and structure Elucidation. J. Nat. Prod. 70:402-406.
3.  Song, D.; Coughlin, J.; Ju, J.; Zhou, X.; Shen, B.; Zhao, C.; Deng, Z. (2008) Alternative method for site-directed mutagenesis of complex polyketide synthase in Streptomyces albus JA3453. Acta Biochim. Biophys. Sinica 40:319-326.
4.  Galm, U.; Wang, L.; Wendt-Pienkowski, E.; Tao, M.; Coughlin, J. M.; Shen, B. (2008) In vivo manipulation of the bleomycin biosynthetic gene cluster in Streptomyces verticillus ATCC15003 revealing new insights into its biosynthetic pathway. J. Biol. Chem. 283:28236-28245.
5.  Galm, U.; Wendt-Pienkowski, E.; Wang, L.; George, N. P.; Oh, T.-J.; Yi, F.; Tao, M.; Coughlin, J. M; Shen, B. (2009) The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC21892.  Mol. BioSyst. 4:77-90.

 Dr. Michael Smanski

2009-2011 

Ph.D. (2011)

Title of research project:
"Platensimycin and platencin biosynthesis and engineering in Streptomyces Platensis"

Postdoctoral position in Prof. Chris Voigt lab, Department of Biological Engineering, MIT, Cambridge, MA;
Email: smanski@mit.edu

Publications:
1. Smanski MJ, Peterson RM, Rajski SR, Shen B (2009) Engineered Streptomyces platensis strains that overproduce antibiotics platensimycin and platencin. Antimicrob. Agents Chemother. 53:1299-1304.
2. Chen Y, Smanski MJ, Shen B (2010) Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation. Appl. Microbiol. Biotechnol. 86:19-25.
3. Yu Z, Smanski MJ, Peterson RM, Marchillo K, Andes D, Rajski SR, Shen B (2010) Engineering ofStreptomyces platensis MA7339 for overproduction of platencin and congeners. Org. Lett. 12:1744-1747.
4. Smanski MJ, Yu Z, Casper J, Lin S, Peterson RM, Chen Y, Wendt-Pienkowski E, Rajski SR, Shen B (2011) Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis. Proc. Natl. Acad. Sci. USA; 108:13498-13503.
5. Smanski MJ, Qu X, Liu W, Shen B (2011) “Biosynthesis of pharmaceutical natural products and their pathway engineering” Chapter 5 in Organic ChemistryBreakthroughs and Perspectives, Ding, K; Dai, L. eds., Wiley-VCH, in press.

 Min Yin

Photo of Min Yin

2010-2012

Dr. Min Yin, who completed his Ph.D. research at TSRI, successfully defended his Ph.D. thesis on May 2, 2012, and has been awarded Ph.D. from the Yunnan University, Yunnan, China.  Min has taken a lecture position at the School of Medicine, Yunnan University.

 Ryan Peterson

 ryanpeterson

2007-2012

Graduate Research Assistant in the Shen lab at UW-Madison and TSRI-Scripps Florida.  Dr. Ryan Peterson successfully defended his Ph.D. thesis on June 4, 2012, and has been awarded Ph.D. from the University of Wisconsin-Madison.

 

 

 

 

 

 

Postdoctoral associates and visiting scholars

Name

Time

Current position

Dr. Liangcheng Du

liangcheng du

1997-2001

Associate Professor, Department of Chemistry, University of Nebraska, Lincoln, Nebraska; Tel. 402-472-2998;
Email: du@unlserve.unl.edu

Dr. Runying Yang

1997-1998

Scottsdale, Arizona

Dr. Cesar Sanchez

cesar sanchez

1997-2000

Locum Associate Editor, Nature Reviews Microbiology, Nature Publishing Group, The Macmillian Bldg 4 Crinan St., London, UK

Dr. Rongkuan Xiang

1998-2000

Scientist, a Biotech company in La Jolla, California

Prof. Doo-Hyun Nam

1998

Professor, Institute of Biotechnology and Department of Pharmacy, Yeungnam University, Gyongsan, Korea

Dr. Scott Standage

1999-2000

Manager, CN Biosciences UK, Cambridge, UK

Dr. Lipin Nie

2001

Assistant Adjunct Professor, Department of Otolaryngology, School of Medicine, UC Davis, Davis, California

Dr. Yi-Qiang (Eric) Cheng

yi-qiang (Eric) Cheng

1999-2003

Associate Professor, Departments of Biological Sciences and Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin; Tel. 414-229-4739, Fax 414-229-3926; Email: ycheng@uwm.edu

Dr. Hyung-Jin Kwon

2000-2003

Associate Professor, Department of Biological Sciences, Division of Bioscience and Bioinformatics, Myongji University, Yongin 449-728, Republic of Korea; Tel. 82-31-330-6470; Email: hjink@mju.ac.kr

Dr. Wen Liu

2000-2003

Professor, National Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, ACS, Shanghai, China

Dr. Gongli Tang

2000-2004

Professor, National Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, ACS, Shanghai, China

Dr. Gudrun Ingenhorst

2001-2002

Germany

Dr. Hao Jiang

2001-2002

Director, Heilongjiang Hongda Bioprocess & Development Center, Harbin, China

Dr. Koichi Nonaka

2001-2003

Senior Director, Biopharmaceutical Research Group I, Biopharmaceutical Technology Research Laboratories, 2716-1, Kurakaka, Akaiwa, Chiyoda-machi, Ohra-gun, Gunman 370-0505, Daiichi Sankyo Co., Ltd, Fukushima, Japan;
Tel. +81-276-86-7342/5002, Fax: +81-276-86-5645; Email: nonaka.koichi.k@daiichisankyo.co.jp

Dr. Tae-Jin Oh

2002-2003

Professor, Department of Pharmaceutical Engineering, SunMoon University, Chungnam 336, Korea; Tel. +82(41)530-2677;
Email: tjoh3782@sunmoon.ac.kr

Dr. Bong-Sik Yun

2002-2004

Senior Researcher, Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University, Jeonbuk, Korea

Dr. Si-Kyu Lim

2002-2006

R & D Director, Genotech, Daejeon, Korea; Telo: 82-42-862-8404; Email: slim@genotech.co.kr

Dr. Jeong-Woo Seo

2004-2006

Applied Microbiology Research Center, Bio-Materials Research Institute (Jeonbuk campus) KRIBB, Korea;  Tel. 82-63-570-5160

Prof. Yuzhong Zhang

2005

Director, Marine Biotechnology Research Center and Professor, State Key Laboratory of Microbial Technology, Shandong University, Jinan, China

Prof. Jiangchun Hu

2005

Professor and Director, Department of Microbial Resources and Microbial Ecology, Institute of Applied Ecology, CAS, Shenyang, China

Prof. Si Zhang

2005

Director, Sanya National Key Research Field Station; Director, Guangdong Key Laboratory of Marine Materia Medica; Professor and Director, South China Sea Institute of Oceanology, CAS, Guangzhou, China

Dr. Dequan Hui

2005-2007

Went back to Germany

Dr. Ikuko Konzone

2006-2007

Went back to Japan

Prof. Yong-Quan Li

2007

Professor of Biochemistry and Molecular Biology; Director, Institute of Biochemistry; Director, Zhejiang Province Key Lab of Microbial Biochemistry and Metabolic Engineering, College of Life Sciences, Zhejiang University, Hangzhou 310058, China
Tel. 086-571-88206632; Email: lyq@zju.edu.cn

Dr. Steven G. Van Lanen

2004-2007

Assistant Professor of Bioorganic and Natural Product Chemistry, College of Pharmacy, University of Kentucky, Lexington, KY
Tel. 859-323-6271, Fax 859-257-7564; Email: svanlanen@uky.edu

Dr. Jianhua Ju

2003-2008

Professor of Chemistry and Chemical Biology, Director, Guangdong Key Laboratory of Marine Materia Medica; Deputy Director, Key Laboratory of Marine Bio-Resources Sustainable Utilization, South China Sea Institute of Oceanology, CAS, Guangzhou 510301, China; Tel. +86-20-89023028 (0); Email: jju@scsio.ac.cn

Dr. Wenli Li

2004-2008

Scientist, Parmaceutical Product Development Inc. (PPD), Madison, WI

Dr. Meifeng Tao

2005-2008

Professor, Shanghai Jiao Tong University; Tel. 86-21-62932943; Email: tao_meifeng@yahoo.com

Dr. Yinggang Luo

2007-2008

Associate Professor, Chengdu Institute of Biology, CAS, Chengdu, China; Tel. +86-28-85229742; Email: yinggluo@cib.ac.cn

Dr. Hui Jiang

2004-2008

Associate Professor, Institute of Biochemisry, College of Life Sciences, Zhejiang University, Zhejiang Province, China;
Tel. +86-571-88208569; Email: jianghuisioc@yahoo.com

Dr. Lixing Zhao

2007-2008

Professor, Yunnan University, Kunming, Yunnan, China

Dr. Ute Galm

2004-2008

Group Leader Spinosyns Metabolic Engineering, Bioprocess R&D, Dow AgroScience, Indianapolis, IN; Tel. 317-337-3547;
Email: uggalm@dow.com

Dr. Shuangjun Lin

2005-2008

Professor, Shanghai Jiaotong University, Shanghai, China

Dr. Jianya Ling

2008-2009

Professor, Shandong University, Jienan, Shandong, China

Dr. Tao Liu

2006-2009

Professor, Tianjin Institute of Industrial Microbiology, CAS, Tianjin, China; Tel. 086-022-24828718; Email: liu_t@tib.cas.cn

Dr. Liyan Wang

2005-2009 

Professor, College of Life Science, Shengzheng University, Shengzheng, China 

Dr. Zhiyang Feng

2006-2009 

Postdoctoral Researcher, Rockefeller University 

Dr. Ninghua Tan

2008-2009

Professor, Kunming Institute of Botany, CAS, Yunnan, China

Evelyn Wendt-Pienkowski 

2001-2010 

Sr. Research Specialist, Department of Bacteriology, UW-Madison, Madison, Wisconsin 

Dr. Claudia Unsin

2008-2010

Trainee Patent Attorney, Hoffmann Eitle Patent Attorneys & Attorneys at Law, Arabellastrasse 4, 81925 Munich, Germany;
Tel. +49 89 92409-0; Email: cunsin@hoffmanneitle.com

Dr. Yihua Chen 

2006-2011 

Professor, Institute of Microbiology, CAS, Beijing 100101, China; Tel. 86-10-62562173; Email: chenyihua@im.ac.cn  

Dr. Guangrong Zhou

2009-2010

Professor and Chair, Department of Pharmaceutical Engineering, College of Chemical Engineering and Technology, Tianjin University, Tianjin, China 

Dr. Wensheng Xiang 

2010

Professor, College of Life Sciences, Northeast Agricultural University, Harbin, China 

Dr. Geoff Horsman

2008-2011 

Assistant Professor of Chemistry, Wilfrid Laurier University, Waterloo, Ontario, Canada; Tel. 519-884-0710 x2985;
Email: ghorsman@wlu.ca

Dr. Scott R. Rajski

2007-2011

Associate Scientist, Division of Pharmaceutical Sciences, School of Pharmacy, UW-Madison

 Xun Guo

xunguo

2012

Ph.D. 2009 - Brown University, Providence, Rhode Island. 

Research area: Stereochemical study in Nanchangmycin synthase module 2 and its dehydratase domain

 Pengfei Xie

pengfei

2012

Ph.D. 2009 - Molecular Microbiology, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences
 

Zhiguo Yu

 Zhiguo

2008 - 2012

Ph.D. 2005 - Shenyang Pharmaceutical University, China.  Major: Pharmaceutical analysis

Dr. Zhiguo Yu has taken a Professor position at Shenyang Agriculture University, China.

Khaled Shaaban Mahmoud

Khaled 

2012 

Ph.D. 2009 - University of Gottingen, Germany.  Ph.D. in organic chemistry.

Thesis: Nafisamycin, Cyclisation Product of a New Enediyne Precursor, Highly Cytotoxic Mansouramycins, Karamomycins Possessing a Novel Heterocyclic Skeleton and Further Unusual Secondary Metabolites from Terrestrial and Marine Bacteria.

Dr. Khaled Mahmoud has taken another postdoctoral position at University of Kentucky.

Shengxiong Huang

 Photo of Shengxiong Huang

2008-2013

2007 - Ph.D. Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China, Prof. Handong Sun 
2004 - M.S. Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China 
1997 - B.S. Shanxi Normal University, Xi’an, Shanxi, China

Dr. Shengxiong Huang will be taking a Professor position at the Kunming Institute of Botany, CAS, Kunming, Yunnan, China. 

Mostafa Ezzat Rateb

mostafarateb3

2012-2013

2011 - Ph.D., Marine and Terrestrial Microbial Natural Products, Marine Biodiscovery Centre, University of Aberdeen, Scotland, U.K.
2000 - BPharm, Faculty of Pharmacy, Cairo University, Egypt

Thomas Kwong

TK

2011-2013

2011 - Ph.D., University of Alberta, Edmonton, AB

2005 - B.Sc., with honors in Cell Biotechnology, University of Alberta, Edmonton, AB

Title of research project:"Regulation of clavam metabolite production in Streptomyces clavuligerus"

Guangbo Xie

Gb

2012-2013

2005 - Ph.D., Medicinal Chemistry, Area of Specialization: Natural Products Chemistry, Sichuan University, West China School of Pharmacy, Chengdu, Sichuan

2002 - M.S., Medicinal Chemistry, Sichuan University

1999 - B.A., Medicinal Chemistry, West China University of Medical Sciences, School of Pharmacy, Chengdu, SichuanPh.D.

Thesis: "Studies on the conversion of the norditerpenoid alkaloids into taxoids"

Dr. Guangbo Xie, who will return to China and resume his position as Associate Professor at School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.

Jeremy Lohman

JRL

2009-2014

2007 - Ph.D., University of Oregon, Eugene, OR, Prof. S. James Remington

2003 - B.S., Washington State University, Pullman, WA

Dr. Jeremy Lohman will be taking an Assistant Professor of Biochemistry in the Department of Biochemistry, Purdue University

Donghui Yang

donghuiyang

2013-2014

1998, 7 – 2000, 10     Postdoctoral Fellow with Prof. Shao-qing Cai        Peking University/School of Pharmaceutical Sciences

1995, 9 – 1998, 7       Ph.D. supervised by Prof. Yong-yan Wang & Prof. Lu-xue Wei    Beijing University of Chinese Medicine

1992, 9 – 1995, 7       M.S. supervised by Prof. Li-juan Liu    Heilongjiang University of Chinese Medicine

1988, 9 – 1992, 7       Bachelor of Sciences, School of Pharmaceutical Sciences,Heilongjiang University of Chinese Medicine

Tingting Huang

tingting

2011-2015

2011 - Ph.D., School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China
2006 - M.Sc., Department of Microbiology, Nanjing Agricultural University

Dr. Tingting Huang will be taking a postdoctoral position in School of Pharmacy, Shanghai Jiao Tong University

Qihui Teng

qihui

2012-2015

2003-2008 - MA.Sc and Ph.D., Microbilogy, Nanjing Agricultural University
2002 - B.E., Qindao Agricultural University

Dr. Qihui Teng will be taking a research assistant position in the School of Life Science and Biotechnology, Shanghai Jiao Tong University

Jakob Fuhrmann

Jakob

2014-2015

2010-Ph.D., Structural Biology, Research Institute of Molecular Pathology, Austria

2005-M.Sc., Molecular Biology, University of Vienna, Austria

Huiming Ge

Huiming

2012-2015

2007 - Ph.D., Natural Product Chemistry, Nanjing University, China

2002 - B.S., Biology, School of Lifescience, Nanjing University

Ph.D. Thesis: "Bioactive metabolites from endophytic fungi and plants"

Ming Ma

MingMa

2011-2016 2006, Ph.D., Pharmaceutical Chemistry, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
2003, M.S., Pharmaceutical Chemistry, Shandong University of Traditional Chinese Medicine, Shandong Province, China

Zhikai Guo

Zhikai

2015-2017 2011 – Ph.D., Natural Product Chemistry, Nanjing University, Nanjing, China
2008 – M.S., Microbiology, Hainan University, Haikou, China
2005 – B.S., Biotechnology, South China University of Tropical Agriculture, Danzhou, China

Ph.D. Thesis: “Bioactive metabolites from endophytic fungi and actinobacteria in plants and insects”

Jianjun Chen

Jianjun

2016-2017 2009 - Ph.D., Organic Chemistry, Lanzhou University, Lanzhou, China
2004 - M.S., Chemical Education, Xinzhou Teacher’s University, Xinzhou, China

HindraHindra

2012-2017 2012 - Ph.D., McMaster University, Canada
2006 - M.Sc., University of Saskatchewan, Canada
2001 - B.Sc., University of Pelita Harapan (UPH), Indonesia

Ph.D. Thesis: "Characterization of novel transcription activators and small RNAs in Streptomyces coelicolor"

Ivana Crnovcic

Ivana Crnovcic

2014-2017

2013 - Ph.D., Technische Universität, Germany

Ph.D. Thesis: "Genetic and enzymatic characterization of the actinomycin biosynthesis in Streptomycesr"

Other graduate students and research technicians

Name

Time

Current position

Eric Lancaster

1995-1996

M.S. from Sacramento State University and teaching in California

Susan Angel

1995-1996

California

Scott Poh

1996-1997

Ph.D. program at Department of Chemistry, UC-Davis, Davis, California

Mei Chen

mei chen

1997-2000

University of Nebraska Redox Biology Center, Lincoln, Nebraska

Sun-Mi Lee

1998

Ph.D. program at Institute of Biotechnology and Department of Pharmacy, Yeungnam University, Gyongsan, Korea

Michael Richardson

1998-1999

California

Steve Crotti

2000-2001

Ph.D. program at Department of Chemistry, UC-Davis, Davis, California

Emily Fogle

2000-2001

Ph.D. program at Department of Chemistry, UC-Davis, Davis, California

Yang Zhang

2001-2002

Ph.D. program at Department of Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin

Juyun Bae

2001-2002

Ph.D. program at the Molecular and Environmental Toxicology Center, UW-Madison, Madison, Wisconsin

Janelle Scharon

2001-2002

Wisconsin

Nicholas P. George

2003-2006

Post-doctoral Research Associate, UW-Madison, Madison, Wisconsin

Guodong Zhang

2005-2007

Food Sciences, UW-Madison, Madison, Wisconsin

Thuy Nguyen

2007-2008

MDTP, UW-madison, Madison, Wisconsin

Paul Dilfer 

2009-2011

Illinois 

2005-2011

Graduate Student, Yunnan Institute of Microbiology, Yunnan University, Kunming, China
Tel. +86 0871 5031339; Email: ym3612003@hotmail.com

Yijun Yan

Photo of Yijun Yan

2011-2013 

Education:
2009-2013 - Ph.D., Biochemistry and Molecular Biology, Northeast Agriculture University, Harbin, P.R. China
2009         - M.S., Biochemistry and Molecular Biology, Northeast Agriculture University, Harbin, P.R. China

Yijun successfully defended his Ph.D. thesis on June 26, 2013 and has been awarded Ph.D. from the Northeast Agricultural University, Harbin, China.

Bo Zhang

Bo

2013-2015

Education:

2011-2015 - Doctoral candidate, Biochemistry and Molecular Biology, Northeast Agriculture University, Harbin, P.R. China

2009-2011 - MA.Sc. in Biochemistry and Molecular Biology, Northeast Agriculture University, Harbin, P.R. China
2005-2009 - B.Eng. in Biology, Northeast Agriculture University, Harbin, P.R. China

Bo Zhang successfully defended his Ph.D. thesis on November 21, 2015, and will be awarded Ph.D. from the Northeast Agricultural University, Harbin, China

Undergraduate students

Name

Time

Current position

Shiang Gwee

1996

McNair Scholar; Associate Scientist II at Gilead Sciences, Oceanside, September-November 2011

Carl Boen

1996

California

Erika Rohr

1996

California

Linda Le

1997

McNair Scholar; Started medical school at Medical College of Wisconsin, Milwaukee, Wisconsin, fall 1998

Lili Zhao

1997

McNair Scholar; Started graduate school at the Pharmacology Program, University of Iowa, Iowa City, IW, fall 1999

Amal Saeed

1997, 1998, 1999

ACS SEED program (for high school students); ACS SEED college scholarship recipient; Started college at UC-Davis, Davis, California, fall 1999

Hilda Alvarez

1999

MURPPS (Mentorship for Undergraduate Research Participants in Physical and Mathematical Sciences) program, UC-Davis, Davis, California

John Welch

2000

California

Leilani Amador

2000

ACS SEED program, California

Ziv R. Lang

2001

California

Eric G. Ponder

2003

Department of Bacteriology, UW-Madison, Madison, Wisconsin

Monica Boyd

2005

From the Southern University-Baton Rouge to participate the REU program, Department of Bacteriology, UW-Madison, Madison, Wisconsin

Yeng Her

2005-2007

Mayo Graduate School post-baccauleate program (M.D./Ph.D)

David G. Bayer 

2008-2009 

Wisconsin 

Drew M. Wuenstel

2008-2010

Wisconsin 

Jeffrey Casper

2009-2010

Wisconsin 

Jillian Zwergel

2009-2010

Wisconsin 

Christina Marcus 

2009 

Medical School, Oregon Health Science University